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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Comparison of extraintestinal pathogenic Escherichia coli strains from human and avian sources reveals a mixed subset representing potential zoonotic pathogens显示文摘 | Johnson T J Wannemuehler Y Johnson S J | 2008 | Appl Envir Microbiol2008，74，22： | 1 |
| 3 | Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation:Interim results of a prospective multicenter surveillance program显示文摘 | Morgan J Wannemuehler KA Marr KA | 2005 | Med Mycol2005，43，1： | 1 |
| 4 | Estimation of the current global burden of eryptococcal meningitis among persons living with HIV/AIDS显示文摘 | Park B J Wannemuehler KA Marston B J | 2009 | Aids2009，23，52： | 1 |
| 5 | Unique genome-wide transcriptome profiles of chicken macrophages exposed to Salmonell~de rived endotoxin 显示文摘 | CIRACI C TUGGLE C K WANNEMUEHLER M J | 2010 | BMC Genomics2010，11，： | 1 |
| 6 | The role of oxygen in the antiviral activity of hypericin and hypocrellin显示文摘 | PARK J ENGLISH D S WANNEMUEHLER Y | 1998 | Photochem Photobiol1998，68，4： | 1 |
| 7 | Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS显示文摘 | Park BJ Wannemuehler KA Marston B J | 2009 | AIDS2009，23，4： | 1 |
| 8 | Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation:interim results of a prospective multicenter surveillance program 显示文摘 | Morgan J Wannemuehler K A Mart K A | 2005 | Med Mycol2005，43，1： | 1 |
| 9 | Chemistry-dependent adsorption of serum proteins'onto polyan- hydride micropartieles differentially influences dendritic cell uptake and activation 显示文摘 | Carrillo-Conde BR Rarner-Tait AE Wannemuehler MJ | 2012 | Acta Bioraater2012，8，10： | 1 |
| 10 | Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS显示文摘 | Park BJ Wannemuehler KA Marston BJ | | 0，，04： | 1 |
| 11 | Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS显示文摘 | Park B J Wannemuehler KA Marston B J | | 0，，04： | 1 |
| 12 | Changing epidemiology fmeasles in Africa 显示文摘 | Goodson JI Masresba BG Wannemuehler K | 2011 | J Infect Dis2011，2041，： | 1 |
| 13 | Multiple independent emer- gences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria显示文摘 | Burns C C Shaw J Jorba J Bukbuk D Adu F Gumede N Pate M A Abanida E A Gasasira A Iber J Chen Q Vincent A Chenoweth P Henderson E Wannemuehler K Naeem A Umarni R N Nishimura Y Shimizu H Baba M Adeniji A Williams A J Kil- patrick D R Oberste M S Wassilak S G Tomori O Pallansch M A Kew O | 2013 | J Virol2013，87，9： | 1 |
| 14 | The role of oxygen in the antiviral activity of hypericin and hypocrellin显示文摘 | Park J English DS Wannemuehler Y | 1998 | Photochem & Photobiol1998，68，4： | 1 |
| 15 | Identification of minimal predictors of avian pathogenic Escherichia coli virulence for use as a rapid diagnostic tool显示文摘 | Johnson T J Wannemuehler Y Doetkott C | 2008 | J Clin Microbiol2008，46，12： | 1 |
| 16 | Identification of minimal predictors of avian pathogenic Escherichia coli virulence for use as a rapid diagnostic tool显示文摘 | Johnson T J Wannemuehler Y Doetkott C | 2008 | J Clin Microbiol2008，46，12： | 1 |
| 17 | Inci- dence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: interim re- suits of a prospective multicenter surveillance pro- gram显示文摘 | Morgan J Wannemuehler KA Marr KA | 2005 | Med Mycol2005，4，1： | 1 |
| 18 | Incidence of invasive aspergillosis following hematopoietic stem cell and solid organ transplantation: Interim results of a prospective multicenter surveillance program 显示文摘 | MORGAN J WANNEMUEHLER K A MARR K A | 2005 | Med Mycol2005，43，1： | 1 |
| 19 | Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS显示文摘 | Park B J Wannemuehler KA Marston B J Govender N Pappas PG Chiller TM | | Aids0，，： | 1 |
| 20 | Evolution of the iss gene in Escherichia coli 显示文摘 | Johnson T J Wannemuehler Y M Nolan L K | 2008 | Appl Environ Microbiol2008，74，8： | 1 |
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