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| 1 | Increased expression of tumor necrosis factor-a is associated with advanced colorectal cancer stages显示文摘AIM:To detect the expression of tumor necrosis factor-a(TNF-a)in colorectal cancer(CRC)cells among Saudi patients,and correlate its expression with clinical stages of cancer.METHODS:Archival tissue specimens were collected from 30 patients with CRC who had undergone surgical intervention at King Khalid University Hospital.Patient demographic information,including age and gender,tumor sites,and histological type of CRC,was recorded.To measure TNF-a m RNA expression in CRC,total RNA was extracted from tumor formalin-fixed,paraffinembedded,and adjacent normal tissues.Reverse transcription and reverse transcription polymerase chain reaction were performed.Colorectal tissue microarrays were constructed to investigate the protein expression of TNF-a by immunohistochemistry.RESULTS:The relative expression of TNF-a m RNA in colorectal cancer was significantly higher than that seen in adjacent normal colorectal tissue.High TNF-a gene expression was associated with StageⅢandⅣneoplasms when compared with earlier tumor stages(P=0.004).Eighty-three percent of patients(25/30)showed strong TNF-a positive staining,while only 10%(n=3/30)of patients showed weak staining,and 7%(n=2/30)were negative.We showed the presence of elevated TNF-a gene expression in cancer cells,which strongly correlated with advanced stages of tumor.CONCLUSION:High levels of TNF-a expression could be an independent diagnostic indicator of colorectal cancer,and targeting TNF-a might be a promising prognostic tool by assessment of the clinical stages of CRC. | Omar A Al Obeed Khayal A Alkhayal Abdulmalik Al Sheikh Ahmad M Zubaidi Mansoor-Ali Vaali-Mohammed Robin Boushey James H Mckerrow Maha-Hamadien Abdulla | 2014 | World Journal of Gastroenterology2014，20，48： | 8 |
| 2 | Effect of hyperoxia on vascular endothelial growth factor levels in a wound model显示文摘 | Sheikh A Y Gibson J J Rollins M D | 2000 | Arch Surg2000，135，11： | 1 |
| 3 | Analytical model for concrete confinement in tied columns 显示文摘 | Sheikh S A Uzumeri S M | 1982 | Journal of the Structural Division ASCE1982，108，12： | 1 |
| 4 | Effica- cy of dexmedetomidine in suppressing cardiovascular and hormonal responses to general anaesthesia for caesarean delivery: a dose -re- sponse study显示文摘 | EL TAHAN M R MOWAFI H A AL SHEIKH L H | 2012 | Int J Obstet Anesth2012，21，3： | 1 |
| 5 | Analytical model for concrete confine- ment in tied columns显示文摘 | Sheikh S A Uzumeri S M | 1982 | Journal of the Structural Division1982，108，12： | 1 |
| 6 | The development of live load for long span bridges显示文摘 | Nowak A S Lutomirska M Sheikh Ibrahim F I | 2010 | Bridge Structures-Assessment Design&Construction2010，6，1： | 1 |
| 7 | Role of ultrasonography in blunt abdominal trauma,a prospective study显示文摘 | Al-Zayat I Sheikh M Mousa I Behbe-hani A | 1996 | Eur J Surg1996，162，： | 1 |
| 8 | A Reliability Model For Fatigue Life Characterization显示文摘 | | 1995 | International Journal of Fatigue1995，17，2： | 1 |
| 9 | Investigation of Heat Partition in High Speed Turning of High Strength Alloy Steel显示文摘 | Abukhshim N A Mativenga P T Sheikh M A | 2005 | International Journal of Machine Tools and Manufacture2005，45，15： | 1 |
| 10 | Retinoic acid and estrogen modulation of insulin-like growth factor binding protein-4 gene expression and the estrogen receptor status of human breast carcinoma cells显示文摘 | SHEIKH M S SHAO Z M HUSSAIN A | 1993 | Biochemical and Biophysical Research Communications1993，193，3： | 1 |
| 11 | A probabilistic approach to the maintenance of heat-transfer equipment subject to fouling显示文摘 | Zubair S M Sheikh A K Shaik M N | 1992 | Energy1992，17，8： | 1 |
| 12 | Analytical model for concrete confinement in tied columns 显示文摘 | Sheikh S A Uzumeri S M | 1982 | J Structural Division ASCE1982，108，12： | 1 |
| 13 | Beam-column moment connections for composite frames:part 1显示文摘 | Sheikh T M Deierlein G G Yura J A | 1989 | Journal of Structural Engineering1989，115，11： | 1 |
| 14 | Role of p53 family members in apoptosis 显示文摘 | Sheikh M S Fornace Jr A J | 2000 | Journal of Cellular Physiology2000，182，： | 1 |
| 15 | Bernstein reliability model:derivation and estimation of parameters显示文摘 | Ahmad M Sheikh A K | 1984 | Reliability Engineering1984，，8： | 1 |
| 16 | Multi- quasiparticle potential-energy surfaces显示文摘 | Xu F R Walker P M Sheikh J A | 1998 | Physics Letter B1998，435，34： | 1 |
| 17 | A statistical evaluation of recent full reference image quality assessment algorith- m显示文摘 | Sheikh H R Sabir M F Bovik A C | 2006 | IEEE Transactions on linage Processing2006，15，11： | 1 |
| 18 | A maintenance strategy for heat-transfer subject to fouling:a probabilistic approach显示文摘 | Zubair S M Sheikh A K Budair M O | 1997 | ASME J Heat Transfer1997，119，3： | 1 |
| 19 | Beam-column moment connections for composite frames:part 2显示文摘 | Deierlein G G Sheikh T M Yura J A | 1989 | Journal of Structural Engineering1989，115，11： | 1 |
| 20 | Laparoscopic versus open partial nephrectomy显示文摘 | Beasley KA AL Omar M Sheikh A | 2004 | Urology2004，64，3： | 1 |
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