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| 1 | Progression in translational research on spinal cord injury based on microenvironment imbalance显示文摘Spinal cord injury(SCI) leads to loss of motor and sensory function below the injury level and imposes a considerable burden on patients, families, and society. Repair of the injured spinal cord has been recognized as a global medical challenge for many years.Significant progress has been made in research on the pathological mechanism of spinal cord injury. In particular, with the development of gene regulation, cell sequencing, and cell tracing technologies, in-depth explorations of the SCI microenvironment have become more feasible. However, translational studies related to repair of the injured spinal cord have not yielded significant results. This review summarizes the latest research progress on two aspects of SCI pathology: intraneuronal microenvironment imbalance and regenerative microenvironment imbalance. We also review repair strategies for the injured spinal cord based on microenvironment imbalance, including medications, cell transplantation, exosomes, tissue engineering, cell reprogramming, and rehabilitation. The current state of translational research on SCI and future directions are also discussed. The development of a combined, precise, and multitemporal strategy for repairing the injured spinal cord is a potential future direction. | Baoyou Fan Zhijian Wei Shiqing Feng | 2022 | Bone Research2022，10，2： | 17 |
| 2 | Comparison of clinical outcomes of Chinese men and women after coronary stenting for coronary artery disease:a multi-center retrospective analysis of 4,334 patients显示文摘The outcome differences between Chinese male and female patients within one-year follow-up after percutaneous coronary intervention(PCI) with stent remain unclear.The present study was aimed to compare clinical outcomes in such two populations.From May 1999 to December 2009,4,334 patients with acute myocardial infarction(MI),unstable angina,stable angina,or silent ischemia,who underwent PCI,were registered at our centers.Among these,3,089 were men and 1,245 were women.We compared these groups with respect to the primary outcomes of MI and secondary outcomes including a composite of major adverse cardiac events(MACE) including cardiac death,MI,target lesion revascularization,target vessel revascularization(TVR),stent thrombosis(ST),definite ST and probable ST at one-year follow-up.Chinese male patients had a higher MACE rate(13%vs.10.7%,P =0.039),mainly led by TVR(9.09%vs.6.98%,P=0.024) at one year,which was significantly different than female patients.Chinese male and female patients showed a significant difference on MACEs.However,there was no significant difference with respect to MI between these groups. | Rajiv Shrestha Jing Xu Dujiang Xie Zhizhong Liu Tian Xu Fei Ye Shiqing Din Xuesong Qian Song Yang Yueqiang Liu Feng Li Aiping Zhang Shaoliang Chen | 2014 | The Journal of Biomedical Research2014，28，5： | 3 |
| 3 | Surface treatment of 3D printed porous Ti6Al4V implants by ultraviolet photofunctionalization for improved osseointegration显示文摘Three-dimensional(3D)-printed porous Ti6Al4V implants play an important role in the reconstruction of bone defects.However,its osseointegration capacity needs to be further improved,and related methods are inadequate,especially lacking customized surface treatment technology.Consequently,we aimed to design an omnidirectional radiator based on ultraviolet(UV)photofunctionalization for the surface treatment of 3D-printed porous Ti6Al4V implants,and studied its osseointegration promotion effects in vitro and in vivo,while elucidating related mechanisms.Following UV treatment,the porous Ti6Al4V scaffolds exhibited significantly improved hydrophilicity,cytocompatibility,and alkaline phosphatase activity,while preserving their original mechanical properties.The increased osteointegration strength was further proven using a rabbit condyle defect model in vivo,in which UV treatment exhibited a high efficiency in the osteointegration enhancement of porous Ti6Al4V scaffolds by increasing bone ingrowth(BI),the bone-implant contact ratio(BICR),and the mineralized/osteoid bone ratio.The advantages of UV treatment for 3D-printed porous Ti6Al4V implants using the omnidirectional radiator in the study were as follows:1)it can significantly improve the osseointegration capacity of porous titanium implants despite the blocking out of UV rays by the porous structure;2)it can evenly treat the surface of porous implants while preserving their original topography or other morphological features;and 3)it is an easy-to-operate low-cost process,making it worthy of wide clinical application. | Chuan Yin Teng Zhang Qingguang Wei Hong Cai Yan Cheng Yun Tian Huijie Leng Caimei Wang Shiqing Feng Zhongjun Liu | 2022 | Bioactive Materials2022，7，1： | 2 |
| 4 | Characterization of DNA damage response deficiency in pancreatic cancer patients from China显示文摘To the editor,Pancreatic ductal adenocarcinoma(PDAC)has the worst prognosis among all common malignant solid tumors,with a 5-year overall survival(OS)rate of less than 10%[1].Few effective targets for anticancer ther-apy have been confirmed in pancreatic cancer.Recently,it was substantiated that pancreatic cancer patients carry-ing deleterious mutations of the DNA damage response(DDR)genes are more likely to benefit from platinum-based chemotherapy[2]and poly(adenosine diphosphate-ribose)polymerase(PARP)inhibitor[3]. | Xiaofei Zhang Tiebo Mao Bei Zhang Haiyan Xu Jiujie Cui Feng Jiao Dongqin Chen Yu Wang Jiong Hu Qing Xia Shumin Li Ming Yue Jingyu Ma Jiayu Yao Yongchao Wang Xiao Zhang Shiqing Chen Yuezong Bai Yuexiang Wang Xuebin Zhang Qiang Liu Yongwei Sun Deliang Fu Yingbin Liu Lei Xiong Liwei Wang | 2022 | Cancer Communications2022，42，1： | 2 |
| 5 | Commutative regulation between endothelial NO synthase and insulin receptor substrate 2 by microRNAs显示文摘Endothelial NO synthase (eNOS) expression is regulated by a number of transcriptional and post-transcriptional mechanisms, but the effects of competing endogenous RNAs (ceRNAs) on eNOS mRNA and the underlying mechanisms are still unknown. Our bioinformatic analysis revealed three highly expressed eNOS-targeting miRNAs (miR-15b, miR-16, and miR-30b) in human endothelial cells (ECs). Among the 1103 mRNA targets of these three miRNAs, 15 mRNAs share a common disease association with eNOS. Gene expression and correlation analysis in patients with cardiovascular diseases identified insulin receptor substrate 2 (IRS2) as the most correlated eNOS-ceRNA. The expression levels of eNOS and IRS2 were coincidentally increased by application of laminar shear but reduced with eNOS or IRS2 siRNA transfection in human ECs, which was impeded by Dicer siRNA treatment. Moreover, luciferase reporter assay showed that these three miRNAs directly target the 3′UTR of eNOS and IRS2. Overexpression of these three miRNAs decreased, whereas inhibition of them increased, both mRNA and protein levels of eNOS and IRS2. Functionally, silencing eNOS suppressed the Akt signal pathway, while IRS2 knockdown reduced NO production in ECs. Thus, we identified eNOS and IRS2 as ceRNAs and revealed a novel mechanism explaining the coincidence of metabolic and cardiovascular diseases. | Xiaoli Sun Huizhen Lv Peng Zhao Jinlong He Qinghua Cui Minxin Wei Shiqing Feng Yi Zhu | 2019 | Journal of Molecular Cell Biology2019，11，6： | 2 |
| 6 | Rapid and effective treatment of traumatic spinal cord injury using stem cell derived exosomes显示文摘Traumatic spinal cord injury is a fatal acute event without effective clinical therapies.Following the trauma,immediate neural protection and microenvironment mitigation are vitally important for nerve tissue repair,where stem cell-based therapies could be eclipsed by the deficiency of cells due to the hostile microenvironment as well as the transport and preservation processes.Effective emergency strategies are required to be convenient,biocompatible,and stable.Herein,we assess an emergency cell-free treatment using mesenchymal stem cell-derived exosomes,which have proven capable of comprehensive mitigation of the inhibitory lesion microenvironment.The clinically validated fibrin glue is utilized to encapsulate the exosomes and in-situ gelates in transected rat spinal cords to provide a substrate for exosome delivery as well as nerve tissue growth.The emergency treatment alleviates the inflammatory and oxidative microenvironment,inducing effective nerve tissue repair and functional recovery.The therapy presents a promising strategy for effective emergency treatment of central nervous system trauma。 | Jiafu Mu Jiahe Wu Jian Cao Teng Ma Liming Li Shiqing Feng Jianqing Gao | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，6： | 1 |
| 7 | Human umbilical cord blood stem cells for spinal cord injury: early transplantation results in better local angiogenesis显示文摘 | Guangzhi Ning Liang Tang Qiang Wu Yulin Li Yan Li Chao Zhang Shiqing Feng | 2013 | Regen Med2013，，3： | 1 |
| 8 | On Two Parallel Matched Gratings Demodulation Method of Fiber Grating Strain Sensor显示文摘The method of demodulation with two parallel matched fiber Bragg gratings( FBGs) system is introduced to enlarge the range of strain that can be detected by the FBG sensor system. | Yage Zhan, Qing Lu, Shiqing Xiang, Huizhong Feng, Xiangzhao WangShanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, P. R. China | 2003 | 光学学报2003，23，S1： | 1 |
| 9 | Transactivating-transduction protein-polyethylene glycol modified liposomes traverse the blood-spinal cord and blood-brain barriers显示文摘Naive liposomes can cross the blood-brain barrier and blood-spinal cord barrier in small amounts. Liposomes modified by a transactivating-transduction protein can deliver antibiotics for the treatment of acute bacterial infection-induced brain inflammation. Liposomes conjugated with polyethylene glycol have the capability of long-term circulation. In this study we prepared transactivating-transduction protein-polyethylene glycol-modified liposomes labeled with fluorescein isothiocyanate. Thus, liposomes were characterized by transmembrane, long-term circulation and fluorescence tracing. Uptake, cytotoxicity, and the ability of traversing blood-spinal cord and blood-brain barriers were observed following coculture with human breast adenocarcinoma cells (MCF-7). Results demonstrated that the liposomes had good biocompatibility, and low cytotoxicity when cocultured with human breast adenocarcinoma cells. Liposomes could traverse cell membranes and entered the central nervous system and neurocytes through the blood-spinal cord and blood-brain barriers of rats via the systemic circulation. These results verified that fluorescein isothiocyanate-modified transactivating-transduction protein-polyethylene glycol liposomes have the ability to traverse the blood-spinal cord and blood-brain barriers. | Xianhu Zhou Chunyuan Wang Shiqing Feng Jin Chang Xiaohong Kong Yang Liu Shijie Gao | 2012 | Neural Regeneration Research2012，7，35： | 1 |
| 10 | Treat of spinal cord injury with cograft of genetically modified schwann cells and fetal spinal cord cell suspension in the rat显示文摘 | Feng Shiqing Kong Xiaohong Guo Shifu | | 0，，12： | 1 |
| 11 | Taste mechanism of kokumi peptides from yeast extracts revealed by molecular docking and molecular dynamics simulation显示文摘Peptides have been used as flavors for decades,however,their tasting mechanism remains not entirely clear.In the present work,10 kokumi peptides identified in yeast extracts were selected as ligands.Their binding mechanism to calcium-sensitive receptors(CaSR)were investigated at molecular level by using molecular docking and molecular dynamics simulations.The results showed that all kokumi peptides could bind to CaSR to form complexes,of whichγ-Glu-Cys-Gly(GSH),γ-Glu-Leu(EL)andγ-Glu-Tyr(EY)being the top 3 peptides with higher affinity.Arg66,Ser147 and Ala168 may be the active sites of CaSR and interact with CaSR through hydrogen bonds;the different kokumi peptides and CaSR mainly rely on hydrogen bonding,electrostatic interaction and hydrophobic interaction to bind each other.This study provides a theoretical reference for the interaction between kokumi peptides and their receptors. | Jincui Chang Tao Feng Haining Zhuang Shiqing Song Min Sun Lingyun Yao Huatian Wang Feina Hou Jian Xiong Fan Li Pei Li Wenhui Zhu | 2022 | Journal of Future Foods2022，2，4： | 0 |
| 12 | Improving hole transfer of boron nitride quantum dots modified PDI for efficient photodegradation显示文摘In recent years,organic photocatalyst under visible-light absorption has shown significant potential for solving environmental problems.However,it is still a great challenge for constructing a highly active organic photocatalyst due to the low separation efficiency of photogenerated carriers.Herein,an effective and robust photocatalyst perylene-3,4,9,10-tetracarboxylic diamide/boron nitride quantum dots(PDI/BNQDs),consisting of selfassemble PDI withπ–πstacking structure and BNQDs,has been constructed and researched under visible light irradiation.The PDI/BNQDs composite gradually increases organic pollutant photodegradation with the loading amount of BNQDs.With 10 mL of BNQDs solution added(PDI/BNQDs-10),the organic pollutant photodegradation performance reaches a maximum,about 6.16 times higher with methylene blue and 1.68 times higher with ciprofloxacin than that of pure PDI supramolecular.The enhancement is attributed to improved separation of photogenerated carriers from self-assembled PDI by BNQDs due to their preeminent ability to extract holes.This work is significant for the supplement of PDI supramolecular composite materials.We believe that this photocatalytic design is capable of expanding organic semiconductors’potential for their applications in photocatalysis. | Shiqing Ma Chundong Peng Zeyu Jia Yanmei Feng Kai Chen Hao Ding Daimei Chen Zhong-Yong Yuan | 2023 | Frontiers of Chemical Science and Engineering2023，17，11： | 0 |
| 13 | SYNTHESIS AND FINE STRUCTURE-PROPERTY RELATIONSHIPS OF ION-CONTAINING BIOMEDICAL POLYETHERURETHANES显示文摘SYNTHESISANDFINESTRUCTURE-PROPERTYRELATIONSHIPSOFION-CONTAININGBIOMEDICALPOLYETHERURETHANESSYNTHESISANDFINESTRUCTURE-PROPERTY... | Chen Huiying Feng Shiqing Sun Xuehui(Department of Chemistry, Peking University, Beijing 100871,China) | 1996 | Chinese Journal of Biomedical Engineering(English Edition)1996，5，2： | 0 |
| 14 | Human umbilical cord mesenchymal stem cell-derived exosomes loaded into a composite conduit promote functional recovery after peripheral nerve injury in rats显示文摘Complete transverse injury of peripheral nerves is challenging to treat.Exosomes secreted by human umbilical cord mesenchymal stem cells are considered to play an important role in intercellular communication and regulate tissue regeneration.In previous studies,a collagen/hyaluronic acid sponge was shown to provide a suitable regeneration environment for Schwann cell proliferation and to promote axonal regeneration.This three-dimensional(3D)composite conduit contains a collagen/hyaluronic acid inner sponge enclosed in an electrospun hollow poly(lactic-co-glycolic acid)tube.However,whether there is a synergy between the 3D composite conduit and exosomes in the repair of peripheral nerve injury remains unknown.In this study,we tested a comprehensive strategy for repairing long-gap(10 mm)peripheral nerve injury that combined the 3D composite conduit with human umbilical cord mesenchymal stem cell-derived exosomes.Repair effectiveness was evaluated by sciatic functional index,sciatic nerve compound muscle action potential recording,recovery of muscle mass,measuring the cross-sectional area of the muscle fiber,Masson trichrome staining,and transmission electron microscopy of the regenerated nerve in rats.The results showed that transplantation of the 3D composite conduit loaded with human umbilical cord mesenchymal stem cell-derived exosomes promoted peripheral nerve regeneration and restoration of motor function,similar to autograft transplantation.More CD31-positive endothelial cells were observed in the regenerated nerve after transplantation of the loaded conduit than after transplantation of the conduit without exosomes,which may have contributed to the observed increase in axon regeneration and distal nerve reconnection.Therefore,the use of a 3D composite conduit loaded with human umbilical cord mesenchymal stem cell-derived exosomes represents a promising cell-free therapeutic option for the treatment of peripheral nerve injury. | Haoshuai Tang Junjin Li Hongda Wang Jie Ren Han Ding Jun Shang Min Wang Zhijian Wei Shiqing Feng | 2024 | Neural Regeneration Research2024，19，4： | 0 |
| 15 | Measurement and model of density,viscosity,and hydrogen sulfide solubility in ferric chloride/trioctylmethylammonium chloride ionic liquid显示文摘The density and viscosity of ferric chloride/trioctylmethylammonium chloride ionic liquid(rFeCl_(3)/[A336]Cl)with different molar ratios(r=0.1-0.8)of FeCl_(3) to[A336]Cl were measured at temperatures from 313.15 to 358.15 K and atmospheric pressure.The density and viscosity data were fitted by the relevant temperature variation equations,respectively.The variation of density and viscosity with temperature and r was obtained.The solubility of rFeCl_(3)/[A336]Cl to H_2S was measured at temperatures from 318.15 to 348.15 K and pressures from 0 to 150 kPa.The effects of temperature,pressure,and r on the solubility of H_(2)S were discussed.The reaction equilibrium thermodynamic model(RETM)was used to fit the H_(2)S solubility data,and the average relative error was less than 1.3%,indicating that the model can relate the solubility data well.And Henry's constant and chemical reaction equilibrium constant were obtained by the RETM fitting.The relationships of Henry's constant and chemical reaction equilibrium constant with temperature and r were analyzed. | Zhonghao Li Yuanyuan Yang Huanong Cheng Yun Teng Chao Li Kangkang Li Zhou Feng Hongwei Jin Xinshun Tan Shiqing Zheng | 2023 | Chinese Journal of Chemical Engineering2023，59，7： | 0 |
| 16 | Transient pressure analysis of polymer flooding fractured wells with oil-water two-phase flow显示文摘The oil-water two-phase flow pressure-transient analysis model for polymer flooding fractured well is established by considering the comprehensive effects of polymer shear thinning,shear thickening,convection,diffusion,adsorption retention,inaccessible pore volume and effective permeability reduction.The finite volume difference and Newton iteration methods are applied to solve the model,and the effects of fracture conductivity coefficient,injected polymer mass concentration,initial polymer mass concentration and water saturation on the well-test type curves of polymer flooding fractured wells are discussed.The results show that with the increase of fracture conductivity coefficient,the pressure conduction becomes faster and the pressure drop becomes smaller,so the pressure curve of transitional flow goes downward,the duration of bilinear flow becomes shorter,and the linear flow appears earlier and lasts longer.As the injected polymer mass concentration increases,the effective water phase viscosity increases,and the pressure loss increases,so the pressure and pressure derivative curves go upward,and the bilinear flow segment becomes shorter.As the initial polymer mass concentration increases,the effective water phase viscosity increases,so the pressure curve after the wellbore storage segment moves upward as a whole.As the water saturation increases,the relative permeability of water increases,the relative permeability of oil decreases,the total oil-water two-phase mobility becomes larger,and the pressure loss is reduced,so the pressure curve after the wellbore storage segment moves downward as a whole.The reliability and practicability of this new model are verified by the comparison of the results from simplified model and commercial well test software,and the actual well test data. | WANG Yang YU Haiyang ZHANG Jia FENG Naichao CHENG Shiqing | 2023 | Petroleum Exploration and Development2023，50，1： | 0 |
| 17 | Ferroptosis inhibition protects vascular endothelial cells and maintains integrity of the blood-spinal cord barrier after spinal cord injury显示文摘Maintaining the integrity of the blood-spinal cord barrier is critical for the recove ry of spinal cord injury.Ferro ptosis contributes to the pathogenesis of spinal cord injury.We hypothesized that ferroptosis is involved in disruption of the blood-s pinal cord barrier.In this study,we administe red the ferroptosis inhibitor liproxstatin-1 intraperitoneally after contusive spinal co rd injury in rats.Liproxstatin-1 improved locomotor recovery and somatosensory evoked potential electrophysiological performance after spinal cord inju ry.Liproxstatin-1 maintained blood-spinal cord barrier integrity by upregulation of the expression of tight junction protein.Liproxstatin-1 inhibited ferroptosis of endothelial cell after spinal cord injury,as shown by the immunofluorescence of an endothelial cell marker(rat endothelium cell antigen-1,RECA-1) and fe rroptosis markers Acyl-CoA synthetase long-chain family member 4 and 15-lipoxygenase.Liproxstatin-1reduced brain endothelial cell ferroptosis in vitro by upregulating glutathione peroxidase 4 and downregulating Acyl-CoA synthetase long-chain family member4 and 15-lipoxygenase.Furthermore,inflammatory cell recruitment and astrogliosis were mitigated after liproxstatin-1 treatment.In summary,liproxstatin-1im proved spinal cord injury recovery by inhibiting ferroptosis in endothelial cells and maintaining blood-s pinal co rd barrier integrity. | Wenxiang Li Xiaoqing Zhao Rong Zhang Xinjie Liu Zhangyang Qi Yang Zhang Weiqi Yang Yilin Pang Chenxi Zhao Baoyou Fan Ning Ran Jiawei Zhang Xiaohong Kong Shiqing Feng Xue Yao | 2023 | Neural Regeneration Research2023，18，11： | 0 |
| 18 | A novel mouse model of central cord syndrome显示文摘Patients with potential spinal stenosis are susceptible to central cord syndrome induced by blunt trauma.Suitable animal models are helpful for studying the pathogenesis and treatment of such injuries.In this study,we established a mouse model of acute blunt traumatic spinal cord injury by compressing the C6 spinal cord with 5 and 10 g/mm~2 compression weights to simulate cervical central cord syndrome.Behavioral testing confirmed that this model exhibited the characteristics of central cord syndrome because motor function in the front paws was impaired,whereas basic motor and sensory functions of the lower extremities were retained.Hematoxylin-eosin staining showed that the diseased region of the spinal cord in this mouse model was restricted to the gray matter of the central cord,whereas the white matter was rarely affected.Magnetic resonance imaging showed a hypointense signal in the lesion after mild and severe injury.In addition,immunofluorescence staining showed that the degree of nerve tract injury in the spinal cord white matter was mild,and that there was a chronic inflammation reaction.These findings suggest that this mouse model of central cord syndrome can be used as a model for preclinical research,and that gray matter is most vulnerable to injury in central cord syndrome,leading to impaired motor function. | Elzat Elham-Yilizati Yilihamu Xiangchuang Fan Zimeng Yang Shiqing Feng | 2023 | Neural Regeneration Research2023，18，12： | 0 |
| 19 | X-irradiation for inhibiting glial scar formation in injured spinal cord显示文摘X-irradiation has a beneficial effect in treating spinal cord injury. We supposed that X-irradiation could improve the microenvironment at the site of a spinal cord injury and inhibit glial scar formation. Thus, this study was designed to observe the effects of 8 Gy X-irradiation on the injury site at 6 hours and 2, 4, 7, and 14 days post injury, in terms of improvement in the microenvironment and hind limb motor function. Immunohistochemistry showed that the expression of macrophage marker ED-1 and the area with glial scar formation were reduced. In addition, the Basso, Beattie and Bresnahan score was higher at 7 days post injury relative to the other time points post injury. Results indicated that X-irradiation at a dose of 8 Gy can inhibit glial scar formation and alleviate the inflammatory reaction, thereby repairing spinal cord injury. X-irradiation at 7 days post spinal cord injury may be the best time window. | Guangzhi Ning Renhui Chen Yulin Li Qiang Wu Qiuli Wu Yan Li Shiqing Feng | 2013 | Neural Regeneration Research2013，8，17： | 0 |
| 20 | Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study显示文摘Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimotor recovery,increasing the awareness rate of clinical guidelines related to high-dose MPSS/MP to reduce the use of the treatment with insufficient evidence. | Hengxing Zhou Yongfu Lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng | 2024 | Neural Regeneration Research2024，19，5： | 0 |
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