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| 1 | Thermally conductive polyvinyl alcohol composite films via introducing hetero-structured MXene@silver fillers显示文摘Ag nanoparticles were in-situ grown on the surface of MXene nanosheets to prepare thermally conductive hetero-structured MXene@Ag fillers.With polyvinyl alcohol(PVA)as the polymer matrix,thermally conductive MXene@Ag/PVA composite films were fabricated by the processes of solution blending,pouring,evaporative self-assembly.With the same mass fraction,MXene@Ag-III(MXene/Ag,2:1,w/w)presents more significant improvement in thermal conductivity coefficient(λ)than MXene@Ag,single MXene,Ag,simply blending MXene/Ag.MXene@Ag-III/PVA composite films show dual functions of excellent thermal conductivity and electromagnetic interference(EMI)shielding.When the mass fraction of MXene@Ag-III is 60 wt.%,the in-planeλ(λ_(∥)),through-planeλ(λ_(⊥)),EMI shielding effectiveness(EMI SE)are 3.72 and 0.41 W/(m∙K),32 dB,which are increased by 3.1,1.3,105.7 times than those of pure PVA film(0.91 and 0.18 W/(m∙K),0.3 dB),respectively.The 60 wt.%MXene@Ag-III/PVA composite film also has satisfying mechanical and thermal properties,with Young’s modulus,glass transition temperature,heat resistance index of 3.8 GPa,58.5 and 175.3℃,respectively. | Mukun Li Yuyao Sun Dianying Feng Kunpeng Ruan Xia Liu Junwei Gu | 2023 | Nano Research2023，16，5： | 10 |
| 2 | A modified similitude analysis method for the electro-mechanical performances of a parallel manipulator to solve the control period mismatch problem显示文摘Due to the discrete feature and performance limitation of the numerical controller,the control period sometimes cannot meet the constraints of the scaled model in similitude analysis,which brings the control period mismatch problem.The traditional similitude analysis methods are not able to solve this problem since the controller is treated as continuous system in these methods.This paper proposes a modified similitude analysis method to solve the control period mismatch problem,and the electro-mechanical performances of a 2-DOF parallel manipulator is predicted.Based on the model of dynamic and control system,most of the similitude laws are derived by taking the controller as continuous system.Then the transfer function of the controller in discrete form is established,and the similitude law related to control period is derived to figure out the cause of mismatch problem.The modified method,named long period equivalent,is proposed to solve the mismatch problem by using the least square method and superposition principles.Finally,the scaled model of the parallel manipulator is determined based on the modified similitude analysis method. | WU Jun SONG YuYao LIU ZiLin LI GuoFa | 2022 | Science China(Technological Sciences)2022，65，3： | 3 |
| 3 | Novel Cascaded Z-Source Neutral Point Clamped Inverter显示文摘Z-source Neutral point clamped(NPC) inverter inherits the advantages of Z-source inverter, which can buck-boost energy and allow the shoot-through states.At the same time, Z-source NPC inverter has high running efficiency and less harmonic content. Hence, it can be widely used in motor drives and fuel cell applications.When increasing the modulation index, one can only get smaller shoot through value in Z-source NPC inverter,therefore the output voltage of the inverter can not be boosted very high. In this paper, a novel cascaded Z-source neutral point clamped inverter is proposed by cascading two Z-source networks in series. An Alternative phase opposition disposition(APOD) carrier-based modulator is applied to control the proposed Z-source inverter. To confirm the operating principle of the new Z-source NPC inverter, a generic APOD carrier-based modulator for the cascaded Z-source NPC Inverter under Matlab/Sinmulink is built. The simulation results show that the boost factor has been increased from 1/(1- 2D) for the traditional Z source NPC inverter to 1/(1- 4D) for the proposed cascaded Z-source NPC inverter. A prototype of the cascaded Z-source NPC inverter has been set up. The experimental results verify that the new topology can increase the boost factor and expand the voltage regulation range of the inverter. | HE Yuyao LIU Hailong FENG Wei LI Jie | 2016 | Chinese Journal of Electronics2016，25，5： | 2 |
| 4 | Connecting Chinese Standards to IEC Standards显示文摘During research on different stan- dards for electrical accessories and household electrical appliances it has been suggested that to connect Chinese standards to IEC(International Electrotechnical Commission)standards we should carry out essential innovations based on assimilat- ing according to our own practical conditions.This method is the only way to standardize and at the same time maintain Chinese characteristics. | Fan Hongbo Li Jianxiang Zou Miaozhang Electrical Safety Testing Center of Ningbo Entry-exit Inspectior and Quarantine Bureau(Yuyao Lab) | 2008 | China Standardization2008，53，3： | 2 |
| 5 | ROS is essential for initiation of energy deprivation-induced autophagy显示文摘Autophagy is a highly conserved degradation process in which intracellular components are engulfed into a double membrane structure,known as the autophagosomes,and then delivered to lysosomes/vacuoles for degradation(Ohsumi,2014).Recently,autophagy has been found to be responsible for maintaining glucose homeostasis in adult animals(Karsli-Uzunbas et al.,2014).However,the molecular mechanism underlying energy deprivation-induced autophagy remains relatively unclear. | Choufei Wu Yixing Li Shu Zhong Yingcong Chen Yu Xie Yuyao Feng Weijing Yao Suping Fu Yanlan Zhu Liefeng Wang Yuting Chen Liqin Zhang Jingjing Tong Cong Yi | 2021 | Journal of Genetics and Genomics2021，48，6： | 1 |
| 6 | Synthesis of a Highly Crystalline Amide-Linked Covalent Organic Framework显示文摘The dilemma for the synthesis of covalent organic frameworks(COFs)is crystallinity and stability.Herein,we present the synthesis of a single-crystalline amide-linked COF,and demonstrate its excellent chemical as well as thermal stabilities.This study will inspire the synthesis of a wide spectrum of highly crystalline and stable COFs,promote their structure-property investigations and boost their applications in selective gas adsorption,storage and separation. | Yuyao Li Zhipeng Zhou Yuexian Hong Xin Dong Yonghang Yang Zihao Liang Junliang Sun Xudong Chen Wei Liu Zhikun Zheng | 2023 | Chinese Journal of Chemistry2023，41，4： | 1 |
| 7 | The effect of heat treatment on the strength and toughness of carbon fiber/silicon carbide composites with different pyrolytic carbon interphase thicknesses显示文摘 | Hui Mei Qianglai Bai Yuyao Sun Haiqing Li Hongqin Wang Laifei Cheng | 2013 | Carbon2013，，： | 1 |
| 8 | The research of dual NURBS curves interpolation algorithm for high speed five-axis machining显示文摘 | LI Yuyao WANG Yuhan FENG Jingchun | 2008 | Intelligent Robotics andApplications2008，5315，2： | 1 |
| 9 | Accelerated high-solids anaerobic digestion of sewage sludge using low-temperature thermal pretreatmant显示文摘 | Xiaoeong Liao Huan Li Yuyao Zhang Can Liu Qingwu Chen | 2016 | International Biodeterioration & Biodegradation2016，，106： | 1 |
| 10 | Influencing mechanism of high solid concentration on anaerobic mono-digestion of sewage sludge without agitation显示文摘污水污泥的高固体的厌氧的消化是一个有希望的过程,但是高稳固的集中否定地影响了甲烷生产。影响机制系统地在全部的固体(TS ) 通过一系列静态的厌氧的消化实验在这研究被分析 3%15% 的内容。结果证明 TS 6% 是在 lowsolids 和高固体的厌氧的消化之间的边界,并且当 TS 从 6% ~ 15% 增加了时,积聚的甲烷收益指数地减少了。厌氧的消化的性能被在甲烷产量和污泥之间的集体转移,和关系的效率直接决定散开的系数被一个力量函数很好描述。因此,增加的 TS 导致了污泥粘性的指数的增加但是在散开的系数的指数的减少。堵住的集体转移导致了不稳定的丰满的酸(VFA ) 和免费的氨的累积。醋性的新陈代谢是主要过程,而奶油并且 propionic 新陈代谢发生在高固体的厌氧的消化的起始的阶段。VFA 的集中在起始的阶段到达了最大值,它仍然比影响 methanogens 的阀值低。免费的氨的集中逐渐地增加了,并且当免费的氨氮超过了 50 mg 景 ? 氠晩时, methanogenesis 被禁止吗? | Yuyao ZHANG Huan LI Can LIU Yingchao CHENG | 2015 | Frontiers of Environmental Science & Engineering2015，9，6： | 1 |
| 11 | HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells显示文摘Purinostat Mesylate(PM)is a novel highly selective and active HDAC I/IIb inhibitor,and the injectable formulation of PM(PMF)based on the compound prescription containing cyclodextrin completely can overcome PM’s poor solubility and improves its stability and pharmacokinetic properties.Here,we showed that PM effectively repressed the survival of Ph+leukemia cells and CD34+leukemia cells from CML patients in vitro.In vivo studies demonstrated that PMF significantly prevented BCR-ABL(T315I)induced CML progression by restraining leukemia stem cells(LSCs),which are insensitive to chemotherapy and responsible for CML relapse.Mechanism studies revealed that targeting HDAC I/IIb repressed several important factors for LSCs survival including c-Myc,β-Catenin,E2f,Ezh2,Alox5,and mTOR,as well as interrupted some critical biologic processes.Additionally,PMF increased glutamate metabolism in LSCs by increasing GLS1.The combination of PMF and glutaminase inhibitor BPTES synergistically eradicated LSCs by altering multiple key proteins and signaling pathways which are critical for LSC survival and self-renewal.Overall,our findings represent a new therapeutic strategy for eliminating LSCs by targeting HDAC I/IIb and glutaminolysis,which potentially provides a guidance for PMF clinical trials in the future for TKI resistance CML patients. | Qiang Qiu Linyu yang Yunyu Feng Zejiang Zhu Ning Li Li Zheng Yuanyuan Sun Cong Pan Huandi Qiu Xue Cui Wei He Fang Wang Yuyao Yi Minghai Tang Zhuang Yang Yunfan Yang Zhihui Li Lijuan Chen Yiguo Hu | 2023 | Bioactive Materials2023，，3： | 1 |
| 12 | Continuous-variable quantum key distribution with on-chip light sources显示文摘Integrated quantum key distribution(QKD)systems based on photonic chips have high scalability and stability,and are promising for further construction of global quantum communications networks.On-chip quantum light sources are a critical component of a fully integrated QKD system;especially a continuous-variable QKD(CVQKD)system based on coherent detection,which has extremely high requirements for the light sources.Here,for what we believe is the first time,we designed and fabricated two on-chip tunable lasers for CV-QKD,and demonstrated a high-performance system based on these sources.Because of the high output power,fine tunability,and narrow linewidth,the involved on-chip lasers guarantee the accurate shot-noise-limited detection of quantum signals,center wavelength alignment of nonhomologous lasers,and suppression of untrusted excess noise.The system’s secret key rate can reach 0.75 Mb/s at a 50 km fiber distance,and the secure transmission distance can exceed 100 km.Our results mark a breakthrough toward building a fully integrated CV-QKD,and pave the way for a reliable and efficient terrestrial quantum-secure metropolitan area network. | LANG LI TAO WANG XINHANG LI PENG HUANG YUYAO GUO LIANGJUN LU LINJIE ZHOU GUIHUA ZENG | 2023 | Photonics Research2023，11，4： | 0 |
| 13 | 愿为山海作桥梁显示文摘Li Guangwen,from southeast China’s Fujian Province,is the principal of Karup District No.2 Middle School,located within the Tibet Autonomous Region’s city of Chamdo.When he walks around on campus,students love to say'Hi'to him,and he always replies in his characteristic Hokkien accent.Since he began working in Tibet nine years ago. | Shen Lin Xu Yuyao Li Nan | 2022 | China's Tibet2022，33，5： | 0 |
| 14 | Enhancing tylosin production by combinatorial overexpression of efflux,SAM biosynthesis,and regulatory genes in hyperproducing Streptomyces xinghaiensis strain显示文摘Tylosin is a 16-membered macrolide antibiotic widely used in veterinary medicine to control infections caused by Gram-positive pathogens and mycoplasmas.To improve the fermentation titer of tylosin in the hyperproducing Streptomyces xinghaiensis strain TL01,we sequenced its whole genome and identified the biosynthetic gene cluster therein.Overexpression of the tylosin efflux gene tlrC,the cluster-situated S-adenosyl methionine(SAM)synthetase gene metK_(cs),the SAM biosynthetic genes adoK_(cs)-metFcs,or the pathway-specific activator gene tylR enhanced tylosin production by 18%,12%,11%,and 11%in the respective engineered strains TLPH08-2,TLPH09,TLPH10,and TLPH12.Co-overexpression of metK_(cs)and adoK_(cs)-metFcs as two transcripts increased tylosin production by 22%in the resultant strain TLPH11 compared to that in TL01.Furthermore,combinational overexpression of tlrC,metK_(cs),adoK_(cs)-metFcs,and tylR as four transcripts increased tylosin production by 23%(10.93g/L)in the resultant strain TLPH17 compared to that in TL01.However,a negligible additive effect was displayed upon combinational overexpression in TLPH17 as suggested by the limited increment of fermentation titer compared to that in TLPH08-2.Transcription analyses indicated that the expression of tlrC and three SAM biosynthetic genes in TLPH17 was considerably lower than that of TLPH08-2 and TLPH11.Based on this observation,the five genes were rearranged into one or two operons to coordinate their overexpression,yielding two engineered strains TLPH23 and TLPH24,and leading to further enhancement of tylosin production over TLPH17.In particular,the production of TLPH23 reached 11.35 g/L.These findings indicated that the combinatorial strategy is a promising approach for enhancing tylosin production in high-yielding industrial strains. | Penghui Dai Yuyao Qin Luyuan Li Haidi Li Lihuo Lv Danying Xu Yuqing Song Tingting Huang Shuangjun Lin Zixin Deng Meifeng Tao | 2023 | Synthetic and Systems Biotechnology2023，8，3： | 0 |
| 15 | Trace Elements of Multi-stage Minerals and Titanite U-Pb Dating for the Gneisses from Liansan Island,Sulu UHPM Belt显示文摘Gneisses with anatectic characteristics from the Liansan island in the Sulu UHPM(ultra-high pressure metamorphic)belt were studied for petrography,titanite U-Pb dating and mineral geochemistry.Three origins of garnets are distinguished:metamorphic garnet,peritectic garnet and anatectic garnet,which are formed in the stages of peak metamorphism,retrograde anatexis and melt crystallization,respectively.The euhedral titanite has a high content of REE and high Th/U ratios,which is interpreted as indicating that it was newly-formed from an anatectic melt.The LA-ICP-MS titanite U-Pb dating yields 214-217 Ma ages for the titanite(melt)crystallization.The distribution of trace elements varies in response to the different host minerals at different stages.At the peak metamorphic stage,Y and HREE are mainly hosted by garnet,Ba and Rb by phengite,Sr,Nb,Ta,Pb,Th,U and LREE by allanite and Y,U and HREE by zircon.During partial melting,Y,Pb,Th,U and REE are released into the melt,which causes a dramatic decline of these element contents in the retrograde minerals.Finally,titanite absorbs most of the Nb,U,LREE and HREE from the melt.Therefore,the different stages of metamorphism have different mineral assemblages,which host different trace elements. | SONG Lihao CAO Yuting XIE Tianhe CHEN Yuyao GAO Yuan WANG Songjie LI Xuping | 2023 | Acta Geologica Sinica(English Edition)2023，97，6： | 0 |
| 16 | Translocation of IGF-1R in endoplasmic reticulum enhances SERCA2 activity to trigger Ca_(ER)^(2+)perturbation in hepatocellular carcinoma显示文摘The well-known insulin-like growth factor 1(IGF1)/IGF-1 receptor(IGF-1R)signaling pathway is overexpressed in many tumors,and is thus an attractive target for cancer treatment.However,results have often been disappointing due to crosstalk with other signals.Here,we report that IGF-1R signaling stimulates the growth of hepatocellular carcinoma(HCC)cells through the translocation of IGF-1R into the ER to enhance sarco-endoplasmic reticulum calcium ATPase 2(SERCA2)activity.In response to ligand binding,IGF-1Rβis translocated into the ER byβ-arrestin2(β-arr2).Mass spectrometry analysis identified SERCA2 as a target of ER IGF-1Rβ.SERCA2 activity is heavily dependent on the increase in ER IGF-1Rβlevels.ER IGF-1Rβphosphorylates SERCA2 on Tyr^(990)to enhance its activity.Mutation of SERCA2-Tyr^(990)disrupted the interaction of ER IGF-1Rβwith SERCA2,and therefore ER IGF-1Rβfailed to promote SERCA2 activity.The enhancement of SERCA2 activity triggered Ca_(ER)^(2+)perturbation,leading to an increase in autophagy.Thapsigargin blocked the interaction between SERCA2and ER IGF-1Rβand therefore SERCA2 activity,resulting in inhibition of HCC growth.In conclusion,the translocation of IGF-1R into the ER triggers Ca_(ER)^(2+)perturbation by enhancing SERCA2 activity through phosphorylating Tyr^(990)in HCC. | Yanan Li Keqin Li Ting Pan Qiaobo Xie Yuyao Cheng Xinfeng Wu Rui Xu Xiaohui Liu Li Liu Jiangming Gao Wenmin Yuan Xianjun Qu Shuxiang Cui | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 17 | Fabrication of Graphene/Cu Composite by Chemical Vapor Deposition and Effects of Graphene Layers on Resultant Electrical Conductivity显示文摘Graphene(Gr)has unique properties including high electrical conductivity;Thus,graphene/copper(Gr/Cu)composites have attracted increasing attention to replace traditional Cu for electrical applications. However,the problem of how to control graphene to form desired Gr/Cu composite is not well solved. This paper aims at exploring the best parameters for preparing graphene with different layers on Cu foil by chemical vapor deposition(CVD)method and studying the effects of different layers graphene on Gr/Cu composite’s electrical conductivity. Graphene grown on single-sided and double-sided copper was prepared for Gr/Cu and Gr/Cu/Gr composites. The resultant electrical conductivity of Gr/Cu composites increased with decreasing graphene layers and increasing graphene volume fraction. The Gr/Cu/Gr composite with monolayer graphene owns volume fraction of less than 0.002%,producing the best electrical conductivity up to59.8 ×10^(6)S/m,equivalent to 104.5% IACS and 105.3% pure Cu foil. | Xinyue Liu Yaling Huang Yuyao Li Jie Liu Quanfang Chen | 2024 | Journal of Harbin Institute of Technology(New Series)2024，31，1： | 0 |
| 18 | PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway显示文摘Prolyl hydroxylase 3(PHD3)hydroxylates HIFαin the presence of oxygen,leading to HIFαdegradation.PHD3 inhibits tumorigenesis.However,the underlying mechanism is not well understood.Herein,we demonstrate that PHD3 inhibits the metastasis of colon cancer cells through the occludin-p38 MAPK pathway independent of its hydroxylase activity.We find that PHD3 inhibits colon cancer cell metastasis in the presence of the PHD inhibitor DMOG,and prolyl hydroxylase-deficient PHD3(H196A)suppresses cell metastasis as well.PHD3 controls the stability of the tight junction protein occludin in a hydroxylase-independent manner.We further find that PHD3-inhibited colon cancer cell metastasis is rescued by knockdown of occludin and that occludin acts as a negative regulator of cell metastasis,implying that PHD3 suppresses metastasis through occludin.Furthermore,knockdown of occludin induces phosphorylation of p38 MAPK,and the p38 inhibitor SB203580 impedes cell migration and invasion induced by occludin knockdown,indicating that occludin functions through p38.Moreover,knockdown of occludin enhances the expression of MKK3/6,the upstream kinase of p38,while overexpression of occludin decreases its expression.Our results suggest that PHD3 inhibits the metastasis of colon cancer cells through the occludin-p38 pathway independent of its hydroxylase activity.These findings reveal a previously undiscovered mechanism underlying the regulation of cancer cell metastasis by PHD3 and highlight a noncanonical hydroxylaseindependent function of PHD3 in the suppression of cancer cells. | Yuyao Li Tanglong Yuan Hongwei Zhang Shuting Liu Jie Lun Jing Guo Yu Wang Yuying Zhang Jing Fang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
| 19 | A Biologically Inspired Cross-Type Ankle–Foot Exotendon:Assisting Plantarflexion Moment and Movement Stability显示文摘Cable-driven ankle–foot exoskeletons have attracted numerous researchers over the previous decade.The assistive forces of most exoskeletons pulled the back bottom of the shoes,across talocrural and subtalar joints.The talocrural joint is inherently mediolateral unstable at the plantarflexion position due to its sliding mortise structure,while the subtalar joint allows inversion/eversion.In this paper,a biologically inspired cross-type double-cable-driven ankle–foot exotendon was proposed to assist not only the plantarflexion moment but also the movement stability.The novel structure was bio-inspired by the behind-calf anatomically symmetric layout and under-foot cross-configuration of the ankle–foot muscles.To examine the combined functions,we conducted a forward pelvis perturbed standing experiment on five subjects without and with exotendon assistance and recorded the biomechanical data.Compared to the unpowered condition,the biological ankle plantarflexion moment was reduced by 39 with 0.1 Nm/kg exotendon assistance for one leg.Besides,the forward margin of stability was increased by 17 during the late perturbation period,which indicated the improvement of balance in the sagittal plane.In addition,the standard deviation of the lateral CoP and three-dimensional marker trajectories for the ankle condylar and heel all descended,which provided evidence for ankle–foot stability improvement.The results suggested that the proposed biological exotendon can provide the compound ankle–foot assistance,reducing plantarflexion moment and improving movement stability. | Yuyao Liu Ronglei Sun Ying Li Miao Zhang Kaijie Zou | 2023 | Journal of Bionic Engineering2023，20，6： | 0 |
| 20 | High-contrast and real-time visualization of membrane proteins in live cells with malachite green-based fluorogenic probes显示文摘Imaging dynamics of membrane proteins of live cells in a wash-free and real-time manner has been a challenging task. Herein, we report unprecedented applications of malachite green(MG), an organic dye widely used in pigment industry, as a switchable fluorophore to monitor membrane enzymes or noncatalytic proteins in live cells. Conformationally flexible MG is non-fluorescent in aqueous solution, yet covalent binding with endogenous proteins of cells significantly enhances its fluorescence at 670 nm by restricting flexibility of dye. Integrating a phosphate-caged quinone methide precursor with MG yielded a covalent labeling fluorogenic probe, allowing real-time imaging of membrane alkaline phosphatase(ALP,a model catalytic protein) activity in live cells with over 100-fold enhancement of fluorescence intensity.Moreover, MG is also applicable to image non-catalytic protein by conjugation with protein-specific ligand. A fluorogenic probe consisted of c-RGDf K peptide and MG proved to be compatible with wash-free and real-time visualization of non-catalytic integrin α_(v)β_(3) in live cells with high contrast. | Yefeng Chen Chenghong Xue Jie Wang Minqiu Xu Yuyao Li Yiru Ding Heng Song Weipan Xu Hexin Xie | 2022 | Chinese Chemical Letters2022，33，3： | 0 |
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