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| 1 | 在 esophagogastroduodenoscopy 使用 lidocaine 的实用性与 propofol 表现在镇静下面显示文摘 AIM:To determine whether topical lidocaine benefits esophagogastroduoduenoscopy(EGD) by decreasing propofol dose necessary for sedation or procedurerelated complications.METHODS:The study was designed as a prospective,single centre,double blind,randomised clinical trial and was conducted in 2012 between January and May(NCT01489891).Consecutive patients undergoing EGD were randomly assigned to receive supplemental topical lidocaine(L;50 mg in an excipient solution which was applied as a spray to the oropharynx) or placebo(P;taste excipients solution without active substance,similarly delivered) prior to the standard propofol sedation procedure.The propofol was administered as a bolus intravenous(iv) dose,with patients in the L and P groups receiving initial doses based on the patient’s American Society of Anaesthesiologists(ASA) classification(ASAⅠ-Ⅱ:0.50-0.60 mg/kg;ASA Ⅲ-Ⅳ:0.25-0.35 mg/kg),followed by 10-20 mg iv dose every 30-60 s at the anaesthetist’s discretion.Vital signs,anthropometric measurements,amount of propofol administered,sedation level reached,examination time,and the subjective assessments of the endoscopist’s and anaesthetist’s satisfaction(based upon a four point Likert scale) were recorded.All statistical tests were performed by the Stata statistical software suite(Release 11,2009;StataCorp,LP,College Station,TX,United States).RESULTS:No significant differences were found between the groups treated with lidocaine or placebo in terms of total propofol dose(310.7 ± 139.2 mg/kg per minute vs 280.1 ± 87.7 mg/kg per minute,P = 0.15) or intraprocedural propofol dose(135.3 ± 151.7 mg/kg per minute vs 122.7 ± 96.5 mg/kg per minute,P = 0.58).Only when the L and P groups were analysed with the particular subgroups of female,< 65-year-old,and lower anaesthetic risk level(ASA Ⅰ-Ⅱ) was a statistically significant difference found(L:336.5 ± 141.2 mg/kg per minute vs P:284.6 ± 91.2 mg/kg per minute,P = 0.03) for greater total propofol requirements).The total incidence of complications was also similar between the two groups,with the L group showing a complication rate of 32.2%(95%CI:21.6-45.0) and the P group showing a complication rate of 26.7%(95%CI:17.0-39.0).In addition,the use of lidocaine had no effect on the anaesthetist’s or endoscopist’s satisfaction with the procedure.Thus,the endoscopist’s satisfaction Likert assessments were equally distributed among the L and P groups:unsatisfactory,[L:6.8%(95%CI:2.2-15.5) vs P:0%(95%CI:0-4.8);neutral,L:10.1%(95%CI:4.2-19.9) vs P:15%(95%CI:7.6-25.7)];satisfactory,[L:25.4%(95%CI:10-29.6) vs P:18.3%(95%CI:15.5-37.6);and very satisfactory,L:57.6%(95%CI:54-77.7) vs P:66.6%(95%CI:44.8-69.7)].Likewise,the anaesthetist’s satisfaction Likert assessments regarding the ease of maintaining a patient at an optimum sedation level without agitation or modification of the projected sedation protocol were not affected by the application of lidocaine,as evidenced by the lack of significant differences between the scores for the placebo group:unsatisfactory,L:5.8%(95%CI:1.3-13.2) vs P:0%(95%CI:0-4.8);neutral,L:16.9%(95%CI:8.9-28.4) vs P:16.7%(95%CI:8.8-27.7);satisfactory,L:15.2%(95%CI:7.7-26.1) vs P:20.3%(95%CI:11.3-31.6);and very satisfactory,L:62.7%(95%CI:49.9-74.3) vs P:63.3%(95%CI:50.6-74.7).CONCLUSION:Topical pharyngeal anaesthesia is safe in EGD but does not reduce the necessary dose of propofol or improve the anaesthetist’s or endoscopist’s satisfaction with the procedure. | Felipe de la Morena Cecilio Santander Carlos Esteban Beatriz de Cuenca Juan Antonio García Javier Sánchez Ricardo Moreno | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 2 | Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment显示文摘根据相关性,脆弱和认知缺陷与 atrial 纤维性颤动(AF ) 考虑老病人的临床的侧面和管理的 BackgroundAvailable 数据是少见的。学习的目的是根据相关性分析 biodemographic 数据,临床的侧面和 antithrombotic 治疗,吗在patients.MethodsCross部分的老 AF 和学习在 75 年与 3 个月在 Spain.ResultsA 在内部药部门出席了的口头的抗凝剂对待的连续 AF 病人执行了的多中心的脆弱和认知缺陷 837 总计病人( 83.0 ???????????????????吗???????????????????￡?? | Jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando José Ruiz Laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao Carmen Suárez | 2018 | Journal of Geriatric Cardiology2018，15，4： | 2 |
| 3 | Safety and efficacy of colistin in Acinetobacter and Pseudomonas infections: a prospective cohort study显示文摘 | Rosa Reina Elisa Estenssoro Gabriela Sáenz Héctor S. Canales Romina Gonzalvo Gabriela Vidal Gustavo Martins Andrea Das Neves Oscar Santander Carlos Ramos | 2005 | Intensive Care Medicine2005，，8： | 1 |
| 4 | Simulating microwave-heated open systems: Tuning competitive sorption in zeofites显示文摘 | Santander J E Gomez S Malinger K A | 2009 | Journal of Physical Chemistry B2009，113，13： | 1 |
| 5 | In vitro osteoinduction of human mesenchymal stem cells in biomimetic surface modified titanium alloy implants 显示文摘 | Santander S | 2012 | Dent Mater J2012，31，5： | 1 |
| 6 | Maternal and congenitalsyphilis in Bolivia, 1996:prevalence and risk factors 显示文摘 | Southwick KL Blanco S Santander A | 2001 | Bull WorldHealth Organ2001，79，1： | 1 |
| 7 | In vitro osteoinduction of human mesenchymal stem cells in biomimetic surface modified titanium alloy implants显示文摘 | Santander S Alcaine C Lyahyai J | | 0，，05： | 1 |
| 8 | Maternal and con- genital syphilis in Bolivia 1996 prevalence and risk factores显示文摘 | Southwick K L Blaneo S Santander A | 2007 | Bull World Health Organ2007，79，1： | 1 |
| 9 | Monocyte-derived dendritic cells from chagasic patients vs healthy donors secrete differential levels of IL-10 and IL-12 when stimulated with a protein fragment of Trypanosoma cruzi heat-shock protein-70显示文摘 | CUELLAR A SANTANDER S P THOMAS M C | 2008 | Immunol Cell Biol2008，86，3： | 1 |
| 10 | Monocyte- derived dendritic cells from chagasic patients vs healthy donors se- crete differential levels of IL-10 and IL-12 when stimulated with a protein fragment of Trypanosoma cruzi heat-shock protein-70 显示文摘 | Cuellar A Santander S P del Carmen Thomas M | 2008 | Immunology and cell biology2008，86，3： | 1 |
| 11 | Electrochemical reduction of Cr(Ⅵ)in the presence of sodium alginate and its application in water purification显示文摘Chromium(Cr)is used in many manufacturing processes,and its release into natural waters is a major environmental problem today.Low concentrations of Cr(Ⅵ)are toxic to human health and living organisms due to the carcinogenic and mutagenic nature of this mineral.This work examined the conversion of Cr(Ⅵ)to Cr(Ⅲ)via electrochemical reduction using gold electrode in an acidic sodium alginate(SA)solution and subsequent removal of the produced Cr(Ⅲ)-SA by the polymer-enhanced ultrafiltration(PEUF)technique.A solution of SA in nitric acid was used both as an electrolytic medium during the voltammetric measurements and bulk electrolysis and as an extracting agent during the PEUF technique.The electroanalysis of Cr(Ⅵ)was performed by linear sweep voltammetry in the presence of acidic SA solution to study its voltammetric behavior as a function of the Cr(Ⅵ)concentration,pH,presence of Cr(Ⅲ),SA concentration and scan rate.In addition,the quantitative reduction of Cr(Ⅵ)to Cr(Ⅲ)was studied through the bulk electrolysis technique.The results showed efficient reduction with well-defined peaks at approximately 0.3 V vs.Ag/AgCl,using a gold working electrode.As the pH increased,the reduction signal strongly decreased until its disappearance.The optimum SA concentration was 10 mmol/L,and it was observed that the presence of Cr(Ⅲ)did not interfere in the Cr(Ⅵ)electroanalysis.Through the quantitative reduction by bulk electrolysis in the presence of acidic SA solution,it was possible to reduce all Cr(Ⅵ)to Cr(Ⅲ)followed by its removal via PEUF. | Bryan Butter Paola Santander Guadalupe del CPizarro Diego POyarzún Federico Tasca Julio Sánchez | 2021 | Journal of Environmental Sciences2021，33，3： | 1 |
| 12 | Myeobaeterial clearance from sputum is delayed during the first phase of treatment in patients with diabetes显示文摘 | Restrepo BI Fisher-Hoch SP Smith B Jeon S Rahbar MH McCormick JB Nuevo Santander Tuberculosis Trackers | 2008 | Am J Trop Med Hyg2008，79，4： | 1 |
| 13 | In vitro osteoinduction of human mesenchymal stem cel s in biomimetic surface modified titanium al oy implants显示文摘 | Santander S Alcaine C Lyahyai J | | 0，，05： | 1 |
| 14 | The Asd+ -DadB+ dual-plasmid system offers a novel means to deliver multiple protective anti- gens by a recombinant attenuated Salmonella vaccine 显示文摘 | Xin W Wanda S Y Zhang X Santander J Scarpellini G Ellis K | 2012 | Infect Immun2012，80，： | 1 |
| 15 | Monocyte-derived dendritic cells from chagasic patients vshealthy donors secrete differential levels of IL-10and IL-12when stimulated with a protein fragment of Trypanosoma cru-zi heat shock protein-70显示文摘 | CUELLAR A SANTANDER S P THOMAS MDEL C | 2008 | Immunol Cell Biol2008，86，3： | 1 |
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