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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | THE CASE STUDY ON THE EFFECT OF CO_2 IN CAVE ATMOSPHERE ON STABILITY OF SPELEOTHEM SCENERY IN YAOLIN CAVE, ZHEJIANG PROVINCE, CHINA显示文摘Because of the development of tourist activities and the facilities in the show cave, the closed system of show cave has been changed into the complicated open system. The great number of the visitors and the landscape lights give great deal of thermoenergy to the show cave system, especially the high intensive lights make the temperature nearby goes up very fast and reduce the humidity. After the visitors leaving and the lights switching off, the temperature goes down and humidity increases even upto saturation, the condensation taken place. In the dry seasons, the cave humidity is relative low, even down to 40 50 percent. The administrations of show cave rushes the water to clean the touristic trails and keep the high humidity as to protect the cave environment. Under the function of artificial readjustment, the humidity of Yaolin cave atmosphere reaches to 97-100 percent throughtout the year. | Song Linhua Yang Jingrong Lin Junshu Group of Karstology and Speleology, Institute of Geography, CAS, Beijing 100101 People’s Republic of ChinaWang Laihong Administration of Yaolin Cave, Tonglu County, Zhejiang Province, 311500 People’s Republic | 1997 | Journal of Geographical Sciences1997，7，3： | 8 |
| 3 | Inside-out Ostwald ripening: A facile process towards synthesizing anatase TiO2 microspheres for high- efficiency dye-sensitized solar cells显示文摘一灵巧在内外面,到 TiO 2 microspheres 的控制形态学的准备的 Ostwald 成熟线路被开发。这里, TiO 2 空 microspheres (HM ) 和稳固的 microspheres (SM ) 被在 solvothermal 过程以 acetylacetone (Acac ) 调整 isopropanol (国际语音学协会) 的体积比率准备。在 HM,稳固的核心的降水,核心的表面上的外部壳的随后的免职,和同时的核心的形成过程期间,溶解和壳再结晶被观察,它验证在内外面 Ostwald 成熟机制。TiO 2 microspheres 的性质(毛孔尺寸,表面区域,和陷井状态) 的设计和优化对 dyesensitized 太阳能电池(DSSC ) 的高效重要。优化 TiO 2 microspheres (rHM 和 rSM ) 在再结晶上由 processing 以后获得了,拥有大毛孔尺寸,高表面区域和减少的陷井状态(Ti 3+ 和氧空缺) ,并且因此是为光电的设备的理想的材料。用 rHM photoanode 制作的 DSSC 的力量变换效率是 11.22% ,它显著地与基于 rSM 的 DSSC 的 10.54% 效率相比被改进。我们的工作为综合提供策略 TiO 2 microspheres 同时提供不同物理性质以表面区域, crystallinity,形态学,和 mesoporosity。 | Yong Ding Xin Xia Wangchao Chen Linhua Hu Li'e Mo Yang Huang Songyuan Dai | 2016 | Nano Research2016，9，7： | 7 |
| 4 | Raman lasing and Fano lineshapes in a packaged fiber-coupled whispering-gallery-mode microresonator显示文摘We report Raman lasing and the optical analog of electromagnetically-induced-transparency(EIT) in a whispering-gallery-mode(WGM) microtoroid resonator embedded in a low refractive index polymer matrix together with a tapered fiber coupler. The microtoroid resonator supports both single mode and multimode Raman lasing with low power thresholds. Observations of Fano and EIT-like phenomena in a packaged microresonator will enable high resolution sensors and can be used in networks where slow-light effect is needed. These results will open up new possibilities for portable, robust, and stable WGM microlasers and resonator-based sensors for applications in various environments. | Guangming Zhao Sahin Kaya Ozdemir Tao Wang Linhua Xu Eshan King Gui-Lu Long Lan Yang | 2017 | Science Bulletin2017，62，12： | 6 |
| 5 | Interpretation of the Traditional Chinese Medicine portion of the diagnosis and treatment protocol for corona virus disease 2019(Trial Version 7)显示文摘The TCM protocol in the Diagnosis and Treatment Protocol for corona virus disease 2019(COVID-19)(Trial Version 7) has been updated from previous versions. The protocol was formulated under the direct leadership of the National Administration of Traditional Chinese Medicine, based on the experience of a panel of experts, supported by evidence from fever clinics and from the outcomes of emergency(EM) observation rooms and inpatients throughout China(especially in Wuhan, Hubei Province) in combination with the latest scientific research results and data. The present interpretation of the TCM protocol is based on an overall understanding of the revised content, and aims to guide and standardize its clinical application to provide a reference for clinicians. | Song Ping Zhao Linhua Li Xiuyang Su Jiansen Jiang Zhaoyuan Song Bin Liu Wenke Tang Shuang Lei Ye Ding Qiyou Yang Ze Lin Jiaran Wei Yu Tong Xiaolin | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 5 |
| 6 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 7 | State-target strategy:a bridge for the integration of Chinese and Western Medicine显示文摘The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individualized treatment.Tong xiao-lin proposed the state-target strategy to build a bridge for the integration of Chinese and Western medicine.It is a model based on modern medical disease concepts and using the method of TCM to balance the pathological states and adopting the achievements of pharmacology of Chinese medicine to focus on the disease targets,symptom targets,and biochemical indicator targets.The reconstruction of TCM diagnosis and treatment system for diabetes is a good example to demonstrate this theory.It could improve the clinical efficacy,support the scientific research,and reinforce the standardization of TCM. | GOU Xiaowen GAO Zezheng YANG Yingying LI Qingwei TONG Xiaolin CHEN Keyu LEI Ye SONG Bin ZHAO Linhua | 2021 | Journal of Traditional Chinese Medicine2021，41，1： | 3 |
| 8 | Phylogenomic Insights into Deep Phylogeny of Angiosperms Based on Broad Nuclear Gene Sampling显示文摘Angiosperms(flowering plants)are the most diverse and species-rich group of plants.The vast majority(99.95%)of angiosperms form a clade called Mesangiospermae,which is subdivided into five major groups:eudicots,monocots,magnoliids,Chloranthales,and Ceratophyllales.The relationships among these Mesangiospermae groups have been the subject of long debate.In this study,we assembled a phylogenomic dataset of 1594 genes from 151 angiosperm taxa,including representatives of all five lineages,to investigate the phylogeny of major angiosperm lineages under both coalescent-and concatenationbased methods.We dissected the phylogenetic signal and found that more than half of the genes lack phylogenetic information for the backbone of angiosperm phylogeny.We further removed the genes with weak phylogenetic signal and showed that eudicots,Ceratophyllales,and Chloranthales form a clade,with magnoliids and monocots being the next successive sister lineages.Similar frequencies of gene tree conflict are suggestive of incomplete lineage sorting along the backbone of the angiosperm phylogeny.Our analyses suggest that a fully bifurcating species tree may not be the best way to represent the early radiation of angiosperms.Meanwhile,we inferred that the crown-group angiosperms originated approximately between 255.1 and 222.2 million years ago,and Mesangiospermae diversified into the five extant groups in a short time span(27 million years)at the Early to Late Jurassic. | Lingxiao Yang Danyan Su Xin Chang Charles SPFoster Linhua Sun Chien-Hsun Huang Xiaofan Zhou Liping Zeng Hong Ma Bojian Zhong | 2020 | Plant Communications2020，1，2： | 2 |
| 9 | Microstructural development of a C f /ZrC composite manufactured by reactive melt infiltration显示文摘 | Linhua Zou Natalie Wali Jenn-Ming Yang Narottam P. Bansal | 2009 | Journal of the European Ceramic Society2009，，6： | 2 |
| 10 | Reversible adhesion surface coating proppant显示文摘Proppant is a key material in the hydraulic fracturing process,which has been widely used in unconventional oil exploitation.Normal proppants are easy to sedimentate and accumulate at the entrance of shale fracture,which will block the diversion of water,oil and gas.Coated proppants(CPs) are fabricated by coating resin on normal ceramic proppants through a simple method,which is dramatically enhanced the supporting properties in shale fracture and easy to scale up.Compared with uncoated ceramic proppants,the self-suspension ability of CPs is ~11 times higher,which are able to migrate and distribute farther and deeper inside the fracture.At the same time,Coating enhanced the 23.7% of adhesive force in maximum,which makes the CPs easier to adhere on the fracture surface to supportthe shale fracture.Besides,the liquid conductivity of CPs is 60% higher than uncoated ceramic proppants at13.6 MPa pressure.This method is expected to fabricated varieties of proppantsfor shale fracture supporting to improve the exploration of unconventional oil and gas resources. | Quan Xu Fan Fan Zhaohui Lu Mao Sheng Shouceng Tian Ye Zhang Linhua Pan Yang Zhou | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 11 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5huxu6ouxwkk5969of.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 12 | Long noncoding RNA PVT1 promotes tumor growth and predicts poor prognosis in patients with diffuse large B-cell lymphoma显示文摘Dear Editor,Diffuse large B-cell lymphoma(DLBCL)is the most common and aggressive subtype of non-Hodgkin lymphoma(NHL),accounting for about 40%of all NHL cases[1].Lacking symptoms at early time and efficient therapeutic methods made DLBCL one of the most life-threatening types of hematopoietic malignancy[2,3].Therefore,identifying novel therapeutic biomarker for early detection and prognosis prediction is urgently needed. | Ruifeng Yang Tingting Shao Manmei Long Yongheng Shi Qiang Liu Linhua Yang Ming Zhan | 2020 | Cancer Communications2020，40，10： | 1 |
| 13 | Podocyte injury and overexpression of vascular endothelial growth factor and transforming growth factor-beta 1 in adriamycin-induced nephropathy in rats显示文摘 | Weina Yang Junjian Wang Lili Shi Linhua Yu Yihua Qian Yong Liu Weixi Wang Shaoli Cheng | 2012 | Cytokine2012，，2： | 1 |
| 14 | A CODEBOOK COMPENSATIVE VOICE MORPHING ALGORITHM BASED ON MAXIMUM LIKELIHOOD ESTIMATION显示文摘This paper presents an improved voice morphing algorithm based on Gaussian Mixture Model(GMM) which overcomes the traditional one in the terms of overly smoothed problems of the converted spectral and discontinuities between frames.Firstly, a maximum likelihood estimation for the model is introduced for the alleviation of the inversion of high dimension matrixes caused by traditional conversion function.Then, in order to resolve the two problems associated with the baseline, a codebook compensation technique and a time domain medial filter are applied.The results of listening evaluations show that the quality of the speech converted by the proposed method is significantly better than that by the traditional GMM method, and the Mean Opinion Score(MOS) of the converted speech is improved from 2.5 to 3.1 and ABX score from 38% to 75%. | Xu Ning Yang Zhen Zhang Linhua | 2009 | Journal of Electronics(China)2009，26，3： | 1 |
| 15 | Microstructural development of a C f /ZrC composite manufactured by reactive melt infiltration显示文摘 | Linhua Zou Natalie Wali Jenn-Ming Yang Narottam P. Bansal | 2009 | Journal of the European Ceramic Society2009，，6： | 1 |
| 16 | Comparison of the In Vitro and In Vivo Toxic Effects of Three Sizes of Zinc Oxide(ZnO)Particles Using Flounder Gill(FG)Cells and Zebrafish Embryos显示文摘Nano-sized zinc oxide(n ZnO) particles are one kind of the most commonly used metal oxide nanoparticles(NPs). This study compared the cytotoxic and embryotoxic effects of three increasing sized ZnO particles(φ30 nm, 80-150 nm and 2 μm) in the flounder gill(FG) cells and zebrafish embryos, and analyzed the contribution of size, agglomeration and released Zn^(2+) to the toxic effects. All the tested ZnO particles were found to be highly toxic to both FG cells and zebrafish embryos. They induced growth inhibition, LDH release, morphological changes and apoptosis in FG cells in a concentration-, size-and time-dependent manner. Moreover, the release of LDH from the exposed FG cells into the medium occurred before the observable morphological changes happened. The ultrasonication treatment and addition of serum favored the dispersion of ZnO particles and alleviated the agglomeration, thus significantly increased the corresponding cytotoxicity. The released Zn^(2+) ions from ZnO particles into the extracellular medium only partially contributed to the cytotoxicity. All the three sizes of ZnO particles tested induced developmental malformations, decrease of hatching rates and lethality in zebrafish embryos, but size-and concentration-dependent toxic effects were not so obvious as in FG cells possibly due to the easy aggregation of ZnO particles in freshwater. In conclusion, both FG cells and zebrafish embryos are sensitive bioassay systems for safety assessment of ZnO particles and the environmental release of ZnO particles should be closely monitored as far as the safety of aquatic organisms is concerned. | HAN Li ZHAI Yanan LIU Yang HAO Linhua GUO Huarong | 2017 | Journal of Ocean University of China2017，16，1： | 1 |
| 17 | An efficient preparation of porous polymeric microspheres by solvent evaporation in foam phase显示文摘This paper reports an efficient method of preparing porous polymeric microspheres by solvent evaporation in foam phase,in which phase separation between polymer and porogen occurs in foam phase instead of that in water phase by using the traditional solvent eva poration method.The method provides outstanding features,including being time-saving,of high-yield and able for continuous production,in which formation of porous polymeric microspheres finished within 3 min with a high production yield up to approximate 95 wt% and the process was able to be developed into a continuous process for production of porous polymeric microspheres.It was also universal to non-crosslinked polymers since the method is a development on the traditional emulsion solvent evaporation method.The new method is efficient and can be used potentially on the industrial scale for continuous production of porous polymeric microsphere s. | Yang Yu Guiying Li Wanqing Han Linhua Zhu Tian Si HongWang Yanlin Sun Yanping He | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 1 |
| 18 | Hepatic SIRT6 deficit promotes liver tumorigenesis in the mice models显示文摘SIRT6 belongs to class III sirtuin family with NAD+-dependent histone deacetylase activities and controls multiple processes including aging,metabolism and inflammation.In recent years,increasing studies showed tumor suppressor role of SIRT6 in HCC development.We established a two-stage DEN followed CC14 induced liver carcinogenesis in the hepatic-specific SIRT6 HKO mice models and found that hepatic S1RT6 deficit significantly promotes liver injury and liver cancer through inhibition of the ERK1/2 pathway.SIRT6 was compensatory up-regulated in mice tumor tissues and human HCC cells and overexpressed SIRT6 inhibits tumor growth both in vitro and in vivo.Taken together,we provide a useful mouse model for delineating the molecular pathways involved in chronic liver diseases and primary liver cancer and suggest that SIRT6 can be a promising target for HCC therapies. | Mei Wang Linhua Lan Fan Yang Shan Jiang Haojun Xu Chengfei Zhang Guoren Zhou Hongping Xia Jinglin Xia | 2022 | Genes & Diseases2022，9，3： | 1 |
| 19 | Localized Electrons Accelerated Ionic and Charge Transfer for Superior Lithium Storage显示文摘The electrochemical energy storage performance is greatly determined by the charge transfer and ion transportation occurring in the electrode materials.Therefore,the enhancement of electric conductivity and ionic mobility is vital for high-performing and stable metal ion batteries.Here,we report the properties of oxygen vacancies(VO)and carbon co-doped TiO_(2) hollow spheres(HS-TiO_(2))and compared them with fully oxidized white TiO_(2) hollow spheres(W-TiO_(2)).Theoretical calculations and experimental results revealed that the introduction of carbon dopant and VO in anatase TiO_(2) reduced the bandgap and the existence of localized electrons,leading to a lower migration barrier of Li ions that promoted faster ion diffusion kinetics,enabling the HS-TiO_(2) with higher reversibility during the insertion and extraction of Li ions than the W-TiO_(2).This HS-TiO_(2) delivered superior lithium storage properties with a specific discharge capacity of 214.6 mAh g^(-1) for the 100th cycle at 200 mA g^(-1) and 116.3 mAh g^(-1) over 2000 cycles at a high rate of 2 A g^(-1). | Zhaoqian Li Yingke Ren Wangchao Chen Tingting Wei Lie Mo Yang Huang Hong Zhang Guozhong Cao Linhua Hu | 2023 | Renewables2023，1，5： | 0 |
| 20 | Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19显示文摘Traditional Chinese medicine(TCM)has played an important role in the prevention and treatment of Coronavirus disease 2019(COVID-19)epidemic in China.The integration of Chinese and Western medicine is an important feature of Chinese COVID-19 prevention and treatment.According to a series of evidence-based studies,TCM can reduce the infection rate of severe acute respiratory syndrome coronavirus 2 in high-risk groups.For patients with mild and moderate forms of COVID-19,TCM can relieve the related signs and symptoms,shorten the period of nucleic-acid negative conversion,and reduce conversion rate to the severe form of the disease.For COVID-19 patients with severe and critical illnesses,TCM can improve inflammatory indicators and blood oxygen saturation,shorten the hospital stay,and reduce the mortality rate.During recovery,TCM can improve patients’symptoms,promote organ function recovery,boost the quality of patients’life,and reduce the nucleic-acid repositive conversion rate.A series of mechanism research studies revealed that capability of TCM to treat COVID-19 through antiviral and anti-inflammatory effects,immune regulation,and protection of organ function via a multicomponent,multitarget,and multipathway approach. | Linhua Zhao Chuanxi Tian Yingying Yang Huifang Guan Yu Wei Yuxin Zhang Xiaomin Kang Ling Zhou Qingwei Li Jing Ma Li Wan Yujiao Zheng Xiaolin Tong | 2023 | Frontiers of Medicine2023，17，6： | 0 |
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