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| 1 | Topical application of glycyrrhizin preparation ameliorates experimentally induced colitis in rats显示文摘AIM:To examine the efficacy of glycyrrhizin preparation(GL-p) in the treatment of a rat model of ulcerative colitis(UC).METHODS:Experimental colitis was induced by oral administration of dextran sodium sulfate.Rats with colitis were intrarectally administered GL-p or saline.The extent of colitis was evaluated based on body weight gain,colon wet weight,and macroscopic damage score.The expression levels of pro-inflammatory cytokines and chemokines in the inflamed mucosa were measured by cytokine antibody array analysis.The effect of GL-p on myeloperoxidase(MPO) activity in the inflamed mucosa and purified enzyme was assayed.RESULTS:GL-p treatment significantly ameliorated the extent of colitis compared to sham treatment with saline.Cytokine antibody array analysis showed that GL-p treatment significantly decreased the expression levels of pro-inflammatory cytokines and chemokines,including interleukin(IL)-1β,IL-6,tumor necrosis factor-α,cytokine-induced neutrophil chemoattractant-2,and monocyte chemoattractant protein-1 in the inflamed mucosa.Furthermore,GL-p inhibited the oxidative activity of mucosal and purified MPO.CONCLUSION:GL-p enema has a therapeutic effect on experimental colitis in rats and may be useful in the treatment of UC. | Tomohiro Kudo Shinichi Okamura Yajing Zhang Takashige Masuo Masatomo Mori | 2011 | World Journal of Gastroenterology2011，17，17： | 23 |
| 2 | Cyclooxygenase 2 1195G〉A polymorphism is associated with chronic obstructive pulmonary disease in Japanese and Chinese patients显示文摘 | CHEN Li-jun XU Wang Yasuyuki Taooka Miki Ohe Hitoshi Takahashi Akihisa Sutani Takashige Kuraki Takeshi Isobe | 2013 | Chinese Medical Journal2013，，12： | 5 |
| 3 | Effect of micro-bubbles on coagulation flotation process of dyeing wastewater显示文摘 | Shu Liu Qunhui Wang Hongzhi Ma Peikun Huang Jun Li Takashige Kikuchi | 2010 | Separation and Purification Technology2010，，3： | 3 |
| 4 | Effect of micro-bubbles on coagulation flotation process of dyeing wastewater显示文摘 | Shu Liu Qunhui Wang Hongzhi Ma Peikun Huang Jun Li Takashige Kikuchi | 2010 | Separation and Purification Technology2010，，3： | 3 |
| 5 | Two acylated anthocyanins from purple sweet potato显示文摘 | Yukihiro Goda Takashige Shimizu Yoshiaki Kato Mikio Nakamura Tamio Maitani Takashi Yamada Norihko Terahara Masaatu Yamaguchi | 1996 | Phytochemistry1996，，1： | 2 |
| 6 | Development history of train control system technology显示文摘 | TAKASHIGE T | 2004 | Railway & Electrical Engineering2004，15，2： | 1 |
| 7 | Mitochondrial Genome Differentiation in the Genus Phyllostachys 显示文摘 | Fumio T Takashige I Toru T | 1998 | Japan Agricultural Research1998，32，1： | 1 |
| 8 | Signalling systems for safe railway transport 显示文摘 | TAKASHIGE T | 1999 | Japan Railway & Transport Review1999，，21： | 1 |
| 9 | Signalling systems for safe railway transport显示文摘 | TAKASHIGE T | 1999 | Japan Railway and Transport Review1999，，21： | 1 |
| 10 | Evaluation of the efficacy and safety of biapenem against pneumonia in the elderly and a study on its pharmacokinetics显示文摘 | Fumi Karino Naoko Deguchi Hibiki Kanda Miki Ohe Keiichi Kondo Mitsuhiro Tada Takashige Kuraki Nobuhiro Nishimura Hidehiko Moriyama Kazuro Ikawa Norifumi Morikawa Takeshi Isobe | 2013 | Journal of Infection and Chemotherapy2013，，1： | 1 |
| 11 | Mitochondrial Genome Differentiation in the Genus Phyllostaehys显示文摘 | Fumio T Takashige I Toru T | 1998 | Japan Agricultural Research1998，32，1： | 1 |
| 12 | Six diacylated anthoeyanins from the storage root of purple sweet potato, Ipomoea batatas显示文摘 | Terahara N Shimizu T Takashige K | 1999 | Biosci Biotechnol Biochem1999，63，8： | 1 |
| 13 | Meander of the Kuroshio front and current variability in the East China Sea显示文摘 | Takashige Sugimoto Shingo Kimura Kuniaki Miyaji | 1988 | Journal of the Oceanographical Society of Japan1988，，3： | 1 |
| 14 | Diaeylated an- thoeyanins from the storage root of purplre sweet potato 显示文摘 | Terahara N Shimizu T Takashige K | 1999 | Biosci Biotechnol Biochem1999，63，8： | 1 |
| 15 | Six diacylated anthocyanins from the storage roots of purple sweet potato, Ipomoea batatas显示文摘 | TERAHARA Norihiko SHIMIZU Takashige KATO Yoshiaki | 1999 | Bioscience Biotechnology and Biochemistry1999，63，8： | 1 |
| 16 | Dielectric properties of crystallization process from amorphous Bi4Ti3O12 显示文摘 | TAKASHIGE M S HAMAZAKI YOSHIDA R | 2001 | Jpn J Appl Phys2001，40，9： | 1 |
| 17 | Six diacylated a nthocyanins from the storage root of purple sweet potato,Ipomoea batatas显示文摘 | Terahara N Shimizu T Takashige K | 1999 | Biosci Biotechnol Biochem1999，63，8： | 1 |
| 18 | Two acylated anthocyanins from purple sweet potato显示文摘 | Yukihiro Goda Takashige Shimizu Yoshiaki Kato Mikio Nakamura Tamio Maitani Takashi Yamada Norihko Terahara Masaatu Yamaguchi | 1996 | Phytochemistry1996，，1： | 1 |
| 19 | Large-scale DNA polymorphism study of Oryza sativa and O. rufipogon reveals the origin and divergence of Asian rice显示文摘 | Sujay Rakshit Arunita Rakshit Hideo Matsumura Yoshihiro Takahashi Yoshitaka Hasegawa Akiko Ito Takashige Ishii Naohiko T. Miyashita Ryohei Terauchi | 2007 | Theoretical and Applied Genetics2007，，4： | 1 |
| 20 | Significance of cox-2 expression in human renal cell carcinoma cell line显示文摘 | QINZHONG CHEN NOBUO SHINOHARA TAKASHIGE A B E | 2004 | Int J Cancer2004，108，6： | 1 |
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