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| 1 | Berberine inhibits inflammatory activation of rat brain microglia显示文摘Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors.Berberine,the effective ingredient of Coptidis Rhizoma and Cortex Phellodendri,has a wide range of pharmacological functions,including anti-inflammatory,anti-atherosclerotic and anti-cancer effects.The neuroprotective potential of berberine has previously been demonstrated.The present study aimed to examine whether berberine could repress microglial activation and can be considered a potential therapeutic candidate to target neurodegenerative diseases.Primary microglial cells and BV2 microglial cells were cultured and stimulated with bacterial lipopolysaccharide (LPS).Berberine chloride was treated prior to LPS or simultaneously with LPS stimulation.Results revealed that berberine was effective at inhibiting nitric oxide release from primary microglial cells when cells were exposed to the compound prior to LPS or simultaneously with LPS.It also reduced the LPS-stimulated production of tumor necrosis factor-α,interleukin-1β,prostaglandin E2,and intracellular reactive oxygen species and nuclear factor-kappa activation.Additionally,berberine reduced nitric oxide release from microglia stimulated with interferon-γ and amyloid β.These results suggest that berberine provides neuroprotection by reducing the production of various neurotoxic molecules from activated microglia. | Kyong Nyon Nam Jae-Hong Kim Hoon-Ji Jung Jung-Mi Park Sang-Kwan Moon Young-Suk Kim Sun Yeou Kim Eunjoo H. Lee | 2010 | Neural Regeneration Research2010，5，18： | 3 |
| 2 | A study of oblique cutting for different low cutting speeds显示文摘 | Zone Citing Lin Yeou Yih Lin | 2001 | Journal of Materials Processing Technology2001，115，： | 1 |
| 3 | Features of mechanics of quasi-brittle crackpropagation in concrete显示文摘 | YEOU S J SHAH S P | 1991 | Intemational Journal of Fracture1991，51，1： | 1 |
| 4 | Lignan constituents of Tilia amurensis and their biological evaluation on antitumor and anti-inflammatory activities显示文摘 | KIM KI HYUN MOON EUNJUNG KIM SUN YEOU | 2012 | Food and Chemical Toxicology2012，50，10： | 1 |
| 5 | Risk analysis for hydraulic design 显示文摘 | Yeou - Koung Tung | 1980 | Journal of Hydraulic Division1980，106，3： | 1 |
| 6 | A novel compensation approach for self- sensing maglev system with controlled-PM electromagnets显示文摘 | Yeou K T Tsih C W | 1995 | IEEE Trans on magnets1995，31，6： | 1 |
| 7 | A Novel Compensation Approach for Self - Sensing Maglev System with Controlled - PM Electromagnets 显示文摘 | Yeou - Kuang Tzeng Tsih C Wang | 1995 | IEEE Transaction on Magnetics1995，31，6： | 1 |
| 8 | Fuzzy multiple criteria selection of government-sponsored frontier technology R&D projects显示文摘 | YEOU GENG HSU GWO HSHING TZENG JOSEPH Z SHYU | 2003 | R&D Management2003，33，5： | 1 |
| 9 | Determination of proline–hydroxyproline dipeptide in rat urine by high-performance anion-exchange chromatography coupled with pulsed amperometric detection显示文摘 | Hee-Jung Sim Eunjung Moon Sun Yeou Kim Seon-Pyo Hong | 2013 | Journal of Chromatography B2013，，： | 1 |
| 10 | Dynamic analysis of the Maglev system using controlled - PM electromagnets and robust zero - power - control strategy 显示文摘 | Yeou Kuang Tzeng Wang TC | 1995 | IEEE Transactions on Magnetics1995，31，6： | 1 |
| 11 | Lignan constituents of Tilia amurensis and their biological evaluation n antitumor and anti-inflammatory activities显示文摘 | Ki Hyun Kim Eunjung Moon Sun Yeou Kim | 2012 | Food and Chemical Toxicology2012，，50： | 1 |
| 12 | Neuroprotective effects of the cyanidin-3- O -β- d -glucopyranoside isolated from mulberry fruit against cerebral ischemia显示文摘 | Tong Ho Kang Jin Young Hur Hyun Bok Kim Jong Hoon Ryu Sun Yeou Kim | 2005 | Neuroscience Letters2005，，3： | 1 |
| 13 | 6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation显示文摘 | Gunhyuk Park Hyo Geun Kim Mi Sun Ju Sang Keun Ha Yongkon Park Sun Yeou Kim Myung Sook Oh | 2013 | Acta Pharmacologica Sinica2013，34，9： | 1 |
| 14 | Removal of chromiμm from water and wastewater by ion exchange resins显示文摘 | Rengaraj S K yeou Ho Yeon Seung Hyeon Moon | 2001 | Journal of Hazardous Materials2001，1387，： | 1 |
| 15 | Phytochemicals That Regulate Neurodegenerative Disease by Targeting Neurotrophins: A Comprehensive Review显示文摘 | Ramu Venkatesan Eunhee Ji Sun Yeou Kim Antoni Camins | 2015 | BioMed Research International2015，，： | 1 |
| 16 | Dynamic analysis of the maglev system using controlled-PM electromagnets and robus tzero-power-control strategy 显示文摘 | Yeou K T Wang T C | 1995 | IEEE Trans on Magnetics1995，31，6： | 1 |
| 17 | Regulation of IL 18 pro duetion by IFN gamma and PGE2 in mouse microglial cells:involvement of NFkB pathway in the regulatory processes显示文摘 | Suk K Yeou Kim S Kim H | 2001 | Immunol Lett2001，77，2： | 1 |
| 18 | Antioxidative flavonoids from the leaves ofMorus alba显示文摘 | Sun Yeou Kim Jian Jun Gao Won-Chu Lee Kang Sun Ryu Kang Ro Lee Young Choong Kim | 1999 | Archives of Pharmacal Research1999，，1： | 1 |
| 19 | High dosage sildenafilinduces hearing impairment in mice显示文摘 | Bin Na Hong Tae Hoo Yi Sun Yeou Kim | 2008 | Biol Pharm Bull2008，31，10： | 1 |
| 20 | Neuroprotective effects of the cyanidin-3- O -β- d -glucopyranoside isolated from mulberry fruit against cerebral ischemia显示文摘 | Tong Ho Kang Jin Young Hur Hyun Bok Kim Jong Hoon Ryu Sun Yeou Kim | 2005 | Neuroscience Letters2005，，3： | 1 |
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