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| 1 | Crystal structure of the swine-origin A (H1N1)- 2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus显示文摘Influenza virus is the causative agent of the seasonal and occasional pandemic flu.The current H1N1 influenza pandemic,announced by the WHO in June 2009,is highly contagious and responsible for global economic losses and fatalities.Although the H1N1 gene segments have three origins in terms of host species,the virus has been named swine-origin influenza virus(S-OIV)due to a predominant swine origin.2009 S-OIV has been shown to highly resemble the 1918 pandemic virus in many aspects.Hemagglutinin is responsible for the host range and receptor binding of the virus and is therefore a primary indicator for the potential of infection.Primary sequence analysis of the 2009 S-OIV hemagglutinin(HA)reveals its closest relationship to that of the 1918 pandemic influenza virus,however,analysis at the structural level is necessary to critically assess the functional significance.In this report,we report the crystal structure of soluble hemagglutinin H1(09H1)at 2.9Å,illustrating that the 09H1 is very similar to the 1918 pandemic HA(18H1)in overall structure and the structural modules,including the five defined antiboby(Ab)-binding epitopes.Our results provide an explanation as to why sera from the survivors of the 1918 pandemics can neutralize the 2009 S-OIV,and people born around the 1918 are resistant to the current pandemic,yet younger generations are more susceptible to the 2009 pandemic. | Wei Zhang Jianxun Qi Yi Shi Qing Li Feng Gao Yeping Sun Xishan Lu Qiong Lu Christopher J.Vavricka Di Liu Jinghua Yan George F.Gao | 2010 | Protein & Cell2010，1，5： | 10 |
| 2 | FN-λ: A new spotlight in innate immunity against influenza virus infection显示文摘 | Yeping Sun Jingwen Jiang Po Tien Wenjun Liu Jing Li | 2018 | Protein & Cell2018，9，10： | 5 |
| 3 | EEG processing and its application in brain-computer interface显示文摘Electroencephalogram (EEG) is an efficient tool in exploring human brains. It plays a very important role in diagnosis of disorders related to epilepsy and development of new interaction techniques between machines and human beings,namely,brain-computer interface (BCI). The purpose of this review is to illustrate the recent researches in EEG processing and EEG-based BCI. First,we outline several methods in removing artifacts from EEGs,and classical algorithms for fatigue detection are discussed. Then,two BCI paradigms including motor imagery and steady-state motion visual evoked potentials (SSMVEP) produced by oscillating Newton's rings are introduced. Finally,BCI systems including wheelchair controlling and electronic car navigation are elaborated. As a new technique to control equipments,BCI has promising potential in rehabilitation of disorders in central nervous system,such as stroke and spinal cord injury,treatment of attention deficit hyperactivity disorder (ADHD) in children and development of novel games such as brain-controlled auto racings. | Wang Jing Xu Guanghua Xie Jun Zhang Feng Li Lili Han Chengcheng Li Yeping Sun Jingjing | 2013 | Engineering Sciences2013，11，1： | 3 |
| 4 | The oral microbiome of pregnant women facilitates gestational diabetes discrimination显示文摘The oral microbiota plays an important role in the development of various diseases,whereas its association with gestational diabetes mellitus (GDM) remains largely unclear.The aim of this study is to identify biomarkers from the oral microbiota of GDM patients by analyzing the microbiome of the saliva and dental plaque samples of 111 pregnant women.We find that the microbiota of both types of oral samples in GDM patients exhibits differences and significantly varies from that of patients with periodontitis or dental caries.Using bacterial biomarkers from the oral microbiota,GDM classification models based on support vector machine and random forest algorithms are constructed.The area under curve (AUC) value of the classification model constructed by combination of Lautropia and Neisseria in dental plaque and Streptococcus in saliva reaches 0.83,and the value achieves a maximum value of 0.89 by adding clinical features.These findings suggest that certain bacteria in either saliva or dental plaque can effectively distinguish women with GDM from healthy pregnant women,which provides evidence of oral microbiome as an informative source for developing noninvasive biomarkers of GDM. | Xiaoqing Li Jiayong Zheng Xiuling Ma Bing Zhang Jinyang Zhang Wenhuan Wang Congcong Sun Yeping Wang Jianqiong Zheng Haiying Chen Jiejing Tao Hai Wang Fengyi Zhang Jinfeng Wang Hongping Zhang | 2021 | Journal of Genetics and Genomics2021，48，1： | 2 |
| 5 | Special features of the 2009 pandemic swine-origin influenza AH1N1 hemagglutinin and neuraminidase显示文摘Since the 2009 pandemic H1N1 swine-origin influenza A virus (09 S-OIV) has reminded the world about the global threat of the ever changing influenza virus,many questions regarding the detailed re-assortment of influenza viruses yet remain unanswered.Influenza A virus is the causative agent of the pandemic flu and contains 2 major antigenic glycoproteins on its surface:(i) hemagglutinin (HA);and (ii) neuraminidase (NA).The structures of the 09 S-OIV HA and NA proteins (09H1 and 09N1) have recently been resolved in our laboratory and provide some clues as to why the 09 S-OIV re-assortment virus is highly infectious with severe consequences in humans.For example,the 09H1 is highly similar to the HA of the 1918 influenza A pandemic virus in overall structure and especially in regards to its 5 defined antibody binding epitopes.For 09N1,its most distinctive feature is the lack of a 150-loop active site cavity,which was previously predicted to be present in all N1 NAs,and we hypothesize that the 150-loop may play a important role in the substrate specificity (α2,3 or α2,6 linked sialic acid receptors) and enzymatic mechanism of influenza NA.Combination of the HA and NA with special characteristics for the 09 S-OIV might contribute to its high increased transmissibility in humans. | VAVRICKA Christopher John LIU Yue LI Qing SHI Yi WU Yan SUN YePing QI JianXun GAO George Fu | 2011 | Chinese Science Bulletin2011，56，17： | 2 |
| 6 | Global motion estimation from coarsely sampled motion vector field and the applications显示文摘 | Su Yeping Sun Mingting Hsu V | 2005 | IEEE Transactions on Circuits and Systems for Video Technology2005，15，2： | 1 |
| 7 | Existence of Global Attractor for the One-Dimensional Bipolar Quantum Drift-Diffusion Model显示文摘In this paper, we investigate a one-dimensional bipolar quantum drift-diffusion model from semiconductor devices. We mainly show the long-time behavior of solutions to the one-dimensional bipolar quantum drift-diffusion model in a bounded domain. That is, we prove the existence of the global attractor for the solution. | LIU Yannan SUN Wenlong LI Yeping | 2017 | Wuhan University Journal of Natural Sciences2017，22，4： | 1 |
| 8 | Gold nanoparticle sensitize radiotherapy of prostate cancer cells by regulation of the cellcycle显示文摘 | Wilson Roa Xiaojing Zhang Linghong Guo Andrew Shaw Xiuying Hu Yeping Xiong Sunil Gulavita Samir Patel Xuejun Sun Jie Chen Ronald Moore James Z Xing | 2009 | Nanotechnology2009，，37： | 1 |
| 9 | Effects of rcconiugated bridges on photovoltaic properties of donor-π-acceptor conjugated copolymers显示文摘 | Wang Xiaochen Sun Yeping Chen Song | 2012 | Macro-molecules2012，45，3： | 1 |
| 10 | Global motion estimation from coarsely sampled motion vector field and the applications显示文摘 | Yeping Su Mingting Sun Vincent Hsu | 2005 | IEEE Circuits and Systems for Video Technology2005，15，： | 1 |
| 11 | Diffuse Nodular Lymphoid Hyperplasia of the Colon显示文摘 | Darren C. Schwartz Carolyn E. Cole Yeping Sun Russell F. Jacoby | 2003 | Gastrointestinal Endoscopy2003，，4： | 1 |
| 12 | The creation of synthetic crystalline bovine insulin显示文摘 | Yeping sun | 2015 | Protein & Cell2015，6，11： | 1 |
| 13 | TiO2 nanoparti- cles promote β-amyloid fibrillation in vitro 显示文摘 | Wu Weihui Sun Xun Yu Yeping | 2008 | Biochem- ical and Biophysical Research Communications2008，373，2： | 1 |
| 14 | Targeting multiple epitopes on the spike protein:a new hope for COVID-19 antibody therapy显示文摘Lihong Liu et al.1 from Columbia University recently reported in Nature the isolation of a collection of 19 SARS-CoV-2-neutralizing monoclonal antibodies(mAbs)from five infected patients with high plasma virus-neutralizing titers.These antibodies can neutralize SARS-CoV-2 in vitro,and nine of them exhibited exquisite potency,with 50%virus-inhibitory concentrations of 9 ng/mL or less.The strategy for isolation of these antibodies included sorting SARS-CoV-2 spike protein(S)-specific memory B cells by flow cytometry and single-cell sequencing. | Yeping Sun Bostjan Kobe Jianxun Qi | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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