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| 1 | Osteoclast activity modulates B-cell development in the bone marrow显示文摘B 房间开发开是依赖的在 B 房间先锋和骨头髓 stromal 房间之间的相互作用,而是在这的骨破折(OCL ) 的角色处理未知的遗体。B lymphocytopenia 是 osteopetrosis 的一个特征,建议由 OCL 活动的 B 淋巴细胞增殖的调整。探讨这个问题,我们首先由树枝状的房间转移在 osteopetrotic oc/oc 鼠标救了 OCL 功能,导致骨头显型和 B 房间开发的恢复。为了推进,探索在 OCL 活动和 B 淋巴细胞增殖之间的连接,我们由 zoledronic 酸(ZA ) 的注射在正常老鼠导致了 osteopetrosis,骨头再吞的一个禁止者。B 房间数字在对待 ZA 的老鼠的骨头髓明确地减少了。ZA 直接没影响 B 房间区别,增长和 apoptosis,但是由 stromal 房间在 CXCL12 和 IL-7 的表示导致减少,与减少的 osteoblastic 约会联系了。在 oc/oc 老鼠的相等的低 osteoblastic 约会证实它在造骨细胞上源于减少的 OCL 活动而非从 ZA 的直接效果。骨头微型环境的这些戏剧的改变为 B 淋巴细胞增殖是不利的,导致在他们在导致 ZA 的 osteopetrotic 模型的骨头髓壁龛外面的 B 房间祖先的保留。总的来说,我们的数据表明 OCL 由控制骨头微型环境和造骨细胞的命运在骨头髓调制 B 房间开发。他们由 OCL 活动在他们的壁龛为 B 房间的保留的规定提供新奇基础。 | Anna Mansour | 2011 | Cell Research2011，21，7： | 6 |
| 2 | Expression of acetylcholine receptor genes in human thymic epithelial cells: implications for myasthenia gravis显示文摘 | Wakkach A Guyon T Bruand C | 1996 | J Immunol1996，157，8： | 2 |
| 3 | Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo 显示文摘 | Wakkach A Fournier N Brun V | 2003 | Immunity2003，18，5： | 1 |
| 4 | Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo显示文摘 | Wakkach A Fournier N Brun V | 2003 | Immunity2003，18，5： | 1 |
| 5 | Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo显示文摘 | Wakkach A Fournier N Brun V | 2003 | Immunity2003，18，5： | 1 |
| 6 | Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo显示文摘 | Wakkach A Fournier N Brun V | 2003 | Immunity2003，18，5： | 1 |
| 7 | Differentiation of regulatory T cells 1 is induced by CD2 costimulation显示文摘 | Cottrez F Groux H | 2001 | J Immunol2001，167，： | 1 |
| 8 | Regulatory dendritic cells that induce tolerance and T regulatory 1 cells differentiation in vivo 显示文摘 | Wakkach A Foumier N Brun V | 2003 | Immunity2003，18，5： | 1 |
| 9 | Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo显示文摘 | Wakkach A Fourrfier N Brun V | 2003 | Immunity2003，18，5： | 1 |
| 10 | Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients显示文摘 | Adeline Bertola Thomas Ciucci Déborah Rousseau Virginie Bourlier Carine Duffaut Stéphanie Bonnafous Claudine Blin-Wakkach Rodolphe Anty Antonio Iannelli Jean Gugenheim Albert Tran Anne Bouloumié Philippe Gual Abdelilah Wakkach | 2012 | Diabetes2012，，9： | 1 |
| 11 | Can interleukin-10 be used as a true immunoregulatory cytokine? 显示文摘 | Wakkach A Cottrez F Groux H | 2000 | Eur Cytokine Netw2000，11，2： | 1 |
| 12 | Characterization of dendritic ceils that induce tolerance and T regulatory 1 cell differentiation in vivo 显示文摘 | Wakkach A Fournier N Brun V Breittmayer JP Cottrez F Groux H | 2003 | Immunity2003，18，5： | 1 |
| 13 | Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo 显示文摘 | Wakkach A Fournier N Bran V | 2003 | Immunity2003，18，5： | 1 |
| 14 | Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo显示文摘 | Wakkach A Fournier N Brun V | 2003 | Immunity2003，18，5： | 1 |
| 15 | Characterization of dendritic cells that induce tolerance and T regulatory I cell differentiation in vivo显示文摘 | Wakkach A Fournier N Brun V | 2003 | Immunity2003，18，5： | 1 |
| 16 | Characterization of dendritic ceils that induce tolerance and T regulatory 1 cell differentiation in vivo显示文摘 | Wakkach A Fournier N Brun V | 2003 | Immunity2003，18，5： | 1 |
| 17 | Osteoimmune interactions in inflammatory bowel disease:central role of bone marrow Th17 TNFαcells in osteoclastogenesis显示文摘 | WAKKACH A ROULEAU M BLIN-WAKKACH C | 2015 | Front Immunol2015，6，： | 1 |
| 18 | Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo显示文摘 | Fournier N Brun V | 2003 | Immunity2003，18，： | 1 |
| 19 | Regulation of acetylcholine receptorgene expression in human myasthenia gravis muscles显示文摘 | Guyon T Wakkach A Poea S | 1998 | J Clin Invest1998，102，1： | 1 |
| 20 | Characterization of dendritic ceils that induce tolerance and T regulatory cell differentiation in vivo 显示文摘 | Wakkach A Foumier N Brun V | 2004 | J Immun2004，18，8： | 1 |
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