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| 1 | Activated and deactivated functional brain areas in the Deqi state: A functional MRI study显示文摘We compared the activities of functional regions of the brain in the Deqi versus non-Deqi state, as reported by physicians and subjects during acupuncture. Twelve healthy volunteers received sham and true needling at the Waiguan (TE5) acupoint. Real-time cerebral functional MRI showed that compared with non-sensation after sham needling, true needling activated Brodmann areas 3, 6, 8, 9, 10, 11, 13, 20, 21, 37, 39, 40, 43, and 47, the head of the caudate nucleus, the parahippocampal gyrus, thalamus and red nucleus. True needling also deactivated Brodmann areas 1, 2, 3, 4, 5, 6, 7, 9, 10, 18, 24, 31, 40 and 46. | Yong Huang Tongjun Zeng Guifeng Zhang Ganlong Li Na Lu Xinsheng Lai Yangjia Lu Jiarong Chen | 2012 | Neural Regeneration Research2012，7，30： | 4 |
| 2 | Specific cerebral activation following true and sham Waiguan(SJ 5) needling Functional magnetic resonance imaging evidence显示文摘Positive activation and negative activation of glucose metabolism can be detected in different brain regions under acupuncture conditions using functional magnetic resonance imaging(fMRI) which reveals acupoint function and location-acupoint specificity.This study observed the regional cerebral activation of the Waiguan(SJ 5) acupoint following true needling at the true Waiguan acupoint,sham needling at the true Waiguan acupoint and true needling at a sham point using fMRI.The fMRI results demonstrated that compared with sham needling,true needling at Waiguan activated the BA8 area and left cerebellum.Compared with needling at the sham point,needling at Waiguan activated the BA2 area,the left cerebellum and the right inferior semilunar lobule.Thus the activated brain areas caused by needling Waiguan may be the basis for treatment of certain diseases. | Yong Huang Xinsheng Lai Baoci Shan Chunzhi Tang Junjun Yang Tongjun Zeng Guifeng Zhang Jiarong Chen Yangjia Lu | 2010 | Neural Regeneration Research2010，5，22： | 3 |
| 3 | Needling at the Waiguan (SJ5) in healthy limbs deactivated functional brain areas in ischemic stroke patients A functional magnetic resonance imaging study显示文摘Deactivation is common in cerebral functional imaging. However, the physiological mechanisms responsible for this phenomenon remain poorly understood. The present study analyzed 12 ischemic stroke patients, who were randomly assigned to two groups: one group underwent sham needling and true needling at the Waiguan (SJ 5) in the healthy upper limb and the other group underwent sham and true needling at a sham point. Functional magnetic resonance imaging results showed no activation points in brain tissues following needling at SJ 5. However, compared with sham needling at SJ 5, true needling at SJ 5 deactivated Broadmann 4, 6, 24, and 32 areas. In addition, compared to needling at the sham point, true needling at SJ 5 deactivated bilateral hypothalamus. Results demonstrated that SJ 5 needling in the healthy upper limb resulted in specific directional brain action, as manifested by deactivation of cerebral areas related to motor (Broadmann 4 and 6), emotion (hypothalamus), and cognition (Broadmann 24, 32). | Yong Huang Huiling Xiao Junqi Chen Shanshan Qu Yu Zheng Yangjia Lu Xinsheng Lai | 2011 | Neural Regeneration Research2011，6，36： | 2 |
| 4 | Quantum programming:From theories to implementations显示文摘This paper surveys the new field of programming methodology and techniques for future quantum computers, including design of sequential and concurrent quantum programming languages, their semantics and implementations. Several verification methods for quantum programs and communication protocols are also reviewed. The potential applications of programming techniques and related formal methods in quantum engineering are pointed out. | YING MingSheng FENG Yuan DUAN RunYao LI YangJia YU NengKun | 2012 | Chinese Science Bulletin2012，57，16： | 2 |
| 5 | Cerebral functional imaging of Waiguan (SJ 5) acupoint specificity using single-photon emission computed tomography显示文摘The action of needling in acupoint therapy has to first be regulated and integrated by the brain,and then it affects the target organ and manifests its therapeutic effects,which is dependent on the specificity of the acupoints.The authors put forward the hypothesis of the 'acupoint-related brain'.Single-photon emission computed tomography was used to explore the activation of brain regions following true needling in true acupoint Waiguan (SJ 5),sham needling in true acupoint Waiguan,true needling in a sham point,and sham needling in a sham point.The relative specificity of Waiguan in normal persons was analyzed by observing changes in regional cerebral blood flow.Compared with the sham needling in true acupoint group and sham needling in the sham point group,acupuncture at Waiguan can activate brain regions controlling movement.Compared with true needling in the sham point group,acupuncture at Waiguan can also activate brain regions controlling movement.The results suggest that the specificity of needling at an acupoint is related to certain activated cerebral functional regions,which are associated with the clinical application of the acupoint. | Yong Huang Yangjia Lu Ganlong Li Xinsheng Lai Hong Zhang Chunzhi Tang JunjunYang Gustav Wik | 2011 | Neural Regeneration Research2011，6，6： | 2 |
| 6 | Vanadium emission during roasting of vanadium-bearing stone coal in chlorine 显示文摘 | Zhang Yimin Hu Yangjia Bao Shenxu | 2012 | Minerals Engineering2012，30，： | 1 |
| 7 | Vanadium emission during roasting of vanadium-bearing stone coal in chlorine显示文摘 | Zhang Yimin Hu Yangjia Bao Shenxu | 2012 | Minerals Engineering2012，，30： | 1 |
| 8 | Vanadium emission during roasting of vanadium-bearing stone coal in chlorine显示文摘 | Yimin Zhang Yangjia Hu Shenxu Bao | 2012 | Minerals Engineering2012，，： | 1 |
| 9 | Effectsofsinteringtemperatureonpropertiesof WCGTiCGTaCGCocementedcarbide显示文摘 | YangJia YeJinwen LiuYing etal | 2011 | JournalofFunctional Materials2011，42，： | 1 |
| 10 | Generating Semi-Algebraic Invariants for Non-Autonomous Polynomial Hybrid Systems显示文摘Hybrid systems are dynamical systems with interacting discrete computation and continuous physical processes, which have become more common, more indispensable, and more complicated in our modern life. Particularly, many of them are safety-critical, and therefore are required to meet a critical safety standard. Invariant generation plays a central role in the verification and synthesis of hybrid systems. In the previous work, the fourth author and his coauthors gave a necessary and sufficient condition for a semi-algebraic set being an invariant of a polynomial autonomous dynamical system, which gave a confirmative answer to the open problem. In addition, based on which a complete algorithm for generating all semi-algebraic invariants of a given polynomial autonomous hybrid system with the given shape was proposed. This paper considers how to extend their work to non-autonomous dynamical and hybrid systems. Non-autonomous dynamical and hybrid systems are with inputs, which are very common in practice; in contrast, autonomous ones are without inputs. Furthermore, the authors present a sound and complete algorithm to verify semi-algebraic invariants for non-autonomous polynomial hybrid systems. Based on which, the authors propose a sound and complete algorithm to generate all invariants with a pre-defined template. | WANG Qiuye LI Yangjia XIA Bican ZHAN Naijun | 2017 | Journal of Systems Science & Complexity2017，30，1： | 1 |
| 11 | 显示文摘 | LIJing(李静) WANGXianBao(王贤保) YANGJia(杨佳) | | 高等学校化学学报0，，： | 1 |
| 12 | A neural network model on real-time prediction of roof Pressure in coal mines显示文摘 | Feng Xiating Wang Yangjia Yao Jianguo | 1996 | International Journal of Rock Mechanics and Mining Sciences1996，33，6： | 1 |
| 13 | Integrating of lipophilic platinum(IV) prodrug into liposomes for cancer therapy on patient-derived xenograft model显示文摘Platinum-based anticancer agents such as cisplatin and its analogues are widely used for treating multiple cancers. However, due to the inferior water-solubility, chemoresistance and consequent adverse side effects, their clinical applications are limited. Herein, choles Pt(IV), a lipophilic platinum(IV) prodrug was synthesized for manufacture of Choles Pt(IV)-Liposomes aiming to resolve the predefined obstacles encountered by platinum drugs. Following systematic screening, Choles Pt(IV)-Liposomes showed a small particle size(105.6 nm), the rapid release of platinum(Pt) ions, and notable apoptosis of cancer cells.In addition, according to the fluidity and safety results of animal experiments in mice, Choles Pt(IV)-Liposomes also showed better therapeutic effect, which significantly inhibited the growth of patientderived xenograft tumors of hepatocellular carcinoma with an inhibition ratio of 80.7%, and effectively alleviated the drug toxicity brought by traditional platinum drugs. Overall, this study provides a promising route to enhance the therapeutic efficiency of platinum drugs in cancer treatment. | Zibo Li Qing Xu Xuefeng Lin Kunyi Yu Ling Lin Yangjia Liu Zhiqiang Yu Tiancai Liu Dixian Luo | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 14 | Differences in functional magnetic resonance imaging following cutaneous and routine acupuncture at different acupoints显示文摘Few studies have examined the effects of different stimuli at a single acupoint using functional magnetic resonance imaging.The present study applied acupuncture at the Neiguan(PC 6),Waiguan(SJ 5),Zhigou(SJ 6) and Yanglingquan(GB 34) acupoints in healthy volunteers.fMRI was used to examine the activation of brain areas in response to different types of acupuncture(cutaneous or routine acupuncture) at each acupoint.There were no significant differences in the distribution of activation in the regions of interest between cutaneous and routine acupuncture at the Neiguan,Waiguan,and Zhigou acupoints,but some differences were observed between the two methods of acupuncture at the Yanglingquan acupoint.There were no significant differences in the intensity of induced activation between cutaneous and routine acupuncture at the Neiguan,Zhigou and Yanglingquan acupoints,but the activation intensity in the right cerebellum induced by routine acupuncture at the Waiguan acupoint was greater than that induced by cutaneous acupuncture.Results confirmed that cutaneous and routine acupuncture at the Neiguan,Waiguan,Zhigou and Yanglingquan acupoints activated different functional brain areas,and caused activation of different intensities in some areas. | Yangjia Lu Junxian Wu Yanqi Zou Junqi Chen Baoci Shan Jiarong Chen Yong Huang | 2011 | Neural Regeneration Research2011，6，15： | 1 |
| 15 | Lipid accumulation and nutrient removal properties of a newly-isolated freshwater microalga Scenedesmus sp LX1 growing in secondary effluent 显示文摘 | LIXin(李鑫) HUHongying(胡洪营) YANGJia(杨佳) | 2010 | 新型生物技术2010，27，1： | 1 |
| 16 | Effect of Calcium on the Vanadium Extraction from High Calcium Type Stone Coal显示文摘The high calcium type stone coal from Hubei province was leached by water and dilute acid separately after being roasted with different dosage of Na Cl. The water leaching rate of vanadium(WLRV) was low and only 26.8% of vanadium can be leached by water when 4% Na Cl was added, but the acid leaching rate of vanadium(ALRV) was relatively high. Calcium in the high calcium type stone coal is greatly superfl uous relative to vanadium, hence, the calcium reacts with vanadium to form Ca(VO3)2, Ca2V2O7 and Ca3(VO4)2orderly during the stone coal roasting process and high temperature is beneficial to the reactions between calcium and vanadium, which was validated by simulated reactions between pure calcium carbonate and vanadium pentoxide. These calcium vanadates are all water insoluble but acid soluble and this causes the low WLRV and relatively high ALRV. After calcium removal by HCl, the WLRV is highly enhanced and reaches about 50% when only 2% Na Cl was added. If the HCl content is too high, the stone coal is easily sintered and the formed glass structure can enwrap vanadium, which leads the WLRV to decline. Single water leaching process is not appropriate to extract vanadium from high calcium type stone coal. | 包申旭 LIANG Liang 张一敏 HAN Shihua HU Yangjia | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，2： | 1 |
| 17 | Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer显示文摘The therapeutic efficacy of metformin in prostate cancer(PCa)appears uncertain based on various clinical trials.Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation,which leads to drug resistance.However,the underlying mechanism is still unclear.In this study,we found evidences that metformin resistance in PCa cells may be linked to cell cycle reactivation.Super-enhancers(SEs),crucial regulatory elements,have been shown to be associated with drug resistance in various cancers.Our analysis of SEs in metformin-resistant(MetR)PCa cells revealed a correlation with Prostaglandin Reductase 1(PTGR1)expression,which was identified as significantly increased in a cluster of cells with metformin resistance through single-cell transcriptome sequencing.Our functional experiments showed that PTGR1 overexpression accelerated cell cycle progression by promoting progression from the G0/G1 to the S and G2/M phases,resulting in reduced sensitivity to metformin.Additionally,we identified key transcription factors that significantly increase PTGR1 expression,such as SRF and RUNX3,providing potential new targets to address metformin resistance in PCa.In conclusion,our study sheds new light on the cellular mechanism underlying metformin resistance and the regulation of the SE-TFs-PTGR1 axis,offering potential avenues to enhance metformin’s therapeutic efficacy in PCa. | Jianheng Ye Shanghua Cai Yuanfa Feng Jinchuang Li Zhiduan Cai Yulin Deng Ren Liu Xuejin Zhu Jianming Lu Yangjia Zhuo Yingke Liang Jianjiang Xie Yanqiong Zhang Huichan He Zhaodong Han Zhenyu Jia Weide Zhong | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 18 | Acupoints combination correlates with activation of cerebral areas A functional MRI study显示文摘Acupoint combination is a method used for acupoint treatment of patients.Traditionally,acupoints are matched along the meridian distribution,which is a common rule in clinical practice,but the underlying mechanism remains unclear.Cerebral scans with functional magnetic resonance imaging(fMRI) have been used in the study of acupuncture and acupoint specifically.In this study,fMRI was used to detect the activation of the brain areas under different acupoints,matched along different meridians,to elucidate the acupoint combination via a modern medical approach.Forty healthy volunteers were randomly divided into the following groups:Waiguan point(SJ 5),Waiguan(SJ 5) + Zhigou(SJ 6)(2 acupoints come from the same meridian),Waiguan(SJ 5) + Neiguan(PC 6)(2 acupoints come from 2 meridians with the relationship of interior-exterior),Waiguan(SJ 5) + Yanglingquan(GB 34)(2 acupoints come from 2 meridians with the same name-Shaoyang Meridian),and sham point groups(needling in different points on the right hand).A real-time cerebral fMRI scan was simultaneously performed.The cerebral activation rate,and the number and strength of different regions of interest were compared among the groups.The fMRI cerebral imaging confirmed that there were some differences in the activation of cerebral areas by the needlings in SJ 5,and in combination with other acupoints.Needling at SJ 5 alone greatly activated the right cerebellum,while needling at both SJ 5 and different co-needling points activated different cerebral functional areas. | Xinsheng Lai Yong Huang Chunzhi Tang Junjun Yang Yanqi Zou Junxian Wu Yangjia Lu Renyong Lin | 2011 | Neural Regeneration Research2011，6，9： | 0 |
| 19 | The study on energy demand forecast of Chongqing显示文摘Energy demand forecasting is the base for programming energy system. With the economy development, the increasing amount of energy consumption is in contradiction with the exhausted resource and destroyed environment. For the sake of the sustainable development, the reasonable energy demand forecasting is needed, and it is the scientific reference for establishing energy developing stratagem and energy policy. But the traditional forecasting methods at present have some Jimitations. Artificial neural network(ANN) is a new and developing subject, whose capability of adaptability and self-study is excellent. Based on the analysis as above, the forecasting model with artificial neural network was established. This model is based on the idea of time series. Compared with the traditional algorithm, this model is more friendly and maneuverability, which is not only able to forecast for a short term, but also able to forecast for a long period. Based on the fact of Chongqing, the energy demand of Chongqing is analyzed, and then it is forecasted from 2002 to 2020 with the model, and the forecasting results are reasonable. | YANGJia WUXiangsheng | 2003 | Journal of Chongqing University2003，2，U10： | 0 |
| 20 | Indoor environment quality in the university dormitory显示文摘The indoor environment quality(IEQ) in the dormitory of 9 universities has been investigated by the questionnaire for three times. The results indicate that the indoor air quality (IAQ) of the dormitory is very poor and it is far beyond the acceptable standard of the IAQ. The discontentment rate of the IEQ in the dorm is rather high, and the factors affecting the IEQ concentrates on the air pollution, awful smell, thermal comfort, narrow individual space, etc. Also the spot tests were done in a university in Chongqing, and the results indicate that the 6 indexes, such as indoor temperature, humidity, the density of CO2, SO2 and dust,the total bacterium, etc, are far beyond the correlative standard. | WUXiangsheng YANGJia AOLu ZHENGZhiyong | 2003 | Journal of Chongqing University2003，2，U10： | 0 |
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