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| 1 | 新生儿重症监护室出生胎龄<34周早产儿呼吸机相关肺炎的多中心流行病学调查显示文摘目的 调查我国新生儿呼吸机相关肺炎(VAP)的流行病学资料及病原菌分布特点.方法 分析2015年5月至2016年4月全国25家医院三级新生儿重症监护室(NICU)收治的出生胎龄<34周所有患儿的临床资料,根据医院性质分组为儿童专科医院和妇婴医院或综合性医院,计算VAP发生率.采用x2检验,t检验或秩和检验进行统计学分析.结果 共纳入患儿7 918例,其中男4 623例(58.4%),出生体重为(1 639 ±415)g,出生胎龄为(31.4±2.0)周,4 654例(58.8%)接受无创通气,2 154例(27.2%)接受有创机械通气.发生VAP 95例,总的VAP发生率为7.0/1 000个呼吸机使用日,各研究单位VAP发生率为(0-34.4)/1 000个呼吸机使用日.根据医院性质分组,7家儿童专科医院与18家妇婴医院或综合性医院VAP发生率差异无统计学意义[(9.6比6.0)/1 000个呼吸机使用日,t=1.002,P=0.327].检出病原菌83株,以革兰阴性杆菌(76株,91.6%)最常见,主要为鲍曼不动杆菌(24株,28.9%),肺炎克雷伯杆菌(23株,27.7%)及铜绿假单胞菌(10株,12.0%).结论 我国NICU平均VAP发生率接近发达国家水平,但不同医院之间差异显著,应加强各NICU医院内感染的定期监测和分析,在此基础上实施有效的感染综合防治措施,降低VAP发生率. | 李淑涓 蒋思远 张羿 Shoo K. Lee 严卫丽 周琦 韩树萍 郭金珍 夏世文 Vibhuti Shah 王三南 冀湧 杨长仪 杨传忠 单若冰 刘玲 易彬 刘江勤 林振浪 王杨 何玲 李明霞 潘新年 郭艳 陈玲 刘翠青 周勤 李晓莺 熊虹 齐宇洁 黑明燕 曹云 | 2017 | 中华儿科杂志2017，55，3： | 52 |
| 2 | Ocular drug delivery systems:An overview显示文摘The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration,especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal,dynamic and static ocular barriers. Also,therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades,ocular drug delivery research acceleratedly advanced towards developing a novel,safe and patient compliant formulation and drug delivery devices/techniques,which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also,it includes development of conventional topical formulations such as suspensions,emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery. On the other hand,for posterior ocular delivery,research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreo-retinal diseases. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topicaldrops. Also,these novel devices and/or formulations are easy to formulate,no/negligibly irritating,possess high precorneal residence time,sustain the drug release,and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies. Current review intends to summarize the existing conventional formulations for ocular delivery and their advancements followed by current nanotechnology based formulation developments. Also,recent developments with other ocular drug delivery strategies employing in situ gels,implants,contact lens and microneedles have been discussed. | Ashaben Patel Kishore Cholkar Vibhuti Agrahari Ashim K Mitra | 2013 | World Journal of Pharmacology2013，2，2： | 18 |
| 3 | Predominance of interaction among wild-type alleles of CYP11B2 in himalayan natives associates with high-altitude adaptation 显示文摘 | RAJPUT C ARIF E VIBHUTI A | 2006 | Bioehem Biophys Res Commun2006，348，2： | 1 |
| 4 | Correlation of oxidative status with BMI and lung function in COPD 显示文摘 | Vibhuti A Arif E Deepak D | 2007 | Clinl Biochem2007，，1314： | 1 |
| 5 | Endothelial nitric oxide synthase gene variants contribute to oxidative stress in COPD显示文摘 | Arif E Ahsan A Vibhuti A | 2007 | Biochem Biophys Res Commun2007，36，1： | 1 |
| 6 | Correlation of oxidative status with BMI and lung function in COPD 显示文摘 | Vibhuti A Arif E Deepak D | 2007 | Clin Biochem2007，40，1314： | 1 |
| 7 | Correla- tion of oxidative status with BMI and lung function in COPD显示文摘 | Vibhuti A ArifE Deepak D | 2007 | Clin Biochcm2007，40，1314： | 1 |
| 8 | Quality Improvement Initiatives in Neonatal Intensive Care Unit Networks: Achievements and Challenges显示文摘 | Vibhuti Shah Ruth Warre Shoo K. Lee | 2013 | Academic Pediatrics2013，，6： | 1 |
| 9 | Maternal family history of hypertension attenuates neonatal pain response显示文摘 | Christopher R. France Anna Taddio Vibhuti S. Shah M. Gabrielle Pagé Joel Katz | 2008 | Pain2008，，3： | 1 |
| 10 | Correlation of oxidative status with BMI and lung function in COPD显示文摘 | Vibhuti A Arif E Deepak D | 2007 | Clinl Biochem2007，140，1314： | 1 |
| 11 | Correlation of oxidative status with BMI and lung function in COPD显示文摘 | VIBHUTI A ARIF E DEEPAK D | 2007 | Clin Biochem2007，40，1314： | 1 |
| 12 | Melanoidins as major colourant insugarcane molasses based distillery effluent andits degradation显示文摘 | RAM CHANDRA RAM NARESH BHARAGAVA VIBHUTI RAI | 2008 | Bioresource Technology2008，99，： | 1 |
| 13 | CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD 显示文摘 | VIBHUTI A ARIF E MISHRA A | 2010 | Clin Chim Acta2010，411，78： | 1 |
| 14 | Melanoidins as major colourant in sugarcane molasses based distillery effuent and its degradation显示文摘 | Ram Chandra Ram Naresh Bharagava Vibhuti Rai | 2008 | Bioresource Technology2008，99，： | 1 |
| 15 | Correlation of oxidative status with BMI and lung function in COPD 显示文摘 | Vibhuti A Arif E Deepak D | 2007 | Clin Biochem2007，10，1314： | 1 |
| 16 | Correlation of oxidative status with BMI and lung function in COPD 显示文摘 | Vibhuti A Arif E Deepak D | 2007 | Clin Biochem2007，140，1314： | 1 |
| 17 | Correlation of oxidative status with BMI and lung function in COPD显示文摘 | Vibhuti A Arif E Deepak D | 2007 | Clin Biochem2007，140，1314： | 1 |
| 18 | Role of Endothelin-1 in Genesis of Coronary Artery Disease显示文摘 | Gurmukh S S Vibhuti G M Arun P M | 2005 | Indian Heart J2005，57，2： | 1 |
| 19 | The Maladies of Belonging 显示文摘 | Patel Vibhuti | 1999 | Newsweek1999，，20： | 1 |
| 20 | Endothelial nitric oxidesynthase gene variants contribute to oxidative stress in C0PD显示文摘 | Arif E Ahsan A Vibhuti A | 2007 | Biochem Biophys Res Commun2007，361，1： | 1 |
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