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| 1 | Mucosal cytokine network in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease (CD) are characterized by ongoing mucosal inflammation in which dysfunction of the host immunologic response against dietary factors and commensal bacteria is involved. The chronic in-flammatory process leads to disruption of the epithelial barrier, and the formation of epithelial ulceration. This permits easy access for the luminal microbiota and dietary antigens to cells resident in the lamina pro-pria, and stimulates further pathological immune cell responses. Cytokines are essential mediators of the interactions between activated immune cells and non-immune cells, including epithelial and mesenchymal cells. The clinical efficacy of targeting TNF-α clearly indicates that cytokines are the therapeutic targets in IBD patients. In this manuscript, we focus on the bio-logical activities of recently-reported cytokines [Inter-leukin (IL)-17 cytokine family, IL-31 and IL-32], which might play a role through interaction with TNF-α in the pathophysiology of IBD. | Akira Andoh Yuhki Yagi Makoto Shioya Atsushi Nishida Tomoyuki Tsujikawa Yoshihide Fujiyama | 2008 | World Journal of Gastroenterology2008，14，33： | 21 |
| 2 | 固定化酶-离子交换组合系统进行青霉素G水解生产6-APA的模型化研究显示文摘采用固定化青霉素酰化酶(Penicillin acylase)在反应器中进行青霉素G水解生产6-APA,同时与离子交换柱相组合以连续地去除反应混合液中的苯乙酸。建立了离子交换柱的分格模型(Compartment model),在确定了青霉素G和苯乙酸沿柱高的浓度分布的基础上,与描述固定化酶反应器的状态方程相结合,得到了固定化酶-离子交换组合系统的数学模型。在将计算机模拟值与实验值进行验证后,探讨了组合系统中树脂量、循环流速和组合起始时间对青霉素G酶解过程的影响。 | 陈坚 Takeshi Omasa Yoshio Katakura Suteaki Shioya Ken-ichi Suga | 1995 | 生物工程学报1995，11，4： | 6 |
| 3 | Enhanced kefiran productionby mixed culture of Lactobacillus kefiranofaciens and Saccharomycescerevisiae显示文摘 | CHEIRSILP B SHIMIZU H SHIOYA S | 2003 | Journal of Biotechnology2003，100，1： | 1 |
| 4 | Col agen-dependent growth suppression and changes in the shape of human dermal fibroblasts显示文摘 | Yoshizato K Taira T Shioya N | | 0，，01： | 1 |
| 5 | Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease 显示文摘 | Shioya M Nishida A Yagi Y | 2007 | Clin Exp lmmunol2007，49，54： | 1 |
| 6 | Increased number of FoxP3^+ CD4^+ regulatory T cells in inflammatory bowel disease 显示文摘 | Ban H Andoh A Shioya M | 2008 | Mol Med Report2008，1，5： | 1 |
| 7 | An analytical method for calcu- lating harmonic currents of a three phase diode-bridge rectifier with DC filter显示文摘 | Sakui M Fujita H Shioya M | 1994 | IEEE Transactions on Power Electronics1994，9，6： | 1 |
| 8 | Encapsulation of mammalian cell with chitosan CMC capsule 显示文摘 | Yoshioka T Hirano Y Shioya T | 1990 | Biotechnol Bioeng1990，35，： | 1 |
| 9 | Development of t-headed bars and Examples of Coir struction显示文摘 | KIMURA K SHIOYA T NAKAZAWA H | 2004 | Concrete Journal2004，42，3： | 1 |
| 10 | The important ofpolymorphonuclear leukocytes in lipopolysaccharide-induced superoxide anion production andlung injury:ex-vivo observation in rat lungs显示文摘 | Tsuji C Minhaz M U Shioya S | 1998 | Lung1998，176，： | 1 |
| 11 | Optimal production of glutathione by controlling the specific growth rate of yeast in fed- hatch culture 显示文摘 | SHIMIZU H ARAKI K SHIOYA S | 1991 | Biotechnol Bioeng1991，38，2： | 1 |
| 12 | Atypical Wallenberg' s syndrome due to spontaneous vertebral arterial dissection: case report显示文摘 | Shioya H Kikuchi K Suda Y | 2004 | No To Shinkei2004，56，： | 1 |
| 13 | Suppressive effects of sivelestat on interleukin8and TNF-alpha production from LPS-stimulated granulocytes in whole blood culture显示文摘 | Shibata S Takahashi G Shioya N | 2010 | J Anesth2010，24，6： | 1 |
| 14 | Genetic epidemiology of Hereditary hemorrhagic telangiectasia in a local community in the northern part of Japan显示文摘 | DAKEISHI M SHIOYA T WADA Y | 2002 | Hum Mutat2002，19，： | 1 |
| 15 | Nonlinear predictive control using neural nets-based local linearization ARX model-stability and industrial application显示文摘 | Peng H Nakano K Shioya H | 2007 | IEEE Transactions on Control Systems Technology2007，15，1： | 1 |
| 16 | A comparative study of fracture behavior between carbon black/poly(ethylene terephthalate) and multiwalled carbon nanotube/poly(ethylene terephthalate) composite films 显示文摘 | Haruki Kobayashi Masatoshi Shioya Tomoya Tanaka | 2007 | Journal of Applied Polymer Science2007，106，1： | 1 |
| 17 | Increased production of nitrotyrosine in lung tissue of rats with radiation-induced acute lung injury显示文摘 | Tsuji C Shioya S Hirota Y | 2000 | Am J Physiol2000，278，4： | 1 |
| 18 | Pharmacokinetic interaction be-tween sorafenib and prednisolone in a patient with hepatocellularcarcinoma 显示文摘 | Noda S Shioya M Him D | 2013 | Cancer Chemother Pharmacol2013，72，： | 1 |
| 19 | A method for calculating harmonic currents of a three-phase bridge uncontrolled rectifier with DC filter显示文摘 | Sakui M Fujita H Shioya M | 1989 | IEEE Transactions on Industrial Electronics1989，36，3： | 1 |
| 20 | Interleukin (IL) -113 is a strong inducer of IL-36/expression in hu- man colonic myofibroblasts 显示文摘 | Takahashi K Nishida A Shioya M | 2015 | PLoS One2015，10，01： | 1 |
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