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| 1 | Deep Learning in Medical Ultrasound Analysis: A Review显示文摘Ultrasound (US) has become one of the most commonly performed imaging modalities in clinical practice. It is a rapidly evolving technology with certain advantages and with unique challenges that include low imaging quality and high variability. From the perspective of image analysis, it is essential to develop advanced automatic US image analysis methods to assist in US diagnosis and/or to make such assessment more objective and accurate. Deep learning has recently emerged as the leading machine learning tool in various research fields, and especially in general imaging analysis and computer vision. Deep learning also shows huge potential for various automatic US image analysis tasks. This review first briefly introduces several popular deep learning architectures, and then summarizes and thoroughly discusses their applications in various specific tasks in US image analysis, such as classification, detection, and segmentation. Finally, the open challenges and potential trends of the future application of deep learning in medical US image analysis are discussed. | Shengfeng Liu Yi Wang Xin Yang Baiying Lei Li Liu Shawn Xiang Li Dong Ni Tianfu Wang | 2019 | Engineering2019，5，2： | 24 |
| 2 | Climate and environment reconstruction during the Medieval Warm Period in Lop Nur of Xinjiang, China显示文摘We made multi-proxy analysis of 14C, grain size, microfossils, plant seeds, and geochemical elements on samples from a profile in the central West Lake of Lop Nur. The grain size suggests relatively stable sedimentary environment around the Medieval Warm Period (MWP) with weak storm effect, which is followed by frequent strong storm events. Abundant microfossils and plant seeds in this stage indicate a warm and humid fresh to brackish lake environment. C, N, and stable elements are high in content in the sediments while Rb/Sr, Ba/Sr, and Ti/Sr are in a steady low level. In addition, plenty of red willows lived here prior to about 700 a B.P., indicating a favorable environmental condition. The results indicate that the environment in Lop Nur and its west bank turned to be favorable at about 2200 a B.P., where the Loulan Culture began to thrive. Then the climate and environment came to be in the good condition in the Tang and Song Dynasties, when the storm effect became weaker, rainfall increased and the salty lake water turned to be brackish to fresh lake water. Hence, limnic biomass increased with higher species diversity. | MA ChunMei WANG FuBao CAO QiongYing XIA XunCheng LI ShengFeng Li XuSheng | 2008 | Chinese Science Bulletin2008，53，19： | 13 |
| 3 | Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates显示文摘MyD88 独立的小径,发信号的二关键 TLR 之一发送,被认为是脊椎动物革新。然而,一个新奇 Toll/interleukin-1 受体(TIR ) 适配器,指明的 bbtTICAM,在基础脊索动物文昌鱼被识别,连接这条小径到无脊椎动物。bbtTICAM 的蛋白质建筑学类似于脊椎动物 TICAM1 的(包含 TIR 适配器 molecule-1,也作为 TRIF 知道) 当种系发生的分析基于 TIR 领域显示了那时, bbtTICAM 是脊椎动物 TICAM1 和 TICAM2 的最旧的 ortholog (包含 TIR 适配器 molecule-2,是也知道电车) 。类似于人的 TICAM1, bbtTICAM 激活 NF-κ以由与受体交往蛋白质交往的一种 MyD88 独立的方式的 B (裂开) 经由它的 RHIM 主题。如此的激活要求 bbtTICAM 形成 homodimers 在里面内涵体,和它可以被文昌鱼 SARM 否定地调整(无菌的 α并且犰狳包含主题的蛋白质) 并且 TRAF2。然而, bbtTICAM 没导致类型的生产我干扰素。因此,我们的学习不仅介绍脊椎动物 TICAM1 和 TICAM2 的祖先的特征,而且从基础脊索动物揭示 MyD88 独立的小径的进化起源,它将帮助理解脊椎动物 TLR 网络的开发。 | Manyi Yang Shaochun Yuan Shengfeng Huang Jun Li Liqun Xu Huiqing Huang Xin Tao Jian Peng Anlong Xu | 2011 | Cell Research2011，21，10： | 5 |
| 4 | A review of real-time multi-GNSS precise orbit determination based on the filter method显示文摘Stable and reliable high-precision satellite orbit products are the prerequisites for the positioning services with high performance.In general,the positioning accuracy depends strongly on the quality of satellite orbit and clock products,especially for absolute positioning modes,such as Precise Point Positioning(PPP).With the development of real-time services,real-time Precise Orbit Determination(POD)is indispensable and mainly includes two methods:the ultra-rapid orbit prediction and the real-time filtering orbit determination.The real-time filtering method has a great potential to obtain more stable and reliable products than the ultra-rapid orbit prediction method and thus has attracted increasing attention in commercial companies and research institutes.However,several key issues should be resolved,including the refinement of satellite dynamic stochastic models,adaptive filtering for irregular satellite motions,rapid convergence,and real-time Ambiguity Resolution(AR).This paper reviews and summarizes the current research progress in real-time filtering POD with a focus on the aforementioned issues.In addition,the real-time filtering orbit determination software developed by our group is introduced,and some of the latest results are evaluated.The Three-Dimensional(3D)real-time orbit accuracy of GPS and Galileo satellites is better than 5 cm with AR.In terms of the convergence time and accuracy of kinematic PPP AR,the better performance of the filter orbit products is validated compared to the ultra-rapid orbit products. | Yidong Lou Xiaolei Dai Xiaopeng Gong Chenglong Li Yun Qing Yang Liu Yaquan Peng Shengfeng Gu | 2022 | Satellite Navigation2022，3，3： | 4 |
| 5 | Diatom-based reconstruction of Holocene environmental changes in Angren Lake,Southern Tibet显示文摘Based on the diatom analysis the climatic sequence between 11 000 and 6 000 aBP in Angren, southern Tibet is established, i.e. cold period (11 095-9 970 aBP)→temperate period (9 970-9 870 aBP)→Anathermal (9 870-9 770 aBP)→cool-dry period (9 770-8 740 aBP) →super-megathermal (8 740-8 590 aBP)→Megathermal (8 590-5 970 aBP). And the opinion that the reaction of diatom to temperature change is more sensitive than to other ecological factors has been pointed out and certified. | Shengfeng Li Fubao Wang Jie Zhang Xuhui Shen Zhaoqi Zeng | 1999 | Chinese Science Bulletin1999，44，12： | 3 |
| 6 | Safety,tolerability,and pharmacokinetics of BAT8001 in patients with HER2-positive breast cancer:An open-label,dose-escalation,phase I study显示文摘Background:The introductions of anti-human epidermal growth factor receptor-2(HER2)agents have significantly improved the treatment outcome of patients with HER2-positive breast cancer.BAT8001 is a novel antibodydrug conjugate targeting human epidermal growth factor receptor-2(HER2)-expressing cells composed of a trastuzumab biosimilar linked to the drug-linker Batansine.This dose-escalation,phase I study was designed to assess the safety,tolerability,pharmacokinetics,and preliminary anti-tumor activity of BAT8001 in patients with HER2-positive locally advanced or metastatic breast cancer.Methods:This trial was conducted in subjects with histologically confirmed HER2-positive breast cancer(having evaluable lesions and an Eastern Cooperative Oncology Group performance status of 0 or 1)using a 3+3 design of escalating BAT8001 doses.Patients received BAT8001 intravenously in a 21-day cycle,with dose escalation in 5 cohorts:1.2,2.4,3.6,4.8,and 6.0 mg/kg.The primary objective was to evaluate the safety and tolerability of BAT8001.Preliminary activity of BAT8001 was also assessed as a secondary objective.Results:Between March 2017 to May 2018,29 HER2-positive breast cancer patients were enrolled.The observed dose-limiting toxicities were grade 4 thrombocytopenia and grade 3 elevated transaminase.The maximum tolerated dose was determined to be 3.6 mg/kg.Grade 3 or greater adverse events(AEs)occurred in 14(48.3%)of 29 patients,including thrombocytopenia in 12(41.4%)patients,aspartate aminotransferase increased in 4(13.8%)patients,γ-glutamyl transferase increased in 2(6.9%)patients,alanine aminotransferase increased in 2(6.9%)patients,diarrhea in 2(6.9%)patients.Objective response was observed in 12(41.4%,95%confidence interval[CI]=23.5%-61.1%)and disease control(including patients achieving objective response and stable disease)was observed in 24(82.8%,95%CI=64.2%-94.2%)patients.Conclusions:BAT8001 demonstrated favorable safety profiles,with promising anti-tumor activity in patients with HER2-positive locally advanced or metastatic breast cancer.BAT8001 has the potential to provide a new therapeutic option in patients with metastatic HER2-positive breast cancer. | Ruoxi Hong Wen Xia Liye Wang Kaping Lee Qianyi Lu Kuikui Jiang Shengfeng Li Jinquan Yu Jin Wei Weijia Tang Danyang Zhou Xin An Jiajia Huang Cong Xue Xiwen Bi Yanxia Shi Zhongyu Yuan Fei Xu Shusen Wang | 2021 | Cancer Communications2021，41，2： | 2 |
| 7 | Effects of surface roughness on the aerodynamic performance of a high subsonic compressor airfoil at low Reynolds number显示文摘The aerodynamic performance of compressor airfoil is significantly affected by the surface roughness at low Reynolds number(Re).In the present study,numerical simulations have been conducted to investigate the impact of surface roughness on the profile loss of a high subsonic compressor airfoil at Re=1.5×10^(5).Four roughness locations,covering 10%,30%,50%and 100%of the suction surface from the leading edge and seven roughness magnitudes(Ra)ranging from 52 to525 lm were selected.Results showed that the surface roughness mainly determined the loss generation process by influencing the structure of the Laminar Separation Bubble(LSB)and the turbulence level near the wall.For all the roughness locations,the variation trend for the profile loss with the roughness magnitude was similar.In the transitionally rough region,the negative displacement effect of the LSB was suppressed with the increase of roughness magnitude,leading to a maximum decrease of 14.6%,16.04%,16.45%and 10.20%in the profile loss at Ra=157 lm for the four roughness locations,respectively.However,with a further increase of the roughness magnitude in the fully rough region,the stronger turbulent dissipation enhanced the growth rate of the turbulent boundary layer and increased the profile loss instead.By comparison,the leading edge roughness played a dominant role in the boundary layer development and performance variation.To take fully advantage of the surface roughness reducing profile loss at low Re,the effects of roughness on suppressing LSB and inducing strong turbulent dissipation should be balanced effectively. | Mingyang WANG Chengwu YANG Ziliang LI Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU | 2021 | Chinese Journal of Aeronautics2021，34，3： | 2 |
| 8 | Effect of Non-Axisymmetric End Wall on a Highly Loaded Compressor Cascade in Multi-Conditions显示文摘As an effective method to influence end wall flow field,non-axisymmetric profiled end wall can improve the aerodynamic performance of compressor cascades.For a highly loaded low pressure compressor cascade,called V103,the study found the optimal non-axisymmetric profiled end wall decreases total pressure loss coefficient by 4.57%,5.48%and 3.04%under incidences of–3°,0°,and 3°,respectively,compared with those of the planar end wall.The optimal non-axisymmetric profiled end wall changes the structure of secondary flow in hub region,generating a corner vortex near suction surface,inhibiting the development of the passage vortex towards suction surface and reducing flow separation.When the inlet Mach numbers are 0.62 and 0.72,the total pressure loss coefficient decreases by 3.19%and 4.58%for optimal non-axisymmetric profiled end wall compared with those of the planar end wall.Though optimal non-axisymmetric profiled end wall increases total pressure loss near hub region in blade passage under different inlet Mach numbers,the peak value and region of high loss coefficient above 10%span in blade passage significantly decrease.In addition,different incidences affect the secondary flow streamlines and vortex structure near the cascade hub region,however,different inlet Mach numbers hardly change the secondary flow streamlines and vortex structure.In short,the optimal non-axisymmetric profiled end wall shows better aerodynamic performance than the planar end wall for the highly loaded compressor cascade in multi-conditions. | HUANG Song YANG Chengwu LI Ziliang HAN Ge ZHAO Shengfeng LU Xin’gen | 2021 | Journal of Thermal Science2021，30，4： | 2 |
| 9 | Recovery of Astaxanthin from Discharged Wastewater During the Production of Chitin显示文摘In this paper, studies were carried out to extract astaxanthin from discharged wastewater during the production of chitin and to reveal the scavenging effect of the obtained pigment on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical. Different ratios of dichloromethane/methanol (V/V) were used to extract astaxanthin. When the ratio of dichloromethane/methanol was 2:8 and the ratio between the mixed organic solvent (dichloromethane/methanol, 2:8, V/V) and wastewater was 1:1, the highest yield of pigment was obtained (8.4 mg/ 50 mL). The concentration of free astaxanthin in the obtained pigment analyzed by HPLC was 30.02%. The obtained pigment possessed strong scavenging ability on DPPH radical and IC50 was 0.84mg/ml. | CHEN Xiaolin YANG Shengfeng XING Ronge YU Huahua LIU Song LI Pengcheng | 2012 | Journal of Ocean University of China2012，11，2： | 1 |
| 10 | Regio- and stereo-selective synthesis of peracetylated carbohydrate esters of aromatic fatty acid using p- toluenesulfonic acid as catalyst显示文摘 | ZHU Zhenyuan LI Shengfeng LIU Rongqiang | 2010 | Chinese Journal of Chemistry2010，28，11： | 1 |
| 11 | XSWRL: an extended semantic Web rule language and prototype implemen- tation显示文摘 | Li Wan Tian Shengfeng | 2011 | Expert Systems with Applications2011，38，3： | 1 |
| 12 | Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease 显示文摘 | LANGRISH J P LI Xi WANG Shengfeng | 2012 | Environmental Health Perspectives2012，120，3： | 1 |
| 13 | Numerical investigation of flow mechanisms of tandem impeller inside a centrifugal compressor显示文摘This study numerically investigated a single stage centrifugal compressor 'Radiver' with a wedge diffuser and several tandem-designed impellers to explore the flow phenomena within the tandem impeller and the potential to enhance compressor performance.The results demonstrate that tandem design and clocking fraction(ks)significantly affects the compressor performance.The compressor stage with tandem impellers of Series A of boundary layer growth interruption alone are observed to have a widely operating range but efficiency and total pressure ratio penalty compared with that of conventional impeller.The tandem impeller with at least the same impeller efficiency as the conventional design is considered as a critical design criteria so that further modification process based on the flow characteristic of tandem impeller is necessary.In order to restrain the inducer wake and exducer shock losses,parameters modification of blade angle and thickness distributions are necessary and the modified tandem impeller of Series B is obtained.The modified tandem impeller with 25%clocking arrangement shows an 8.45%stall margin increase and maintains the total pressure ratio and efficiency as the conventional design,which proves the potential of tandem impeller to improve compressor stage performance.It is noteworthy that the tandem impellers of Radiver have not shown obviously balanced exit flow field and the fundamental mechanism of stall margin extending of tandem impeller lies on the improved impeller/diffuser matching performance resulting from the incidence angle variation at diffuser inlet. | Ziliang LI Xin’gen LU Shengfeng ZHAO Ge HAN Chengwu YANG Yanfeng ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，12： | 1 |
| 14 | The Progress of IGS Analysis Center at Wuhan University显示文摘As one of the Analysis Centers(AC)of the International GNSS Service(IGS),Wuhan University(WHU)has been contributing to the IGS by providing ultra-rapid as well as rapid orbit and clock solutions for the established GPS and GLONASS since 2012.In the same year,the IGS initiated the Multi-GNSS Experiment(MGEX)to support the analysis of the emerging GNSS systems and prepare the IGS for Multi-GNSS,which includes GPS,GLONASS,the European Galileo system,the Chinese Beidou Navigation Satellite System(BDS),the Japanese Quasi-Zenith Satellite System(QZSS)and the Indian Regional Navigation Satellite System(IRNSS/NaVIC).The major products,i.e.,orbits,Earth Orientation Parameters(EOPs),satellite clock as well as attitude have also been provided by WHU since 2012.More recently,WHU has engaged the third reprocessing of IGS for generating the highly accurate station coordinates as inputs for establishment of the International Terrestrial Reference Frame(ITRF)2020 during 2019—2020.This article presents the recent major advancements of the IGS AC at Wuhan University,including precise products,real-time products,bias products,antenna phase center calibration,and the non-linear motion modeling for GNSS Reference Stations. | Weiping JIANG Qile ZHAO Min LI Jing GUO Jianghui GENG Zhao LI Shengfeng GU Qiang ZHANG Zhigang HU Na WEI | 2023 | Journal of Geodesy and Geoinformation Science2023，6，3： | 1 |
| 15 | Integrated geometric error modeling, identification and compensation of CNC machine tools显示文摘 | Shaowei Zhu Guofu Ding Shengfeng Qin Jiang Lei Li Zhuang Kaiyin Yan | 2011 | International Journal of Machine Tools and Manufacture2011，，1： | 1 |
| 16 | ON DISTRIBUTED H^(1) SHAPE GRADIENT FLOWS IN OPTIMAL SHAPE DESIGN OF STOKES FLOWS:CONVERGENCE ANALYSIS AND NUMERICAL APPLICATIONS显示文摘We consider optimal shape design in Stokes flow using H^(1) shape gradient flows based on the distributed Eulerian derivatives.MINI element is used for discretizations of Stokes equation and Galerkin finite element is used for discretizations of distributed and boundary H^(1) shape gradient flows.Convergence analysis with a priori error estimates is provided under general and different regularity assumptions.We investigate the performances of shape gradient descent algorithms for energy dissipation minimization and obstacle flow.Numerical comparisons in 2D and 3D show that the distributed H1 shape gradient flow is more accurate than the popular boundary type.The corresponding distributed shape gradient algorithm is more effective. | Jiajie Li Shengfeng Zhu | 2022 | Journal of Computational Mathematics2022，40，2： | 1 |
| 17 | γ-Polyglutamic acid (γ-PGA) produced by Bacillus amyloliquefaciens C06 promoting its colonization on fruit surface显示文摘 | Jun Liu Dan He Xiu-zhen Li Shengfeng Gao Huijun Wu Wenzhe Liu Xuewen Gao Ting Zhou | 2010 | International Journal of Food Microbiology2010，，1： | 1 |
| 18 | The effect of Mo on the glass forming ability, mechanical and magnetic properties of FePC ternary bulk metallic glasses显示文摘 | Xiaohui Yang Xiuhua Ma Qiang Li Shengfeng Guo | 2012 | Journal of Alloys and Compounds2012，，： | 1 |
| 19 | Vortex dynamics and entropy generation in separated transitional flow over a compressor blade at various incidence angles显示文摘The transition process within a Laminar Separation Bubble(LSB)that formed on a compressor blade surface was investigated using Large Eddy Simulations(LESs)at a Reynolds number of 1.5×10;and incidence angles of 0°,+3°,and+5°.The vortex dynamics in the separated shear layers were compared at various incidence angles and its effects on the loss generation were clarified through entropy analysis.Results showed that transition onset,which was accurately identified by the Linear Stability Theory(LST),was significantly promoted at the increased incidence angle.As such,the development of LSB was suppressed and the relative role of viscous instability played in the transition process was weakened.At the incidence angle of 0°,two-dimensional spanwise vortices detached from the blade surface and roiled up periodically,which were further stretched and eventually evolved into large-scale hairpin vortices.As time passed,the fully developed hairpin vortices broke down into small-scale eddies.Meanwhile,the flow near the wall reversely ejected into the outer separated shear layers and a sweeping process happened subsequently,forcing the separated shear layers to reattach and accelerating the generation of turbulent fluctuations.By comparison,the strength of vortex rolling-up was weakened at higher incidence angles,and the vortex pairing and breakdown of large-scale vortices were less pronounced.Therefore,the level of turbulent fluctuations that generated in the separated shear layers was reduced.Detailed entropy analysis showed that the turbulent dissipation effect related to the Reynolds shear stresses determined the largest amount of positive entropy generation,which declined to a lower level as the incidence angle increased from 0°to+5°.Correspondingly,the profile loss was reduced by 50.4%. | Mingyang WANG Ziliang LI Ge HAN Chengwu YANG Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU | 2022 | Chinese Journal of Aeronautics2022，35，3： | 1 |
| 20 | Climatic variations recorded by the sediments from Erhai Lake,Yunnan Province,southwest China during the past 8000 a显示文摘Erhai Lake is a large lake with important climatic significance in Yunnan Province, southwest China. The multi-proxy sedimentary records from Erhai Lake indicate the 9 stages of climatic changes with the alternation of warm-dry and cool-wet during the past 8000 a. The variations of Asian monsoon systems were the main cause for the climatic changes in southwest China. The warm-dry period was coincident with the intensification of India monsoon and Northwest Pacific Sub-tropical High Pressure, and the cool-wet corresponding to weak of India monsoon and its main rain belt moving back to southwest China. | ZHANG Zhenke YANG Xiangdong SHEN Ji LI Shengfeng ZHU Yuxin WU Ruijin | 2001 | Chinese Science Bulletin2001，46，S1： | 0 |
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