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| 1 | Alternatives for large-scale production of cultured beef: A review显示文摘Cultured beef is a method where stem cells from skeletal muscle of cows are cultured in vitro to gain edible muscle tissue. For large-scale production of cultured beef, the culture technique needs to become more efficient than today's 2-dimensional(2D) standard technique that was used to make the first cultured hamburger. Options for efficient large-scale production of stem cells are to culture cells on microcarriers, either in suspension or in a packed bed bioreactor, or to culture aggregated cells in suspension. We discuss the pros and cons of these systems as well as the possibilities to use the systems for tissue culture. Either of the production systems needs to be optimized to achieve an efficient production of cultured beef. It is anticipated that the optimization of large-scale cell culture as performed for other stem cells can be translated into successful protocols for bovine satellite cells resulting in resource and cost efficient cultured beef. | Matilda S M Moritz Sanne E L Verbruggen Mark J Post | 2015 | Journal of Integrative Agriculture2015，14，2： | 7 |
| 2 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 3 | Effect of vaccine use in the evolution of Mexican Lineage H5N2 avian influenza virus显示文摘 | Lee C W Sanne D A Suarez D L | 2004 | J Virol2004，78，15： | 1 |
| 4 | Recombination resulting in vindence shift in avian influenza outbreak, Chile显示文摘 | Suarez D L Sanne D A Banks J | 2004 | Emerg Infect Dis2004，10，4： | 1 |
| 5 | Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, non-oxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases显示文摘 | OWEN C A CAMPBELL M A SANNE P L | 1995 | J Cell Biol1995，131，： | 1 |
| 6 | A comprehensive study on the cell chemistry of the sodium superoxide (NaOz) battery显示文摘 | Hartmann P Bender C L Sann J | 2013 | Physical Chemistry Chemical Physics2013，15，11： | 1 |
| 7 | Ultrasound diagnosis of midgut volvulus:the whirlpool sign显示文摘 | Pracros JP Sann L Genin G | 1992 | Pediatr Radiol1992，22，： | 1 |
| 8 | Mathematical model of influenza a virus production in Large- Scale microcarrier culture显示文摘 | MOHLER L FLOCKERZI D SANN H | 2005 | Biotechnology and Bioengineering2005，90，： | 1 |
| 9 | Defined flanking spacers and enhanced proteolysis is essential for eradication of established tumors by an epitope string DNA Vaccine 1 显示文摘 | Velders M P Sanne Weijzen Eiben G L | 2001 | J Immunology2001，166，9： | 1 |
| 10 | Defined flanking spacers and enhanced proteolysis is essential for eradication of established rumors by an epitope string DNA vaccine显示文摘 | Markwin PV Sanne W Gretchen L | 2001 | Immunologv2001，166，： | 1 |
| 11 | VEGF pathway genetic variants as biomarkers of treatment outcome with bevacizumab: an analysis of data from the AViTA and AVOREN randomised trials显示文摘 | Diether Lambrechts Bart Claes Paul Delmar Joke Reumers Massimiliano Mazzone Betül T Yesilyurt Roland Devlieger Chris Verslype Sabine Tejpar Hans Wildiers Sanne de Haas Peter Carmeliet Stefan J Scherer Eric Van Cutsem | 2012 | Lancet Oncology2012，，7： | 1 |
| 12 | Ultrasound diagnosis of midgut volvulus : The whirlpool sign 显示文摘 | Pracros JP Sann L Tran - Minhl VA | 1992 | Pediatr Radiol1992，22，1： | 1 |
| 13 | A comprehensive study on the cell chemistry of the sodium superoxide(Na O2)battery显示文摘 | HARTMANN P BENDER C L SANN J | 2013 | Physical Chemistry Chemical Physics2013，15，11： | 1 |
| 14 | Serum vitamin K1 concentrations after oral administration of vitamin K1 in low birth weight infants显示文摘 | Sann L Leclercq M Guillaumont M | 1985 | J Pediatr1985，107，4： | 1 |
| 15 | Defined flanking spacers and enchanced proteolysis is essential for eradication of ostablished tumors by an epitope string DNA vaccine显示文摘 | Markwin P V Sanne W Gretchen L | 2001 | Immunology2001，166，： | 1 |
| 16 | Effect of vaccine use in the evolution of Mexican Lineage H5N2 avian influenza virus显示文摘 | Lee C W Sanne D A Suarez D L | 2004 | J Virol2004，78，15： | 1 |
| 17 | Ultrasound diagnosis ofmidgut volvulus:the “whirlpool” sign显示文摘 | Pracros JP Sann L Genin G | 1992 | Pediatr Radiol1992，22，： | 1 |
| 18 | Clinical Practice:Chronic fatigue syndrome显示文摘 | CHARLOTTE L SANNE L ELISE M | 2013 | J Pediatr2013，172，10： | 1 |
| 19 | Serumvitamin K1 concentrations after oral administration of vitaminK1 in low birth weight infants显示文摘 | Leclercq M Guill aumont M | 1985 | J Pediatr1985，107，4： | 1 |
| 20 | Surum Vitamin K1 concentrations after oral administration of Vitamin K1 in low birth weight infants 显示文摘 | Sann L Leclercq M Guillamount M Trouyez R Bethenod M Bourgeay-Causse M | 1985 | J Pediatr1985，107，4： | 1 |
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