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| 1 | Diagnostic and therapeutic single-operator cholangiopancreatoscopy in biliopancreatic diseases:Prospective multicenter study in Japan显示文摘AIM: To assess the utility and safety of single-operator cholangiopancreatoscopy(SOCPS) using the Spy Glass system in widespread clinical application for biliary and pancreatic diseases.METHODS: This study was a prospective case series conducted in 20 referral centers in Japan. There were 148 patients who underwent SOCPS; 124 for biliary diseases and 24 for pancreatic diseases. The attempted interventions were SOCPS examination, SOCPS-directed tissue sampling, and therapy for stone removal, among others. The main outcomes were related to the procedure success rate in terms of visualizing the target lesions, SOCPS-directed adequate tissue sampling, and complete stone removal. RESULTS: A total of 148 patients were enrolled for the diagnosis of indeterminate biliary and pancreatic lesions or treatment of biliary and pancreatic disease. The overall procedure success rate of visualizing the target lesions was 91.2%(135/148). The overall procedural success rates of visualizing the target lesions of diagnostic SOCPS in the bile duct and pancreatic duct were 95.5%(84/89) and 88.2%(15/17), respectively. Diagnosis: the overall adequate tissue for histologic examination was secured in 81.4% of the 86 patients who underwent biopsy under SOCPS(bile duct, 60/75, 80.0%; pancreatic duct, 10/11, 90.9%). The accuracy of histologic diagnosis using SOCPS-directed biopsies in indeterminate bile duct lesions was 70.7%(53/75). In the pancreatic duct, the accuracy of SOCPS visual impression of intraductal papillary mucinous neoplasm was 87.5%(14/16). Stone therapy: complete biliary and pancreatic stone clearance combined with SOCPS-directed stone therapy using electrohydraulic lithotripsy or laser lithotripsy was achieved in 74.2%(23/31) and 42.9%(3/7) of the patients, respectively. Others: SOCPS using the Spy Glass system was used in cannulation of the cystic duct in two patients and for passing across the obstructed self-expandable metallic stent for a malignant biliary stricture in two patients. All procedures were successful in both SOCPS-guided therapies. The incidence of procedure-related adverse events was 5.4%(8/148). CONCLUSION: SOCPS with direct visualization and biopsy for diagnosis and SOCPS-directed therapy for biliary and pancreatic diseases can be safely performed with a high success rate. | Toshio Kurihara Ichiro Yasuda Hiroyuki Isayama Toshio Tsuyuguchi Taketo Yamaguchi Ken Kawabe Yoshinobu Okabe Keiji Hanada Tsuyoshi Hayashi Takao Ohtsuka Syuhei Oana Hiroshi Kawakami Yoshinori Igarashi Kazuya Matsumoto Kiichi Tamada Shomei Ryozawa Hiroki Kawashima Yutaka Okamoto Iruru Maetani Hiroyuki Inoue Takao Itoi | 2016 | World Journal of Gastroenterology2016，22，5： | 20 |
| 2 | Differential effects on D 2 dopamine receptor and prolactin gene expression by haloperidol and aripiprazole in the rat pituitary显示文摘 | Atsuko Inoue Mayumi Seto Sayori Sugita Izumi Hide Tsuyoshi Hirose Nobuyuki Koga Tetsuro Kikuchi Yoshihiro Nakata | 1998 | Molecular Brain Research1998，，2： | 2 |
| 3 | Screening of agonistic activities against four nuclear receptors in wastewater treatment plants in Japan using a yeast two-hybrid assay显示文摘To assess the potential endocrine disruptive effects through multiple nuclear receptors(NRs),especially non-steroidal NRs,in municipal wastewater,we examined the agonistic activities on four NRs(estrogen receptor α,thyroid hormone receptor α,retinoic acid receptor α and retinoid X receptor α) of untreated and treated wastewater from municipal wastewater treatment plants(WWTPs) in Japan using a yeast two-hybrid assay.Investigation of the influent and effluent of seven WWTPs revealed that agonistic activities against steroidal and non-steroidal NRs were always detected in the influents and partially remained in the effuents.Further investigation of four WWTPs employing conventional activated sludge,pseudo-anoxic-oxic,anoxic-oxic and anaerobic-anoxic-oxic processes revealed that the ability to reduce the agonistic activity against each of the four NRs varies depending on the treatment process.These results indicated that municipal wastewater in Japan commonly contains endocrine disrupting chemicals that exert agonistic activities on steroidal and non-steroidal NRs,and that some of these chemicals are released into the natural aquatic environment.Although the results obtained in yeast assays suggested that measured levels of non-steroidal NR agonists in the effluent of WWTPs were not likely to cause any biological effect,further study is required to assess their possible risks in detail. | Daisuke Inoue Koki Nakama Kazuko Sawada Taro Watanabe Hisae Matsui Kazunari Sei Tsuyoshi Nakanishi Michihiko Ike | 2011 | Journal of Environmental Sciences2011，23，1： | 2 |
| 4 | Clinicopathological and prognostic significance of microRNA-107 andits relationship to DICER1 mRNA expression in gastric cancer显示文摘 | Taisuke Inoue Hisae Iinuma Etsushi Ogawa Tsuyoshi Inaba Ryoji Fukushima | 2012 | Oncology Reports2012，，6： | 2 |
| 5 | Effect of Chemical Composition on Recrystallization Behavior and r-Value in Ti-Added Ultra Low Carbon Sheet Steel显示文摘 | Yoda Rika Tsukatani Ichiro Inoue Tsuyoshi | 1994 | ISIJ International1994，34，1： | 1 |
| 6 | New quasicrystals in Al65Cu20M15 (M = Cr, Mn or Fe) systems prepared by rapid solidification显示文摘 | An-Pang Tsai Akihisa Inoue Tsuyoshi Masumoto | 1988 | Journal of Materials Science Letters1988，，4： | 1 |
| 7 | Mutation screening of the human Clock gene in circadian rhythm sleep disorders显示文摘 | Toshio Iwase Naofumi Kajimura Makoto Uchiyama Takashi Ebisawa Kimio Yoshimura Yuichi Kamei Kayo Shibui Keiko Kim Yoshinao Kudo Masaaki Katoh Tsuyoshi Watanabe Toru Nakajima Yuji Ozeki Mariko Sugishita Toru Hori Masaaki Ikeda Ryoichi Toyoshima Yuichi Inoue | 2002 | Psychiatry Research2002，，2： | 1 |
| 8 | Quasicrystalline phase in Al-Si-Mn system prepared by annealing of amorphous phase显示文摘 | Akihisa Inoue Yoshio Bizen Tsuyoshi Masumoto | 1988 | Metallurgical Transactions A1988，，2： | 1 |
| 9 | Preparation of a new Al-Cu-Fe quasicrystal with large grain sizes by rapid solidification显示文摘 | An-Pang Tsai Akihisa Inoue Tsuyoshi Masumoto | 1987 | Journal of Materials Science Letters1987，，12： | 1 |
| 10 | Effect of H elicobacter pylori infection on esophagogastric variceal bleeding in patients with liver cirrhosis and portal hypertension显示文摘 | Yoshihiro Sakamoto Kazuhiko Oho Atsushi Toyonaga Masafumi Kumamoto Tsuyoshi Haruta Hiroto Inoue Keigo Emori Osamu Tsuruta Michio Sata | 2013 | J Gastroenterol Hepatol2013，，9： | 1 |
| 11 | Angiopoietin-2 is related to tumor aniogenesis in gastric cacinoma:possible in vivo regulation via Induction of proteases显示文摘 | Hiroshi Inoue Shinji Tanaka | 2001 | Cancer Reserch2001，61，： | 1 |
| 12 | Amorphous (Ti,Zr,Hf)-Ni-Cu ternary alloys with a wide supercooled liquid region显示文摘 | Akihisa Inoue Tsuyoshi Masumoto | 1994 | Materials Science and Engineering A1994，，： | 1 |
| 13 | Nb-Poor Fe–Nb–B nanocrystalline soft magnetic alloys with small amount of P and Cu prepared by melt-spinning in air显示文摘 | Akihiro Makino Teruo Bitoh Akihisa Inoue Tsuyoshi Masumoto | 2003 | Scripta Materialia2003，，7： | 1 |
| 14 | Overexpression of the miR-34 family suppresses invasive growth of malignantmelanoma with the wild-type p53 gene显示文摘 | Hitoshi Yamazaki Tsuyoshi Chijiwa Yoshimasa Inoue Yoshiyuki Abe Hiroshi Suemizu Kenji Kawai Masatoshi Wakui Daisuke Furukawa Masaya Mukai Sadahito Kuwao Makoto Saegusa Masato Nakamura | 2012 | Experimental and Therapeutic Medicine2012，，5： | 1 |
| 15 | Effect of additives on dechlorination of PVC by mechanochemical treatment显示文摘 | Shu Saeki Junya Kano Fumio Saito Kaoru Shimme Seiichi Masuda Tsuyoshi Inoue | 2001 | Journal of Material Cycles and Waste Management2001，，1： | 1 |
| 16 | Effect of Chemical Composition on Recrystallization Behavior and r - value in Ti - added Ultra LowCarbon Sheet Steel 显示文摘 | Rika YODA Ichiro TSUKATAN1 Tsuyoshi INOUE | 1994 | ISU International1994，34，： | 1 |
| 17 | Measurement of chloride ion concentration in concrete structures using terahertz time domain spectroscopy (THz-TDS)显示文摘 | Saroj R. Tripathi Hidehiro Ogura Hiroyuki kawagoe Hiroo Inoue Tsuyoshi Hasegawa Kei Takeya Kodo Kawase | 2012 | Corrosion Science2012，，： | 1 |
| 18 | Isolation and some properties of a mesophilic and mixotrophic ironoxidizing bacterium,OKM-9显示文摘 | Inoue Takao Kamimura Kazuo Sugio Tsuyoshi | 2000 | Bioscience Biotechnology and Biochemistry2000，64，10： | 1 |
| 19 | Development of Cold Rolling Mill Rolls of High Speed Steel Type by Using Continuous Pouring Process for Cladding显示文摘 | Taku Tanaka Tsuyoshi Inoue | 2002 | ISIJ International2002，42，9： | 1 |
| 20 | Possible involvement and the mechanisms of excess trans -fatty acid consumption in severe NAFLD in mice显示文摘 | Noriyuki Obara Koji Fukushima Yoshiyuki Ueno Yuta Wakui Osamu Kimura Keiichi Tamai Eiji Kakazu Jun Inoue Yasuteru Kondo Norihiko Ogawa Kenta Sato Tsuyoshi Tsuduki Kazuyuki Ishida Tooru Shimosegawa | 2010 | Journal of Hepatology2010，，2： | 1 |
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