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| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 2 | Hepatocellular carcinoma in viral and autoimmune liver diseases:Role of CD4+CD25+Foxp3+regulatory T cells in the immune microenvironment显示文摘More than 90%of cases of hepatocellular carcinoma(HCC)occurs in patients with cirrhosis,of which hepatitis B virus and hepatitis C virus are the leading causes,while the tumor less frequently arises in autoimmune liver diseases.Advances in understanding tumor immunity have led to a major shift in the treatment of HCC,with the emergence of immunotherapy where therapeutic agents are used to target immune cells rather than cancer cells.Regulatory T cells(Tregs)are the most abundant suppressive cells in the tumor microenvironment and their presence has been correlated with tumor progression,invasiveness,as well as metastasis.Tregs are characterized by the expression of the transcription factor Foxp3 and various mechanisms ranging from cell-to-cell contact to secretion of inhibitory molecules have been implicated in their function.Notably,Tregs amply express checkpoint molecules such as cytotoxic T lymphocyte-associated antigen 4 and programmed cell-death 1 receptor and therefore represent a direct target of immune checkpoint inhibitor(ICI)immunotherapy.Taking into consideration the critical role of Tregs in maintenance of immune homeostasis as well as avoidance of autoimmunity,it is plausible that targeting of Tregs by ICI immunotherapy results in the development of immune-related adverse events(irAEs).Since the use of ICI becomes common in oncology,with an increasing number of new ICI currently under clinical trials for cancer treatment,the occurrence of irAEs is expected to dramatically rise.Herein,we review the current literature focusing on the role of Tregs in HCC evolution taking into account their opposite etiological function in viral and autoimmune chronic liver disease,and we discuss their involvement in irAEs due to the new immunotherapies. | Alessandro Granito Luigi Muratori Claudine Lalanne Chiara Quarneti Silvia Ferri Marcello Guidi Marco Lenzi Paolo Muratori | 2021 | World Journal of Gastroenterology2021，27，22： | 11 |
| 3 | Osteoclast activity modulates B-cell development in the bone marrow显示文摘B 房间开发开是依赖的在 B 房间先锋和骨头髓 stromal 房间之间的相互作用,而是在这的骨破折(OCL ) 的角色处理未知的遗体。B lymphocytopenia 是 osteopetrosis 的一个特征,建议由 OCL 活动的 B 淋巴细胞增殖的调整。探讨这个问题,我们首先由树枝状的房间转移在 osteopetrotic oc/oc 鼠标救了 OCL 功能,导致骨头显型和 B 房间开发的恢复。为了推进,探索在 OCL 活动和 B 淋巴细胞增殖之间的连接,我们由 zoledronic 酸(ZA ) 的注射在正常老鼠导致了 osteopetrosis,骨头再吞的一个禁止者。B 房间数字在对待 ZA 的老鼠的骨头髓明确地减少了。ZA 直接没影响 B 房间区别,增长和 apoptosis,但是由 stromal 房间在 CXCL12 和 IL-7 的表示导致减少,与减少的 osteoblastic 约会联系了。在 oc/oc 老鼠的相等的低 osteoblastic 约会证实它在造骨细胞上源于减少的 OCL 活动而非从 ZA 的直接效果。骨头微型环境的这些戏剧的改变为 B 淋巴细胞增殖是不利的,导致在他们在导致 ZA 的 osteopetrotic 模型的骨头髓壁龛外面的 B 房间祖先的保留。总的来说,我们的数据表明 OCL 由控制骨头微型环境和造骨细胞的命运在骨头髓调制 B 房间开发。他们由 OCL 活动在他们的壁龛为 B 房间的保留的规定提供新奇基础。 | Anna Mansour | 2011 | Cell Research2011，21，7： | 6 |
| 4 | 严重创伤病人心肌肌钙蛋白Ⅰ释放的发生率及其意义显示文摘 | Alain R.Edouard Marie-Louise Felten Jean-Louis Hebert Claudine Cosson Laurent Martin Dan Benhamou 钟敏(译) 曾因明(审) | 2005 | 国外医学(麻醉学与复苏分册)2005，26，1： | 6 |
| 5 | αV integrin:A new gastrin target in human pancreatic cancer cells显示文摘AIM:To analyse αV integrin expression induced by gas-trin in pancreatic cancer models. METHODS:αV integrin mRNA expression in human pan-creatic cancer cells was analysed using a 'cancer genes' array and confirmed by real-time reverse transcription-polymerase chain reaction (PCR). Western blotting and semi-quantitative immunohistochemistry were used to examine protein levels in human pancreatic cancer cell lines and pancreatic tissues, respectively. The role of αV integrin on gastrin-induced cell adhesion was examined using blocking anti-αV integrin monoclonal antibodies. Adherent cells were quantified by staining with crystal violet.RESULTS: Using a 'cancer genes' array we identified αV integrin as a new gastrin target gene in human pancreatic cancer cells. A quantitative real-time PCR approach was used to confirm αV integrin gene expression. We also demonstrate that Src family kinases and the PI 3-kinase, two signalling pathways specifically activated by the CCK-2 receptor (CCK2R), are involved in gastrin-mediated αV integrin expression. In contrast, inhibition of the ERK pathway was without any effect on αV integrin expression induced by gastrin. Our results also show that gastrin modulates cell adhesion via α V integrins. Indeed, in vitro adhesion assays performed on fibronectin show that gastrin significantly increases adhesion of pancreatic cancer cells. The use of blocking anti-αV integrin monoclonal antibodies completely reversed the increase in cell-substrate adhesion induced by gastrin. In addition, we showed in vivo that the targeted CCK2R expression in the pancreas of Elas-CCK2 mice, leads to the overexpression of αV integrin. This process may contribute to pancreatic tumour development observed in these transgenic animals. CONCLUSION:αV integrin is a new gastrin target in pancreatic cancer models and contributes to gastrin effects on cell adhesion. | Celine Cayrol Claudine Bertrand Aline Kowalski-Chauvel Laurence Daulhac Elizabeth Cohen-Jonathan-Moyal Audrey Ferrand Catherine Seva | 2011 | World Journal of Gastroenterology2011，17，40： | 4 |
| 6 | Obesity and cancer risk among white and black United States veterans显示文摘 | Claudine Samanic Gloria Gridley Wong-Ho Chow Jay Lubin Robert N. Hoover Joseph F. Fraumeni | 2004 | Cancer Causes and Control2004，，1： | 2 |
| 7 | Low temperature induced changes in activity and protein levels of the enzymes associated to conversion of starch to sucrose in banana fruit显示文摘 | Roberta Ghedini Der Agopian Fernanda Helena Gon?alves Peroni-Okita Claudinéia Aparecida Soares Janaína Aparecida Mainardi Jo?o Roberto Oliveira do Nascimento Beatriz Rosana Cordenunsi Franco Maria Lajolo Eduardo Purgatto | 2011 | Postharvest Biology and Technology2011，，2： | 2 |
| 8 | 抗生素对细枝木麻黄愈伤组织再生及农杆菌生长的影响显示文摘以细枝木麻黄3个无性系水培苗作为材料,研究了硫酸卡那霉素(kanamycin sulfate,Km)对细枝木麻黄愈伤组织诱导、增殖和芽分化的影响,以及头孢霉素(cefotaxime,Cef)、羧苄青霉素(carbenicillin,Cab)和氨苄青霉素(ampicillin,Amp)对农杆菌的抑制效果。结果表明,Km对细枝木麻黄愈伤组织诱导适宜的选择压力是20mg/L,Km选择性筛选愈伤组织增殖的适宜质量浓度为40mg/L,愈伤组织芽分化的选择压力是40~50mg/L。在抗生素抑菌效果方面,Cef质量浓度为200mg/L、Cab300mg/L和Amp500mg/L能完全抑制农杆菌的生长。综合比较,对细枝木麻黄遗传转化研究最理想的抑菌剂是Cef,使用质量浓度低且能有效抑制根癌农杆菌的生长。 | 姜清彬 仲崇禄 曾炳山 张勇 Didier Bogusz Claudine Franche | 2010 | 东北林业大学学报2010，38，9： | 2 |
| 9 | 作为一种城市管理方法的历史城市景观:文献回顾显示文摘2011年UNESCO通过了《关于历史城市景观的建议》,并呼吁对一种景观方法的应用,借此来确保将文化遗产政策和管理的问题纳入到更广泛的城市可持续发展中。本文回顾了这种景观方法应用到遗产保护中的起源,并系统分析了2010—2018年初关于历史城市景观的100多篇文献。研究表明,尽管已有的讨论大量集中在价值领域,但是,以价值为基础的操作方法仍然比较缺乏。这主要是由于不能完全融入到当地的遗产话语语境和遗产治理的动态性之中。研究还表明,已有诸多案例研究在'非西方'城市中得以应用,因此,也开启了一系列有关在一种政治权力语境下的价值方法的问题讨论,并开始关心那些将保护实践导向为经济价值的地区。然而,将一种国际导则重新放在地方性行动和政策的语境之下,仍然困难重重。 | Manal Ginzarly Claudine Houbart Jacques Teller 王思渝 | 2019 | 中国文化遗产2019，0，6： | 2 |
| 10 | Mechanism for Src activation by the CCK2 receptor:Patho-physiological functions of this receptor in pancreas显示文摘瞄准:调查在活体内, CCK2 受体(CCK2R ) 是否调整蛋白质,知道在房间增长和癌症开发和分析在试管内起一个关键作用导致 Src 激活的分子的机制;特别地,那在这激活被含有在 CCK2R 顺序以内识别领域。方法:Src 和英皇家空军之阶级最低之兵的表示和激活是学习在活体内使用免疫荧光和西方污点的技术。我们使用了从在胰腺的腺泡表示了 CCK2R 的野类型或 Elas-CCK2 老鼠导出的胰腺的纸巾,显示了增加的胰腺的生长并且开发了肿瘤前损害。短暂地表示内长的 CCK2R 或 COS-7 房间的胰腺的肿瘤房间线 AR4-2J 有野类型或变异的 CCK2R 的 transfected 被用作在试管内模型学习 Src 激活的机制。Src 激活被在试管内激酶试金测量,由用 anti-phospho-ERK 抗体和在由 MTT 的导致 gastrin 的房间增长的 Src 的参与的西方的污点的英皇家空军之阶级最低之兵激活测试。结果:我们出现了因为在 Elas-CCK2 鼠标的胰的指向的 CCK2R 表达式,导致了 Src 和 ERK 小径的激活。Src 被激活由在胰腺的弦音器的 CCK2R 的 ERK 小径在上游口头的房间并且贡献了增生的效果由这受体调停了。在试管内结果证明由 CCK2R 的 Src/ERK 小径的激活要求了 NPXXY 主题,在第 7 transmembrane 领域的结束在 CCK2R 顺序以内定位了,并且建议了在这机制的 Gq 的通常认为的角色。结论:由 CCK2R 的 Src/ERK 小径的解除管制可能代表贡献房间增长,肿瘤前损害的形成和胰腺的肿瘤开发的早步。 | Audrey Ferrand Sebastien Vatinel Aline Kowalski-Chauvel Claudine Bertrand Chantal Escrieut Daniel Fourmy Marlene Dufresne Catherine Seva | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 11 | Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells显示文摘瞄准:为了调查 Src, JAK2 和 phosphatidylinositol 3-kinase (PI3K ) 小径是否涉及人的结肠的瘤房间的增长,由扩大 glycine 的促胃液素导致了(G-gly ) ,先锋在 ated 促胃液素中并且到成熟阐明在响应这肽的这三家族 ases 之间的分子的相互作用。方法:用人的结肠的瘤,房间作为一个模型衬里 HCT116,我们首先测量了 PI3K, p60-Src 和 JAK2 的激活响应 G-gly 由在试管内激酶试金。然后,我们由 MTT 测试在 G-gly-induced 房间增长调查了这些家族 ases 的参与。结果:G-gly,刺激在 HCT116 导致了 p60-Src, JAK2 和 PI3K 激活。不同小径涉及房间导致了由的人的结肠癌的增长 G-gly。而且,我们发现 Src 和 JAK2 对由这肽的 PI3K 规定必要。然而,我们没发现在二酷氨酸家族 ases 之间的任何串音。结论:我们的结果建议 p60-Src/PI3K 和 JAK2/PI3K 小径独立地行动调停人的结肠的瘤房间上的 G-gly 增生的的效果。 | Audrey Ferrand Aline Kowalski-Chauvel Claudine Bertrand Daniel Fourmy Marlene Dufresne Catherine Seva Julie Pannequin | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 12 | Epigenetic mechanisms involved in developmental nutritional programming显示文摘The ways in which epigenetic modifications fix the effects of early environmental events,ensuring sustained responses to transient stimuli,which result in modified gene expression patterns and phenotypes later in life,is a topic of considerable interest.This review focuses on recently discovered mechanisms and calls into question prevailing views about the dynamics,position and functions of epigenetic marks.Most epigenetic studies have addressed the long-term effects on a small number of epigenetic marks,at the global or individual gene level,of environmental stressors in humans and animal models.In parallel,increasing numbers of studies based on high-throughput technologies and focusing on humans and mice have revealed additional complexity in epigenetic processes,by highlighting the importance of crosstalk between the different epigenetic marks.A number of studies focusing on the developmental origin of health and disease and metabolic programming have identified links between early nutrition,epigenetic processes and long-term illness.The existence of a self-propagating epigenetic cycle has been demonstrated.Moreover,recent studies demonstrate an obvious sexual dimorphism both for programming trajectories and in response to the same environmental insult.Despite recent progress,we are still far from understanding how,when and where environmental stressors disturb key epigenetic mechanisms.Thus,identifying the original key marks and their changes throughout development during an individual's lifetime or over several generations remains a challenging issue. | Anne Gabory Linda Attig Claudine Junien | 2011 | World Journal of Diabetes2011，2，10： | 2 |
| 13 | Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial显示文摘 | Philipp Schuetz Alexander Kutz Eva Grolimund Sebastian Haubitz Désirée Demann Alaadin V?geli Fabienne Hitz Mirjam Christ-Crain Robert Thomann Claudine Falconnier Claus Hoess Christoph Henzen Robert J. Marlowe Werner Zimmerli Beat Mueller | 2014 | International Journal of Cardiology2014，，3： | 2 |
| 14 | Nestin expression in the retina of rats with inherited retinal degeneration显示文摘 | Fatemeh Valamanesh Julie Monnin Nadège Morand-Villeneuve Germaine Michel Murhaf Zaher Sofiane Miloudi Deborah Chemouni Jean-Claude Jeanny Claudine Versaux-Botteri | 2013 | Experimental Eye Research2013，，： | 1 |
| 15 | Relation of body mass index to cancer risk in 362,552 Swedish men显示文摘 | Claudine Samanic Wong-Ho Chow Gloria Gridley Bengt Jarvholm Joseph F. Fraumeni | 2006 | Cancer Causes & Control2006，，7： | 1 |
| 16 | PAP IB, a new member of the Reg gene family: Cloning, expression, structural properties, and evolution by gene duplication显示文摘 | Emmanuelle Laurine Xavier Manival Claudine Montgelard Chantal Bideau Jean-Louis Bergé-Lefranc Monique érard Jean-Michel Verdier | 2005 | BBA - Gene Structure and Expression2005，，3： | 1 |
| 17 | On aeolian transport:Grain- scale interactions,dynamical mechanisms and scaling laws显示文摘 | Duran O Claudin P Andreotti B | 2011 | Aeolian Research2011，3，： | 1 |
| 18 | Raman spectroscopic studies of carbonates part I:High-pressure and high-temperature behaviour of calcite,magnesite,dolomite and aragonite显示文摘 | Philippe Gillet Claudine Biellmann Bruno Reynard | 1993 | Physics and Chemistry of Minerals1993，20，1： | 1 |
| 19 | Endostatin exhibits a Direct antitumor effect in addition to its antiangiogenic activity in colon cancer cells显示文摘 | Fatima D He L Claudine S | 2003 | Human Gene Therapy2003，14，1： | 1 |
| 20 | Molecularsystematics of sciurognathi ( Rodentia) : The Mitochondrial cyto-chrome b and 12S rRNA Genes support the Anomaluroidea( Pedu-tidae and Anomaluridae) 显示文摘 | Claudine Montgelard SophieBentz Claire Tirard | 2002 | Molecular Phylogenetics and Evolu-tion2002，22，2： | 1 |
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