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您的检索式：作者名="Silvia Bozza"
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| 1 | Prospects for dendritic cell vaccination against fungal infections in hematopoietic transplantation显示文摘 | Katia Perruccio Silvia Bozza Claudia Montagnoli Silvia Bellocchio Franco Aversa Massimo Martelli Francesco Bistoni Andrea Velardi Luigina Romani | 2004 | Blood Cells, Molecules and Diseases2004，，： | 1 |
| 2 | Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO显示文摘Innate responses combine with adaptive immunity to generate the most effective form of anti-Aspergillus immune resistance.Whereas the pivotal role of dendritic cells in determining the balance between immunopathology and protective immunity to the fungus is well established,we determined that epithelial cells(ECs)also contributes to this balance.Mechanistically,EC-mediated protection occurred through a Toll-like receptor 3/Toll/IL-1 receptor domain-containing adaptor-inducing interferon(TLR3/TRIF)-dependent pathway converging on indoleamine 2,3-dioxygenase(IDO)via non-canonical nuclear factor-kB activation.Consistent with the high susceptibility of TRIF-deficient mice to pulmonary aspergillosis,bone marrow chimeric mice with TRIF unresponsive ECs exhibited higher fungal burdens and inflammatory pathology than control mice,underexpressed the IDO-dependent T helper 1/regulatory T cell(Th1/Treg)pathway and overexpressed the Th17 pathway with massive neutrophilic inflammation in the lungs.Further studies with interferon(IFN)-c,IDO or IL-17R unresponsive cells confirmed the dependency of immune tolerance to the fungus on the IFN-c/IDO/Treg pathway and of immune resistance on the MyD88 pathway controlling the fungal growth.Thus,distinct immune pathways contribute to resistance and tolerance to the fungus,to which the hematopoietic/non-hematopoietic compartments contribute through distinct,yet complementary,roles. | Antonella de Luca Silvia Bozza Teresa Zelante Silvia Zagarella Carmen D’Angelo Katia Perruccio Carmine Vacca Agostinho Carvalho Cristina Cunha Franco Aversa Luigina Romani | 2010 | Cellular & Molecular Immunology2010，7，6： | 1 |
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