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| 1 | Melatonin enhances radiofrequency-induced NK antitumor immunity,causing cancer metabolism reprogramming and inhibition of multiple pulmonary tumor development显示文摘Surgery is the comm on treatme nt for early lung cancer with multiple pulm onary no dules,but it is often accompanied by the problem of significant malignancy of other nodules in non-therapeutic areas.In this study,we found that a combined treatment of local rad iofreq ue ncy ablati on(RFA)and melatonin(MLT)greatly improved clinical outcomes for early lung cancer patie nts with multiple pulmonary nodules by minimizing lung function injury and reducing the probability of malignant transformation or enlargement of nodules in non-ablated areas.Mechanically,as demonstrated in an associated mouse lung tumor model,RFA not only effectively remove treated tumors but also stimulate antitumor immunity,which could inhibit tumor growth in non-ablated areas.MLT enhanced RFA-stimulated NK activity and exerted synergistic antitumor effects with RFA.Transcriptomics and proteomics analyses of residual tumor tissues revealed enhanced oxidative phosphorylation and reduced acidification as well as hypoxia in the tumor microenvironment,which suggests reprogrammed tumor metabolism after combined treatment with RFA and MLT.Analysis of residual tumor further revealed the depressed activity of MAPK,NF-kappa B,Wnt,and Hedgehog pathways and upregulated P53 pathway in tumors,which was in line with the inhibited tumor growth.Combined RFA and MLT treatment also reversed the Warburg effect and decreased tumor malignancy.These findings thus demonstrated that combined treatment of RFA and MLT effectively inhibited the malignancy of non-ablated nodules and provided an innovative non-invasive strategy for treating early lung tumors with multiple pulmonary nodules.Trial registration:www.chictr.org.cn,identifier ChiCTR2100042695,http://gffzz62a03ee25e6f4a77hn0u0b6xn05kb65bw.ffgz.tsg.suse.edu.cn/showproj.aspx?proj=120931. | Ming Li Bingjie Hao Menghuan Zhang Russel J.Reiter Shumeng Lin Tiansheng Zheng Xiangyun Chen Yanbei Ren Liduo Yue Baigenzhin Abay Guojie Chen Xiao Xu Yufeng Shi Lihong Fan | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 2 | Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis显示文摘 | Lin He Xinhua Liu Jianguo Yang Wanjin Li Shumeng Liu Xujun Liu Ziran Yang Jie Ren Yue Wang Lin Shan Chengjian Guan Fei Pei Liandi Lei Yu Zhang Xia Yi Xiaohan Yang Jing Liang Rong Liu Luyang Sun Yongfeng Shang | 2018 | Cell Research2018，28，9： | 5 |
| 3 | Non-conjugated Polynorbornene Hosts with High Triplet Energy Levels for Solution-processed Narrowband Blue OLEDs显示文摘Three polymer hosts(namely PNB-tBuCz,PNB-Ac,PNB-TAc)containing non-conjugated polynorbornene(PNB)backbone and hole-transporting arylamine segments(carbazole,acridan and dendritic teracridan)in side chains are developed for solution-processed narrowband blue organic light-emitting diodes(OLEDs).It is found that the non-conjugated polynorbornenes can keep high triplet energy(ET)levels in range of 3.12-3.20 eV by interrupting the conjugation of repeating units,making them capable as host materials for blue emitters.Meanwhile,by increasing the electron-donating capability of side chain arylamine from carbazole to acridan and dendritic teracridan,the highest occupied molecular orbital(HOMO)levels for the polymer hosts are elevated from-5.50 eV to-5.11 eV,beneficial for reducing the hole injection barrier from anode to emissive layer.As a result,solution-processed OLEDs employing polynorbornenes with dendritic teracridan side chain(PNB-TAc)as host and boron,selenium,nitrogen-containing multiple resonance thermally activated delayed fluorescence emitter as dopant reveal efficient narrowband blue electroluminescence with emission peak at 474 nm,full-width at half maximum of 30 nm,together with maximum external quantum efficiency of 20.2%,representing the state-of-the-art device efficiency for solution-processed OLEDs with narrowband blue emission. | LI Qiang CHEN Liang WANG Xingdong WANG Shumeng SHAO Shiyang WANG Lixiang | 2023 | Chemical Research in Chinese Universities2023，39，5： | 1 |
| 4 | Precisely engineering a dual-drug cooperative nanoassembly for proteasome inhibition-potentiated photodynamic therapy显示文摘Photodynamic therapy(PDT) has been widely investigated for cancer therapy. The intracellular accumulation of reactive oxygen species(ROS)-damaged protein facilitates tumor cell apoptosis. However, there is growing evidence that the ubiquitin-proteasome pathway(UPP) significantly impedes PDT by preventing the enrichment of ROS-damaged proteins in tumor cells. To tackle this challenge, we report a facile dual-drug nanoassembly based on the discovery of an interesting co-assembly of bortezomib(BTZ, a proteasome inhibitor) and pyropheophorbide a(PPa) for proteasome inhibition-mediated PDT sensitization.The precisely engineered nanoassembly with the optimal dose ratio of BTZ and PPa demonstrates multiple advantages, including simple fabrication, high drug co-loading efficiency, flexible dose adjustment,good colloidal stability, long systemic circulation, favorable tumor-specific accumulation, as well as significant enrichment of ROS-damaged proteins in tumor cells. As a result, the cooperative nanoassembly exhibits potent synergistic antitumor activity in vivo. This study provides a novel dual-drug engineering modality for multimodal cancer treatment. | Fujun Yang Qingyu Ji Rui Liao Shumeng Li Yuequan Wang Xuanbo Zhang Shenwu Zhang Haotian Zhang Qiming Kan Jin Sun Zhonggui He Bingjun Sun Cong Luo | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 5 | Customizable Ligand Exchange for Tailored Surface Property of Noble Metal Nanocrystals显示文摘It is highly desirable,while still challenging,to obtain noble metal nanocrystals with custom capping ligands,because their colloidal synthesis relies on specific capping ligands for the shape control while conventional ligand exchange processes suffer from“the strong replaces the weak”limitation,which greatly hinders their applications.Herein,we report a general and effective ligand exchange approach that can replace the native capping ligands of noble metal nanocrystals with virtually any type of ligands,producing flexibly tailored surface properties.The key is to use diethylamine with conveniently switchable binding affinity to the metal surface as an intermediate ligand.As a strong ligand,it in its original form can effectively remove the native ligands;while protonated,it loses its binding affinity and facilitates the adsorption of new ligands,especially weak ones,onto the metal surface.By this means,the irreversible order in the conventional ligand exchange processes could be overcome.The efficacy of the strategy is demonstrated by mutual exchange of the capping ligands among cetyltrimethylammonium,citrate,polyvinylpyrrolidone,and oleylamine.This novel strategy significantly expands our ability to manipulate the surface property of noble metal nanocrystals and extends their applicability to a wide range of fields,particularly biomedical applications. | Qikui Fan Hao Yang Juan Ge Shumeng Zhang Zhaojun Liu Bo Lei Tao Cheng Youyong Li Yadong Yin Chuanbo Gao | 2020 | Research2020，，1： | 1 |
| 6 | Chromodomain protein CDYL is required for transmission/restoration of repressive histone marks显示文摘象通过代的压抑的 histone 修正那样的 epigenetic 信息的忠诚传播或恢复为房间身份的维护是批评的。我们这里报导那 chromodomain 象 Y 一样蛋白质(CDYL ) ,包含 chromodomain 抄写 corepressor,身体上与染色质集会因素 1 被联系(CAF-1 ) 并且 replicative helicase 看建筑群。我们证明 CDYL 衔接 CAF-1 和看,便于在 DNA 复制期间的 histone 转移和免职。我们证明到复制的 CDYL 成员修改 histone 酶 G9a, SETDB1,和 EZH2 分叉,导致最新扔的 histone H3 上的 H3K9me2/3 和 H3K27me2/3 的增加。显著地, CDYL 的弄空阻碍早 S 阶段前进并且敏化房间到 DNA 损坏。我们的数据显示 CDYL 在压抑的 histone 标记的传播 / 恢复起一个重要作用,从而为房间身份的维护保存 epigenetic 风景。 | Yongqing Liu Shumeng Liu Shuai Yuan Huajing Yu Yu Zhang Xiaohan Yang Guojia Xie Zhe Chen Wanjin Li Bosen Xu Luyang Sun Yongfeng Shang Jing Liang | 2017 | Journal of Molecular Cell Biology2017，9，3： | 0 |
| 7 | Metal complexes induced ferroptosis for anticancer therapy显示文摘Metal complexes for anti-tumor treatment have been developed rapidly in recent decades since the application of cisplatin in clinics.However,some tumor cells are resistant to apoptosis and not sensitive to metallodrugs that function through the apoptotic pathway.Recently,metal complexes have been reported to cause ferropto-sis against tumor cells,which offers new opportunities for anticancer therapy.In this perspective,ferroptosis-inducing metal complexes and their working mechanisms are introduced,while the challenges and opportunities are also discussed. | Shumeng Li Hao Yuan Yuncong Chen Zijian Guo | 2023 | Fundamental Research2023，3，4： | 0 |
| 8 | The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry显示文摘The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid(TCA)cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise supply/consumption of these metabolites is achieved in the nucleus.We report here the identification of a nonclassical TCA cycle in the nucleus(nTCA cycle).We found that all the TCA cycle-associated enzymes including citrate synthase(CS),aconitase 2(ACO2),isocitrate dehydrogenase 3(IDH3),oxoglutarate dehydrogenase(OGDH),succinyl-CoA synthetase(SCS),fumarate hydratase(FH),and malate dehydrogenase 2(MDH2),except for succinate dehydrogenase(SDH),a component of electron transport chain for generating ATP,exist in the nucleus.We showed that these nuclear enzymes catalyze an incomplete TCA cycle similar to that found in cyanobacteria.We propose that the nTCA cycle is implemented mainly to generate/consume metabolic intermediates,not for energy production.We demonstrated that the nTCA cycle is intrinsically linked to chromatin dynamics and transcription regulation.Together,our study uncovers the existence of a nonclassical TCA cycle in the nucleus that links the metabolic pathway to epigenetic regulation. | Xujun Liu Wenzhe Si Lin He Jianguo Yang Yani Peng Jie Ren Xiaoping Liu Tong Jin Huajing Yu Zihan Zhang Xiao Cheng Wenting Zhang Lu Xia Yunchao Huang Yue Wang Shumeng Liu Lin Shan Yu Zhang Xiaohan Yang Haixia Li Jing Liang Luyang Sun Yongfeng Shang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 9 | Structural insights into photosynthetic cyclic electron transport显示文摘During photosynthesis,light energy is utilized to drive sophisticated biochemical chains of electron transfers,converting solar energy into chemical energy that feeds most life on earth.Cyclic electron transfer/flow(CET/CEF)plays an essential role in efficient photosynthesis,as it balances the ATP/NADPH ratio required in various regulatory and metabolic pathways.Photosystem I,cytochrome b6f,and NADH dehydrogenase(NDH)are large multisubunit protein complexes embedded in the thylakoid membrane of the chloroplast and key players in NDH-dependent CEF pathway.Furthermore,small mobile electron carriers serve as shuttles for electrons between these membrane protein complexes.Efficient electron transfer requires transient interactions between these electron donors and acceptors.Structural biology has been a powerful tool to advance our knowledge of this important biological process.A number of structures of the membrane-embedded complexes,soluble electron carrier proteins,and transient complexes composed of both have now been determined.These structural data reveal detailed interacting patterns of these electron donor-acceptor pairs,thus allowing us to visualize the different parts of the electron transfer process.This review summarizes the current state of structural knowledge of three membrane complexes and their interaction patterns with mobile electron carrier proteins. | Shumeng Zhang Baohua Zou Peng Cao Xiaodong Su Fen Xie Xiaowei Pan Mei Li | 2023 | Molecular Plant2023，16，1： | 0 |
| 10 | Investigating the crucial roles of aliphatic tails in disulfide bond-linked docetaxel prodrug nanoassemblies显示文摘Disulfide bond-bridging strategy has been extensively utilized to construct tumor specificity-responsive aliphatic prodrug nanoparticles(PNPs) for precise cancer therapy. Yet, there is no research shedding light on the impacts of the saturation and cis-trans configuration of aliphatic tails on the self-assembly capacity of disulfide bond-linked prodrugs and the in vivo delivery fate of PNPs. Herein, five disulfide bond-linked docetaxelfatty acid prodrugs are designed and synthesized by using stearic acid, elaidic acid, oleic acid, linoleic acid and linolenic acid as the aliphatic tails, respectively. Interestingly, the cistrans configuration of aliphatic tails significantly influences the self-assembly features of prodrugs, and elaidic acid-linked prodrug with a trans double bond show poor self-assembly capacity. Although the aliphatic tails have almost no effect on the redox-sensitive drug release and cytotoxicity, different aliphatic tails significantly influence the chemical stability of prodrugs and the colloidal stability of PNPs, thus affecting the in vivo pharmacokinetics, biodistribution and antitumor efficacy of PNPs. Our findings illustrate how aliphatic tails affect the assembly characteristic of disulfide bond-linked aliphatic prodrugs and the in vivo delivery fate of PNPs, and thus provide theoretical basis for future development of disulfide bond-bridged aliphatic prodrugs. | Yuequan Wang Cong Luo Shuang Zhou Xinhui Wang Xuanbo Zhang Shumeng Li Shenwu Zhang Shuo Wang Bingjun Sun Zhonggui He Jin Sun | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，5： | 0 |
| 11 | Intercalated MXene-based layered composites:Preparation and application显示文摘Combining high conductivity,hydrophilicity and excellent electrochemical perfo rmance in one,MXe nes have attracted increasing attention since their inception.However,easy to stack caused by the van der Waals’force between the layers limits their practical application.Fortunately,intercalating other substances between layers of MXe nes and getting intercalated MXene-based layered composites(IMLCs)with open structure can improve their physical and chemical properties effectively.Larger available surface helps expose more active sites and enlarged layer spacing facilitates ion transport.In addition,other substances fixed in the interlayers by MXenes’two-dimensional confinement effect can produce synergistic effect and expand their applicable range greatly.This review is dedicated to summarizing the preparation methods and applications of IMLCs,emphasizing the advantages of them in the fields of energy storage,catalysis,sensors,electromagnetic interference(EMI)shielding and biomedicine.Furthermore,prospects and further developments in these gratifying fields are also commented. | Shumeng Wu He Wang Li Li Meixia Guo Zhichong Qi Qingyou Zhang Yanmei Zhou | 2020 | Chinese Chemical Letters2020，31，4： | 0 |
| 12 | Hypoglycemic activities of flowers of Xanthoceras sorbifolia and identification of anti-oxidant components by off-line UPLC-QTOF-MS/MS-free radical scavenging detection显示文摘Objective: To identify phytochemical constituents present in the extract of flowers of Xanthoceras sorbifolia and evaluate their anti-oxidant and anti-hyperglycemic capacities.Methods: The AlCl3colorimetric method and Prussian Blue assay were used to determine the contents of total flavonoids and total phenolic acids in extraction layers, and the bioactive layers was screened through anti-oxidative activity in vitro. The Waters ACQUITY UPLC system and a Waters ACQUITY UPLC BEH C18column(2.0 mm × 150 mm, 5 μm) were used to identify the ingredients. And anti-oxidative ingredients were screened by off-line UPLC-QTOF-MS/MS-free radical scavenging. The ameliorative role of it was further evaluated in a high-fat, streptozotocin-induced type 2 diabetic rat model and the study was carried out on NADPH oxidase(PDB ID: 2CDU) by molecular docking.Results: Combined with the results of activity screening in vitro, the anti-oxidative part was identified as the ethyl acetate layer. A total of 24 chemical constituents were identified by liquid chromatographymass spectrometry in the ethyl acetate layer and 13 main anti-oxidative active constituents were preliminarily screened out through off-line UPLC-QTOF-MS/MS-free radical scavenging. In vivo experiments showed that flowers of X. sorbifolia could significantly reduce the blood glucose level of diabetic mice and alleviate liver cell damage. Based on the results of docking analysis related to the identified phytocompounds and oxidase which involved in type 2 diabetes, quercetin 3-O-rutinoside, kaempferol-3-O-rhamnoside, isorhamnetin-3-O-glucoside, and isoquercitrin showed a better inhibitory profile.Conclusion: The ethyl acetate layer was rich in flavonoids and phenolic acids and had significant anti-oxidant activity, which could prevent hyperglycemia. This observed activity profile suggested X. sorbifolia flowers as a promising new source of tea to develop alternative natural anti-diabetic products with a high safety margin. | Xiajing Xu Yongli Guo Menglin Chen Ning Li Yi Sun Shumeng Ren Jiao Xiao Dongmei Wang Xiaoqiu Liu Yingni Pan | 2024 | Chinese Herbal Medicines2024，16，1： | 0 |
| 13 | CDYL作为丁烯酰辅酶A水合酶调控组蛋白丁烯酰化及精子发生显示文摘文章简介本研究发现,转录辅抑制因子CDYL具有负调控组蛋白赖氨酸丁烯酰化的功能。有趣的是,CDYL负调控组蛋白丁烯酰化并不是通过直接从底物赖氨酸上去除丁烯酰基的方式实现的,而是利用CDYL的丁烯酰辅酶A水合酶活性。 | Shumeng Liu Huajing Yu Yongqing Liu Xinhua Liu Yu Zhang Chen Bu Shuai Yuan Zhe Chen Guojia Xie Wanjin Li Bosen Xu Jianguo Yang Lin He Tong Jin Yundong Xiong Luyang Sun Xiaohui Liu Chunsheng Han Zhongyi Cheng 梁静 尚永丰 | 2018 | 科学新闻2018，0，4： | 0 |
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