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| 1 | The BUD2 mutation affects plant architecture through altering cytokinin and auxin responses in Arabidopsis显示文摘植物生长素和细胞激动素的比率在由支持或镇压调整天线建筑学起一个关键作用腋的芽长出。我们以前鉴别了显示的 Arabidopsis 变异的 bud2 改变了根和射击建筑学,它源于 S-adenosylmethionine decarboxylase 的 loss-of-function 4 (SAMDC4 ) 。在这研究,我们证明 BUD2 能被植物生长素导致,并且正式就职依赖于植物生长素发信号。BUD2 的变化导致弱敏到植物生长素和超敏性到细胞激动素,它被胼胝正式就职试金证实。我们的学习建议 polyamines 可以在通过影响细胞激动素和敏感的动态平衡到植物生长素和细胞激动素调整植物建筑学起他们的作用。 | Xia Cui Chunmin Ge Renxiao Wang Huanzhong Wang Weiqi Chen Zhiming Fu Xiangning Jiang Jiayang Li Yonghong Wang | 2010 | Cell Research2010，20，5： | 12 |
| 2 | Modeling xeroderma pigmentosum associated neurological pathologies with patients-derived iPSCs显示文摘干皮病 pigmentosum (XP ) 是联系 XP 的基因的变化引起的一组基因混乱,导致 DNA 修理的缺陷。XP 病人经常展出神经病学的退化,而是内在的机制是未知的,部分地由于合适的疾病模型的缺乏。这里,我们产生了包括 XPA, XPB, XPC, XPG,和 XPV 在五不同 XP 基因怀有变化的病人特定的导致的 pluripotent 干细胞(iPSCs ) 。这些 iPSCs 进一步被区分到神经房间,并且他们到 DNA 损坏应力的危险性被调查。在神经干细胞(NSC ) 或神经原的 XPA 的变化导致了严重 DNA 损坏修理缺点,并且有变异的 XPA 的这些神经房间对 DNA 导致损坏的 apoptosis 过分敏感。因此, XP 变异的神经房间代表珍贵工具在 XP 病人澄清神经病学的畸形的分子的机制。 | Lina Fu Xiuling Xu Ruotong Ren Jun Wu Weiqi Zhang Jiping Yang Xiaoqing Ren Si Wang Yang Zhao Liang Sun Yang Yu Zhaoxia Wang Ze Yang Yun Yuan Jie Qiao Juan Carlos Izpisua Belmonte Jing Qu Guang-Hui Liu | 2016 | Protein & Cell2016，7，3： | 11 |
| 3 | Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells显示文摘Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a rare hereditary cerebrovascular disease caused by a NOTCH3 mutation.However,the underlying cellular and molecular mechanisms remain unidentified.Here,we generated non-integrative induced pluripotent stem cells(iPSCs)from fibroblasts of a CADASIL patient harboring a heterozygous NOTCH3 mutation(c.3226C>T,p.R1076C).Vascular smooth muscle cells(VSMCs)differentiated from CADASIL-specific iPSCs showed gene expression changes associated with disease phenotypes,including activation of the NOTCH and NF-kB signaling pathway,cytoskeleton disorganization,and excessive cell proliferation.In comparison,these abnormalities were not observed in vascular endothelial cells(VECs)derived from the patients iPSCs.Importantly,the abnormal upregulation of NF-kB target genes in CADASIL VSMCs was diminished by a NOTCH pathway inhibitor,providing a potential therapeutic strategy for CADASIL.Overall,using this iPSCbased disease model,our study identified clues for studying the pathogenic mechanisms of CADASIL and developing treatment strategies for this disease. | Chen Ling Zunpeng Liu Moshi Song Weiqi Zhang Si Wang Xiaoqian Liu Shuai Ma Shuhui Sun Lina Fu Qun Chu Juan Carlos Izpisua Belmonte Zhaoxia Wang Jing Qu Yun Yuan Guang-Hui Liu | 2019 | Protein & Cell2019，10，4： | 7 |
| 4 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 5 | Tumorigenic bacteria in colorectal cancer:mechanisms and treatments显示文摘Colorectal cancer(CRC)is the third most common and the second most fatal cancer.In recent years,more attention has been directed toward the role of gut microbiota in the initiation and development of CRC.Some bacterial species,such as Fusobacterium nucleatum,Escherichia coli,Bacteroides fragilis,Enterococcus faecalis,and Salmonella sp.have been associated with CRC,based upon sequencing studies in CRC patients and functional studies in cell culture and animal models.These bacteria can cause host DNA damage by genotoxic substances,including colibactin secreted by pks+Escherichia coli,B.fragilis toxin(BFT)produced by Bacteroides fragilis,and typhoid toxin(TT)from Salmonella.These bacteria can also indirectly promote CRC by influencing host-signaling pathways,such as E-cadherin/β-catenin,TLR4/MYD88/NF-κB,and SMO/RAS/p38 MAPK.Moreover,some of these bacteria can contribute to CRC progression by helping tumor cells to evade the immune response by suppressing immune cell function,creating a proinflammatory environment,or influencing the autophagy process.Treatments with the classical antibacterial drugs,metronidazole or erythromycin,the antibacterial active ingredients,M13@Ag(electrostatically assembled from inorganic silver nanoparticles and the protein capsid of bacteriophage M13),berberine,and zerumbone,were found to inhibit tumorigenic bacteria to different degrees.In this review,we described progress in elucidating the tumorigenic mechanisms of several CRC-associated bacteria,as well as progress in developing effective antibacterial therapies.Specific bacteria have been shown to be active in the oncogenesis and progression of CRC,and some antibacterial compounds have shown therapeutic potential in bacteria-induced CRC.These bacteria may be useful as biomarkers or therapeutic targets for CRC. | Sha Li Jinyi Liu Xiangjin Zheng Liwen Ren Yihui Yang Wan Li Weiqi Fu Jinhua Wang Guanhua Du | 2022 | Cancer Biology & Medicine2022，19，2： | 3 |
| 6 | Active control of EIT-like response in a symmetry-broken metasurface with orthogonal electric dipolar resonators显示文摘The active control of electromagnetic response in metamaterial and mutual coupling between resonant building blocks is of fundamental importance in realizing high-quality metamaterials. In this work, we propose and experimentally demonstrate the tunabilities of symmetry-broken metasurfaces made of orthogonal electric dipolar resonators. The metasurface with vertical and horizontal wires is integrated with a PIN diode for active control.It is found that the electromagnetically induced transparency(EIT)-like spectrum appears due to the destructive or constructive interferences between the two electric dipolar modes when the structural symmetry broken is introduced to the metasurface. Different from previous works on the EIT-like effect, there is only electric dipole response in our metasuface. The microscopic response of the metasurface is numerically calculated to illustrate the mode coupling between the orthogonal electric dipolar resonators. By applying temporal coupled-mode theory,the interaction between the electromagnetic wave and the symmetry-broken metasurface is described, and the characteristic parameters of the resonator system, which determine the electromagnetic response of the metasurface, are acquired. | RUISHENG YANG QUANHONG FU YUANCHENG FAN WEIQI CAI KEPENG QIU WEIHONG ZHANG FULI ZHANG | 2019 | Photonics Research2019，7，9： | 3 |
| 7 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 8 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | LUO Weiqi HUAN Shuangyan FU Haiyan | 2011 | Food Chemistry2011，128，2： | 1 |
| 9 | Associations Between Specific Diets, Dietary Diversity, and Cognitive Frailty in Older Adults — China, 2002–2018显示文摘Summary What is already known about this topic?The relationship between specific dietary patterns and dietary diversity with cognitive frailty continues to be a subject of ambiguity.What is added by this report?This research revealed that regular consumption of fruit,meat,bean products,garlic,and tea was connected to a decreased risk of cognitive frailty.Compared to participants with dietary diversity score(DDS)≤6 points,those with DDS of 9–10,11–12,and≥12 had a lower risk of cognitive frailty. | Qingmei Huang Wenfang Zhong Ziting Chen Zhihao Li Peidong Zhang Yujie Zhang Peiliang Chen Qi Fu Weiqi Song Yuebin Lyu Xiaoming Shi Chen Mao | 2023 | China CDC weekly2023，5，39： | 1 |
| 10 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Weiqi Luo Shuangyan Huan Haiyan Fu | | 0，，02： | 1 |
| 11 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Weiqi Luo Shuangyan Huan Haiyan Fu | | 0，，02： | 1 |
| 12 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Weiqi Luo Shuangyan Huan Haiyan Fu | 2011 | Food Chemistry2011，，128： | 1 |
| 13 | A novel locus of coralliform cataract mapped to chromosome 2p24-pter显示文摘 | Linghan Gao Wei Qin Hao Cui Guoyin Feng Ping Liu Weiqi Gao Lin Ma Pu Li Lin He Songbin Fu | 2005 | Journal of Human Genetics2005，，6： | 1 |
| 14 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Luo Weiqi Huan Shuangyan Fu Haiyan | 2011 | Food Chemistry2011，128，2： | 1 |
| 15 | Preliminary study on the application of near infrared spectroscopy and pattern recognition methods to classify different types of apple samples显示文摘 | Luo Weiqi Huan S Fu H | 2011 | Food Chemistry2011，128，2： | 1 |
| 16 | Dissecting the contributions of organic nitrogen aerosols to global atmospheric nitrogen deposition and implications for ecosystems显示文摘Atmospheric deposition of particulate organic nitrogen(ON_(p))is a significant process in the global nitrogen cycle and may be pivotally important for N-limited ecosystems.However,past models largely overlo oked the spatial and chemical inhomogeneity of atmospheric ON_(p)and were thus deficient in assessing global ON_(p)impacts.We constructed a comprehensive global model of atmospheric gaseous and particulate organic nitrogen(ON),including the latest knowledge on emissions and secondary formations.Using this model,we simulated global atmospheric ON_(p)abundances consistent with observations.Our estimated global atmospheric ON deposition was 26 Tg N yr^(-1),predominantly in the form of ON_(p)(23 Tg N yr^(-1))and mostly from wildfires(37%),oceans(22%)and aqueous productions(17%).Globally,ON_(p)contributed as much as 40%to 80%of the total N deposition downwind of biomass-burning regions.Atmospheric ON_(p)deposition thus constituted the dominant external N supply to the N-limited boreal forests,tundras and the Arctic Ocean,and its importance maybe amplified in a future warming climate. | Yumin Li Tzung-May Fu Jian Zhen Yu Xu Yu Qi Chen Ruqian Miao Yang Zhou Aoxing Zhang Jianhuai Ye Xin Yang Shu Tao Hongbin Liu Weiqi Yao | 2023 | National Science Review2023，10，12： | 0 |
| 17 | Single-cell transcriptomic atlas of mouse cochlear aging显示文摘Progressive functional deterioration in the cochlea is associated with age-related hearing loss(ARHL).However,the cellular and molecular basis underlying cochlear aging remains largely unknown.Here,we established a dynamic single-cell transcriptomic landscape of mouse cochlear aging,in which we characterized aging-associated transcriptomic changes in 27 different cochlear cell types across five different time points.Overall,our analysis pinpoints loss of proteostasis and elevated apoptosis as the hallmark features of cochlear aging,highlights unexpected age-related transcriptional fluctuations in intermediate ceils localized in the stria vascularis(SV)and demonstrates that upregulation of endoplasmic reticulum(ER)chaperon protein HSP90AA1 mitigates ER stress-induced damages associated with aging.Our work suggests that targeting unfolded protein response pathways may help alleviate aging-related sVatrophyand hencedelay theprogressionofARHL. | Guoqiang Sun Yandong Zheng Xiaolong Fu Weiqi Zhang Jie Ren Shuai Ma Shuhui Sun Xiaojuan He QiaoranWang zhejun ji Fang Cheng KaowenYan Ziyi Liu Juan Carloszpisuaemonte Jing Qu Si Wang Renjie Chai Guang-Hui Liu | 2023 | Protein & Cell2023，14，3： | 0 |
| 18 | Detecting Doppler ultrasound embolic signals using the wavelet-based feature extraction algorithm显示文摘有 Doppler 超声技术的传播 emboli 的非侵略的察觉具有在临床的 applications.In 顺序的活跃意义消除探针或病人的运动带的人工制品的缺点并且精确地检测 emboli ,相关特征参数从信号波形的 Doppler signals.The 奇特的小浪变换的二个角度被提取基于它的小浪由易到难的试题程序被分析;然后横向、纵的参数被提取到 | CHEN Yijiao WANG Yuanyuan WANG Weiqi ZHOU Hualin FU Jianhui | 2008 | Chinese Journal of Acoustics2008，27，4： | 0 |
| 19 | Fano-Resonant Hybrid Metamaterial for Enhanced Nonlinear Tunability and Hysteresis Behavior显示文摘Artificial resonant metamaterial with subwavelength localized filed is promising for advanced nonlinear photonic applications.In this article,we demonstrate enhanced nonlinear frequency-agile response and hysteresis tunability in a Fano-resonant hybrid metamaterial.A ceramic cuboid is electromagnetically coupled with metal cut-wire structure to excite the high-Q Fano-resonant mode in the dielectric/metal hybrid metamaterial.It is found that the significant nonlinear response of the ceramic cuboid can be employed for realization of tunable metamaterials by exciting its magnetic mode,and the trapped mode with an asymmetric Fano-like resonance is beneficial to achieve notable nonlinear modulation on the scattering spectrum.The nonlinear tunability of both the ceramic structure and the ceramic/metal hybrid metamaterial is promising to extend the operation band of metamaterials,providing possibility in practical applications with enhanced light-matter interactions. | Yuancheng Fan Xuan He Fuli Zhang Weiqi Cai Chang Li Quanhong Fu Nataliia V.Sydorchuk Sergey L.Prosvirnin | 2021 | Research2021，，1： | 0 |
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