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| 1 | Ythdc2 is an N^6-methyladenosine binding protein that regulates mammalian spermatogenesis显示文摘N 6-methyladenosine (m 6 一) 是在真核细胞的 mRNA 的最普通的内部修正。它动态地被安装并且搬迁,并且充当 mRNA 新陈代谢,包括干细胞 pluripotency 的调整生物过程,房间区别,和精力动态平衡的新层。m 6 A 被选择有约束力的蛋白质认出;YTHDF1 和 YTHDF3 在音乐会工作影响 m 6包含 A 的 mRNAs, YTHDF2 帮助 mRNA 腐烂,和 YTHDC1 影响它的目标的原子处理。YTHDC2 的生物功能, YTH 蛋白质家庭,的最后的成员仍然保持未知。我们报导 YTHDC2 有选择地绑 m 6 在它的一致主题的 A。YTHDC2 提高它的目标的翻译效率并且也减少他们的 mRNA 丰富。Ythdc2 猛烈老鼠是不肥沃的;男性们让显著地更小的睾丸和女性同窝出生的人与那些相比有显著地更小的卵巢。Ythdc2 猛烈老鼠的细菌房间不经过 zygotene 阶段发展,因此,当成熟分裂开始, Ythdc2 是在睾丸的 upregulated。因此, YTHDC2 是 m 6 在精子发生期间起关键作用的 A 绑定蛋白质。 | Phillip J Hsu Yunfei Zhu Honghui Ma Yueshuai Guo Xiaodan Shi Yuanyuan Liu Meijie Qi Zhike Lu Hailing Shi Jianying Wang Yiwei Cheng Guanzheng Luo Qing Dai Mingxi Liu Xuejiang Guo Jiahao Sha Bin Shen Chuan He | 2017 | Cell Research2017，27，9： | 96 |
| 2 | Therapeutic effect of recombinant tissue plasminogen activator on acute cerebral infarction at different times显示文摘BACKGROUND:The study aimed to compare the therapeutic effect of recombinant tissue plasminogen activator(rt-PA) on the onset of acute cerebral infarction(ACI) at different time points of the first 6 hours.METHODS:A retrospective analysis was conducted in 74 patients who received rt-PA thrombolysis treatment within 4.5 hours after ACI and another 15 patients who received rt-PA thrombolysis treatment between 4.5-6 hours after ACI.RESULTS:National Institute of Health Stroke Scale(NIHSS) scores were statistically decreased in both groups(P>0.05) at 24 hours and 7 days after ACI.There was no significant difference in modified ranking scores and mortality at 90 days after the treatment between the two groups(P>0.05).CONCLUSIONS:The therapeutic effect and mortality of rt-PA treatment in patients with ACI between 4.5-6 hours after the onset of the disease were similar to those in patients who received rtPA within 4.5 hours after the onset of this disease.Therefore,intravenous thrombolytic therapy for ACI within 4.5-6 hours after ACI was effective and safe. | Ming Liu Hai-rong Wang Jia-fu Liu Hao-jun Li Shen-xing Chen Sha Shen Shu-ming Pan | 2013 | World Journal of Emergency Medicine2013，4，3： | 20 |
| 3 | Effects of Salvia miltiorrhiza on intestinal microflora in rats with ischemia/reperfusion liver injury显示文摘BACKGROUND: Hepatic ischemia/reperfusion injury may induce intestinal microflora imbalance. Salvia miltiorrhiza is effective in promoting blood circulation and counteracting peroxidation in tissues. The aim of the present study was to determine the effects of Salvia miltiorrhiza on intestinal mi- croflora, endotoxemia, and bacterial translocation in rats with hepatic I/R injury. METHODS: Sprague-Dawley rats in specific pathogen free grade were divided into 3 groups: group I(n =6) for sham operation: groups ( n = 7) for liver ische- mia for 20 minutes and reperfusion for 22 hours. Group was also pretreated with 4 ml/day of Salvia miltiorrhiza solu- tion (250 mg/kg) by daily gavage for 7 days. The levels of serum alanine aminotransferase (ALT), aspartate amino- transferase (AST), malondialdehyde ( MDA) and supero- xide dismutase ( SOD ) in liver tissues, serum endotoxin, intestinal bacterial counts, intestinal mucosal histology and bacterial translocation were studied. RESULTS: The levels of ALT, AST, plasma endotoxin and MDA in liver tissues were decreased more markedly in group (57.57 ± 18.08 U/L, 147.57 ±40.84 U/L, 0.42 ± 0.144 EU/ml and 0. 52 ±0.19 nmol/mg-prot respectively) in group 295.9±216.92 U/L, 0.80± 0.262 EU/ml and 0.72±0.12 nmol/mg-prot; P <0.05-0.01 respectively). Liver SOD activity was increased more sig- nificantly in group (318.47±64.62 U/mg-prot) than in group U/mg-prot, P<0.05). The counts of Bifidobacteria and Bacteroides increased more significantly in group than in group but were similar to those in group I. Bacterial translocation to the kidney in group was 50% (5/10), whereas no bacterial translocation to the kidney occurred in the other two groups (P <0. 01). Ileal mucosal structure was markedly ameliorated in group as compared with group CONCLUSIONS: Salviae miltiorrhiza could partially restore intestinal microflora balance, improve intestinal mucosal integrity, and reduce bacterial translocation and plasma en- dotoxin in rats with hepatic ischemia/reperfusion injury. | Hui-Chun Xing, Lan-Juan Li, Kai-Jin Xu, Tian Shen, Yun-Bo Chen, Yu Chen, Su-Zhen Fu, Ji-Fang Sheng, Chun-Lei Chen, Jian-Guo Wang, Dong Yan, Fang-Wei Dai and Xiao-Ying Sha Hangzhou, China Key Laboratory of Infectious Diseases, Ministry of Public Health of China, and Institute of Infectious Diseases, Department of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China Zhejiang Academy of Medical Sciences, Hangzhou 310012, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，2： | 14 |
| 4 | Knockdown of OsHox33, a member of the class III homeodomain-leucine zipper gene family, accelerates leaf senescence in rice显示文摘The class III homeodomain-leucine zipper(HD-Zip III)gene family plays important roles in plant growth and development,including regulation of apical embryo patterning,embryonic shoot meristem formation,leaf polarity,vascular development,and meristem function,with a particularly crucial function in leaf development.Although HD-Zip III members are highly conserved in land plants,previous studies,such as genetic analyses based on multiple mutants in Arabidopsis and other plants,suggest that various HD-Zip III family genes have evolved with distinct functions and pleiotropic effects on plant growth and development.In this study,we analyzed a HD-Zip III member,OsHox33,and demonstrated that it plays an important role in age-dependent leaf senescence in rice.We constructed two specific RNAi vectors derived from the 5′-end region and 3′-UTR of OsHox33 to knockdown its expression.Transgenic plants harboring either RNAi construct displayed similar phenotypes of precocious leaf senescence symptoms,suggesting that knockdown of OsHox33 accelerates leaf senescence in rice.pOsHox33::GUS fusion expression and RT-PCR revealed that OsHox33 is highly expressed in young organs,especially in young meristems such as shoot apical meristems,intercalary meristems,and young callus.In addition,real-time PCR indicated that OsHox33 was more highly expressed in young leaves than in old leaves.To further investigate OsHox33 function,we analyzed chloroplast ultrastructure in different-aged leaves of RNAi plants,and found that OsHox33 knockdown accelerated chloroplast degradation,which is consistent with RNAi phenotypes.Finally,real-time PCR studies showed that OsHox33 can regulate the expression of GS1 and GS2,two senescence-associated genes.Taken together,the work presented here provides new insights into the function of HD-Zip III members in plants. | LUAN WeiJiang SHEN Ao JIN ZhiPing SONG SuSheng LI ZhengLong SHA AiHua | 2013 | Science China(Life Sciences)2013，56，12： | 13 |
| 5 | Single-cell RNA sequencing reveals atlas of dairy goat testis cells显示文摘Single-cell RNA sequencing(scRNA-seq)is useful for exploring cell heterogeneity.For large animals,however,little is known regarding spermatogonial stem cell(SSC)selfrenewal regulation,especially in dairy goats.In this study,we described a high-resolution scRNA-seq atlas derived from a dairy goat.We identified six somatic cell and five spermatogenic cell subtypes.During spermatogenesis,genes with significantly changed expression were mainly enriched in the Notch,TGF-β,and Hippo signaling pathways as well as the signaling pathway involved in the regulation of stem cell pluripotency.We detected and screened specific candidate marker genes(TKTL1 and AES)for spermatogonia.Our study provides new insights into goat spermatogenesis and the development of testicular somatic cells. | Xiu-Wei Yu Tong-Tong Li Xiao-Min Du Qiao-Yan Shen Meng-Fei Zhang Yu-Dong Wei Dong-Hui Yang Wen-Jing Xu Wen-Bo Chen Chun-Ling Bai Xue-Ling Li Guang-Peng Li Na Li Sha Peng Ming-Zhi Liao Jin-Lian Hua | 2021 | Zoological Research2021，42，4： | 9 |
| 6 | Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys显示文摘 | Yongchang Chen Yiqiang Cui Bin Shen Yuyu Niu Xiaoyang Zhao Lei Wang Jianying Wang Wei Li Qi Zhou Weizhi Ji Jiahao Sha Xingxu Huang | 2015 | Cell Research2015，25，2： | 8 |
| 7 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 8 | Transforming growth factor-β1 upregulates the expression of CXC chemokine receptor 4 (CXCR4) in human breast cancer MCF-7 cells显示文摘 | Xiao-ping ZHAO Yong-yao HUANG Yu HUANG Ping LEI Ji-lin PENG Sha WU Min WANG Wen-han LI Hui-fen ZHU Guan-xin SHEN | 2010 | Acta Pharmacologica Sinica2010，31，3： | 5 |
| 9 | Comparative analysis of the clinical outcomes between wavefront-guided and conventional femtosecond LASIK in myopia and myopia astigmatism显示文摘AIM:To compare the clinical outcomes of wavefront guided femtosecond LASIK(WFG LASIK)and conventional femtosecond LASIK(NWFG LASIK)in eyes with myopia and myopia astigmatism.METHODS:This was a retrospective,nonrandomized,comparative investigation enrolling 236 eyes of 122 patients(18-50 y)with low&moderate and high myopia.The WFG group including 97 eyes(50 patients)undergone WFG LASIK and the NWFG group including 139 eyes(72 patients)undergone conventional LASIK.Mean efficacy index,high order aberrations(HOAs),pupil size and the quality of visual questionnaire were evaluated 6 mo postoperatively.RESULTS:There is no difference between WFG group(-0.054±0.049 in logMAR)and NWFG group(-0.040±0.056)in uncorrected distance visual acuity(UDVA)postoperatively.The myopia astigmatism is higher in WFG group than that in NWFG group(P<0.05).However,the mean efficacy index(MEI)in the WFG group(1.09±0.106)is better than that in the NWFG group(1.036±0.124;P<0.001).Increased HOAs were observed in NWFG group(0.30±0.196)than that in WFG group(0.146±0.188;P<0.001).The pupil size is larger in WFG group(5.15±0.76 mm)than that in NWFG group(4.32±0.52 mm).The patients are satisfied with the clinical surgery,yet WFG group showed better visual quality using the questionnaire survey.Meanwhile,high myopia would result in worse MEI,HOAs and visual quality than low&moderate myopia.CONCLUSION:WFG and NWFG FS-LASIK are both effective and safe procedures to correct low&moderate and high myopia,but WFG FS-LASIK gives a better postoperative MEI,aberrometric control and predictable outcome.Meanwhile,WFG FS-LASIK is better than NWFG FS-LASIK in correction of myopia astigmatism.Low&moderate myopia allow better clinical outcomes than high myopia using any surgical method. | Xiao Gui Rui Zhang Sha Li Na Zhao Hao-Rui Zhang Yu-Kun Zhou Chen-Yang Huan Chun-Yan Zhao Hong-Ying Wang Hong-Yuan Song Wei Shen Jian-Hua Zhang | 2021 | International Journal of Ophthalmology(English edition)2021，14，10： | 5 |
| 10 | LIN28A inhibits DUSP family phosphatases and activates MAPK signaling pathway to maintain pluripotency in porcine induced pluripotent stem cells显示文摘LIN28A,an RNA-binding protein,plays an important role in porcine induced pluripotent stem cells(piPSCs).However,the molecular mechanism underlying the function of LIN28A in the maintenance of pluripotency in piPSCs remains unclear.Here,we explored the function of LIN28A in piPSCs based on its overexpression and knockdown.We performed total RNA sequencing(RNA-seq)of piPSCs and detected the expression levels of relevant genes by quantitative real-time polymerase chain reaction(qRT-PCR),western blot analysis,and immunofluorescence staining.Results indicated that piPSC proliferation ability decreased following LIN28A knockdown.Furthermore,when LIN28A expression in the shLIN28A2 group was lower(by 20%)than that in the negative control knockdown group(shNC),the pluripotency of piPSCs disappeared and they differentiated into neuroectoderm cells.Results also showed that LIN28A overexpression inhibited the expression of DUSP(dual-specificity phosphatases)family phosphatases and activated the mitogen-activated protein kinase(MAPK)signaling pathway.Thus,LIN28A appears to activate the MAPK signaling pathway to maintain the pluripotency and proliferation ability of piPSCs.Our study provides a new resource for exploring the functions of LIN28A in piPSCs. | Xiao-Long Wu Zhen-Shuo Zhu Xia Xiao Zhe Zhou Shuai Yu Qiao-Yan Shen Ju-Qing Zhang Wei Yue Rui Zhang Xin He Sha Peng Shi-Qiang Zhang Na Li Ming-Zhi Liao Jin-Lian Hua | 2021 | Zoological Research2021，42，3： | 5 |
| 11 | A Rapid and Effective HPLC Method for Identification of Bovis Calculus in Chinese Patent Medicines显示文摘Objective Due to the limited resource and the large demand,many kinds of Bovis Calculus(BC)including artificial Bovis Calculus(ABC),in vivo cultured Bovis Calculus(in vivo CBC),and in vitro cultured Bovis Calculus(in vitro CBC)were used in Chinese patent medicines(CPMs).Previous studies have shown that the chemical constituents of ABC and their properties were different from other BC.The two types of CBC with much higher price than ABC were approximately equivalent with natural Bovis Calculus in quality and clinical effect.The aim of the study is to establish a rapid and effective method for the identification of BC in CPMs.Methods An HPLC method with the higher specificity for analyzing bilirubin was established to distinguish ABC from other three kinds of BC by comparing the change of bilirubin content with the addition of EDTA-2Na as the extraction solvent and stabilizer.Results The bilirubin content in CPMs containing ABC was basically unchanged,while that in CPMs containing other kinds of BC showed significant difference.The proposed method was employed to analyze a variety of CPMs containing Bovis Calculus(CPMBCs)and proven to be universal.Conclusion An effective analytical method is established for the quality control of CPMBCs and further ensures the safety and efficacy of these drugs in clinical practice. | XIA Jing XIA Li WANG Wei-yi SHA Yi-wei WANG Ke JI Shen | 2013 | Chinese Herbal Medicines2013，5，3： | 3 |
| 12 | Complete mitochondrial genome of the Japanese snapping shrimp Alpheus japonicus(Crustacea:Decapoda:Caridea):Gene rearrangement and phylogeny within Caridea显示文摘The complete sequence of the mitochondrial genome of the Japanese snapping shrimp Alpheus japonicus Miers(Crustacea:Decapoda:Caridea) is presented here.A comparative analysis based on the currently available mitochondrial genomic data revealed many previously unknown characteristics of the mitochondrial genomes of caridean shrimps.The A.japonicus mitochondrial genome is 16487 bp long and contains the typical set of 37 metazoan genes.The gene arrangements in the mitochondrial genomes of four previously studied carideans(Macrobrachium rosenbergii,M.nipponense,M.lanchesteri and Halocaridina rubra) were found to be identical to the pancrustacean ground pattern;thus,it was considered that gene rearrangements probably did not occur in the suborder Caridea.In the present study,a translocation of the trnE gene involving inversion was found in Alpheus mitochondrial genomes.This phenomenon has not been reported in any other crustacean mitochondrial genome that has been studied so far;however,the translocation of one transfer RNA gene(trnP or trnT) was reported in the mitochondrial genome of Exopalaemon carinicauda.When the ratios of the nonsynonymous and synonymous substitutions rates(Ka/Ks) for the 13 protein coding genes from two Alpheus species(A.japonicus and A.distinguendus) and three Macrobrachium species(M.rosenbergii,M.nipponense,M.lanchesteri) were calculated,the Ka/Ks values for all the protein coding genes in Alpheus and Macrobrachium mitochondrial genomes were found to be less than 1(between 0.0048 and 0.2057),indicating that a strong purification selection had occurred.The phylogenetic tree that was constructed based on the mitochondrial protein coding genes in the genomes of nine related species indicated that Palaemonidae and Alpheidae formed a monophyly and shared a statistically significant relationship,(Palaemonidae+Alpheidae)+Atyidae,at the family level. | SHEN Xin LI Xiao SHA ZhongLi YAN BinLun XU QiHua | 2012 | Science China(Life Sciences)2012，55，7： | 3 |
| 13 | Preparation of New Cementitious System using Fly Ash and Dehydrated Autoclaved Aerated Concrete显示文摘We experimentally studied the interaction between pozzolanic material(fly ash) and dehydrated autoclaved aerated concrete(DAAC). The DAAC powder was obtained by grinding aerated concrete waste to particles fi ner than 75μm and was then heated to temperatures up to 900 ℃. New cementitious material was prepared by proportioning fly ash and DAAC, named as AF. X-ray diffraction(XRD) was employed to identify the crystalline phases of DAAC before and after rehydration. The hydration process of AF was analyzed by the heat of hydration and non-evaporable water content(Wn). The experimental results show that the highest reactivity of DAAC can be obtained by calcining the powder at 700 ℃ and the dehydrated products are mainly β-C2 S and CaO. The cumulative heat of hydration and Wn was found to be strongly dependent on the replacement level of fl y ash, increasing the replacement level of fl y ash lowered them in AF. The strength contribution rates on pozzolanic effect of fl y ash in AF are always negative, showing a contrary tendency of that of cement-fl y ash system. | 水中和 LU Jianxin TIAN Sufang SHEN Peiliang DING Sha | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，4： | 3 |
| 14 | PNAS:科学家发现新的精子运动调节器显示文摘南京医科大学生殖医学国家重点实验室、基础医学院组织胚胎学系刘明兮课题组与贝勒医学院MartinM.Matzuk课题组、大阪大学MasahitoIkawa课题组等共同解析了一个精子运动调节基因TCTE1,结果发表于《美国科学院院刊》(PNAs)。 | Castaneda, Julio M. Hua, Rong Miyata, Haruhiko Oji, Asami Guo, Yueshuai Cheng, Yiwei Zhou, Tao Guo, Xuejiang Cui, Yiqiang Shen, Bin Wang, Zibin Hu, Zhibin Zhou, Zuomin Sha, Jiahao Prunskaite-Hyyrylainen, Renata Yu, Zhifeng Ramirez-Solis, Ramiro Ikawa, Masahito Matzuk, Martin M. Liu, Mingxi | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 15 | Comparative proteome profile of immature rat ovary during primordial follicle assembly and development显示文摘 | Wang, N. L. Zhang, P. Guo, X. J. Xie, J. Huo, R. Wang, F. Q. Chen, L. Shen, J. Zhou, Z. M. Shi, Q. H. Zhao, B. G. Sha, J. H. | 2009 | 南京医科大学学报(自然科学版)2009，29，11： | 3 |
| 16 | Scaled-up synthesis of defect-rich layered double hydroxide monolayers without organic species for efficient oxygen evolution reaction显示文摘The scaled-up synthesis of organic-free monolayer nanomaterials is highly desirable,especially in obtaining green energy by electrocatalysis.In this study,a method for the scaled-up synthesis of the series of monolayer layered double hydroxides(LDHs)without the addition of organic solvents is reported via the separate nucleation and aging steps process.The resulting monolayer LDHs with the thicknesses of less than 1 nm showed a narrow thickness distribution.X-ray absorption fine-structure revealed that monolayer NiFe-LDH nanosheets have a number of oxygen and metal vacancies defects.As a practical application,monolayer NiFe-LDH nanosheets containing defects showed an enhanced electrocatalytic water oxidation activity compared with that of bulk NiFe-LDH.Density functional theory calculations uncovered that excellent catalytic activity is attributed to vacancies defects.The proposed method is an economical and universally applicable strategy for the scaled-up production of monolayer LDHs. | Haoyuan Chi Jingwen Dong Tian Li Sha Bai Ling Tan Jikang Wang Tianyang Shen Guihao Liu Lihong Liu Luyi Sun Yufei Zhao Yu-Fei Song | 2022 | Green Energy & Environment2022，7，5： | 2 |
| 17 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 18 | Antigen-binding characteristics of AbCD71 and its inhibitory effect on PHA-induced lymphoproliferation显示文摘瞄准:调查准备 recombinant 的 anti-lymphoproliferative 效果 71 单音的同种细胞的抗体(AbCD71 ) 它是创作了的区别(CD ) 的妄想的人 / 鼠科的反簇导出老鼠,抗原绑定变量区域和导出人的经常的区域。方法:在原生质标志建设和 transfection 以后,在 transfectoma 上层清液的 AbCD71 的表示被三明治 ELISA 决定。间接免疫荧光试金被用来测量抗原绑定特征和百分比表示 CD71 的外部血单音的原子房间(PBMC ) 。抗体经由 diethylaminoethyl (DEAE ) 从腹水被净化 -Sephadex A-50 层析然后由 SDS 页识别了。最后,导致公众房产管理局的 PBMC 增长上的 AbCD71 的禁止的效果被甲基 thiazolyl tetrazolium (MTT ) 计算试金。结果:重链(C (H)) 和 AbCD71 的轻链(C (L)) 的经常的领域分别地在人的 Cgamma 家庭和人的 Ckappa 家庭。AbCD71 能与它的原来的鼠科的 mAb 竞争与 CD71 积极的人的白血病房间线 CEM 房间绑。AbCD71 能禁止单音的原子房间增长由 phytohemagglutinin (公众房产管理局) 导致了的外部血以一种剂量依赖者方式的在试管内,特别在时间点 0 和 12 h 在以后感应。没有统计差别什么时候与原来的鼠科的 mAb 相比。结论:AbCD71 是有希望的抑制免疫力的药。我们与妄想的人 / 鼠科的 mAb 堵住 CD71 的途径为延长紧密相联的接枝幸存提供新奇策略。 | Ping LEI Yong HE Qing YE Hui-fen ZHU Xiao-mei YUAN Jing LIE Wei XING Sha WO Wei DAI Xin SHEN Guo-bin WANG Guan-xin SHEN | 2007 | Acta Pharmacologica Sinica2007，28，10： | 2 |
| 19 | An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice显示文摘 | Yue Zhang Rui Guo Yiqiang Cui Zhiping Zhu Yingwen Zhang Hao Wu Bo Zheng Qiuling Yue Shun Bai Wentao Zeng Xuejiang Guo Zuomin Zhou Bin Shen Ke Zheng Mingxi Liu Lan Ye Jiahao Sha | 2017 | Cell Research2017，27，11： | 2 |
| 20 | Effect of Human WEE1 and Stem Cell Factor on Human CD34^+ Umbilical Cord Blood Cell Damage Induced by Chemotherapeutic Agents显示文摘Myelosuppression 是大多数反癌症 drugs.Toachieve myeloprotection 的主要副作用之一,一 bicistronic 向量编码 anti-apoptotic 蛋白质人 WEE1 (WEEIHu ) 和刺激增长的干细胞因素(SCF ) 被产生。在这研究,我们选择了是的人的脐的绳索血 CD34^+cells 在里面在一次尝试到的 vitro 模型调查 whetherWEEIHu ,而非常规药抵抗的基因,能被介绍由象 cisplatin , adriamycin , mitomycin-c 和5氟尿嘧啶那样的化学疗法的代理人救房间免于损坏 .Cellviability 和 cytotoxicity 试金,在文化试金和外表表现 ofphospholipid phosphatidylserine 分析的形成殖民地的单位出现了在 CD34^+cellsprovided 的 WEEIHu 和 SCF 的表示有一些保护的房间。这些调查结果建议 WEEIHu andSCF 的表示可能救 CD34^+cells 免于导致化疗的 myelosuppression。 | Ping LEI Yong HE Wenfang SHI Jilin PENG Sha WU Huifen ZHU Jianguo CHEN Guanxin SHEN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，8： | 2 |
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