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| 1 | Endoscopic retrograde cholangiopancreatography associated pancreatitis:A 15-year review显示文摘The aim of this article is to review the literature regarding post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis.We searched for and evaluated all articles describing the diagnosis,epidemiology,pathophysiology,morbidity,mortality and prevention of post-ERCP pancreatitis(PEP) in adult patients using the PubMed database.Search terms included endoscopic retrograde cholangiopancreatography,pancreatitis,ampulla of vater,endoscopic sphincterotomy,balloon dilatation,cholangiography,adverse events,standards and utilization.We limited our review of articles to those published between January 1,1994 and August 15,2009 regarding human adults and written in the English language.Publicat ions from the reference sections were reviewed and included if they were salient and fell into the time period of interest.Between the dates queried,seventeen large(> 500 patients) prospective and four large retrospective trials were conducted.PEP occurred in 1-15 in the prospective trials and in 1-4 in the retrospective trials.PEP was also reduced with pancreatic duct stent placement and outcomes were improved with endoscopic sphincterotomy compared to balloon sphincter dilation in the setting of choledocholithiasis.Approximately 34 pharmacologic agents have been evaluated for the prevention of PEP over the last f ifteen years in 63 trials.Although 22 of 63 trials published during our period of review suggested a reduction in PEP,no pharmacologic therapy has been widely accepted in clinical use in decreasing the development of PEP.In conclusion,PEP is a well-recognized complication of ERCP.Medical treatment for prevention has been disappointing.Proper patient selection and pancreatic duct stenting have been shown to reduce the complication rate in randomized clinical trials. | Kevin E Woods Field F Willingham | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，5： | 20 |
| 2 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 3 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 4 | Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features显示文摘 | Walter F Stewart Joshua N Liberman Robert S Sandler Michael S Woods Annette Stemhagen Elsbeth Chee Richard B Lipton Christina E Farup | 1999 | The American Journal of Gastroenterology1999，，12： | 2 |
| 5 | Multiscale modeling of spatially variable water and energy balance process显示文摘 | Famiglietti J S Wood E F | 1998 | Water Resources Research1998，30，11： | 2 |
| 6 | An adaptive algorithm for analyzing short term structural and parameter changes in hydrologic prediction models显示文摘 | Wood E F Szollosi-Nagy A | 1978 | Water Resources Research1978，14，4： | 2 |
| 7 | A wind erosion equation显示文摘 | Wood ruff N P Siddoway F H | 1965 | Proc Soil Sci Soc Am1965，，29： | 1 |
| 8 | Microalgae and Antarctic seaice显示文摘 | Bunt J S Wood Z J F | 1963 | Nature1963，199，2： | 1 |
| 9 | Aliskiren, a novel, orally effec- tive nmin inhibitor, lowers blood pressure in rnannosets and spontaneous- ly hypertemive rats显示文摘 | Wood JM Schnell CR Cumin F | 2005 | J Hypertens2005，23，2： | 1 |
| 10 | ASCO/SSO re-view of current role of risk-reducing surgery in common he-reditary cancer syndromes显示文摘 | Guillem J G Wood W C Moley J F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 11 | Effects of spatial variabilily and scale with implication to hydrologic modeling显示文摘 | Wood E F Sivapalan M Bern K J el at | 1988 | Journal of Hydrology1988，102，： | 1 |
| 12 | The use of bivalves as bio-indicators in the assessment of marine pollution along a coastal area 显示文摘 | Yusof A M Yanta N F Wood A K H | 2004 | Journal of Radioanalytical and Nuclear Chemistry2004，259，1： | 1 |
| 13 | Full-scale tests of bridge components strengthened using carbon fiber-reinforced polymer composites显示文摘 | BRENA S F WOOD S L KREGER M E | 2003 | ACI Structural Journal2003，100，6： | 1 |
| 14 | Duloxetine in the treatment of major depressive disorder:a placebo and paroxetiue controlled trial显示文摘 | Perahia DC Wang F Ed Wood | 2006 | Eur Psychiatry2006，21，6： | 1 |
| 15 | Employee perceptions of diabetes education needs: a focus group study显示文摘 | Wood F Jacobson S | 2005 | AAOHN J2005，53，10： | 1 |
| 16 | Further aspects of design by P-Delta method显示文摘 | Wood B R Beaulieu D Adams P F | 1976 | Journal of the Structural Division ASCE1976，102，3： | 1 |
| 17 | Effects of nitrogen and sulfur fertilizer on protein composition,mixing requirements,and dough strength of four wheat cultivars显示文摘 | Wooding A R Kavale S Macritchie F | 2000 | Cereal Chem2000，77，6： | 1 |
| 18 | Laparoscopic partial nephrectomy of solid renal masses without hilar clamping using a monopolar radio frequency device显示文摘 | Urena R Meudez F Woods M | 2004 | J Urol2004，171，3： | 1 |
| 19 | Direct myocardial revasularization wihoute edtracorporeal circulation显示文摘 | Benetti F J Naselli G Wood M | 1991 | Chest1991，100，： | 1 |
| 20 | Enhanced Feedback Sensitivity to Prednisolone in Chronic Fa- tigue Syndrome显示文摘 | Jerjes W K Taylor N F Wood P J | 2007 | Psychoneuroendocrinology2007，，32： | 1 |
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