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| 1 | Characterization of personal exposure concentration of fine particles for adults and children exposed to high ambient concentrations in Beijing, China显示文摘In China, the health risk from overexposure to particles is becoming an important public health concern. To investigate daily exposure characteristics to PM 2.5 with high ambient concentration in urban area, a personal exposure study was conducted for school children, and office workers in Beijing, China. For all participants (N = 114), the mean personal 24-hr exposure concentration was 102.5, 14.7, 0.093, 0.528, 0.934, 0.174 and 0.703 μg/m 3 for PM 2.5 , black carbon, Mn, Al, Ca, Pb, and Fe. Children's exposure concentrations of PM 2.5 were 4-5 times higher than those in related studies. The ambient concentration of PM 2.5 (128.5 μg/m 3 ) was significantly higher than the personal exposure concentration (P < 0.05), and exceed the reference concentration (25 μg/m 3 ) of WHO air quality guideline. Good correlation relationships and significant differences were identified between ambient concentration and personal exposure concentration. The relationships indicate that the ambient concentration is the main factor influencing personal exposure concentration, but is not a good indicator of personal exposure concentration. Outdoor activities (commute mode, exposure to heating, workday or weekend travel) influenced personal exposure concentrations significantly, but the magnitude of the influence from indoor activities (exposure to cooking) was masked by the high ambient concentrations. | Xuan Du Qian Kong Weihua Ge Shaojun Zhang Lixin Fu | 2010 | Journal of Environmental Sciences2010，22，11： | 24 |
| 2 | Tool Wear in Turning of Titanium Alloy after Thermohydrogen Treatment显示文摘The influence of hydrogen contents on the tool wear has been mainly focused on the flank wear of the common tool,and the influence of hydrogen contents on the rake crater wear(main wear type) of the tool,particularly for the fine granular material tool,has been less investigated comprehensively.In this paper,for the purpose of researching the influence of hydrogen contents on tool wear,the titanium alloy Ti-6Al-4V is hydrogenated at 800 ℃ by thermohydrogen treatment technology and the turning experiments are carried out by applying uncoated WC-Co cemented carbide tool.The three-dimensional video microscope is used to take photos and measure tool wear.The results show that both of crater wear depth(KT) and average flank wear width(VB) firstly decreases and then increases with the increasing of hydrogen content.The maximum reducing amplitude of KT and VB is about 50% and 55%,respectively.Under the given conditions,the optimum hydrogen content is 0.26%.It is considered that the reduction of cutting temperature is an important factor for improving tool wear after the Ti-6Al-4V alloy is properly hydrogenated.Furthermore,the reasons of hydrogen effect on the tool wear are chiefly attributed to comprehensive effect of hydrogen contents on microstructure,physical properties and dynamic mechanical properties of the Ti-6Al-4V alloy.The proposed research provides the basic data for evaluating the machinability of hydrogenation Ti-6Al-4V alloy,and promotes practical application of thermohydrogen treatment technology in titanium alloys. | WEI Weihua XU Jiuhua FU Yucan YANG Shubao | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 5 |
| 3 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 4 | Concise and efficient direct-view generation of arbitrary cylindrical vector beams by a vortex half-wave plate显示文摘A concise, efficient, and practical direct-view scheme is presented to generate arbitrary cylindrical vector(CV)beams, including CV beams, vortex beams, and cylindrical vector vortex(CVV) beams, by a vortex half-wave plate(VHP). Six kinds of first-order and other high-order CV beams, such as azimuthally polarized(AP) beams, antivortex radial polarization mode beams, and three-order AP beams, are formed by simply rotating a half-wave plate. The Stokes parameters and double-slit interference of multitype CV beams are investigated in detail.The polarization parameters, including degree of polarization, polarization azimuth, and ellipticity, are obtained,which demonstrates the efficient generation of CV beams. In addition, the double-slit interference experiment is introduced in the setup, and fringe misplacement and tilt appear for CVV beams, in which the misplacement number M is 2P+1 for P ≤ 2 and 2P-1 for P ≥ 3, where P is the polarization order number, and the fringe tilt offset is positively related to the topological charge number l of CVV beams. In addition, new types of VHPs can be formed by cascading two or more VHPs when the types of available VHPs are limited, assisting in more flexible generation of multitype CV beams. It is experimentally demonstrated that arbitrary CV beams with high quality are effectively achieved by the proposed setup, and the double-slit interference method can be utilized to determine and analyze CV beams rapidly and concisely by practical performance, which shows the potential to be implemented as a commercial device. | JUNLI QI WEIHUA WANG BO SHI HUI ZHANG YANAN SHEN HAIFEI DENG WENJING PU XIN LIU HUIHUI SHAN XIAOMIN MA LIANQIANG ZHANG WEI LU MEICHENG FU XIUJIAN LI | 2021 | Photonics Research2021，9，5： | 4 |
| 5 | Nobiletin downregulates the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and shows synergistic effects with palbociclib on renal cell carcinoma显示文摘Objective:Natural extracts,including nobiletin,have been reported to enhance the efficacy and sensitivity of chemotherapeutic drugs.However,whether and how nobiletin affects tumor growth and progression in renal cell carcinoma(RCC)are still unclear.Methods:Cell proliferation,cell cycle and apoptosis analyses,colony-formation assays,immunoblotting analysis,and q RT-PCR analysis were performed to investigate how nobiletin affected RCC cell proliferation in vitro.The nude mouse model was used to test the efficacy of nobiletin alone or in combination with palbociclib.Results:Nobiletin inhibited cell proliferation by inducing G1 cell cycle arrest and cell apoptosis in RCC cells.Mechanistically,nobiletin decreased SKP2 protein expression by reducing its transcriptional level.The downregulated SKP2 caused accumulation of its substrates,p27 and p21,which further inhibited the activity of the G1 phase-related protein,CDK2,leading to inhibition of cell proliferation and tumor formation.A higher SKP2 protein level indicated less sensitivity to the CDK4/6 inhibitor,palbociclib.A combination of nobiletin and palbociclib showed a synergistic tumor inhibition in vitro and in an in vivo model.Conclusions:Nobiletin downregulated the SKP2-p21/p27-CDK2 axis to inhibit tumor progression and showed synergistic tumor inhibition effects with the CDK4/6 inhibitor,palbociclib,on RCC,which indicates a potential new therapeutic strategy. | Tingting Chen Liu Liu Yonghong Zou Xiaoyan Hu Wenfeng Zhang Tao Zhou Xi Luo Weihua Fu Jie Xu | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 6 | The chimeric gene atp6c confers cytoplasmic male sterility in maize by impairing the assembly of the mitochondrial ATP synthase complex显示文摘Cytoplasmic male sterility(CMS)is a powerful tool for the exploitation of hybrid heterosis and the study of signaling and interactions between the nucleus and the cytoplasm.C-type CMS(CMS-C)in maize has long been used in hybrid seed production,but the underlying sterility factor and its mechanism of action remain unclear.In this study,we demonstrate that the mitochondrial gene atp6c confers male sterility in CMS-C maize.The ATP6C protein shows stronger interactions with ATP8 and ATP9 than ATP6 during the assembly of F1F0-ATP synthase(F-type ATP synthase,ATPase),thereby reducing the quantity and activity of assem-bled F_(1)F_(o)-ATP synthase.By contrast,the quantity and activity of the F1'component are increased in CMS-C lines.Reduced F1F0-ATP synthase activity causes accumulation of excess protons in the inner membrane space of the mitochondria,triggering a burst of reactive oxygen species(ROS),premature programmed cell death of the tapetai cells,and pollen abortion.Collectively,our study identifies a chimeric mitochondrial gene(ATP6C)that causes CMS in maize and documents the contribution of ATP6C to F1F0-ATP synthase assembly,thereby providing novel insights into the molecular mechanisms of male sterility in plants. | Huili Yang Yadong Xue Bing Li Yanan Lin Haochuan Li Zhanyong Guo Weihua Li Zhiyuan Fu Dong Ding Jihua Tang | 2022 | Molecular Plant2022，15，5： | 2 |
| 7 | Melt grafting of maleic anhydride onto polypropylene with assistance of a- methylstyrene显示文摘 | Luo Weihua Liu Xingxing Fu Yujuan | 2012 | Polymer Engineering and Science2012，52，4： | 1 |
| 8 | How does cancer cell metabolism affect tumor migration and invasion?显示文摘 | Tianyu Han De Kang Daokun Ji Xiaoyu Wang Weihua Zhan Minggui Fu Hong-Bo Xin Jian-Bin Wang | 2013 | Cell Adhesion & Migration2013，，5： | 1 |
| 9 | Navigation jamming signal recognition based on long short-term memory neural networks显示文摘This paper introduces the time-frequency analyzed long short-term memory(TF-LSTM) neural network method for jamming signal recognition over the Global Navigation Satellite System(GNSS) receiver. The method introduces the long shortterm memory(LSTM) neural network into the recognition algorithm and combines the time-frequency(TF) analysis for signal preprocessing. Five kinds of navigation jamming signals including white Gaussian noise(WGN), pulse jamming, sweep jamming, audio jamming, and spread spectrum jamming are used as input for training and recognition. Since the signal parameters and quantity are unknown in the actual scenario, this work builds a data set containing multiple kinds and parameters jamming to train the TF-LSTM. The performance of this method is evaluated by simulations and experiments. The method has higher recognition accuracy and better robustness than the existing methods, such as LSTM and the convolutional neural network(CNN). | FU Dong LI Xiangjun MOU Weihua MA Ming OU Gang | 2022 | Journal of Systems Engineering and Electronics2022，33，4： | 1 |
| 10 | Application of High Solids-content Nanosize Polymeric Microlatexes in Water-borne Coatings显示文摘 | Zhao Yiqiang Ming Weihua Fu Shoukuan | 1999 | Journal of Fudan University (Natural Science)1999，38，6： | 1 |
| 11 | Serum Helicobacter pylori CagA antibody may not be used as a tumor marker for diagnosing gastric cancer in east Asian countries显示文摘 | Zhicheng Zhao Yuhong Li Shengxin Liu Weihua Fu | 2014 | Tumor Biology2014，，12： | 1 |
| 12 | Synthesis of nanosize poly(methyl methacrylate) microlatexes with high polymer content by a modified microemulsion polymerization显示文摘 | Weihua Ming Frank N. Jones Shoukuan Fu | 1998 | Polymer Bulletin1998，，6： | 1 |
| 13 | Progress of molecular targeted therapies for prostate cancers显示文摘 | Weihua Fu Elena Madan Marla Yee Hongtao Zhang | 2011 | BBA - Reviews on Cancer2011，，2： | 1 |
| 14 | Speciation analysis of lead in marine animals by using capillary electrophoresis couple online with inductively coupled plasma mass spectrometry显示文摘 | Yiquan Chen Limei Huang Weihua Wu Yajuan Ruan Zujian Wu Zhimin Xue FengFu Fu | 2014 | ELECTROPHORESIS2014，，9： | 1 |
| 15 | Preparation of a Mono-sheet Bipolar Membrane by Simultaneous Irradiation Grafting Polymerization of Acrylic Acid and Chloromethylstyrene显示文摘 | Fu Rongqiang Xu Tongwen Yang Weihua | 2003 | Journal of Applied Polymer Science2003，90，： | 1 |
| 16 | Synthesis of nanosize poly( methyl methacrylate) microlatexes with high polymer content by a modified microemulsion polymerization 显示文摘 | Ming Weihua Frank N J Fu Shoukuan | 1998 | Polym Bull1998，40，6： | 1 |
| 17 | Synthesis of nanosize poly(methyl methacrylate) microemulsion with high polymer content by a modified microemulsion polymerization显示文摘 | Weihua Ming Frank N Jones Shoukuan Fu | 1998 | Polymer Bulletin1998，40，： | 1 |
| 18 | High solids content nanosize polymer latexes made by mieroemulsion polymerization 显示文摘 | Ming Weihua Jones F N Fu Shoukuan | 1998 | Macromol Chem Phys1998，199，6： | 1 |
| 19 | Overexpression of a sugarcane ScCaM gene negatively regulates salinity and drought stress responses in transgenic Arabidopsis thaliana显示文摘Calmodulin(CaM)proteins play a key role in signal transduction under various stresses.In the present study,the effects of a sugarcane ScCaM gene(NCBI accession number:GQ246454)on drought and salt stress tolerance in transgenic Arabidopsis thaliana and Escherichia coli cells were evaluated.The results demonstrated a significant negative role of ScCaM in the drought and salt stress tolerance of transgenic lines of A.thaliana,as indicated by the phenotypes.In addition,the expression of AtP5CS and AtRD29A,two genes tightly related to stress resistance,was significantly lower in the overexpression lines than in the wild type.The growth of E.coli BL21 cells expressing ScCaM showed weaker tolerance under mannitol and NaCl stress.Taken together,this study revealed that the ScCaM gene plays a negative regulatory role in both mannitol and NaCl stresses,and it possibly exerts protective mechanisms common in both prokaryotes and eukaryotes under stress conditions. | JINXIAN LIU JINGFANG FENG CHANG ZHANG YONGJUAN REN WEIHUA SU GUANGHENG WU XIANYU FU NING HUANG YOUXIONG QUE HUI LING JUN LUO | 2023 | BIOCELL2023，47，1： | 0 |
| 20 | Identification of the Diterpenoids Produced by Endophytic Fungus of Torreya fargesii and Its Inhibitory Effect on Hela Cells显示文摘[Objectives] The purpose of this study is to dissociate endophytic fungus producing diterpenoids from Torreya fargesii tissue and examines its inhibiting effect on tumor cells. [Methods]Plant endophytes were isolated and purified to study their resistance to Gram-positive( G+) and Gram-negative bacteria( G-). High performance liquid chromatography( HPLC) was used for analysis of the retention time,relative peak area and percentage content of its metabolite. By liquid chromatography-mass spectrometry( HPLC-MS),the material characteristic of the ion pair information of the metabolites was measured. The bacterial strain was also classified. [Results] The results showed that the secondary metabolites produced by the strain BP6 T3 possessed double resistance to G+and G-bacteria. The strain was identified as Penicillium sp by preliminary classification. Through HPLC analysis,the retention time of fermentation extracts was 12. 8 min with almost the same as the standard of taxol. According to the chromatograph,the relative peak area was 12 887. 11,the average relative percentage was about 15. 8%,and the content of taxol analogs in fermentation broth reached 16. 59 mg/L. The material characteristic of the formation of ion fragments of taxane analogues in metabolic extracts was identical to that of the taxol standard determined by HPLC-MS. It can be initially determined that strain BP6 T3 can produce taxane compounds. Taxol substance produced by this strain had obvious inhibitory effect on Hela cells with the concentration increasing. Different precursors had a significant effect on the production of paclitaxel metabolites in this strain. L-phenylalanine was used as the precursor and the yield increased most,with an increase rate of 425. 7%. [Conclusions] The strain is expected to be used for mass production in antitumor drug taxol. | Weihua JIN Junwei CAO Yi TU Yi TANG Ran GE Jingwen CHEN Fu XU Qijie XIONG | 2019 | Medicinal Plant2019，10，3： | 0 |
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