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| 1 | Selective ablation of type 3 adenylyl cyclase in somatostatin-positive interneurons produces anxiety-and depression-like behaviors in mice显示文摘BACKGROUND Major depressive disorder(MDD)is a highly disabling psychiatric syndrome associated with deficits of specific subpopulations of cortical GABAergic interneurons;however,the underlying molecular mechanism remains unknown.Type 3 adenylyl cyclase(ADCY3,AC3),which is important for neuronal excitability,has been implicated in MDD in a genome-wide association study in humans.Moreover,a study reported that ablation of AC3 in mice caused similar symptoms as MDD patients.AIM To determine if disruption of the AC3 gene in different subtypes of GABAergic interneurons of mice causes depression-like behaviors.METHODS Using immunohistochemistry,we investigated the expression of AC3 in two major subtypes GABAergic interneurons:Somatostatin-positive(SST+)and parvalbumin-positive(PV+)neurons.Genetic manipulations were used to selectively disrupt AC3 expression in SST+or PV+interneurons.A series of behavior tests including rotarod test,open field test(OFT),elevated plus maze test(EPM),forced swimming test(FST),and tail suspension test(TST)were used to evaluate the motor ability,anxiety-and depression-like behaviors,respectively.RESULTS Our results indicate that approximately 90.41%of SST+and 91.22%of PV+interneurons express AC3.After ablation of AC3 in SST+interneurons,the mice spent comparable time in the center area in OFT,but significantly less time in the open arms and low frequency of entries to the open arms in EPM.Furthermore,these mice showed prolonged immobility in FST and more freezing in TST.However,there were no significant changes in these behaviors after specific disruption of AC3 in PV+interneurons.CONCLUSION This study indicates that ablation of AC3 in SST+interneurons of mice increases anxiety-and depression-like behaviors in mice,supporting the general hypothesis that decreased AC3 activity may play a role in human depression. | Xiao-Yu Yang Zhao-Liang Ma Daniel R Storm Hong Cao Yu-Qiu Zhang | 2021 | World Journal of Psychiatry2021，11，2： | 3 |
| 2 | Differential evolution--a simple and efficient heuristic for global optimization over continuous spaees显示文摘 | STORM R PRICE K | 1997 | Journal of Global Optimization1997，11，4： | 1 |
| 3 | Management of the major coagulopathy with onset during iaparotomy 显示文摘 | STONE H H STORM P R MULLINS R J | 1983 | Ann Surg1983，197，5： | 1 |
| 4 | Flocculation of asphaltenes in heavy oil at elevated temperatures显示文摘 | Storm D Barresi R J Sheu E | 1996 | Fuel Science & Tech- nology International1996，14，12： | 1 |
| 5 | Mycotox-ins in silage显示文摘 | Storm I D M Srensen J L Rasmussen R R | 2008 | Stewart Postharvest Review2008，4，6： | 1 |
| 6 | Extent of cutaneous metabolism during percutaneous absorption of xenobiotics 显示文摘 | Bronaugh R L Stewart R F Storm J E | 1989 | Toxicology and Applied Pharmacology1989，99，： | 1 |
| 7 | Cranial irradiation increases risk of stroke in pediatric brain tumor survivors显示文摘 | Campen CJ Kranick SM Kasner SE Kessler SK Zimmerman RA Lust-ig R Phillips PC Storm PB Smith SE Ichord R Fisher MJ | | 0，，： | 1 |
| 8 | Multi-Mycotoxin Analysis of Maize Silage by LC-MS/MS显示文摘 | RASMUSSEN R R STORM I M L D RASMUSSEN P H | 2010 | Analytical and Bioanalytical Chemistry2010，397，2： | 1 |
| 9 | Role of signal transduction crosstalk between adenylyl cyclase and MAP kinase in hippocampus-dependent memory 显示文摘 | Xia Z Storm D R | 2012 | Learn Mere2012，19，9： | 1 |
| 10 | Tracking multiple independent targets evidence for a parallel tracking mechanism显示文摘 | PYLYSHN Z M STORM R W | | 0，，03： | 1 |
| 11 | Polymyxin and related peptide antibiotics显示文摘 | Storm D R Rosenthal K S Swanson P E | 1977 | Annu Rev Biochem1977，46，6： | 1 |
| 12 | The coupling mechanism of P - glycoprotein involves residue L339 in the sixth membrane spanning segment 显示文摘 | Rothnie A Storm J M cMahon R | 2005 | FEBS Lett2005，579，18： | 1 |
| 13 | Reduction of azodycs during in vitro percutaneous absorption显示文摘 | Collier SW Storm JE Bronaugh R L | | 0，，118： | 1 |
| 14 | Biochemistry: Is pyrroloquinoline quinone a vitamin? 显示文摘 | RUCKER R STORMS D SHEETS A | 2005 | Nature2005，433，7025： | 1 |
| 15 | Effects of treatment with small interfering RNA on joint inflammation in mice with cillagen-induced arthritis显示文摘 | Schiffelers R M Xu J Storm G | 2005 | Rheum2005，52，4： | 1 |
| 16 | Extended dynamic range from a combined linear-logarith- mic CMOS image sensor显示文摘 | Storm G Henderson R Hurwitz J E D Crenshaw D Purcell M | 2006 | IEEE J Sofid-State Circuits2006，41，9： | 1 |
| 17 | Differential evolution-a simple and efficient heuristic for global optimization over continuous space显示文摘 | Storm R Price K | 1997 | Global Optimization1997，11，4： | 1 |
| 18 | 查看详情显示文摘 | Katzer D S Storm D E Binari S C Roussos J A Shanabrook B V Glaser E R | | 0，，： | 1 |
| 19 | Effect on nitrogen and phosphorus losses in surface runoff显示文摘 | FLANAGAN D C FOSTER G R STORM P | 1989 | Transactions of the ASAE1989，32，2： | 1 |
| 20 | Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation显示文摘 | Rizzieri DA Storms R Chen DF | 2010 | Biol Blood Marrow Transplant2010，16，： | 1 |
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