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| 1 | High-Efficiency Genome Editing in Arabidopsis Using YAO Promoter-Driven CRISPR/Cas9 System显示文摘 | Yan, Liuhua Wei, Shaowei Wu, Yaorong Hu, Ruolan Li, Hongju Yang, Weicai Xie, Qi | 2015 | Molecular Plant2015，8，12： | 50 |
| 2 | Association of emergency room visits for respiratory diseases with sources of ambient PM2.5显示文摘Previous studies have reported associations of short-term exposure to different sources of ambient fine particulate matter(PM2.5)and increased mortality or hospitalizations for respiratory diseases.Few studies,however,have focused on the short-term effects of source-specific PM2.5 on emergency room visits(ERVs)of respiratory diseases.Source apportionment for PM2.5 was performed with Positive Matrix Factorization(PMF)and generalized additive model was applied to estimate associations between source-specific PM2.5 and respiratory disease ERVs.The association of PM2.5 and total respiratory ERVs was found on lag4(RR=1.011,95%CI:1.002,1.020)per interquartile range(76μg/m3)increase.We found PM2.5 to be significantly associated with asthma,bronchitis and chronic obstructive pulmonary disease(COPD)ERVs,with the strongest effects on lag5(RR=1.072,95%CI:1.024,1.119),lag4(RR=1.104,95%CI:1.032,1.176)and lag3(RR=1.091,95%CI:1.047,1.135),respectively.The estimated effects of PM2.5 changed little after adjusting for different air pollutants.Six primary PM2.5 sources were identified using PMF analysis,including dust/soil(6.7%),industry emission(4.5%),secondary aerosols(30.3%),metal processing(3.2%),coal combustion(37.5%)and traffic-related source(17.8%).Some of the sources were identified to have effects on ERVs of total respiratory diseases(dust/soil,secondary aerosols,metal processing,coal combustion and traffic-related source),bronchitis ERVs(dust/soil)and COPD ERVs(traffic-related source,industry emission and secondary aerosols).Different sources of PM2.5 contribute to increased risk of respiratory ERVs to different extents,which may provide potential implications for the decision making of air quality related policies,rational emission control and public health welfare. | Rui Chi Hongyu Li Qian Wang Qiangrong Zhai Daidai Wang Meng Wu Qichen Liu Shaowei Wu Qingbian Ma Furong Deng Xinbiao Guo | 2019 | Journal of Environmental Sciences2019，31，12： | 8 |
| 3 | Recent Advances in Self-Supported Layered Double Hydroxides for Oxygen Evolution Reaction显示文摘Electrochemical water splitting driven by clean and sustainable energy sources to produce hydrogen is an efficient and environmentally friendly energy conversion technology.Water splitting involves hydrogen evolution reaction(HER)and oxygen evolution reaction(OER),in which OER is the limiting factor and has attracted extensive research interest in the past few years.Conventional noble-metal-based OER electrocatalysts like IrO_(2) and RuO_(2) suffer from the limitations of high cost and scarce availability.Developing innovative alternative nonnoble metal electrocatalysts with high catalytic activity and long-term durability to boost the OER process remains a significant challenge.Among all of the candidates for OER catalysis,selfsupported layered double hydroxides(LDHs)have emerged as one of the most promising types of electrocatalysts due to their unique layered structures and high electrocatalytic activity.In this review,we summarize the recent progress on self-supported LDHs and highlight their electrochemical catalytic performance.Specifically,synthesis methods,structural and compositional parameters,and influential factors for optimizing OER performance are discussed in detail.Finally,the remaining challenges facing the development of self-supported LDHs are discussed and perspectives on their potential for use in industrial hydrogen production through water splitting are provided to suggest future research directions. | Libo Wu Luo Yu Xin Xiao Fanghao Zhang Shaowei Song Shuo Chen Zhifeng Ren | 2020 | Research2020，，1： | 7 |
| 4 | RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes显示文摘There remains a significant gap in our quantitative understanding of crosstalk between apoptosis and necroptosis pathways.By employing the SWATH-MS technique,we quantified absolute amounts of up to thousands of proteins in dynamic assembling/de-assembling of TNF signaling complexes.Combining SWATH-MS-based network modeling and experimental validation,we found that when RIP1 level is below~1000 molecules/cell(mpc),the cell solely undergoes TRADD-dependent apoptosis.When RIP1 is above~1000 mpc,pro-caspase-8 and RIP3 are recruited to necrosome respectively with linear and nonlinear dependence on RIP1 amount,which well explains the co-occurrence of apoptosis and necroptosis and the paradoxical obser-vations that RIP1 is required for necroptosis but its increase down-regulates necroptosis.Higher amount of RIP1(>~46,000 mpc)suppresses apoptosis,leading to necroptosis alone.The relation between RIP1 level and occurrence of necroptosis or total cell death is biphasic.Our study provides a resource for encoding the com-plexity of TNF signaling and a quantitative picture how distinct dynamic interplay among proteins function as basis sets in signaling complexes,enabling RIP1 to play diverse roles in governing cell fate decisions. | Xiang Li Chuan-Qi Zhong Rui Wu Xiaozheng Xu Zhang-Hua Yang Shaowei Cai Xiurong Wu Xin Chen Zhiyong Yin Qingzu He Dianjie Li Fei Xu Yihua Yan Hong Qi Changchuan Xie Jianwei Shuai Jiahuai Han | 2021 | Protein & Cell2021，12，11： | 5 |
| 5 | Competition between Populus euphratica and Tamarix ramosissima seedlings under simulated high groundwater availability显示文摘Desert riparian plants experience high variability in water availability due to hydrological fluctuations. How riparian plants can survive with low water availability has been well studied, however, little is known about the effects of high water availability on plant community structuring. We conducted a mesocosm experiment to test whether seedling competition under simulated high groundwater availability can explain the shift of co-dominance of Populus euphratica and Tamarix ramosissima in early communities to P. euphratica dominance in mature ones along the Tarim River in northwestern China. Seedlings of these two plant species were grown in monoculture and mixture pools with high groundwater availability. Results indicated that the above-ground biomass and relative yield of T. ramosissima were higher than those of P. euphratica. The competitive advantages of T. ramosissima included its rapid response in growth to groundwater enrichment and its water spender strategy, as evidenced by the increased leaf biomass proportion and the inert stomatal response to leaf-to-air vapor pressure deficit(VPD). In comparison, P. euphratica showed a conservative strategy in water use, with a sensitive response to leaf-to-air VPD. Result of the short-term competition was inconsistent with the long-term competition in fields, suggesting that competition exclusion is not the mechanism structuring the desert riparian plant communities. Thus, our research highlights the importance of mediation by environmental fluctuations(such as lessening competition induced by disturbance) in structuring plant communities along the Tarim riparian zones. | WU Guilin JIANG Shaowei LIU Weiyang ZHAO Chengyi LI Jun | 2016 | Journal of Arid Land2016，8，2： | 4 |
| 6 | Diversity, novelty, antimicrobial activity, and new antibiotics of cultivable endophytic actinobacteria isolated from psammophytes collected from Taklamakan Desert显示文摘Three hundred and twenty endophytic actinobacterial strains were isolated from psammophytes collected from Taklamakan Desert and identified. Among them, three strains already had been identified as new species of two genera and sixteen isolates showed relatively low 16 S rRNA similarities < 98.6% to validly described species. Seventy-five of the isolates were selected as representative strains to screen antibacterial activity and mechanism. Forty-seven strains showed antagonistic activity against at least one of the indicator bacteria. Two Streptomyces strains produced bioactive compounds inducing DNA damage, and two Streptomyces strains produced bioactive compounds with inhibitory activity on protein biosynthesis. Notably, the strain Streptomyces sp. 8P21H-1 that demonstrated both strong antibacterial activity and inhibitory activity on protein biosynthesis was prioritized for exploring new antibiotics.Under the strategy of integrating genetics-based discovery program and MS/MS-based molecular networking, two new streptogramin-type antibiotics, i.e., acetyl-griseoviridin and desulphurizing griseoviridin, along with known griseoviridin, were isolated from the culture broth of strain 8P21H-1. Their chemical structures were determined by HR-MS, and 1D and 2D NMR. Desulphurizing griseoviridin and griseoviridin exhibited antibacterial activities by inhibiting translation. | Ting Wang Feina Li Qinpei Lu Gang Wu Zhongke Jiang Shaowei Liu Xugela Habden Elizaveta A.Razumova Ilya A.Osterman Petr V.Sergiev Olga A.Dontsova Xinxin Hu Xuefu You Chenghang Sun | 2021 | Journal of Pharmaceutical Analysis2021，11，2： | 2 |
| 7 | Microstructure and Properties of an Al 6061/Galvanized Plate Fabricated by CMT Welding显示文摘Aluminum alloy 6061 was welded with zinc coated low carbon steel by cold metal transfer (CMT).The microstructure composition,morphology and growth process of the welding joint and the HAZ were researched.The weld area on the side of the galvanized steel sheet mainly contains Fe2Al5.And on the side of the aluminum alloy substrate,it is mainly filled with a needle-like FeAl3.At the same time,Al8Fe2Si is formed at the edge of FeAl3.The zinc-rich region on the side of the aluminum alloy mainly contains an aluminum-zinc solid solution and an aluminum-zinc co-crystal,and the current size had no significant effect on the type and morphology of the compounds produced in the interface layer. | 张琪 张培磊 于治水 YAN Hua SHI Haichuan WU Di LI Shaowei TIAN Yingtao | 2020 | Journal of Wuhan University of Technology(Materials Science)2020，35，5： | 2 |
| 8 | Prediction of a common neutralizing epitope of H5N1 avian influenza virus by in silico molecular docking显示文摘The H5N1 avian influenza virus (AIV) has widely spread in Asia, Europe and Africa, making a large amount of economic loss. Recently, our research group has screened a common neutralizing mono- clonal antibody named 8H5, which can neutralize almost all H5 subtype AIV ever isolated so far. Obvi- ously, this monoclonal antibody would benefit for research and development of the universal AIV vac- cine and design of the drug against H5N1 AIV in high mutation rate. In this study, the homology mod- eling was applied to generate the 3D structure of 8H5 Fab fragment, and 'canonical structure' method was used to define the specified loop conformation of CDR regions. The model was subjected to en- ergy minimization in cvff force field with Discovery module in Insight II program. The resulting model has correct stereochemistry as gauged from the Ramachandran plot calculation and good 3D-structure compatibility as assessed by interaction energy analysis, solvent accessible surface (SAS) analysis, and Profiles-3D approach. Furthermore, the 8H5 Fab model was subjected to docking with three H5 subtype hemagglutinin (HA) structures deposited in PDB (ID No: 1jsm, 2ibx and 2fk0) respectively. The result indicates that the three docked complexes share a common binding interface, but differ in bind- ing angle related with HA structure similarity between viral subtypes. In the light of the three HA inter- faces with structural homology analysis, the common neutralizing epitope on HA recognized by 8H5 consists of 9 incontinuous amino acid residues: Asp68, Asn72, Glu112, Lys113, Ile114, Pro118, Ser120, Tyr137, Tyr252 (numbered as for 1jsm sequence). The primary purpose of the present work is to provide some insight into structure and binding details of a common neutralizing epitope of H5N1 AIV, thereby aiding in the structure-based design of universal AIV vaccines and anti-virus therapeutic drugs. | YAN YuanQing LI ShaoWei YANG ChunYan LUO WenXin WANG MingQiao CHEN YiXin LUO HaiFeng wu Ting ZHANG Jun XIA NingShao | 2008 | Chinese Science Bulletin2008，53，6： | 2 |
| 9 | Association of Heart Rate Variability in Taxi Drivers with Marked Changes in Particulate Air Pollution in Beijing in 2008显示文摘 | Wu Shaowei Deng Furong Niu Jie Huang Qinsheng Liu Youcheng Guo Xinbiao | 2010 | Environmental Health Perspectives2010，，1： | 1 |
| 10 | Effect of anaerobic reaction time on denitrifying phosphorus removal and N 2 O production显示文摘 | Yayi Wang Junjun Geng Zhongjia Ren Weitao He Meiyan Xing Min Wu Shaowei Chen | 2011 | Bioresource Technology2011，，10： | 1 |
| 11 | Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children:A Repeated-Measure Panel Study显示文摘Ozone is one of the major gaseous pollutants associated with short-term adverse cardiopulmonary effects,even at concentrations below the current indoor air quality limits.However,the underlying biological mechanisms of cardiorespiratory changes with exposure to ozone remain unclear.To further explore molecular linkages between indoor ozone exposure and relevant cardiorespiratory effects,a repeated-measure panel study including 46 schoolchildren was conducted and real-time exposure measurements including ozone were performed inside classrooms every weekday during the study period.Repeated health measurements and urine sample collection were conducted in each participant.Ultra-high-performance liquid chromatography/tandem mass spectrometry and meet-in-metabolite approach were used in metabolomics analysis.Methods including mixed-effect models were adopted to identify metabolites associated with ozone exposure or health indices.Nine metabolites were found to be associated with ozone after mixed-effect model analysis,which are mainly involved in amino acid and bile acid metabolism.Boys may have a greater decrease in bile acid and RNA related metabolites.Four of the nine ozone-related metabolites were also associated with cardiorespiratory function indices.Furthermore,26.67%of the positive association between ozone and heart rate was mediated by cholestane-3,7,12,25-tetrol-3-glucuronide.Exposure to ozone below the current indoor standards was associated with the deteriorated cardiovascular function by disturbing bile acid and endogenous nitric oxide-related oxidation and inflammation,and associated with the exacerbated airway inflammation by reducing GPx-related anti-oxidation.The results provide metabolic evidence of the cardiorespiratory effects of indoor ozone exposure.Indoor ozone pollution should be controlled further,and more attention should be paid to preventing its adverse health effects,especially in children. | Shan Liu Qingyu Huang Xi Zhang Wei Dong Wenlou Zhang Shaowei Wu Di Yang Bingru Nan Jie Zhang Heqing Shen Xinbiao Guo Furong Deng | 2021 | The Innovation2021，2，1： | 1 |
| 12 | Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal显示文摘Thimerosal has been widely used as a preservative in drug and vaccine products for decades.Due to the strong propensity to modify thiols in proteins,conformational changes could occur due to covalent bond formation between ethylmercury(a degradant of thimerosal)and thiols.Such a conformational change could lead to partial or even complete loss of desirable protein function.This study aims to investigate the effects of thimerosal on the capsid stability and antigenicity of recombinant human papillomavirus(HPV)18 virus-like particles(VLPs).Dramatic destabilization of the recombinant viral capsid upon thimerosal treatment was observed.Such a negative effect on the thermal stability of VLPs preserved with thimerosal was shown to be dependent on the thimerosal concentration.Two highly neutralizing antibodies,13H12 and 3C3,were found to be the most sensitive to thimerosal treatment.The kinetics of antigenicity loss,when monitored with 13H12 or 3C3 as probes,yielded two distinctly different sets of kinetic parameters,while the data from both monoclonal antibodies(mAbs)followed a biphasic exponential decay model.The potential effect of thimerosal on protein function,particularly for thiolcontaining proteinaceous active components,needs to be comprehensively characterized during formulation development when a preservative is necessary. | Xiaofen Huang Yike Li Meifeng Nie Mingxi Yue Yufang Li Zhijie Lin Huirong Pan Mujin Fang Ting Wu Shaowei Li Jun Zhang Ningshao Xia Qinjian Zhao | 2021 | Journal of Pharmaceutical Analysis2021，11，5： | 1 |
| 13 | 显示文摘 | Wu XianMing Wang ShaoWei | 2001 | Materials Research Bulletin2001，36，： | 1 |
| 14 | Synthesis and characterization of LiMn2O4 powders by the combustion-assisted sol- gel technique显示文摘 | Wu Xianming Li Xinhai Wang Shaowei | 2004 | Materials Chemistry and Physics2004，84，1： | 1 |
| 15 | Double inlet pulse tube refrigerators : an important improvement 显示文摘 | Zhu Shaowei Wu Peiyi Chen Zhongqi | 1990 | Cryo- genics1990，30，6： | 1 |
| 16 | Acoustic Prediction and Risk Evaluation of Shallow Gas in Deep-Water Areas显示文摘Shallow gas is a potential risk in deep-water drilling that must not be ignored,as it may cause major safety problems,such as well kicks and blowouts.Thus,the pre-drilling prediction of shallow gas is important.For this reason,this paper conducted deep-water shallow gas acoustic simulation experiments based on the characteristics of deep-water shallow soil properties and the theory of sound wave speed propagation.The results indicate that the propagation speed of sound waves in shallow gas increases with an in-crease in pressure and decreases with increasing porosity.Pressure and sound wave speed are basically functions of the power expo-nent.Combined with the theory of sound wave propagation in a saturated medium,this paper establishes a multivariate functional relationship between sound wave speed and formation pressure and porosity.The numerical simulation method is adopted to simulate shal-low gas eruptions under different pressure conditions.Shallow gas pressure coefficients that fall within the ranges of 1.0-1.1,1.1-1.2,and exceeding 1.2 are defined as low-,medium-,and high-risk,respectively,based on actual operations.This risk assessment me-thod has been successfully applied to more than 20 deep-water wells in the South China Sea,with a prediction accuracy of over 90%. | YANG Jin WU Shiguo TONG Gang WANG Huanhuan GUO Yongbin ZHANG Weiguo ZHAO Shaowei SONG Yu YIN Qishuai XU Fei | 2022 | Journal of Ocean University of China2022，21，5： | 1 |
| 17 | A Sin- gle Stage Double Inlet Pulse Tube Refrigerator Capable of Reaching 42 K 显示文摘 | ZHU Shaowei WU Peiyi CHEN Zhongqi | 1990 | Cryogenics1990，30，： | 1 |
| 18 | Silver nanocubes monolayers as a SERS substrate for quantitative analysis显示文摘Surface-enhanced Raman scattering(SERS)is a powerful spectroscopic tool in quantitative analysis of molecules,where the substrate plays a critical role in determining the detection performance.Herein,a silver nanocubes/polyelectrolyte/gold film sandwich structure was prepared as a reproducible,highperformance SERS substrate by the wate r/oil inte rfacial assembly method.In addition to the hot spots on the nanocubes surface,the edge-to-edge interspace of the Ag nanocubes led to marked enhancement of the SERS intensity,with a limit of detection of 10~(11)mol/L and limit of quantitation of 10~(10)mol/L for crystal violet.When rhodamine 6 G and crystal violet were co-adsorbed on the Ag nanocube surfaces,the characteristic SERS peaks of the two molecules remained well resolved and separated,and the peak intensities varied with the respective concentration,which could be exploited for concurrent detection of dual molecules.Results from this work indicate that organized ensembles of Ag nanocubes can serve as effective SERS substrate can for sensitive analysis for complex molecular systems. | Ziang Zhou Xiuhui Bai Peishen Li Changzheng Wang Ming Guo Yang Zhang Peiren Ding Shaowei Chen Yunyun Wu Qiang Wang | 2021 | Chinese Chemical Letters2021，32，4： | 1 |
| 19 | A homologous and molecular dual-targeted biomimetic nanocarrier for EGFR-related non-small cell lung cancer therapy显示文摘The abnormal activation of epidermal growth factor receptor(EGFR)drives the development of non-small cell lung cancer(NSCLC).The EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked efficacy in patients with NSCLC who have an EGFR mutation.However,free osimertinib administration exhibits an inadequate response in vivo,with only~3%patients demonstrating a complete clinical response.Consequently,we designed a biomimetic nanoparticle(CMNP^(@Osi))comprising a polymeric nanoparticle core and tumor cell-derived membrane-coated shell that combines membrane-mediated homologous and molecular targeting for targeted drug delivery,thereby supporting a dual-target strategy for enhancing osimertinib efficacy.After intravenous injection,CMNP^(@Osi)accumulates at tumor sites and displays enhanced uptake into cancer cells based on homologous targeting.Osimertinib is subsequently released into the cytoplasm,where it suppresses the phosphorylation of upstream EGFR and the downstream AKT signaling pathway and inhibits the proliferation of NSCLC cells.Thus,this dual-targeting strategy using a biomimetic nanocarrier can enhance molecular-targeted drug delivery and improve clinical efficacy. | Bin Xu Fanjun Zeng Jialong Deng Lintong Yao Shengbo Liu Hengliang Hou Yucheng Huang Hongyuan Zhu Shaowei Wu Qiaxuan Li Weijie Zhan Hongrui Qiu Huili Wang Yundong Li Xianzhu Yang Ziyang Cao Yu Zhang Haiyu Zhou | 2023 | Bioactive Materials2023，，9： | 1 |
| 20 | Experimental exploration of five-qubit quantum error-correcting code with superconducting qubits显示文摘Quantum error correction is an essential ingredient for universal quantum computing.D espite tremendous experimental efforts in the study of quantum error correction,to date,there has been no demonstration in the realis ation of universal quantum error-correcting code,with the subsequent verification of all key features including the identification of an arbitrary physical error,the capability for transversal manipulation of the logical state and state decoding.To address this challenge,we experimentally realise the [5,1,3]code,the so-called smallest perfect code that permits corrections of generic single-qubit errors.In the experiment,having optimised the encoding circuit,we employ an array of superconducting qubits to realise the [5,1,3] code for several typical logical states including the magic state,an indispensable resource for realising non-Clifford gates.The encoded states are prepared with an average fidelity of 57.1(3)% while with a high fidelity of 98.6(1)% in the code space.Then,the arbitrary single-qubit errors introduced manually are identified by measuring the stabilisers.We further implement logical Pauli operations with a fidelity of 97.2(2)% within the code space.Finally,we realise the decoding circuit and recover the input state with an overall fidelity of 74.5(6)%,in total with 92 gates.Our work demonstrates each key aspect of the [5,1,3] code and verifies the viability of experimental realisation of quantum error-correcting codes with superconducting qubits. | Ming Gong Xiao Yuan Shiyu Wang Yulin Wu Youwei Zhao Chen Zha Shaowei Li Zhen Zhang Qi Zhao Yunchao Liu Futian Liang Jin Lin Yu Xu Hui Deng Hao Rong He Lu Simon C.Benjamin Cheng-Zhi Peng Xiongfeng Ma Yu-Ao Chen Xiaobo Zhu Jian-Wei Pan | 2022 | National Science Review2022，9，1： | 1 |
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