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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | Ethyl pyruvate protects against experimental acute-on-chronic liver failure in rats显示文摘AIM:To investigate the protective effects of ethyl pyruvate(EP) on acute-on-chronic liver failure(ACLF) in rats.METHODS:An ACLF model was established in rats,and animals were randomly divided into normal,model and EP treatment groups.The rats in EP treatment group received EP(40 mg/kg) at 3 h,6 h,12 h and 24 h after induction of ACLF.Serum endotoxin,high mobility group box-1(HMGB1),alanine transaminase(ALT),tumor necrosis factor-(TNF-),interferon-(IFN-),interleukin(IL)-10 and IL-18 levels,changes of liver histology and HMGB1 expressions in liver tissues were detected at 48 h after induction of ACLF.The effects of EP on the survival of ACLF rats were also observed.RESULTS:Serum levels of endotoxin(0.394 ± 0.066 EU/mL vs 0.086 ± 0.017 EU/mL,P < 0.001),HMGB1(35.42 ± 10.86 g/L vs 2.14 ± 0.27 g/L,P < 0.001),ALT(8415.87 ± 3567.54 IU/L vs 38.64 ± 8.82 IU/L,P < 0.001),TNF-(190.77 ± 12.34 ng/L vs 124.40 ± 4.12 ng/L,P < 0.001),IFN-(715.38 ± 86.03 ng/L vs 398.66 ± 32.91 ng/L,P < 0.001),IL-10(6.85 ± 0.64 ng/L vs 3.49 ± 0.24 ng/L,P < 0.001) and IL-18(85.19 ± 3.49 ng/L vs 55.38 ± 1.25 ng/L,P < 0.001) were significantly increased,and liver tissues presented severe pathological injury in the model group compared with the normal group.However,EP administration significantly improved hepatic histopathology and reduced the serum levels of endotoxin(0.155 ± 0.045 EU/mL vs 0.394 ± 0.066 EU/mL,P < 0.001) and inflammatory cytokines(11.13 ± 2.58 g/L vs 35.42 ± 10.86 g/L for HMGB1,3512.86 ± 972.67 IU/L vs 8415.87 ± 3567.54 IU/L for ALT,128.55 ± 5.76 ng/L vs 190.77 ± 12.34 ng/L for TNF-,438.16 ± 38.10 ng/L vs 715.38 ± 86.03 ng/L for IFN-,3.55 ± 0.36 ng/L vs 6.85 ± 0.64 ng/L for IL-10,and 60.35 ± 1.63 ng/L vs 85.19 ± 3.49 ng/L for IL-18,respectively,P < 0.001),and the levels of HMGB1 in liver tissues regardless of treatment time after induction of ACLF.EP treatment at the four time points prolonged the median survival time of ACLF rats(60 h) to 162 h,120 h,102 h and 78 h,respectively(2 = 41.17,P < 0.0001).CONCLUSION:EP administration can protect against ACLF in rats,and is a potential and novel therapeutic agent for severe liver injury. | Lu-Wen Wang Li-Kun Wang Hui Chen Cheng Fan Xun Li Can-Ming He Zuo-Jiong Gong | 2012 | World Journal of Gastroenterology2012，18，40： | 14 |
| 3 | Down-regulation of the let-7i facilitates gastric cancer invasion and metastasis by targeting COL1A1显示文摘Dear Editor,Globally,gastric cancer is the most common malignant tumor and the second highest contributor to cancer deaths after lung cancer(Murray et al.,2012).Despite improved success with treatment of early stage gastric cancer(Fuse et al.,2016),the five-year survival rate of advanced staged gastric cancer patients is still low.The aggressive growth characteristics of the tumor and metastasis are key factors responsible for poor overall survival in these patients(Ozkan et al.,2005).Therefore,investigation of the molecular mechanisms that underlie the aggressive behavior of gastric cancers,and identification of potential target genes for therapeutic interventions,is a key imperative. | Yue Shi Zipeng Duan Xun Zhang Xiaotian Zhang Guoqing Wang Fan Li | 2019 | Protein & Cell2019，10，2： | 9 |
| 4 | Production of glass-ceramics using Municipal solid waste incineration fly ash显示文摘Municipal solid waste incineration(MSWI) fly ash is a by-product from municipal waste incineration.According to incomplete statistics, each year more than one million tons MSWI fly ash was produced in China. Owing to high heavy elements content, widely used disposal methods of landfill are not suitable for MSWI fly ash treatment. In this study, by using MSWI fly ash as raw materials, glassceramics was synthesized for the solidification of heavy metals and waste recycle. Process parameters, including composition, heat treatment temperature and time, were studied and optimized. Under optimizing conditions, the product has good properties of density of 3.42 g·cm^(-3) and Vickers hardness of 6.91 GPa. Moreover, the leaching concentration of heavy metal elements meets allowable values of toxicity characteristic leaching procedure(TCLP).This study offers an alternative for MSWI fly ash recycle. | Wen-Di Fan Bo Liu Xun Luo Jian Yang Bin Guo Shen-Gen Zhang | 2019 | Rare Metals2019，38，3： | 8 |
| 5 | A Novel Surgery Classification for Endoscopic Approaches to Middle Ear Cholesteatoma显示文摘This study aimed to develop a novel surgery classification for an endoscopic approach to middle ear cholesteatoma.We retrospectively analyzed the surgical approaches and outcomes of patients with middle ear cholesteatoma.Middle ear cholesteatoma surgeries were divided into four types and two special types as follows:type I,attic retraction pocket,which only requires tympanostomy tube placement or retraction pocket resection and cartilage reconstruction;typeⅡ,cholesteatoma which is limited to the attic or in which endoscopy can confirm complete removal of mastoid cholesteatoma lesions,including type Ⅱa,requiring only use of a curette,and type Ⅱ b,requiring use of an electric drill or chisel;type Ⅲ,cholesteatoma not limited to the attic,in which endoscopy cannot confirm complete removal of mastoid cholesteatoma lesions,requiring the combined use of endoscope and microscope to perform endoscopic tympanoplasty and'Canal Wall Up'mastoidectomy;type Ⅳ,extensive involvement of mastoid cavity cholesteatoma lesions and/or cases with a potential risk of complications,removal of which can only be performed under a microscope for'Canal Wall Down'mastoidectomy.In addition,there were two special types:'difficult external auditory canal'and congenital cholesteatoma in children.In our system,type I and type U middle ear cholesteatoma surgery was completely performed under an endoscope alone.However,estimating the extent of the lesions,determining the choice of mastoid opening and reestablishing ventilation are the key points for an endoscopic approach to middle ear cholesteatoma.The classification of endoscopic middle ear cholesteatoma surgery may benefit the selection of surgical indications. | Yu SUN En-hao WANG Jin-tao YU Gang ZHONG Li-xin ZHU-Yi WANG Niu XUN Hong YU Wen ZHOU Zhen XIE Kun ZHANG Guo-run FAN Yi ZHONG Hong-jun XIAO Wei-jia KONG | 2020 | Current Medical Science2020，40，1： | 8 |
| 6 | Sodium butyrate protects against toxin-induced acute liver failure in rats显示文摘BACKGROUND: Acute liver failure(ALF) is a serious clinical syndrome with high mortality. Sodium butyrate has been shown to alleviate organ injury in a wide variety of preclinical models of critical diseases. The aim of this study was to investigate the protective effect of sodium butyrate on ALF in rats.METHODS: All rats were randomly divided into control,model and sodium butyrate treatment groups. Except the control group, the rats were induced ALF animal model by subcutaneous injection of human serum albumin+D- galactosamine+lipopolysaccharide. After induction of ALF,the rats in the treatment group received sodium butyrate(500mg/kg) at 12-hour or 24-hour time point. Fourty-eight hours after ALF induction, the animals were sacrificed and samples were harvested. Serum endotoxin, high mobility group box-1(HMGB1), liver function parameters, tumor necrosis factoralpha(TNF-α) and interferon-gamma(IFN-γ) were measured.The expression of HMGB1 and nuclear factor-kappa B(NF-κB)p65 protein in liver tissue was detected by Western blotting. The histological changes of liver and intestine were examined. The survival duration was also observed.RESULTS: Serum endotoxin, alanine aminotransferase, HMGB1,TNF-α and IFN-γ were significantly increased and the liver histology showed more severe histopathological injury in the model group compared with the control group(P<0.05).Compared to the model group, sodium butyrate treatment significantly improved the histopathological changes in the liver and intestine, reduced serum endotoxin and inflammatory cytokines, suppressed HMGB1 and NF-кB p65 proteins in liver tissue, and prolonged the survival duration regardless of treatment at 12 hours or 24 hours after induction of ALF(P<0.05).CONCLUSIONS: Sodium butyrate protected the liver from toxin-induced ALF in rats. The mechanisms may be due to direct hepatoprotection and decreased intestinal permeability. | Fan Yang Li-Kun Wang Xun Li Lu-Wen Wang Xiao-Qun Han Zuo-Jiong Gong | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，3： | 6 |
| 7 | Study on precipitation and transition mechanisms from the magnetic properties of silicon steel during annealing显示文摘Precipitates play an important role in determining the mechanical and magnetic properties of silicon steel. This paper aims to investigate the growth kinetics of precipitates in commercial silicon steel by analyzing its magnetic properties during isothermal annealing at 200°C. The growth of precipitates was studied by optical microscopy, scanning electron microscopy, transmission electron microscopy, and magnetic measurements. In combination with the coercive field and initial susceptibility, this technique offers the advantage of being non-destructive and providing quantitative information about the number, mean radius of precipitates, and fraction of transformation. An observed decrease in the number of precipitated particles indicates that the transformation starts from particles of appreciable initial size. | Yong-fei Fan Hao Yu Jing Sun Pan Tao Cheng-hao Song Xun Zeng | 2014 | International Journal of Minerals,Metallurgy and Materials2014，21，4： | 6 |
| 8 | Drone-based entanglement distribution towards mobile quantum networks显示文摘Satellites have shown free-space quantum-communication ability;however,they are orbit-limited from full-time all-location coverage.Meanwhile,practical quantum networks require satellite constellations,which are complicated and expensive,whereas the airborne mobile quantum communication may be a practical alternative to offering full-time all-location multi-weather coverage in a cost-effective way.Here,we demonstrate the first mobile entanglement distribution based on drones,realizing multi-weather operation including daytime and rainy nights,with a Clauser-Horne-Shimony-Holt S-parameter measured to be 2.41±0.14 and 2.49±0.06,respectively.Such a system shows unparalleled mobility,flexibility and reconfigurability compared to the existing satellite and fiber-based quantum communication,and reveals its potential to establish a multinode quantum network,with a scalable design using symmetrical lens diameter and single-mode-fiber coupling.All key technologies have been developed to pack quantum nodes into lightweight mobile platforms for local-area coverage,and arouse further technical improvements to establish wide-area quantum networks with high-altitude mobile communication. | Hua-Ying Liu Xiao-Hui Tian Changsheng Gu Pengfei Fan Xin Ni Ran Yang Ji-Ning Zhang Mingzhe Hu Jian Guo Xun Cao Xiaopeng Hu Gang Zhao Yan-Qing Lu Yan-Xiao Gong Zhenda Xie Shi-Ning Zhu | 2020 | National Science Review2020，7，5： | 6 |
| 9 | Recognition and localization system of the robot for harvesting Hangzhou White Chrysanthemums显示文摘To realize the robotic harvesting of Hangzhou White Chrysanthemums,the quick recognition and 3D vision localization system for target Chrysanthemums was investigated in this study.The system was comprised of three main stages.Firstly,an end-effector and a simple freedom manipulator with three degrees were designed to meet the quality requirements of harvesting Hangzhou White Chrysanthemums.Secondly,a segmentation based on HSV color space was performed.A fast Fuzzy C-means(FCM)algorithm based on S component was proposed to extract the target image from irrelevant background.Thirdly,binocular stereo vision was used to acquire the target spatial information.According to the shape of Hangzhou White Chrysanthemums,the centroids of stamens were selected as feature points to match in the right and left images.The experimental results showed that the proposed method was able to recognize Hangzhou White Chrysanthemums with the accuracy of 85%.When the distance between target and baseline was 150-450 mm,the errors between the calculated and measured distance were less than 14 mm,which could meet the requirements of the localization accuracy of the harvesting robot. | Qinghua Yang Chun Chang Guanjun Bao Jun Fan Yi Xun | 2018 | International Journal of Agricultural and Biological Engineering2018，11，1： | 5 |
| 10 | Performance Analysis of WLAN Medium Access Control Protocols in Simulcast Radio-Over-Fiber-Based Distributed Antenna Systems显示文摘The performance of three wireless local-area network(WLAN) media access control(MAC) protocols is investigated and compared in the context of simulcast radioover-fiber-based distributed antenna systems(RoF-DASs) where multiple remote antenna units(RAUs) are connected to one access point(AP) with different-length fiber links.The three WLAN MAC protocols under investigation are distributed coordination function(DCF) in basic access mode,DCF in request/clear to send(RTS/CTS) exchange mode,and point coordination function(PCF).In the analysis,the inter-RAU hidden nodes problems and fiber-length difference effect are both taken into account.Results show that adaptive PCF mechanism has better throughput performances than the other two DCF modes,especially when the inserted fiber length is short. | LI Jianqiang FAN Yuting CHEN Hao LU Xun XU Kun | 2014 | China Communications2014，11，5： | 5 |
| 11 | Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice显示文摘AIM: To investigate the effects of class phosphatidy-linositol 3-kinase (PI3K) inhibitor LY294002 on the invasiveness and related mechanisms of implanted tumors of SGC7901 human gastric carcinoma cells in nude mice. METHODS: Nude mice were randomly divided into model control groups and LY294002 treatment groups. On days 5, 10 and 15 after treatment, the inhibitory rate of tumor growth, pathological changes in tumor specimens, expression levels of matrix metalloproteinase (MMP)-2, MMP-9, CD34 [representing microvessel density (MVD)] and vascular endothelial growth factor (VEGF), as well as apoptosis indexes in tumor samples were observed.RESULTS: In this study, we showed that treatingthe tumors with LY294002 could significantly inhibit carcinoma growth by 11.3%, 29.4% and 36.7%, after 5, 10 and 15 d, respectively, compared to the control group. Hematoxylin & eosin staining indicated that the rate of inhibition increased progressively (23.51% ± 3.11%, 43.20% ± 3.27% and 63.28% ± 2.10% at 5, 10 and 15 d, respectively) along with apoptosis. The expression of MMP-2 was also downregulated (from 71.4% ± 1.6% to 47.9% ± 0.7%, 31.9% ± 0.9% and 7.9% ± 0.7%). The same effects were observed in MMP-9 protein expression (from 49.4% ± 1.5% to 36.9% ± 0.4%, 23.5% ± 0.9% and 7.7% ± 0.6%), the mean MVD (from 51.2% ± 3.1% to 41.9% ± 1.5%, 30.9% ± 1.7% and 14.9% ± 0.8%), and the expression of VEGF (from 47.2% ± 3.1% to 25.9% ± 0.5%, 18.6% ± 1.2% and 5.1% ± 0.9%) by immunohistochemical staining.CONCLUSION: The classPI3K inhibitor LY294002could inhibit the invasiveness of gastric cancer cells by downregulating the expression of MMP-2, MMP-9, and VEGF, and reducing MVD. | Chun-Gen Xing Bao-Song Zhu Xiao-Qing Fan Hui-Hui Liu Xun Hou Kui Zhao Zheng-Hong Qin | 2009 | World Journal of Gastroenterology2009，15，40： | 5 |
| 12 | Novel trichromatic phosphor Co-doped with Eu, Tb in SiO_2 gel matrix显示文摘The Eu, Tb co-doped SiO2 matrix tricolor fluorescence system was prepared by sol-gel technique. Red emission at 618 nm, green emission at 543 nm and blue emission at 350―500 nm were observed in the PL spectra of the sample, indicating that Eu3+, Eu2+ and Tb3+ ions coexisted in the matrix. In the co-doped sample, the blue emission of Eu2+ was much stronger than that of the sample single doped with Eu, which implied that the electron transfer between Eu3+ and Tb3+ maybe happened in the SiO2 matrix. The influences of the annealing temperature and Tb concentration on the PL spectra of the samples were investigated. The optimal doped concentration of Tb was determined to be 0.2% and the optimal annealing temperature 850℃. Annealed at 600℃, Tb3+ had a sensitizing effect on Eu3+ in the SiO2 matrix, and the emission intensity of Eu3+ in the Eu, Tb co-doped sample was more than four times that of the single doped sample, which could be attributed to the energy transfer from Tb3+ to Eu3+. | HU XiaoYun FAN Jun LI Ting ZHANG DeKai BAI Jinmao REN ZhaoYu HOU Xun | 2007 | Chinese Science Bulletin2007，52，4： | 5 |
| 13 | Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma显示文摘We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)extract.Upon exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and eosinophils.The increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune responses.Moreover,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in vitro.Asthmatic mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung injury.Metrnβalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway models.Moreover,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic asthma.These results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma. | Xun Gao Ting-Fan Leung Gary Wing-Kin Wong Wing-Hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang Ben Chung-Lap Chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam Chun-Kwok Wong | 2022 | Cellular & Molecular Immunology2022，19，2： | 5 |
| 14 | Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis显示文摘Dear Editor,The axolotl,Ambystoma mexicanum,has extraordinary capability to fully recover multiple tissues after lost,whereas such capability has disappeared in mammals.Thus,deci-phering detailed mechanisms underlying axolotl regenera-tion could provide valuable lessons for regenerative medicine.However,many questions,such as the origin of essential progenitor cells and key responses of individual types of cells for regeneration remain elusive(Haas and Whited,2017).Newly developed single-cell RNA sequenc-ing(scRNA-seq)method enables researchers to observe cellular and molecular dynamics in axolotl regeneration at the single-cell resolution(Gerber et al.,2018;Leigh et al.,2018),but the reported transcriptome landscapes are only for certain cell types or in certain regenerative stages.A complete overview of the regeneration process for all cell types is still lacking. | Hanbo Li Xiaoyu Wei Li Zhou Weiqi Zhang Chen Wang Yang Guo Denghui Li Jjianyang Chen Tianbin Liu Yingying Zhang Shuai Ma Congyan Wang Fujian Tan Jiangshan Xu Yang Liu Yue Yuan Liang Chen Qiaoran Wang Jing Qu Yue Shen Shanshan Liu Guangyi Fan Longqi Liu Xin Liu Yong Hou Guang-Hui Liu Ying Gu Xun Xu | 2021 | Protein & Cell2021，12，1： | 3 |
| 15 | The baroreflex afferent pathway plays a critical role in H_(2)S-mediated autonomic control of blood pressure regulation under physiological and hypertensive conditions显示文摘Hydrogen sulfide(H_(2)S),which is closely related to various cardiovascular disorders,lowers blood pressure(BP),but whether this action is mediated via the modification of baroreflex afferent function has not been elucidated.Therefore,the current study aimed to investigate the role of the baroreflex afferent pathway in H_(2)S-mediated autonomic control of BP regulation.The results showed that baroreflex sensitivity(BRS)was increased by acute intravenous NaHS(a H_(2)S donor)administration to renovascular hypertensive(RVH)and control rats.Molecular expression data also showed that the expression levels of critical enzymes related to H_(2)S were aberrantly downregulated in the nodose ganglion(NG)and nucleus tractus solitarius(NTS)in RVH rats.A clear reduction in BP by the microinjection of NaHS or L-cysteine into the NG was confirmed in both RVH and control rats,and a less dramatic effect was observed in model rats.Furthermore,the beneficial effects of NaHS administered by chronic intraperitoneal infusion on dysregulated systolic blood pressure(SBP),cardiac parameters,and BRS were verified in RVH rats.Moreover,the increase in BRS was attributed to activation and upregulation of the ATP-sensitive potassium(KATP)channels Kir6.2 and SUR1,which are functionally expressed in the NG and NTS.In summary,H_(2)S plays a crucial role in the autonomic control of BP regulation by improving baroreflex afferent function due at least in part to increased KATP channel expression in the baroreflex afferent pathway under physiological and hypertensive conditions. | Ying Li Yan Feng Li Liu Xue Li Xin-yu Li Xun Sun Ke-xin Li Rong-rong Zha Hong-dan Wang Meng-di Zhang Xiong-xiong Fan Di Wu Yao Fan Hao-cheng Zhang Guo-fen Qiao Bai-yan Li | 2021 | Acta Pharmacologica Sinica2021，42，6： | 3 |
| 16 | Effect of electropulsing treatment on static recrystallization behavior of cold-rolled magnesium alloy ZK60 with different reductions显示文摘Effect of electropulsing treatment(EPT) on recrystallization behavior of cold-rolled Mg alloy ZK60 strips was investigated. It was found that EPT significantly improved nucleation rate and migration ability of grain boundaries, leading to accelerated recrystallization of the deformed metals at relatively low temperature. After the recrystallization induced by EPT, the average grain size of 20% rolling reduction samples decreased from 113 um to around 10 um, meanwhile the typical basal-type texture of the coldrolled sample was weakened. EPT was normally accompanied with a thermal and an athermal effects. The athermal effect played a dominated role in increasing nucleation rate, while the thermal effect promoted grain growth. A fewer recrystallized grains originated along the grain boundaries in the 10% reduction samples, while most of the recrystallization took place inside the twins in the 20% reduction samples. | Huijun Guo Xun Zeng Jianfeng Fan Hua Zhang Qiang Zhang Weiguo Li Hongbiao Dong Bingshe Xu | 2019 | Journal of Materials Science & Technology2019，35，6： | 2 |
| 17 | Nature inspired hierarchical structures in nano-cellular epoxy/graphene-Fe3O4 nanocomposites with ultra-efficient EMI and robust mechanical strength显示文摘Hierarchical layered structures,whether in a compact form like nacre or a porous manner like bone,are well known for their combined features of high stiffness,strength,and lightweight,inspiring many man-made materials and structures for high performance applications.The use of nacre/bone like hierarchical structures in polymer nanocomposites can achieve excellent mechanical and functional properties with high filler volume fractions after carefully aligning functional nanofillers,although the fabrication and processing remain a great challenge.In this work,a bio-inspired lightweight nano-cellular epoxy/graphene-Fe_(3)O_(4) nanocomposite with high nanofiller loading of 75 wt.%was successfully fabricated by combining features from both nacre and bone structures,via a simple compression molding process together with an eco-friendly supercritical CO_(2) foaming process to achieve robust mechanical strength and excellent electromagnetic interference(EMI)shielding effectiveness(SE)simultaneously.Highly aligned graphene-Fe_(3)O_(4) nanoplatelets with well controlled nanoscale porous structures(52.6 nm)enabled both low density(1.26 g/cm^(3))and high specific EMI SE>5200 dB/cm^(2)/g,as well as preserved tensile strength of 67 MPa.This study provides a sustainable route to fabricate nature mimicked structures with high performance and high flexibility for a wide range of applications,from portable electronics to healthcare devices. | Xun Fan Fengchao Wang Qiang Gao Yu Zhang Fei Huang Ronglin Xiao Jianbin Qin Han Zhang Xuetao Shi Guangcheng Zhang | 2022 | Journal of Materials Science & Technology2022，，8： | 2 |
| 18 | Dissecting the genome of star fruit(Averrhoa carambola L.)显示文摘Averrhoa carambola is commonly known as star fruit because of its peculiar shape,and its fruit is a rich source of minerals and vitamins.It is also used in traditional medicines in countries such as India,China,the Philippines,and Brazil for treating various ailments,including fever,diarrhea,vomiting,and skin disease.Here,we present the first draft genome of the Oxalidaceae family,with an assembled genome size of 470.51 Mb.In total,24,726 protein-coding genes were identified,and 16,490 genes were annotated using various well-known databases.The phylogenomic analysis confirmed the evolutionary position of the Oxalidaceae family.Based on the gene functional annotations,we also identified enzymes that may be involved in important nutritional pathways in the star fruit genome.Overall,the data from this first sequenced genome in the Oxalidaceae family provide an essential resource for nutritional,medicinal,and cultivational studies of the economically important star-fruit plant. | Yannan Fan Sunil Kumar Sahu Ting Yang Weixue Mu Jinpu Wei Le Cheng Jinlong Yang Ranchang Mu Jie Liu Jianming Zhao Yuxian Zhao Xun Xu Xin Liu Huan Liu | 2020 | Horticulture Research2020，7，1： | 2 |
| 19 | Elimination of a Retrotransposon for Quenching Genome Instability in Modern Rice显示文摘Transposable elements(TEs)constitute the most abundant portions of plant genomes and can dramatically shape host genomes during plant evolution.They also play important roles in crop domestication.However,whether TEs themselves are also selected during crop domestication has remained unknown.Here,we identify an active long terminal repeat(LTR)retrotransposon,HUO,as a potential target of selection during rice domestication and breeding.HUO is a low-copy-number LTR retrotransposon,and is active under natural growth conditions and transmitted through male gametogenesis,preferentially inserting into genomic regions capable of transcription.HUO exists in all wild rice accessions and about half of the archaeological rice grains(1200–7000 years ago)and landraces surveyed,but is absent in almost all modern varieties,indicating its gradual elimination during rice domestication and breeding.Further analyses showed that HUO is subjected to strict gene silencing through the RNA-directed DNA methylation pathway.Our results also suggest that multiple HUO copies may trigger genomic instability through altering genome-wide DNA methylation and small RNA biogenesis and changing global gene expression,resulting in decreased disease resistance and yield,coinciding with its elimination during rice breeding.Together,our study suggests that negative selection of an active retrotransposon might be important for genome stability during crop domestication and breeding. | Yu Peng Yingying Zhang Yijie Gui Dong An Junzhong Liu Xun Xu Qun Li Junmin Wang Wen Wang Chunhai Shi Longjiang Fan Baorong Lu Yiwen Deng Sheng Teng Zuhua He | 2019 | Molecular Plant2019，12，10： | 2 |
| 20 | Factors influencing Li^(+)migration in garnet-type ceramic electrolytes显示文摘Garnet-type ceramic electrolyte with exceptionally high Li^(+) conductivity has attracted wide interests for the development of safe electrochemical devices.However,the factors affecting the ionic migration still deserve more attentions.In this study,five garnet-types ceramic electrolyte were chosen to investigate the factors.The thermal behavior of garnet-type electrolyte during sintering was studied to achieve high conductivity.The electrochemical properties are correlated with crystal structure,migrating route and lattice parameters.Nine influening factors were discussed to analyze the ionic migration in garnet-type ceramic electrolyte. | Yu Huan Yi Fan Yining Li Baoyi Yin Xun Hu Dehua Dong Tao Wei | 2019 | Journal of Materiomics2019，5，2： | 2 |
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