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| 1 | Chronic obstructive pulmonary disease as a risk factor for lung cancer显示文摘The association between chronic obstructive pulmonary disease(COPD) and lung cancer has long been a subject of intense debate. The high prevalence of COPD in elderly smokers inevitably strengthens their coincidence. In addition to this contingent coincidence, recent studies have revealed a close association between the two diseases that is independent of the smoking history; that is, the existence of COPD is an independent risk factor for the development of lung cancer. Molecular-based evidence has been accumulating as a result of the efforts to explain the underlying mechanisms of this association. These mechanisms may include the following: the retention of airborne carcinogens followed by the activation of oncogenes and the suppression of tumor suppressor genes; the complex molecular mechanism associated with chronic inflammation in the distal airways of patients with COPD; the possible in-volvement of putative distal airway stem cells; and gel netic factors that are common to both COPD and lung cancer. The existence of COPD in patients with lung l cancer may potentially affect the process of diagnosis, surgical resection, radiotherapy, chemotherapy, and end-of-life care. The comprehensive management of COPD is extremely important for the appropriate treatment of lung cancer. Surgical resections with the aid of early interventions for COPD are often possible, even for patients with mild-to-moderate COPD. New challenges, such as lung cancer CT screening for individuals t at high risk, are now in the process of being implemented. Evaluating the risk of lung cancer in patients with COPD may be warranted in community-based lung cancer screening. | Yuichi Takiguchi Ikuo Sekine Shunichiro Iwasawa Ryota Kurimoto Koichiro Tatsumi | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 2 | Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors显示文摘AIM: To investigate the expressions of omithine decarboxylase (ODC), MMP-2, and Erk, and their relationship in human colon tumors.METHODS: ODC activity, MMP-2 expression, and mitogenactivated protein (MAP) kinase activity (Erk phosphorylation) were determined in 58 surgically removed human colon tumors and their adjacent normal tissues, using [1-14C]-ornithine as a substrate, ELISA assay, and Western blotting, respectively.RESULTS: ODC activity, MMP-2 expression, and Erk phosphorylation were significantly elevated in colon tumors, compared to those in adjacent normal tissues. A significant correlation was observed between ODC activities and MMP-2 levels.CONCLUSION: This is the first report showing a significant correlation between ODC activities and MMP-2 levels in human colon tumors. As MMP-2 is involved in cancer invasion and metastasis, and colon cancer overexpresses ODC, suppression of ODC expression may be a rational approach to treat colon cancer which overexpresses ODC. | Takahiro Nemoto Shunichiro Kubota Hideyuki Ishida Nobuo Murata Daijo Hashimoto | 2005 | World Journal of Gastroenterology2005，11，20： | 12 |
| 3 | Intestinal stasisassociated bowel in flam mation显示文摘 | Shunichiro Komatsu 1, Yuji Nimura 1 and D.Neil Granger 2 | 1999 | World Journal of Gastroenterology1999，5，6： | 5 |
| 4 | IDH 1 and IDH 2 mutations confer an adverse effect in patients with acute myeloid leukemia lacking the NPM 1 mutation显示文摘 | Shunichiro Yamaguchi Eisaku Iwanaga Kenji Tokunaga Tomoko Nanri Taizo Shimomura Hitoshi Suzushima Hiroaki Mitsuya Norio Asou | 2014 | Eur J Haematol2014，，6： | 2 |
| 5 | The genus bifidobacterium for cancer gene therapy显示文摘 | Fujimori Minoru Amano Jun Taniguchi Shunichiro | 2002 | Curr opin discow devel2002，5，2： | 1 |
| 6 | 显示文摘 | Roland W Takashi S Shunichiro U | 2002 | Chemosphere2002，49，： | 1 |
| 7 | Increased depression and anxiety in infertile Japanese women resulting from lack of husband's support and feelings of stress显示文摘 | Hidehiko Matsubayashi Takashi Hosaka Shunichiro Izumi | 2004 | General Hospital Psychiatry2004，26，： | 1 |
| 8 | Correlation of PCDD/PCDF and CO values in a MSW incinerator––indication of memory effects in the high temperature/cooling section显示文摘 | Roland Weber Takeshi Sakurai Shunichiro Ueno Junya Nishino | 2002 | Chemosphere2002，，2： | 1 |
| 9 | PbTaSe2拓扑表面态诱导的向列超导电性显示文摘通过平面内磁场转角的电阻和点接触谱的测量,作者发现拥有Dirac节点线的拓扑材料PbTaSe2中超导能隙存在明显的二重对称行为,低于PbTaSe2六角晶格结构的对称性,表明向列超导电性的存在.这种二重对称性会一直持续到表面超导的上临界场Hc2R,尽管体超导在体上临界场c2RH< | 乐天 孙悦 金汇可 车利强 尹礼长 李洁 庞贵明 徐春强 赵凌霄 Shunichiro Kittaka Toshiro Sakakibara Kazushige Machida Raman Sankar 袁辉球 陈根富 许晓峰 李世燕 周毅 路欣 | 2020 | Science Bulletin2020，65，16： | 1 |
| 10 | Large-scale hybrid monitoring system for temperature, strain and vibration using fiber Bragg grating sensors 显示文摘 | Akio Sumita Shunichiro Makino | 2002 | Proc of SPIE2002，4920，： | 1 |
| 11 | Evolutionary Segmentation of Texture Image Using Genetic Algorithms Towards Aautomatic Decision of Optimum Number of Segmentation Areas显示文摘 | Motohide Yoshimura Shunichiro Oe | 1999 | Pattern Recognition1999，32，： | 1 |
| 12 | Increased depression and anxiety in infertile Japanese woman resulting form lack of husband’s support and feeling of stress显示文摘 | Hidehiko M Takashi H Shunichiro I | 2004 | General Hospital Psychiatry2004，26，： | 1 |
| 13 | A long-term study of implanted artieial hydroxyapatite particles surrounding the carotid artery in adult dogs显示文摘 | Minoru M Shunichiro N | 2000 | Biomaterials2000，21，5： | 1 |
| 14 | In- creased depression and anxiety in infertile Japanese women resul- ting from lack of husbands support and feeling of stress显示文摘 | Hidehiko Matsbayashi Takashi Hosaka Shunichiro Izum | 2004 | Gener- al Hospital Psychiatry2004，26，5： | 1 |
| 15 | Experimental rat model for alcohol‐induced osteonecrosis of the femoral head显示文摘 | Shunichiro Okazaki Satoshi Nagoya Kenji Tateda Ryuichi Katada Keisuke Mizuo Satoshi Watanabe Toshihiko Yamashita Hiroshi Matsumoto | 2013 | Int J Exp Path2013，，5： | 1 |
| 16 | Photodynamic Therapy Using Upconversion Nanoparticles Prepared by Laser Ablation in Liquid显示文摘 | Tomohiro Ikehata Yuji Onodera Takashi Nunokawa Tomohisa Hirano Shunichiro Ogura Toshiaki Kamachi Osamu Odawara Hiroyuki Wada | 2014 | Applied Surface Science2014，，： | 1 |
| 17 | Prenatal diagnosis of sirenomelia in the late second thrimester with three- dimensional helical computed tomography显示文摘 | Tetsuo O Daisuke K Shunichiro T | 2011 | Tohoku J Exp Med2011，225，： | 1 |
| 18 | MRI evalua- tion of the uterine structure after myomectomy显示文摘 | SHUNICHIRO T KENTARO T IZUMI I | 2006 | Gynecol Obstet Invest2006，61，： | 1 |
| 19 | Enzymatic basis for sialyl-Tn expression in human colon cancer cells显示文摘 | Inka Brockhausen Jimmy Yang Nathalie Dickinson Shunichiro Ogata Steven H Itzkowitz | 1998 | Glycoconjugate Journal1998，，6： | 1 |
| 20 | Increased depression and anxiety in infertile Japanese women resulting from lack of husbands support and feeling of stress显示文摘 | Hidehiko Matsbayashi Takashi Hosaka Shunichiro lzum | | 0，，26： | 1 |
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