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| 1 | E2FBP1 antagonizes the p16^(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability显示文摘Cellular senescence is an irreversible cell cycle arrest triggered by the activation of oncogenes or mitogenic signaling as well as the enforced expression of tumor suppressors such as p53, p16 INK4A and promyelocytic leukemia protein (PML) in normal cells. E2F-binding protein 1 (E2FBP1), a transcription regulator for E2F, induces PML reduction and suppresses the formation of PML-nuclear bodies, whereas the down-regulation of E2FBP1 provokes the PML-dependent premature senescence in human normal fibroblasts. Here we report that the depletion of E2FBP1 induces the accumulation of PML through the Ras-dependent activation of MAP kinase signaling. The cellular levels of p16 INK4A and p53 are elevated during premature senescence induced by depletion of E2FBP1, and the depletion of p16 INK4A , but not p53 rescued senescent cells from growth arrest. Therefore, the premature senescence induced by E2FBP1 depletion is achieved through the p16 INK4A -Rb pathway. Similar to human normal fibroblasts, the growth inhibition induced by E2FBP1 depletion is also observed in human tumor cells with intact p16 INK4A and Rb. These results suggest that E2FBP1 functions as a critical antagonist to the p16 INK4A -Rb tumor suppressor machinery by regulating PML stability. | Yayoi Fukuyo Akiko Takahashi Eiji Hara Nobuo Horikoshi Tej K. Pandita Takuma Nakajima | 2011 | International Journal of Oral Science2011，3，4： | 11 |
| 2 | Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity显示文摘Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and polycarbonate.BPA,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum worldwide.The pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 responses.The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th response.In the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in DCs.In addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 deviation.BPA exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 polarization.These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions. | Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling | 2010 | Cellular & Molecular Immunology2010，7，3： | 6 |
| 3 | Retrocaval liver lifting maneuver and modifications of total hepatic vascular exclusion for liver tumor resection显示文摘AIM: To evaluate the efficacy of technical modifications of total hepatic vascular exclusion(THVE) for hepatectomy involving inferior vena cava(IVC).METHODS: Of 301 patients who underwent hepatectomy during the immediate previous 5-year period, 8(2.7%) required THVE or modified methods of IVC cross-clamping for resection of liver tumors with massive involvement of the IVC. Seven of the patients had diagnosis of colorectal liver metastases and 1 had diagnosis of hepatocellular carcinoma. All tumors involved the IVC, and THVE was unavoidable for combined resection of the IVC in all 8 of the patients. Technical modifications of THVE were applied to minimize the extent and duration of vascular occlusion, thereby reducing the risk of damage.RESULTS: Broad dissection of the space behind the IVC coupled with lifting up of the liver from the retrocaval space was effective for controlling bleeding around the IVC before and during THVE. The procedures facilitate modification of the positioning of the cranial IVC cross-clamp. Switching the cranial IVC cross-clamp from supra- to retrohepatic IVC or to the confluence of hepatic vein decreased duration of the THVE while restoring hepatic blood flow or systemic circulation via the IVC. Oblique cranial IVC cross-clamping avoided ischemia of the remnant hemi-liver. With these technicalmodifications, the mean duration of THVE was 13.4 ± 8.4 min, which was extremely shorter than that previously reported in the literature. Recovery of liver function was smooth and uneventful for all 8 patients. There was no case of mortality, re-operation, or severe complication(i.e., Clavien-Dindo grade of Ⅲ or more).CONCLUSION: The retrocaval liver lifting maneuver and modifications of cranial cross-clamping were useful for minimizing duration of THVE. | Saiho Ko Yuuki Kirihatayfa Yayoi Matsumoto Tadataka Takagi Masanori Matsusaka Tomohide Mukogawa Hirofumi Ishikawa Akihiko Watanabe | 2016 | World Journal of Hepatology2016，8，8： | 5 |
| 4 | Efficacy of preoperative endoscopic nasobiliary drainage for hilar cholangiocarcinoma显示文摘 | Norikazu Arakura Mari Takayama Yayoi Ozaki Masafumi Maruyama Yoshimi Chou Ryou Kodama Yasuhide Ochi Hideaki Hamano Takenari Nakata Shouji Kajikawa Eiji Tanaka Shigeyuki Kawa | 2009 | Journal of Hepato - Biliary - Pancreatic Surgery2009，，4： | 2 |
| 5 | Long-Term Follow-Up of Autoimmune Pancreatitis: Characteristics of Chronic Disease and Recurrence显示文摘 | Shigeyuki Kawa Hideaki Hamano Yayoi Ozaki Tetsuya Ito Ryou Kodama Yoshimi Chou Mari Takayama Norikazu Arakura | 2009 | Clinical Gastroenterology and Hepatology2009，，11： | 2 |
| 6 | Mechanisms and anatomical risk factors of pneumothorax after Bevacizumab use:A case report显示文摘BACKGROUND Bevacizumab is an antiangiogenic agent,and that synergizes with chemotherapeutic drugs.When used in combination therapies,Bevacizumab is associated with adverse events such as hemorrhage,gastrointestinal perforation,delayed wound healing,and pneumothorax.However,the molecular mechanisms underlying these adverse events are not fully understood.CASE SUMMARY A 45-year-old female with multiple lung metastases that were derived from primary breast cancer,was placed on Bevacizumab+paclitaxel therapy,since this combination has a potent antitumor effect.She reported dyspnea before cycle 3,day 1 and we therefore ran a chest X-ray,which detected a right pneumothorax.The coronal plane computed tomography revealed that one solid mass rapidly necrosed and was replaced by a cavity that passed through the bronchus in the right lower lobe.The cavity eventually ruptured the pleura and made the bronchopleural fistula that led to this pneumothorax.Thoracic cavity drainage using an intercostal catheter was performed.On the 7th day of drainage,the patient was discharged from our hospital on recovery.Recurrence of pneumothorax was not reported,and continuation of chemotherapy was made possible by changing the regimen.CONCLUSION Patients with lung metastases surrounding the bronchi and on the pleura should be monitored for pneumothorax by Bevacizumab-containing chemotherapies. | Yuri Ozaki Akiyo Yoshimura Masataka Sawaki Masaya Hattori Naomi Gondo Haruru Kotani Yayoi Adachi Ayumi Kataoka Kayoko Sugino Nanae Horisawa Yuka Endo Kazuki Nozawa Shoko Sakamoto Hiroji Iwata | 2020 | World Journal of Clinical Oncology2020，11，7： | 2 |
| 7 | Liberation of actin from actomyosin in meats heated to 65°C显示文摘 | Akihiro Okitani Naoki Ichinose Jun Itoh Yuika Tsuji Yayoi Oneda Keiko Hatae Koshiro Migita Masanori Matsuishi | 2008 | Meat Science2008，，3： | 2 |
| 8 | Thyroxine for transient hypothyroxinemia and cerebral palsy in extremely pretenn in- fants显示文摘 | Hiroshi Suzumura Akihisa Nitta Yayoi Tsuboi | 2011 | Pediatr Int2011，53，4： | 1 |
| 9 | Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells显示文摘If induced pluripotent stem(iPS)cells are to be used to treat damaged tissues or repair organs in elderly patients,it will be necessary to establish iPS cells from their tissues.To determine the feasibility of using this technology with elderly patients,we asked if it was indeed possible to establish iPS cells from the bone marrow(BM)of aged mice.BM cells from aged C57BL/6 mice carrying the green fluorescence protein(GFP)gene were cultured with granulocyte macrophage-colony stimulating factor(GM-CSF)for 4 days.Four factors(Oct3/4,Sox2,Klf4 and c-Myc)were introduced into the BM-derived myeloid(BM-M)cells.The efficiency of generating iPS cells from aged BM cultured in GM-CSF was low.However,we succeeded in obtaining BM-M-iPS cells from aged C57BL/6 mice,which carried GFP.Our BM-M-iPS cells expressed SSEA-1 and Pou5f1 and were positive for alkaline phosphatase staining.The iPS cells did make teratoma with three germ layers following injection into syngeneic C57BL/6 mice,and can be differentiated to three germ layers in vitro.By co-culturing with OP9,the BM-M-iPS cells can be differentiated to the myeloid lineage.The differentiated BM-M-iPS cells proliferated well in the presence of GM-CSF,and lost expression of Nanog and Pou5f1,at least in part,due to methylation of their promoters.On the contrary,Tnf and Il1b gene expression was upregulated and their promoters were hypomethylated. | Zhao Cheng Sachiko Ito Naomi Nishio Hengyi Xiao Rong Zhang Haruhiko Suzuki Yayoi Okawa Toyoaki Murohara Ken-ichi Isobe | 2011 | Journal of Molecular Cell Biology2011，3，2： | 1 |
| 10 | Increased serum soluble CD147 levels in patients with systemic sclerosis: association with scleroderma renal crisis显示文摘 | Koichi Yanaba Yoshihide Asano Yayoi Tada Makoto Sugaya Takafumi Kadono Yasuhito Hamaguchi Shinichi Sato | 2012 | Clinical Rheumatology2012，，5： | 1 |
| 11 | Crucial Role of Extraccllular Polysaccharides in Desiccation and Freezing Tolerance in the Terrestrial Cyaffobactcrium Nostoc commune显示文摘 | Yoshiyuki Tamaru Yayoi Takani Takayuki Yoshida Toshio sakamoto | 2005 | Applied and Environmental Microbiology2005，71，： | 1 |
| 12 | Early detection of non-palpable (T0) breast cancer: the diagnostic procedure for pathological discharge from the nipple 显示文摘 | Yayoi E Furukawa J Sekimoto M | 1994 | Gan To Kagaku Ryoho1994，21，2： | 1 |
| 13 | Trans- cutaneous immunization using a dissolving microneedle array pro- tects againsttetanus, diphtheria, malaria, and influenza 显示文摘 | Kazuhiko Matsuo Sachiko Hirobe Yayoi Yokota | 2012 | J Control Release2012，160，2012： | 1 |
| 14 | High color fastness printing on leather 显示文摘 | Yoshida Yayoi | 2006 | Hikaku Kagaku2006，52，3： | 1 |
| 15 | Birth of parthenogenetic mice that can develop to adulthood 显示文摘 | Kono Tomohiro Obata Yayoi Wu Qiong | 2004 | Nature2004，428，： | 1 |
| 16 | Manganese, ceri- um and iron in the Sulu,Celebes and Philippine Seas显示文摘 | Hajime Obata Takashi Doi Yayoi Hongo | 2007 | Deep- Sea Research U2007，，54： | 1 |
| 17 | Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis显示文摘 | Hideaki Hamano Norikazu Arakura Takashi Muraki Yayoi Ozaki Kendo Kiyosawa Shigeyuki Kawa | 2006 | Journal of Gastroenterology2006，，12： | 1 |
| 18 | Assessment system for dioxin absorption in the small intestine and prevention of its absorption by food factors 显示文摘 | Yayoi Natsume Hideo Satsu Kazushige Kitamura | 2004 | Bio Factors2004，21，： | 1 |
| 19 | Mechanism for Mouse Strain Differences in the Protective Effect of Sudan III Against the in Vivo Genotoxicity of Dimethybeznz显示文摘 | Shigeki Hatakeyama Yayoi Hayasaki Makihiko Masuda | 1996 | Anthracene Toxicology Letters1996，89，： | 1 |
| 20 | Oral administration of Lactobacillus plantarum strain Lq80 to weaning piglets stimulates the grow of indigenous lactobacilli to modify the lactobacillal population显示文摘 | SHUNSUKE T YAYOI E NOBUYUKI S | 2007 | Journal of General and Applied Microbiology2007，53，： | 1 |
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