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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | A restoration-promoting integrated floating bed and its experimental performance in eutrophication remediation显示文摘Numerous studies on eutrophication remediation have mainly focused on purifying water first, then restoring submerged macrophytes. A restoration-promoting integrated floating bed(RPIFB) was designed to combine the processes of water purification and macrophyte restoration simultaneously. Two outdoor experiments were conducted to evaluate the ecological functions of the RPIFB. Trial 1 was conducted to compare the eutrophication purification among floating bed, gradual-submerging bed(GSB) and RPIFB technologies. The results illustrated that RPIFB has the best purification capacity. Removal efficiencies of RPIFB for TN, TP, NH+ 4-N, NO-3-N, CODCr, Chlorophyll-a and turbidity were 74.45%, 98.31%, 74.71%, 88.81%, 71.42%, 90.17% and 85%, respectively. In trial 2, influences of depth of GSB and photic area in RPIFB on biota were investigated. When the depth of GSB decreased and the photic area of RPIFB grew, the height of Potamogeton crispus Linn. increased, but the biomass of Canna indica Linn. was reduced. The mortalities of Misgurnus anguillicaudatus and Bellamya aeruginosa in each group were all less than 7%. All results indicated that when the RPIFB was embedded into the eutrophic water, the regime shift from phytoplankton-dominated to macrophyte-dominated state could be promoted. Thus, the RPIFB is a promising remediation technology for eutrophication and submerged macrophyte restoration. | Yiming Guo Yunguo Liu Guangming Zeng Xinjiang Hu Xin Li Dawei Huang Yunqin Liu Yicheng Yin | 2014 | Journal of Environmental Sciences2014，26，5： | 18 |
| 3 | Schisandra sphenanthera extract(Wuzhi Tablet)protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice显示文摘Alcohol abuse leads to alcoholic liver disease and no effective therapy is currently available.Wuzhi Tablet(WZ), a preparation of extract from Schisandra sphenanthera that is a traditional hepatoprotective herb, exerted a significant protective effect against acetaminophen-induced liver injury in our recent studies, but whether WZ can alleviate alcohol-induced toxicity remains unclear. This study aimed to investigate the contribution of WZ to alcohol-induced liver injury by using chronic-binge and acute models of alcohol feeding. The activities of ALT and AST in serum were assessed as well as the level of GSH and the activity of SOD in the liver. The expression of CYP2E1 and proteins in the NRF2-ARE signaling pathway including NRF2, GCLC, GCLM, HO-1 were measured, and the effect of WZ on NRF2 transcriptional activity was determined. We found that both models resulted in liver steatosis accompanied by increased transaminase activities, but that liver injury was significantly attenuated by WZ. WZ administration also inhibited CYP2E1 expression induced by alcohol, and elevated the level of GSH and the activity of SOD in the liver. Moreover, the NRF2-ARE signaling pathway was activated by WZ andthe target genes were all upregulated. Furthermore, WZ significantly activated NRF2 transcriptional activity. Collectively, our study demonstrates that WZ protected against alcohol-induced liver injury by reducing oxidative stress and improving antioxidant defense, possibly by activating the NRF2-ARE pathway. | Xuezhen Zeng Xi Li Chenshu Xu Fulin Jiang Yufei Mo Xiaomei Fan Yaoting Li Yiming Jiang Dongshun Li Min Huang Huichang Bi | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 13 |
| 4 | In situ preparation of g-C3N4/Bi4O5I2 complex and its elevated photoactivity in Methyl Orange degradation under visible light显示文摘A graphite carbon nitride(g-C3N4)modified Bi4O5I2 composite was successfully prepared insitu via the thermal treatment of a g-C3N4/Bi OI precursor at 400°C for 3 hr.The as-prepared g-C3N4/Bi4O5I2 showed high photocatalytic performance in Methyl Orange(MO)degradation under visible light.The best sample presented a degradation rate of 0.164 min^-1,which is 3.2 and 82 times as high as that of Bi4O5I2 and g-C3N4,respectively.The g-C3N4/Bi4O5I2 was characterized by X-ray powder diffractometer(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),Raman,X-ray photoelectron spectroscopy(XPS),ultraviolet-visible diffuse reflectance spectra(DRS),electrochemical impedance spectroscopy(EIS)and transient photocurrent response in order to explain the enhanced photoactivity.Results indicated that the decoration with a small amount of g-C3N4 influenced the specific surface area only slightly.Nevertheless,the capability for absorbing visible light was improved measurably,which was beneficial to the MO degradation.On top of that,a strong interaction between g-C3N4 and Bi4O5I2 was detected.This interplay promoted the formation of a favorable heterojunction structure and thereby enhanced the charge separation.Thus,the g-C3N4/Bi4O5I2 composite presented greater charge separation efficiency and much better photocatalytic performance than Bi4O5I2.Additionally,g-C3N4/Bi4O5I2 also presented high stability.·O2^- and holes were verified to be the main reactive species. | Zhe Feng Lin Zeng Qingle Zhang Shifeng Ge Xinyue Zhao Hongjun Lin Yiming He | 2020 | Journal of Environmental Sciences2020，32，1： | 12 |
| 5 | Hydrothermal activities and seawater acidification in the Late Devonian F-F transition:Evidence from geochemistry of rare earth elements显示文摘Rare-earth elements(REE) in limestones were measured by ICP-MS from the Yangdi section across the Frasnian-Famennian(F-F) transition in Guilin,Guangxi of South China.The averageΣREE contents of measured samples are 33.32 ppm.The average LREE/HREE ratio is 6.35.Data show LREE-enriched REE distribution pattern in the Yangdi section.Most of samples are characterized by positive Eu anomaly with average of 1.13,and there are two maxima of Eu anomaly just below the F-F boundary.Almost all analytical samples show obvious tetrad effects.Remarkable M-shaped tetrad effects are observed in these samples with positive Eu anomaly.The characters of REE and some relative elements(Fe,Mn,Al,etc.) indicate that hydrothermal activities occurred and resulted in seawater acidification in Upper and Lower Kellwasser horizons of the Late Devonian.The changes of marine environment caused by hydrothermal activities,such as seawater acidification,heavy metal pollution,and eutrophication,would destroy the neritic ecosystem and finally result in the F-F mass extinction. | ZENG JianWei XU Ran GONG YiMing | 2011 | Science China Earth Sciences2011，54，4： | 11 |
| 6 | Effect of organic wastes on the plant-microbe remediation for removal of aged PAHs in soils显示文摘The effectiveness of in-situ bioremediation of polycyclic aromatic hydrocarbons(PAHs) may be inhibited by low nutrients and organic carbon.To evaluate the effect of organic wastes on the PAHs removal efficiency of a plant-microbe remediation system,contaminated agricultural soils were amended with different dosages of sewage sludge(SS) and cattle manure(CM) in the presence of alfalfa(Medicago sativa L.) and PAHs-degraders(Bacillus sp.and Flavobacterium sp.).The results indicated that the alfalfa mean biomasses varied from 0.56 to 2.23 g/pot in root dry weight and from 1.80 to 4.88 g/pot in shoot dry weight.Low dose amendments,with rates of SS at 0.1% and CM at 1%,had prominent effects on plant growth and soil PAHs degradation.After 60-day incubation,compared with about 5.6% in the control,25.8% PAHs removal was observed for treatments in the presence of alfalfa and PAHs-degraders;furthermore,when amended with different dosages of SS and CM,the removed PAHs from soils increased by 35.5%-44.9% and 25.5%-42.3%,respectively.In particular,the degradation of high-molecular-weight PAHs was up to 42.4%.Dehydrogenase activities(DH) ranged between 0.41 and 1.83 μg triphenylformazan/(g dry soil·hr) and the numbers of PAHs-degrading microbes(PDM) ranged from 1.14×10 6 to 16.6×10 6 most-probable-number/g dry soil.Further investigation of the underlying microbial mechanism revealed that both DH and PDM were stimulated by the addition of organic wastes and significantly correlated with the removal ratio of PAHs.In conclusion,the effect of organic waste application on soil PAHs removal to a great extent is dependent on the interactional effect of nutrients and dissolved organic matter in organic waste and soil microorganisms. | Jing Zhang Xiangui Lin Weiwei Liu Yiming Wang Jun Zeng Hong Chen | 2012 | Journal of Environmental Sciences2012，24，8： | 11 |
| 7 | Devonian Frasnian-Famennian transitional event deposits of Guangxi, South China and their possible tsunami origin显示文摘A suite of event deposits, isochronous and interrelated in origin, occurs widely near the Frasnian- Famennian boundary in Guangxi, South China. It is mainly distributed in the facies areas of the platform-margin slope and inter-platform rift-trough. The rudstone or calcirudite occur in the Liujing section of Hengxian and Luoxiu and Baqi sections of Xiangzhou in the facies area of platform-margin slope. The turbidites are observed in the sections of Yangdi and Baisha of Guilin, Du'an of Debao, Nandong and Sanli of Wuxuan, Xiangtian, Ma'anshan of Xiangzhou, Nayi of Chongzuo, Yunpan of Shanglin in the facies area of inter-platform rift-trough. The massive homogenites occur in sections of Mangchang, Luofu and Road from Nandan to Tian'e and Ma'anshan etc in the facies area of inter-platform rift-trough. Herein event deposits can be correlated in stratohorizon to the turbidite in the bottom of the Lower triangularis Zone in Hony railroad cut of Belgium, Devils Gate of Nevada, USA, Atrous of Morocco, South Urals and Fore-Kolyma of northeastern Siberia of Russia, and erosional discontinuities and brecciation in the Frasnian-Famennian boundary in South Polish-Moravian shelf. The event deposits could be caused by a violent tsunami related to bolide impacts into ocean. | DU YuanSheng GONG YiMing ZENG XiongWei HUANG HongWei YANG JiangHai ZHANG Zhe HUANG ZhiQiang | 2008 | Science China Earth Sciences2008，51，11： | 6 |
| 8 | eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses显示文摘It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic data.Here,we describe multi-functional software named evolutionary GenotypePhenotype Systems(eGPS)that enables users to perform comprehensive multiomic and evolutionary analyses.The eGPS combines the power of cloud computing and the advantage of desktop application,has a user-friendly graphic interface and is highly interactive. | Dalang Yu Lili Dong Fangqi Yan Hailong Mu Bixia Tang Xiao Yang Tao Zeng Qing Zhou Feng Gao Zhonghuang Wang Ziqian Hao Hongen Kang Yi Zheng Hongwei Huang Yuzhang Wei Wei Pan Yaochen Xu Junwei Zhu Shilei Zhao Ciran Wang Pengyu Wang Long Dai Mushan Li Li Lan Yiwei Wang Hua Chen Yi-Xue Li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-Nan Chen Guo-Qing Zhang Wenming Zhao Haipeng Li | 2019 | National Science Review2019，6，5： | 4 |
| 9 | The Global Landscape of SARS-CoV-2 Genomes, Variants, and Haplotypes in 2019nCoVR显示文摘On January 22,2020,China National Center for Bioinformation(CNCB)released the 2019 Novel Coronavirus Resource(2019nCoVR),an open-access information resource for the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).2019nCoVR features a comprehensive integration of sequence and clinical information for all publicly available SARS-CoV-2 isolates,which are manually curated with value-added annotations and quality evaluated by an automated in-house pipeline.Of particular note,2019nCoVR offers systematic analyses to generate a dynamic landscape of SARS-CoV-2 genomic variations at a global scale.It provides all identified variants and their detailed statistics for each virus isolate,and congregates the quality score,functional annotation,and population frequency for each variant.Spatiotemporal change for each variant can be visualized and historical viral haplotype network maps for the course of the outbreak are also generated based on all complete and high-quality genomes available.Moreover,2019nCoVR provides a full collection of SARS-CoV-2 relevant literature on the coronavirus disease 2019(COVID-19),including published papers from PubMed as well as preprints from services such as bioRxiv and medRxiv through Europe PMC.Furthermore,by linking with relevant databases in CNCB,2019nCoVR offers data submission services for raw sequence reads and assembled genomes,and data sharing with NCBI.Collectively,SARS-CoV-2 is updated daily to collect the latest information on genome sequences,variants,haplotypes,and literature for a timely reflection,making 2019nCoVR a valuable resource for the global research community.2019nCoVR is accessible at http://gffzzdbc7b6aaae734bddsxb969uqfxnxp66fw.ffgz.tsg.suse.edu.cn/ncov/. | Shuhui Song Lina Ma Dong Zou Dongmei Tian Cuiping Li Junwei Zhu Meili Chen Anke Wang Yingke Ma Mengwei Li Xufei Teng Ying Cui Guangya Duan Mochen Zhang Tong Jin Chengmin Shi Zhenglin Du Yadong Zhang Chuandong Liu Rujiao Li Jingyao Zeng Lili Hao Shuai Jiang Hua Chen Dali Han Jingfa Xiao Zhang Zhang Wenming Zhao Yongbiao Xue Yiming Bao | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 4 |
| 10 | Coupling relationships between brachiopods and Girvanella during the Late Devonian F-F transition in Guilin, South China显示文摘The abundance curves derived from area proportions of brachiopods and Girvanella in the thin sections from the Yangdi section, South China, exhibits complex relationships during the Late Devonian Frasnian-Famennian transition. The living activity of brachiopods such as grazing and borrowing did great damage to the growth of Girvanella. However, there was more to just a mere a survival competing relationship between them, Girvanella actually improved marine environments by oxygenating the dysoxic ambient sea-water through photosynthesis in the lower Kellwasser Horizon. Profited from this improvement brachiopods' abundance increased subsequently and suppressed Girvanella again. Nonetheless, without Girvanella's photosynthesis, brachiopods were wiped out by the farther anoxic environments in the upper Kellwasser Horizon. The complex relationships between Girvanella and brachiopods may be a key to unlocking the relationships between geomicrobes and metazoans in the geological overturn periods. | XU Ran GONG YiMing ZENG JianWei | 2008 | Science China Earth Sciences2008，51，11： | 2 |
| 11 | A new kind of magnetic targeting induction heating drug carrier and its physical and biological properties显示文摘Nano-carbon and iron composite―carbon-coated iron nanoparticles (CCINs) produced by carbon arc method can be used as a new kind of magnetic targeting induction heating drug carrier for cancer therapy. The structure and morphology of CCINs are studied by X-ray diffraction (XRD) and transmission electron microscope (TEM). Mossbauer spectra of these nanoparticles show that they contain only iron and carbon, without ferric carbide and ferric oxide. CCINs can be used as the magnetic drug carrier, with the effect of targeting magnetic induction heating in its inner core and higher drug adsorption in its nano-carbon shell outside because of its high specific surface area. CCINs can absorb Epirubicin (EPI) of 160 μg/mg measured by an optical spectrometer. In acute toxicity experiment with mice, the median lethal dose (LD50) of EPI is 16.9 mg/kg, while that of EPI-CCINs mixture is 20.7 mg/kg and none of the mice died after pure CCINs medication. The results show that pure CCINs belong to non-toxic grade and EPI delivery in mixture with CCINs can reduce its acute toxicity in mice. The magnetic properties of CCINs and their magnetic induction heating are investigated. The iron nanoparticle in its inner core has better magnetism with a good effect on targeting magnetic induction heating. When the CCINs are mixed with physiological salt water and are injected uniformly in pig's liver, the temperature goes up to 48℃. While in the case that CCINs are filled in a certain section of pig's liver, the temperature goes up to 52℃. In both cases the temperature is high enough to kill the cancer cell. CCINs have potential applications in cancer therapy. | ZHANG HaiYan CHEN YiMing ZHENG Yun LAO XiangMing ZENG GuoXun PANG JinShan WU QiGuang LI JinQing | 2009 | Science China(Technological Sciences)2009，52，10： | 2 |
| 12 | An efficient scheme for multi-party quantum state sharing via non-maximally entangled states显示文摘We present a new scheme for investigating the usefulness of non-maximally entangled states for multi-party quantum state shar-ing in a simple and elegant manner.In our scheme,the sender,Alice shares n various probabilistic channels composed of non-maximally entangled states with n agents in a network.Our protocol involves only Bell-basis measurements,single qubit measurements,and a two-qubit unitary transformation operated by free optional agents.Our scheme is a more convenient realiza-tion because no other multipartite joint measurements are needed.Furthermore,in our scheme various probabilistic channels lessen the requirement for quantum channels,which makes it more practical for physical implementation. | JIANG Min HUANG Xu ZHOU LiuLei ZHOU YiMing ZENG Jia | 2012 | Chinese Science Bulletin2012，57，10： | 2 |
| 13 | Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System显示文摘Photosynthetic biohybrid systems exhibit promising performance in biosynthesis;however,these systems can only produce a single metabolite and cannot further transform carbon sources into highly valuable chemical production.Herein,a photosynthetic biohybrid system integrating biological and chemical cascade synthesis was developed for solar-driven conversion of glucose to value-added chemicals.A new ternary cooperative biohybrid system,namely bacterial factory,was constructed by self-assembling of enzyme-modified light-harvesting donor-acceptor conjugated polymer nanoparticles(D-A CPNs)and genetically engineered Escherichia coli(E.coli).The D-A CPNs coating on E.coli could effectively generate electrons under light irradiation,which were transferred into E.coli to promote the 37%increment of threonine production by increasing the ratio of nicotinamide adenine dinucleotide phosphate(NADPH).Subsequently,the metabolized threonine was catalyzed by threonine deaminase covalently linking with D-A CPNs to obtain 2-oxobutyrate,which is an important precursor of drugs and chemicals.The 2-oxobutyrate yield under light irradiation is increased by 58%in comparison to that in dark.This work provides a new organic semiconductor-microorganism photosynthetic biohybrid system for biological and chemical cascade synthesis of highly valuable chemicals by taking advantage of renewable carbon sources and solar energy. | Wen Yu Haotian Bai Yue Zeng Hao Zhao Shengpeng Xia Yiming Huang Fengting Lv Shu Wang | 2022 | Research2022，，3： | 2 |
| 14 | Porous polyphenylene sulfide membrane with high durability against solvents by the thermally induced phase-separation method 显示文摘 | Ding Huaiyu Zeng Yiming | 2006 | J Appl Polym Sci2006，102，3： | 1 |
| 15 | Regional total factor energy efficiency : an empirical analysis of industrial sector in China显示文摘 | Wang Zhaohua Zeng Hualin Wei Yiming | 2012 | Applied Energy2012，97，9： | 1 |
| 16 | Optimal charging plan for electric bus considering time-of-day electricity tariff显示文摘Purpose–The purpose of this study is to develop an optimization method for charging plans with the implementation of time-of-day(TOD)electricity tariff,to reduce electricity bill.Design/methodology/approach–Two optimization models for charging plans respectively with fixed and stochastic trip travel times are developed,to minimize the electricity costs of daily operation of an electric bus.The charging time is taken as the optimization variable.The TOD electricity tariff is considered,and the energy consumption model is developed based on real operation data.An optimal charging plan provides charging times at bus idle times in operation hours during the whole day(charging time is 0 if the bus is not get charged at idle time)which ensure the regular operation of every trip served by this bus.Findings–The electricity costs of the bus route can be reduced by applying the optimal charging plans.Originality/value–This paper produces a viable option for transit agencies to reduce their operation costs. | Yuhan Liu Linhong Wang Ziling Zeng Yiming Bie | 2022 | Journal of Intelligent and Connected Vehicles2022，5，2： | 1 |
| 17 | The thermal properties of controllable diameter carbon nanotubos synthesized by using AB5 alloy of micrometer magnitude es catalyst显示文摘 | YIMING CHEN GUOXUN ZENG | 2007 | Materials Science and Engineering:A2007，464，12： | 1 |
| 18 | Re- gional total factor energy efficiency: An empirical anal- ysis of industrial sector in China显示文摘 | Wang Zhaohua Zeng Hualin Wei Yiming | 2012 | Applied Energy2012，97，9： | 1 |
| 19 | Transbron- choscopic selective bronchial occlusion for intractable pneumothorax 显示文摘 | Yiming ZENG Minli HONG Huaping ZHANG | 2010 | Respirology2010，15，1： | 1 |
| 20 | Hedgehog pathway orchestrates the interplay of histone modifications and tailors combination epigenetic therapies in breast cancer显示文摘Epigenetic therapies that cause genome-wide epigenetic alterations,could trigger local interplay between different histone marks,leading to a switch of transcriptional outcome and therapeutic responses of epigenetic treatment.However,in human cancers with diverse oncogenic activation,how oncogenic pathways cooperate with epigenetic modifiers to regulate the histone mark interplay is poorly understood.We herein discover that the hedgehog(Hh)pathway reprograms the histone methylation landscape in breast cancer,especially in triple-negative breast cancer(TNBC).This facilitates the histone acetylation caused by histone deacetylase(HDAC)inhibitors and gives rise to new therapeutic vulnerability of combination therapies.Specifically,overexpression of zinc finger protein of the cerebellum 1(ZIC1)in breast cancer promotes Hh activation,facilitating the switch of H3K27 methylation(H3K27me)to acetylation(H3K27ac).The mutually exclusive relationship of H3K27me and H3K27ac allows their functional interplay at oncogenic gene locus and switches therapeutic outcomes.Using multiple in vivo breast cancer models including patient-derived TNBC xenograft,we show that Hh signaling-orchestrated H3K27me and H3K27ac interplay tailors combination epigenetic drugs in treating breast cancer.Together,this study reveals the new role of Hh signaling-regulated histone modifications interplay in responding to HDAC inhibitors and suggests new epigenetically-targeted therapeutic solutions for treating TNBC. | Xiaomin Wang Jun Xu Yiming Sun Siyuwei Cao Hanlin Zeng Nan Jin Matthew Shou Shuai Tang Yi Chen Min Huang | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 1 |
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