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68篇 您的检索式:作者名="Tang KK"
    题名 作者 年代 出处 被引量
1Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang 2014Cell Research2014,,6:16
2Screening for vestibular schwannoma by magnetic resonance imaging:Analysis of 1821 patients显示文摘Kwan TL Tang KW Pak KK 2004Hong Kong Med J2004,10,:1
3A single-centre experience of 40 laparoscopic Liver resections显示文摘 Tsui kk Ha Jpy 2006HongKong Med2006,12,6:1
4Transcriptional induction of endothelial nitric oxide synthase type by lysophosphatidylcholine显示文摘Zembowicz A Tang J Wu KK 1995J Biol Chem1995,270,17:1
5Laparoscopic versus open appendectomy for complicated appendicitis 显示文摘Yau KK Siu WT Tang CN 2007J Am Coil Surg2007,205,1:1
6Mixed dentition analysis for Hong Kong Chinese显示文摘Yuen KK Tang EL So LL 0,,01:1
7Mapping cyclic change of regional myocardial blood volume using steady-state susceptibility effect of iron oxide nanoparticles 显示文摘Wu EX Tang H Wong KK 2004J Magn Reson Imaging2004,19,1:1
8Laparoscopic versus open appendectomy for complicated appendicitis显示文摘Yau KK Siu WT Tang CN 2007J Am Coll Surg2007,205,1:1
9Linkage and association of myocilin (MYOC)polymorphism with high myopia in a Chinese population显示文摘Tang WC Yip SPo k KK 2007Mol Vis2007,13,:1
10A single-centre experience of 40 laparoscopic liver resections 显示文摘CN Tang KK Tsui JPY Ha 2006Hong Kong Med2006,12,6:1
11Human metapneumovirus infection in an immunocompetent adult presenting as mononucleosis-like illness显示文摘Li IW To KK Tang BS 2008J Infect2008,56,5:1
12Neuroblastoma imaging using a combined CT scanner-scintillation camera and ^131I-MIBG 显示文摘Tang HR Da Silva AJ Matthay KK 2001J Nucl Med2001,42,2:1
13Linkage and association of myocilin (MYOC) polymorphisms with high myopia in a Chinese population显示文摘Tang WC Yip SP Lo KK 2007Mol Vis2007,13,:1
14Idiopathic normal pressure hydrocephalus: correlating magnetic resonance imaging biomarkers with clinical response 显示文摘Ng SE Low AM Tang KK 2009Ann Acad Med ( Singapore )2009,38,9:1
15Double peel using triameinolone acetonide and trypan blue in the management of myopic maeu- lax hole with retinal detachment: a ease-contrel study显示文摘Li KK Tang EW Li PS 2010Clin Experiment Ophthalmol2010,38,7:1
16Mapping cyclic change of regional myocardial blood volume using steady-state susceptibility effect of iron oxide nanoparticles显示文摘Wu EX Tang H Wong KK 2004J Magn Reson Imaging2004,19,1:1
17Laparoscopic versus open appen- dectomy for complicated appendicitis 显示文摘Yau KK Siu WT Tang CN 2007J Am Coil Surg2007,205,1:1
18显示文摘Tang WY Lo KK Lam WY 1995Br J Dermatol1995,133,3:1
19Double peel using triamcinolone acetonede and trypan blue in the management of myopic macular hole with retinal detachment: a case-control study显示文摘Li KK Tang EW Li PS 2010Clin Exper- iment Ophthalmol2010,38,7:1
20Linkage and association of myocilin (MYOC) polymorphisms with high myopia in a Chinese population显示文摘Tang WC Yip SP Lo KK 2007Mol Vis2007,13,:1
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