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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Random Early Detection Gateways for Congestion Avoidance显示文摘 | Floyd S Jacobson V | | 0，，： | 3 |
| 3 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 4 | Random early detection gateways for congestion avoidance 显示文摘 | Floyd S Jacobson V | 1993 | IEEE/ACM Transactions on Networking1993，1，4： | 2 |
| 5 | A new low-meltingpoint aluminium braze显示文摘 | Jacobson D M Humpston G and Sangha S P S | 1996 | Welding Journal1996，75，8： | 2 |
| 6 | Random early detection gateways for congestion avoidance显示文摘 | Floyd S Jacobson V | 1993 | IEEE/ACM Transactions on Networking1993，1，4： | 2 |
| 7 | Random early detection gateways for congestion avoidance显示文摘 | Floyd S JACOBSON M | | 0，，： | 2 |
| 8 | A new low-melting-point aluminum braze显示文摘 | Jacobson D M Humpston G Sangha S P S | 1996 | Welding Journal1996，，8： | 1 |
| 9 | Selective antagonism of the hepatic glucocorticoid receptor reduces hepatic glucose production显示文摘 | Edgerton D S Jacobson P B Opgenorth T Jet cd | 2006 | Metabolism2006，55，9： | 1 |
| 10 | Random Early Detection Gateways for Congestion Avoidance显示文摘 | S Floyd V Jacobson | 1993 | IEEE/ACM Trans on Networking1993，1，4： | 1 |
| 11 | Random Early Detection Gateways for Congestion Avoidance显示文摘 | Floyd S Jacobson V | 1993 | IEEE ACM Transactions on Networking1993，1，4： | 1 |
| 12 | Random early detection gate- way for congestion avoidance 显示文摘 | FLOYD S JACOBSON V | 1993 | IEEE/ACM Transac- tions on Networking1993，1，4： | 1 |
| 13 | Oxygen exchange kinetics of epitaxial PrBaCo2O5+δ thin films显示文摘 | KIM G WANG S JACOBSON A J | 2006 | Appl Phys Lett2006，88，02： | 1 |
| 14 | Mixed dentition analysis for Asian-Americans显示文摘 | Lee-Chan S Jacobson BN Chwa KH | | 0，，03： | 1 |
| 15 | Meta-analysis of comparison of effectiv-eness of lowering apolipoprotein B ver- sus low-density lipoprotein cholesterol and non high-density lipoprotein cholesterol for cardiovascular risk reduction in randomized trims 显示文摘 | ROBINSON J G WANG S JACOBSON T A | 2012 | Am J Cardiol2012，110，10： | 1 |
| 16 | CRH deficiency impairs but does not block pituitaryadrenal responses to diverse stressors显示文摘 | Jacobson L Muglia L J Weninger S C | 2000 | Neuroendocrinology2000，71，： | 1 |
| 17 | Random early detection gateways for congestion avoidance显示文摘 | Floyd S Jacobson V | 1993 | IEEE ACM Transactions on Networking1993，，8： | 1 |
| 18 | Using laboratory experiments in public economics显示文摘 | Aim J Jacobson S | 2007 | National Tax Journal2007，60，1： | 1 |
| 19 | Friction Behavior and Squeal Generation of Disc Brakes at Low Speeds显示文摘 | Eriksson M Jacobson S | 2001 | Proceedings of the Institution of Mechanical Engineers Part D: Journal of Automobile Engineering2001，215，5： | 1 |
| 20 | Random Early Detection Gateways for Congestion Avoidance显示文摘 | Floyd S Jacobson V | 1993 | IEEE/ACM Transactions on Networking1993，4，1： | 1 |
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