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| 1 | Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages显示文摘 | Xianfa Yang Boqiang Hu Yu Hou Yunbo Qiao Ran Wang Yingying Chen Yun Qian Su Feng Jun Chen Chang Liu Guangdun Peng Fuchou Tang Naihe Jing | 2018 | Cell Research2018，28，5： | 5 |
| 2 | Synthesis and Photocatalytic Activity of Ti-pillared Bentonite显示文摘支柱 Ti 的火山灰成胶状黏土成功地用那能导致 TiO_2 支柱的转变从的一个修改方法被准备了对在低温度(150 deg C ) 的锐钛矿阶段非结晶。=1.94 nm 由支柱 Ti 的火山灰成胶状黏土获得了的 d_(001 ) 的价值比相应未加工的泥土(1.56 nm ) 的大。由于形成的大量 Ti 支柱,支柱 theTi 的火山灰成胶状黏土在吸附玫瑰精 B (RB ) 显示出一个优秀能力。photocatalyticactivity 和运动方程被在紫外照耀下面分解 RB 答案调查。支柱 Ti 的火山灰成胶状黏土显示出超级相片,这被发现为 RB 答案的降级的催化活动与未经治疗的火山灰成胶状黏土和纯 TiO_2 相比,并且 RB 答案的降级的运动方程是一个 1.5 颂诗方程。 | TANG Jianwen WU Pingxiao ZHENG Shaoyan LIU Yun WANG Feifei XIE Xianfa | 2006 | Acta Geologica Sinica(English Edition)2006，80，2： | 3 |
| 3 | TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs显示文摘pluripotent 干细胞(PSC ) 的临床的治疗基于移植被 teratomas 或肿瘤的经常的开发在动物模型和临床的病人妨碍了。因此,在干细胞治疗澄清 carcinogenesis 的机制为减少 tumorigenicity 的风险是很重要的。这里,我们区分 Oct4-GFP 老鼠胚胎的干细胞(mESCs ) 进神经祖先房间(NPC ) 并且发现少数 Oct4+ 房间连续地以 Oct4+ 状态被支撑。这些房间能在标准转换字符媒介被充实并且增殖。有趣地,这些充实的房间的区别潜力紧与许多更高的 tumorigenic 活动被限制,它是因此定义的同样区别抵抗的转换字符(医生转换字符) 。Transcriptomic 和 epigenomic 分析证明医生转换字符被初发的细菌描绘像房间的基因签名(Dazl, Rec8, Stra8, Blimp1,等等) 并且从 mESCs 不同的特定的 epigenetic 模式。而且,医生转换字符拥有细菌房间潜力产生 Sycp3+ haploid 房间并且能居住在 busulfan 导致的没有精子的输精管。最后,我们发现 TGF 发信号是在 TGF 发信号的医生转换字符,和抑制的 overactivated 由导致医生转换字符的完整的区别消除导出 mESC 的 NPC 的 tumorigenicity。这些数据表明那像房间的医生转换字符是的这些 TGF-hyperactivated 细菌为导出转换字符的目标房间治疗的 tumorigenicity 和在导出转换字符的 NPC 移植发信号的 TGF 的那抑制的主要贡献者能急速地减少肿瘤开发的风险。 | Xianfa Yang Ran Wang Xiongjun Wang Guoqing Cai Yun Qian Su Feng Fangzhi Tan Kun Chen Ke Tang Xingxu Huang Naihe Jing Yunbo Qiao | 2018 | Journal of Molecular Cell Biology2018，10，3： | 2 |
| 4 | Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development显示文摘Primary germ layers have the potential to form all tissues in the mature organism,and their formation during gastrulation requires precise epigenetic modulation of both proximal and distal regulatory elements.Previous studies indicated that spatial and temporal patterns of gene expression in the gastrula predispose individual regions to distinct cell fates.However,the underlying epigenetic mechanisms remain largely unexplored.Here,we profile the spatiotemporal landscape of the epigenome and transcriptome of the mouse gastrula.We reveal the asynchronous dynamics of proximal chromatin states during germ layer formation as well as unique gastrula-specific epigenomic features of regulatory elements,which have strong usage turnover dynamics and clear germ layerspecific signatures.Importantly,we also find that enhancers around organogenetic genes,which are weakly expressed at the gastrulation stage,are frequently pre-marked by histone H3 lysine 27 acetylation(H3K27ac)in the gastrula.By using the transgenic mice and genome editing system,we demonstrate that a pre-marked enhancer,which is located in the intron of a brain-specific gene 25W009E07Rik,exhibits specific enhancer activity in the ectoderm and future brain tissue,and also executes important function during mouse neural differentiation.Taken together,our study provides the comprehensive epigenetic information for embryonic patterning during mouse gastrulation,demonstrates the importance of gastrula pre-marked enhancers in regulating the correct development of the mouse embryo,and thus broadens the current understanding of mammalian embryonic development and related diseases. | Xianfa Yang Boqiang Hu Jiaoyang Liao Yunbo Qiao Yingying Chen Yun Qian Su Feng Fang Yu Ji Dong Yu Hou He Xu Ran Wang Guangdun Peng Jinsong Li Fucnou Tang Naihe Jing | 2019 | Cell Research2019，29，11： | 1 |
| 5 | A rare variant in COL11A1 is strongly associated with adult height in Chinese Han population显示文摘Human height is a highly heritable trait in which multiple genes are involved. Recent genome-wide association studies(GWASs) have identified that COL11A1 is an important susceptibility gene for human height. To determine whether the variants of COL11A1 are associated with adult and children height,we analyzed splicing and coding single-nucleotide variants across COL11A1 through exome-targeted sequencing and two validation stages with a total 20,426 Chinese Han samples. A total of 105 variants were identified by exome-targeted sequencing, of which 30 SNPs were located in coding region. The strongest association signal was chr1_103380393 with P value of 4.8 * 10^(-7). Chr1_103380393 also showed nominal significance in the validation stage(P = 1.21 * 10^(-6)). Combined analysis of 16,738 samples strengthened the original association of chr1_103380393 with adult height(P_(combined)= 3.1 * 10^(-8)), with an increased height of 0.292sd(standard deviation) per G allele(95% CI:0.19-0.40). There was no evidence(P = 0.843) showing that chr1_103380393 altered child height in 3688 child samples. Only the group of 12-15 years showed slight significance with P value of 0.0258.This study firstly shows that genetic variants of COL11A1 contribute to adult height in Chinese Han population but not to children height, which expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height. | Changbing Shen Xiaodong Zheng Jing Gao Caihong Zhu Randy Ko Xianfa Tang Chao Yang Jinfa Dou Yan Lin Yuyan Cheng Lu Liu Shuangjun Xu Gang Chen Xianbo Zuo Xianyong Yin Liangdan Sun Yong Cui Sen Yang Xuejun Zhang Fusheng Zhou | 2016 | Journal of Genetics and Genomics2016，43，9： | 1 |
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