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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Tillage effects on soil hydraulic properties in space and time:State of the science显示文摘 | Mark W S Timothy R G James C A | 2008 | Soil and Tillage Research2008，99，1： | 1 |
| 3 | Methodology of organic-rich shale lithofacies identification and prediction:a case study from Marcellus Shale in the appalachian basin显示文摘 | WANG G C TIMOTHY R | 2012 | Computers & Geosciences2012，49，： | 1 |
| 4 | Biological con trol in greenhouse systems显示文摘 | Timothy C Paulitz Richard R Belanger | 2001 | Reviews2001，39，： | 1 |
| 5 | The surgical treat ment of metastatic disease of the spine显示文摘 | Hatrick N C Lucas J D Timothy A R | 2000 | Radiother Oncol2000，56，3： | 1 |
| 6 | Alkylation of acetylacetone with isopropyl alcohol by means of boron fluoride显示文摘 | TIMOTHY F C CHARLES R H | 1967 | J Org Chem1967，32，8： | 1 |
| 7 | Insect ryanodine receptors:molecular targets for novel pest control chemicals显示文摘 | David B S Daniel C Timothy R C | 2008 | Invent Neurosci2008，8，： | 1 |
| 8 | Non-coding RNAs: regulators of disease 显示文摘 | Ryan J Taft Ken C Pang Timothy R Mercer | 2010 | J Pathology2010，220，2： | 1 |
| 9 | Foodborne Campylobacter: Infections, Metabolism, Pathogenesis and Reservoirs显示文摘 | Epps Sharon V R Harvey Roger B Hume Michael E Phillips Timothy D Anderson Robin C Nisbet David J | 2013 | International Journal of Environmental Research and Public Health2013，，12： | 1 |
| 10 | Early psychological adjustment in breast cancer patients-A prospective study显示文摘 | Chiara N Jonathan V R Timothy C | 2002 | J Psycho Res2002，53，6： | 1 |
| 11 | Architecture and stratigraphy of alluvial deposits,Morrison Formation(Upper Jurassic),Utah显示文摘 | Audun V K Edwin R S Timothy A C | 2008 | AAPG Bull2008，92，8： | 1 |
| 12 | Stategic risk:an ordinal approach 显示文摘 | JAMES M C TIMOTHY W R | 1992 | Management Science1992，，12： | 1 |
| 13 | Accuracy of drug infusion pump under computer control显示文摘 | STEPHEN B C TIMOTHY J Q JAMES R J | 1992 | IEEE Transactions on Biomedical Engineering1992，39，9： | 1 |
| 14 | Prognostic significance of expression of a ras protein with a molecular weight of 21,000 by human breast cancer显示文摘 | Timothy C Willian R Miller D | 1987 | Cancer Res1987，47，： | 1 |
| 15 | Multiple envi ronmental controls on phytoplankton growth strategies determine adaptive responses of the N : P ratio 显示文摘 | Stuart J D James R C Timothy M L | 2014 | E cology Letters2014，17，4： | 1 |
| 16 | Evaluation of WHO criteria for identifying patients with severe acute respiratory syndrome out -of- hospital: prospective observational study显示文摘 | Timothy H R Peter A C Devilliers S | 2003 | BMJ2003，326，21： | 1 |
| 17 | Influence of the molar mass distribution on the elongational behavior of polymer solutions in capillary breakup显示文摘 | Lucy E R Timothy P S Justin J C | | 0，，1： | 1 |
| 18 | Tillage effects on soil hydraulic properties in space and time: State of the science 显示文摘 | Mark W S Timothy R G James C A | 2008 | Soil and Tillage Research2008，99，1： | 1 |
| 19 | Dealer and Manufacturer Margins显示文摘 | Timothy F B Peter C R | 1985 | The RAND Journal of Economics1985，2，16： | 1 |
| 20 | Europe adapts to climate change: comparing national adaptation strategies 显示文摘 | Biesbroek G R Swart R J Timothy R C | 2010 | Global Environmental Change2010，20，： | 1 |
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