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| 1 | Survival factors after resection of small hepatocellular carcinoma显示文摘Early resection of hepatocellular carcinoma is a key measure to prolong the survival of patients. This study was designed to summarize our experience in surgical resection of small hepatocellular carcinoma (HCC), and to analyze the factors influencing the postoperative survival of patients. METHODS:The clinicopathologic data of 105 patients with small HCC after resection from 1986 through 2003 were analyzed ; the patients had been followed up for more than half a year (median 33 months). Nine clinicopathologic factors, preoperative α-fetoprotein (AFP) level, liver cirrhosis, Child-Pugh score, tumor size (>2cm vs.≤2 cm) and number (single vs. multiple), capsule formation, portal vein tumor thrombi (PVTT), Edmondson tumor grade and surgical method, were analyzed by the log-rank test and the Cox proportional harzards model analysis. RESULTS:The cumulative 1-,3- and 5-year survival rates after the operation were 86.5%, 70.3% and 55.2%, respectively, and the 1-, 3- and 5-year disease-free survival rates were 78%, 58. 9% and 45. 6%, respectively. One patient died from esophagogastric varices hemorrhage in 2 weeks after reoperation. Thirty-six patients had intrahepatic recurrence or metastasis postoperatively and 34 patients died. The Kaplan-Meier method and the Cox proportional harzards model analysis indicated that poor Child-Pugh score, tumor more than 2 cm in diameter, PVTT and multiple lesions (including satellitic lesions) were adverse factors affecting postoperative survival. The Cox proportional harzards model analysis indicated that tumor size, PVTT and multiple lesions were the factors influencing postoperative disease-free survival. CONCLUSIONS:Limited hepatectomy with a margin more than 1 cm is an appropriate surgical approach. Adverse preoperative Child-Pugh score and postoperative intrahepatic recurrences are the main factors leading to the death of patients with small HCC. | Departments of Surgical Oncology (Wu FS, Zhao WH, Ma ZM, Teng LS and Wang M) and General Surgery ( Liang TB and Zheng SS) , First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 5 |
| 2 | Effects of a nurse-led heart failure clinic on hospital readmission and mortality in Hong Kong显示文摘 | Ho Yu Cheng Sek Ying Chair Qun Wang Janet WH Sit Eliza ML Wong Siu Wai Tang | 2016 | Journal of Geriatric Cardiology2016，13，5： | 5 |
| 3 | 社区人群血压和颈动脉血流速度与脑容量和脑小血管病的关系显示文摘做脑磁共振成像(magnetic resonance imaging,MRI)经常发现脑小血管病(cerebral small vessel disease,CSVD)。研究已证明高血压和低颈动脉血流速度与脑血管病存在关联。但是,这种关联与脑容量和CSVD的相关性仍有待研究。本文纳入基于社区的I-Lan纵向衰老研究(I-Lan longitudinal aging study)中年龄≥50岁的成年人721例进行分析,采用多普勒超声测量颈总动脉和颈内动脉血流速度,包括收缩期峰值血流速度(peak systolic velocity,PSV)和舒张终末期血流速度(end-diastolic velocity,EDV)。 | 袁源(摘译) 郑武洪(审校) Chuang SY Wang PN Chen LK Chou KH Chung CP Chen CH Mitchell GF Pan WH Cheng HM | 2021 | 中华高血压杂志2021，29，9： | 4 |
| 4 | Blockade of the swelling-induced chloride current attenuates the mouse neonatal hypoxic-ischemic brain injury in vivo显示文摘胀大导致 Cl 电流的激活(我 Cl,胀大 ) 在新生的组织缺氧局部缺血期间(嗨) 可以导致大脑损坏。Hypoxic-ischemic 大脑损害在出生不满一月的婴儿以及尖锐死亡引起长期的神经病学的病态。在这研究,我们调查了角色我 Cl,胀大在用选择 blocker 的 hypoxic-ischemic 大脑损害的 , 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl ) oxybutyric 酸(DCPIB ) 。在主要有教养的外皮的神经原, 30% 张力减退的答案的灌注激活我 Cl,胀大是的 , 完全由 DCPIB (10 mol/L ) 的申请堵住了。角色我 Cl,胀大在在 vivo 的新生的 hypoxic-ischemic 大脑损害的 在一个修改新生的 hypoxic-ischemic 大脑损害模型被评估。在收到 ischemic 侮辱前,老鼠小狗与 DCPIB 被注射(10 mg/kg, ip ) 。我们发现有 DCPIB 的那个预告的处理显著地减少了用 TTC 染色, Nissl 染色和整个大脑成像估计的大脑损坏,并且改进了在 neurobehavioural 测试评估的感觉运动、门厅的恢复结果(即趋地性 reex,和峡谷回避 reex ) 。这些结果证明 DCPIB 在新生的 hypoxic-ischemic 大脑损害上有 neuroprotective 效果,并且 I Cl,胀大 可以为 hypoxic-ischemic encephalopathy 的处理用作一个治疗学的目标。 | Raymond WONG Ahmed ABUSSAUD Joseph WH LEUNG Bao-feng XU Fei-ya LI Sammen HUANG Nai-hong CHEN Guan-lei WANG Zhong-ping FENG Hong-shuo SUN | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 5 | Effects of fluoride on the expression of NCAM, oxidative stress, and apoptosis in primary cultured hippocampal neurons 显示文摘 | Zhang M Wang AG He WH | 2007 | Toxicology2007，236，3： | 1 |
| 6 | Gastrointestinal stromal tumors: clinicopathological study of Chinese cases 显示文摘 | Wang X Mori I Tang WH | 2001 | Pathol Int2001，51，9： | 1 |
| 7 | Inverse PCR-based RFLP scanning identifies low-level mutation signatures in colon cell and turmors显示文摘 | Liu WH Kaur M Wang G | 2004 | Cancer Res2004，64，： | 1 |
| 8 | The polymorphisms of inter- leukin 17A(IL17A) gene and its association with pediatric asthma in Taiwanese population显示文摘 | Wang JY Shyur SD Wang WH | 2009 | Allergy2009，64，7： | 1 |
| 9 | Hepatocellular carcinoma with tumour thrombi in the bile duct显示文摘 | Wang HJ Kim JH Kim WH | 1999 | Hepato Gastroenterol1999，46，28： | 1 |
| 10 | Evaluation of antiseptic -impregnated central venous catheters for prevention of catheter -related infection in intensive care unit patients显示文摘 | Sheng WH Ko WJ Wang JT | 2000 | Diagn Microbiol Infect Dis2000，38，1： | 1 |
| 11 | Increased serum leptin concentrations correlate with soluble tumour necrosis factor receptor levels in patients with cirrhosis 显示文摘 | Lin SY Wang YY Sheu WH | 2002 | Clin Endocrinol (Oxf)2002，57，6： | 1 |
| 12 | Maxillary reconstruction using vascularized fibu- lar osteomyoeutaneous flap and iliac bone through modified lateral fip-submandibular approach 显示文摘 | Wang WH Xu B | 2013 | J Craniofac Surg2013，24，4： | 1 |
| 13 | Isolation and properties of a blood coagulation factor Ⅹ activator from the venom of king cobra( Ophiophagus hannah )显示文摘 | Lee WH Zhang Y Wang WY | 1995 | Toxicon1995，33，10： | 1 |
| 14 | Bubble Formation at a Submerged Orifice in Non-Newtonian Liquids 显示文摘 | T Miyahara WH Wang T Takahashi | 1988 | J Chem Engng Japan1988，21，6： | 1 |
| 15 | Histopathologicaiexamination of chemo-sympathectomy in cats显示文摘 | WANG YC LEE WH CHN WY | 2000 | Neurol Res2000，22，4： | 1 |
| 16 | Transcriptional profiling by c DNAAFLP analysis showed differential transcript abundance in response to water stress in Populus hopeiensis显示文摘 | SONG YP WANG ZL BO WH | 2012 | BMC Genomics2012，13，： | 1 |
| 17 | Prediction of chromosome misalignment among in vitro matured human oocytes by spindle imaging with the PolScope显示文摘 | Wang WH Keefe DL | 2002 | Fertil Steril2002，78，5： | 1 |
| 18 | The screening of inbom errors ofmetabolism in sick Chinese infants by tandem mass spectrometryand gas chromatography/mass spectrometry 显示文摘 | WH Sun Y Wang Y Yang | 2011 | Clinica ChimicaActa2011，412，： | 1 |
| 19 | Incidence of NIDDM and the effects of gender, obesity and hyperinsulinemia in Taiwan 显示文摘 | Wang SL Pan WH Hwu CM | 1997 | Diabetologia1997，40，12： | 1 |
| 20 | Some altered concentrations of elements in semen of workers exposed to trinitrotoluene显示文摘 | Liu HX Qin WH Wang GR | | 0，，： | 1 |
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