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| 1 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Inhibition of oxidant-induced chemical and structural changes of whey protein by BHA and a-tocopherol显示文摘 | Kong BH Sun Y Jiang LZ | 2012 | International Journal of Dairy Technology2012，65，3： | 1 |
| 3 | Compressive behavior of 3 D angle- interlock woven fabric composites at various strain rates显示文摘 | Sun BZ Gu BH Ding X | 2005 | Polymer Testing2005，24，4： | 1 |
| 4 | Rosiglitazone protects against cyclospofine-induced pancreatic and renal injury in rats显示文摘 | Chung BH Li C Sun BK | 2005 | Am J Transplant2005，5，8： | 1 |
| 5 | Taurine protected kidney from oxidative injury through mitochondrial-linked pathway in a rat model of nephrolithiasis显示文摘 | LI CY DENG YL SUN BH | 2009 | Urol Res2009，37，4： | 1 |
| 6 | New developments in osteoarthritis 显示文摘 | Sun BH Wu CW Kalunian KC | 2007 | Rheum Dis Clin North Am2007，33，1： | 1 |
| 7 | EGF and HB-EGF modulate inward potassium current in human bladder urothelial cells from normal and interstitial cystitis patients 显示文摘 | Sun Y Chen M Lowentritt BH | 2007 | Am J Physiol Cell Physiol2007，292，1： | 1 |
| 8 | Effect of endobronchial blocker tube in the pulmonary carcinoma with video-assisted thoracic surgery 显示文摘 | Sun LR Gu LB Ren Bh | 2011 | Chinese-German J Clin Oncol2011，10，4： | 1 |
| 9 | Rosiglitazone protects against cyclosporine- induced pancreatic and renal injury in rats显示文摘 | Chung BH Li C Sun BK | 2005 | Am J Transplant2005，5，8： | 1 |
| 10 | Self-assembly of synthetic hydroxyapatite nanorods into an enamel prism-like structure 显示文摘 | Chen HF Clarkson BH Sun K | 2005 | J Colloid Interface Sci2005，288，： | 1 |
| 11 | A meta-analysis on the effect of corticosteroid therapy in Kawasaki disease 显示文摘 | Zhu BH Lv HT Sun L | 2012 | Eur J Pediatr2012，171，3： | 1 |
| 12 | The effects of avermectin on a- mino acid neurotransmitters and their receptors in the pigeon brain显示文摘 | Chen LJ Sun BH Cao Y | 2014 | Pestic Bioehem Physiol2014，110，： | 1 |
| 13 | Fine-tuning of pre-balanced excitation and inhibition during auditory cortical development显示文摘 | Sun YJ Wu GK Liu BH | 2010 | Nature2010，465，7300： | 1 |
| 14 | Technology Innovation and Implications for Customer Relationship Management显示文摘 | Sun BH | | 0，，06： | 1 |
| 15 | Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro:therapeutic implication for excessive scarring显示文摘 | Phan TT Sun L Bay BH | 2003 | J Trauma2003，54，6： | 1 |
| 16 | Suberoylanilide hydroxamicacid induces apoptosis and sub-Gj arrest of 320 HSR colon cancercells显示文摘 | Sun PC Tzao C Chen BH | 2010 | J Biomed Sci2010，17，： | 1 |
| 17 | Self-assembly of synthetic hydroxyapatite nanorods into an enamel prism-like structure显示文摘 | Chen HF Clarkson BH Sun K | 2005 | J Colloid Interface Sci2005，288，1： | 1 |
| 18 | Intervening inhibition underlies simple-cell receptive field structure in visual cortex显示文摘 | Liu BH Li P Sun YJ | 2010 | Nat Neurosci2010，13，1： | 1 |
| 19 | Hepatoprotective activity of the constituents in Swertia pseudochinensis 显示文摘 | Li JC Feng L Sun BH | 2005 | Biol Phann Bull2005，28，： | 1 |
| 20 | Cytogenetic and genomic relationship of Thinopyrum elongatum with two Psathyrostachys species and with Leymus secalinus(Triticeae:Poaceae) 显示文摘 | Sun GL Wu BH Liu F | 1995 | P1 Syst Evol1995，，197： | 1 |
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