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| 1 | Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China显示文摘The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers. | 无 Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong Zhou Yuying Zhou | 2020 | Neuroscience Bulletin2020，36，3： | 7 |
| 2 | Geochemistry and petrology of nephrite from Alamas, Xinjiang, NW China显示文摘 | Yan Liu Jun Deng Guanghai Shi Tzen-Fu Yui Guibin Zhang Maituohuti Abuduwayiti Liqiang Yang Xiang Sun | 2011 | Journal of Asian Earth Sciences2011，，3： | 3 |
| 3 | A New Ductile Fracture Criterion and Its Application to the Prediction of Forming Limit in Deep Drawing显示文摘With considering the influence of equivalent plastic strain on void-damage and taking Lemaitre damage equivalent stress as plastic potential, based on continuous damage mechanics theory, a new criterion for ductile fracture is derived. The two key material constants in the criterion are determined by the combination of tension tests with FE (finite element) simulation. On the basis of the values of stress and strain calculated from commercial finite element software, the forming limit in cylindrical deep drawing of annealed aluminum alloy LY12(M) is predicted by means of the new ductile fracture criterion. Experiments verify that the predicted results are in agreement with the experimental ones. Hence, it is reliable to predict the forming limit in deep drawing by means of the new ductile fracture criterion. | Yuying YANG Zhongqi YU Xuechun LI Zhenzhong SUN | 2003 | Journal of Materials Science & Technology2003，19，z1： | 3 |
| 4 | Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns(With video)显示文摘Background:Burn shock caused by vascular leakage is one of the main causes of high mortality in severe burn injury.However,the pathophysiological mechanism of vascular leakage is still unclear.The purpose of this study was to explore the molecular mechanism of vascular leakage in the early stage of severe burn and provide a new target for the treatment of severe burns.Methods:Neutrophils were isolated from human peripheral blood by magnetic beads sorting.ELISA was used to detect neutrophil-derived granule proteins and glycocalyx injury products in plasma.The vascular leakage and neutrophil movement were assessed by in vivo laser confocal imaging in mice,and high-quality video were provided.Adhesion-related molecules were investigated by qRT-PCR.The damage to glycocalyx of mice vascular endothelial cellswas observed by transmission electron microscope and scanning electron microscope.Proteomic analysis,flow cytometry and immunofluorescence were used to further study the relationship between human peripheral blood neutrophil-derived hypochlorite(HOCl)and CD44 of human vascular endothelial cells.Results:In this study,we found that rapidly increasing activated neutrophils secrete heparin binding protein(HBP)andmyeloperoxidase(MPO)after severe burn injury.Increased HBP triggers vascular leakage with synergy of MPO,results in systemic edema and burn shock.Furthermore,we found that the MPO catalytic product HOCl but not MPO triggers CD44 extracellular domain shedding from vascular endothelial cells to damage the glycocalyx.Damage to the glycocalyx results in firm adhesion of neutrophils and increases vascular leakage.However,MPO inhibitors partially protect the glycocalyx of vascular endothelial cells.The combination of HBP and MPO inhibitors markedly reduces vascular leakage and systemic edema in the early stage of severe burns.Conclusions:Taken together,these data reveal that neutrophil-derived HBP and MPO play an important synergies role in triggering vascular leakage at the early stage of severe burns.Targeted intervention in these two biomolecules may introduce new strategies for helping to reduce large amount of fluid loss and subsequent burn shock. | Lu Liu Yiming Shao Yixuan Zhang Yunxi Yang Jiamin Huang Linbin Li Ran Sun Yuying Zhou Yicheng Su Bingwei Sun | 2021 | Burns & Trauma2021，9，1： | 3 |
| 5 | A Hierarchical Forecasting Model for China's Foreign Trade显示文摘Analyzing the underlying characteristics of trade values movements has attracted much attention in the domestic research.However,the proposed understanding of these characteristics is limited by the intrinsic complexity of the imports/exports.Since economic systems are naturally organized by hierarchies,a novel hierarchical model is proposed in this paper to forecast China's foreign trade.First,the foreign trade data are disaggregated from perspectives of trading partners and trading products,forming two independent hierarchical models with total exports and imports as target variables.Second,a bottom-up strategy is applied.All bottom time series are modelled by corresponding control variables according to trading theories.Forecasts for bottom time series are then combined to generate initial forecasts for total exports and imports.Finally,forecasts for total imports and exports from the two hierarchical models,plus a single VECM model are combined to generate final forecasts.Empirical experiments show that this proposed forecasting model approach significantly outperforms benchmark models and produces consistent forecasts for both total imports and exports or detailed items,which helps a lot for analyzing future trading structure evolution and making foreign trade policies. | SUN Yuying ZHANG Xun WANG Shouyang | 2020 | Journal of Systems Science & Complexity2020，33，3： | 3 |
| 6 | Morphological Development of Fuel Droplets after Impacting Biomimetic Structured Surfaces with Different Temperatures显示文摘To improve the controllability for the evaporation process of fuel spray impinging on the cylinder wall,an experimental study on the development of morphological process of different fuel droplets on aluminium alloy surfaces is carried out.The metal surfaces with different wettability are prepared by laser etching and chemical etching for the experiments.In total,three different fuels are tested and compared under different surface temperatures,including diesel,n-butanol and dimethyl carbonate(DMC).The results show that under a lower wall temperature,the surface wettability,viscosity and surface tension of the fuels have significant effects on spreading and rebounding behaviour of the droplets.As the wall temperature rises over the boiling points of the fuel but below its Leidenfrost temperature,the contact angles between the fuels and surfaces are varying according to the surface wettability,boiling point and Leidenfrost temperature of the fuels.When the temperature of the surface exceeds the Leidenfrost temperature of all the fuels,after impacting the surfaces,different fuel droplets tend to have the same development pattern,regardless of the surface wettability.The rebound level is mainly affected by the amount of fuel vapour generated during the wall-hitting process.Viscosity,surface tension and other properties of the fuel have little effect on post-impacting behaviour of the droplet when the wall temperature is higher than the Leidenfrost temperature of the fuel. | Liang Guo Yuheng Gao Ningning Cai Degang Li Yuying Yan Wanchen Sun | 2020 | Journal of Bionic Engineering2020，17，4： | 2 |
| 7 | The earthquake precursor detected in a granular medium and a proposed model for the propagation of precursive stress-strain signal显示文摘A way to detect the seismic precursor in granular medium is described and a model of propagation for precursive stress-strain signals is proposed.A strain sensor buried in a sandpit is used to measure a seismic precursor signal.The signal has been investigated and confirmed to originate from a specific earthquake.A comparison of simulated and experimental signals indicates that the signal results from the strain in the earth's strata.Based on the behavioral characteristics of granular materials,an analysis of why this method can be so sensitive to the seismic strain signal is undertaken and a model for the propagation of this stress-strain signal is proposed.The Earth's lithosphere is formed of tectonic plates,faults and fault gouges at their boundaries.In the case of the quasi-static mechanics of seismic precursory stress-strain propagation,the crustal lithosphere should be treated as a large-scale granular system.During a seismogenic event,accumulated force generates the stick-slip motion of adjacent tectonic plates and incrementally pushes blocks farther apart through stick-slip shift.The shear force released through this plate displacement causes soil compression deformation.The discrete properties of the sand in the sandpit lead to the sensitive response of the sensor to the deformation signal which enables it to detect the seismic precursor.From the analysis of the mechanism of the stress-strain propagation in the lithosphere,an explanation is found for the lack of signal detection by sensors installed in rocks.The principles and method presented in this paper provide a new technique for investigating seismic precursors to shallow-source earthquakes. | LU KunQuan HOU MeiYing WANG Qiang PENG Zheng SUN Wei SUN XiaoMing WANG YuYing TONG XiaoHui JIANG ZeHui LIU JiXing | 2011 | Chinese Science Bulletin2011，56，11： | 2 |
| 8 | Drug resistance mutation profiles of the drug-nave and first-line regimen-treated HIV-1-infected population of Suzhou, China显示文摘Little is known about the prevalence of drug-resistant mutations in HIV-1-positive individuals in Suzhou, China. To elucidate the transmitted drug resistance(TDR) and acquired drug resistance mutation(ADR) profiles, we collected blood specimens from 127 drug-naive and 117 first-line drugtreated HIV-1-infected individuals sampled from 2014 to 2016 in Suzhou. We successfully amplified po/fragments from 100 drug-naive and 20 drug-treated samples. We then determined the drugresistant mutations to protease(PR) and reverse-transcriptase(RT) inhibitors according to the Stanford drug resistance database. Overall, 11 and 13 individuals had transmitted(drug-naive group) and acquired(treated group) resistance mutations, respectively. Six transmitted drugresistant mutations were found, including two mutations(L33F and L76V) in the protease region and four(K70N/E and V179D/E) in the RT region. Only L76 V was a major mutation, and K70N/E and V179D/E are known to cause low-level resistance to RT inhibitors. All 13 treated participants who had major drug resistance mutations demonstrated intermediate to high resistance to efavirenz and nevirapine, and six had a treatment duration of less than three months. No major mutations to RT inhibitors were found, implying that the epidemic of transmitted resistance mutations was not significant in this area. Our results suggest that more frequent virus load and drug resistance mutation tests should be conducted for individuals receiving antiretroviral treatment, especially for newly treated patients. Our research provides insights into the occurrence of HIV-1 drug resistance in Suzhou and will help to optimize the treatment strategy for this population. | Tingting Li Feng Qian Ting Yuan Weilu Xu Li Zhu Jinlong Huang Haiyan Wang Yueping Zhu Yinling Wang Xiaohong Li Saihong Gu Zhuqing Tan Hui Chen Xiangrong Luo Wei Zhu Weniuan Lu Ping Xu Ming Li Yuying Chen Yong Gao Rongge Yang Chuanwu Zhu Binlian Sun | 2017 | Virologica Sinica2017，32，4： | 2 |
| 9 | Molecular assembly of recombinant chicken type II collagen in the yeast Pichia pastoris显示文摘Effective treatment of rheumatoid arthritis can be mediated by native chicken type II collagen(n CCII), recombinant peptide containing n CCII tolerogenic epitopes(CTEs), or a therapeutic DNA vaccine encoding the full-length CCOL2 A1 c DNA. As recombinant CCII(r CCII) might avoid potential pathogenic virus contamination during n CCII preparation or chromosomal integration and oncogene activation associated with DNA vaccines, here we evaluated the importance of propeptide and telopeptide domains on r CCII triple helix molecular assembly. We constructed p C-and p N-procollagen(without N-or Cpropeptides, respectively) as well as CTEs located in the triple helical domain lacking both propeptides and telopeptides, and expressed these in yeast Pichia pastoris host strain GS115(his4, Mut+) simultaneously with recombinant chicken prolyl-4-hydroxylase α and β subunits. Both p C-and p N-procollagen monomers accumulated inside P. pastoris cells, whereas CTE was assembled into homotrimers with stable conformation and secreted into the supernatants, suggesting that the large molecular weight p C-or p N-procollagens were retained within the endoplasmic reticulum whereas the smaller CTEs proceeded through the secretory pathway. Furthermore, resulting recombinant chicken type II collagen p Cα1(II) can induce collagen-induced arthritis(CIA) rat model, which seems to be as effective as the current standard n CCII. Notably, protease digestion assays showed that r CCII could assemble in the absence of C-and N-propeptides or telopeptides. These findings provide new insights into the minimal structural requirements for r CCII expression and folding. | Caixia Xi Nan Liu Fei Liang Xiao Zhao Juan Long Fang Yuan Song Yun Yuying Sun Yongzhi Xi | 2018 | Science China(Life Sciences)2018，61，7： | 2 |
| 10 | The impact of the atmospheric turbulence-development tendency on new particle formation:a common finding on three continents显示文摘A new mechanism of new particle formation(NPF)is investigated using comprehensive measurements of aerosol physicochemical quantities and meteorological variables made in three continents,including Beijing,China;the Southern Great Plains site in the USA;and SMEARⅡStation in Hyytiala,Finland.D espite the considerably different emissions of chemical species among the sites,a common relationship was found between the characteristics of NPF and the stability intensity.The stability parameter(ζ=Z/L,where Z is the height above ground and L is the Monin-Obukhov length)is found to play an important role;it drops significantly before NPF as the atmosphere becomes more unstable,which may serve as an indicator of nucleation bursts.As the atmosphere becomes unstable,the NPF duration is closely related to the tendency for turbulence development,which influences the evolution of the condensation sink.Presumably,the unstable atmosphere may dilute pre-existing particles,effectively reducing the condensation sink,especially at coarse mode to foster nucleation.This new mechanism is confirmed by model simulations using a molecular dynamic model that mimics the impact of turbulence development on nucleation by inducing and intensifying homogeneous nucleation events. | Hao Wu Zhanqing Li Hanqing Li Kun Luo Yuying Wang Peng Yan Fei Hu Fang Zhang Yele Sun Dongjie Shang Chunsheng Liang Dongmei Zhang Jing Wei Tong Wu Xiaoai Jin Xinxin Fan Maureen Cribb Marc L.Fischer Markku Kulmala Tuukka Petaja | 2021 | National Science Review2021，8，3： | 2 |
| 11 | PERFORMANCE OF ULTRA-LOW FREQUENCY PASSIVE VERTICAL VIBRATION ISOLATION SYSTEM WITH REVERSE PENDULUM显示文摘A novel long period passive vertical vibration isolator constructed by mounting reverse pendu-lums on two pairs of torsion springs is presented.By theoretical analysis and nmnerical calculation,it isshown that the isolator can achieve much longer resonant period due to gravitational positive feedback and issmaller in size than the current torsion spring isolators with the same geometric parameters. | Zhao Pengfei Huang Yuying Tang Mengxi Sun Shijun | 2002 | Acta Mechanica Solida Sinica2002，15，1： | 2 |
| 12 | Do trace metal(loid)s in road soils pose health risks to tourists?A case of a highly-visited national park in China显示文摘Nowadays,more people tend to spend their recreational time in large national parks,and trace metal(loid)s in soils have attracted long-term attention due to their possible harm to human health.To investigate the pollution levels,potential sources and health risks of trace metal(loid)s in road soils,a total of eight trace metal(loid)s(including As,Cd,Cr,Cu,Ni,Pb,Zn and Hg)from 47 soil samples along roads were studied in the Huangshan National Park in Southeast China.The results showed that the concentrations of As,Cd,Pb,Zn and Hg appeared different degrees of pollution compared with their corresponding background values.According to the pollution indices,Hg and Cd were recognized as significant pollutants presenting moderate to high ecological risk.Combining principal component analysis and positive matrix factorization model,the results showed that traffic,industrial,agricultural and natural sources were the potential origins of trace metal(loid)s in this area,with contribution rates of 39.93%,25.92%,10.53%and 23.62%,respectively.Non-carcinogenic risks were all negligible,while the carcinogenic risk of As was higher than the limit(1×10^(-6)).Moreover,children were more susceptible to trace metal(loid)s by ingestion which appeared to be a more important exposure pathway than dermal contact and inhalation.The contribution rates of different sources to non-carcinogenic risks and carcinogenic risks were similar among children and adults,while traffic and industrial sources have a significant impact on health risks.This study will give more insights to control the environmental risks of trace metal(loid)s in national parks. | Jingling Huang Yuying Wu Yanyao Li Jiaxun Sun Yujing Xie Zhengqiu Fan | 2022 | Journal of Environmental Sciences2022，34，1： | 2 |
| 13 | Amino-metalloporphyrin polymers derived Fe single atom catalysts for highly efficient oxygen reduction reaction显示文摘Recently,nitrogen-doped porous carbon supported single atom catalysts(SACs)have become one of the most promising alternatives to precious metal catalysts in oxygen reduction reaction(ORR)due to their outstanding performance,especially those derived from porphyrin-based materials.However,most of them involve other metal residuals,which would cause the tedious pre-and/or post-treatment,even mislead the mechanistic investigations and active-site identification.Herein,we report a precursor-dilution strategy to synthesize Fe SACs through the Schiff-based reaction via co-polycondensation of amino-metalloporphyrin,followed by pyrolysis at high temperature.Systematic characterization results provide the compelling evidence of the dominant presence of atomically dispersed Fe-Nxspecies.Our catalyst shows superior ORR performance with positive half-wave potential(E1/2=0.85 V vs.RHE)in alkaline condition and moderate activity(E1/2=0.68 V vs.RHE)under the acidic condition,excellent methanol tolerance and good long-term stability.All the results indicate Fe SACs would be a promising candidate for replacing the precious Pt in metal-air batteries and fuel cells. | Qian He Yuying Meng Hao Zhang Ying Zhang Qingdi Sun Tao Gan Huajian Xiao Xiaohui He Hongbing Ji | 2020 | Science China Chemistry2020，63，6： | 2 |
| 14 | Effects of NPY Gene on Total Number of Eggs at 300 Days of Age in Donglan Black-bone Chicken显示文摘In this study,PCR-RFLP technique was employed to detect the genetic polymorphism of NPY gene and analyze the effects of various genotypes on the total number of eggs at 300 days of age in 135 Donglan black-bone chicken. According to the results,there were three genotypes( AA,AB and BB) of NPY gene in Donglan black-bone chicken group. Different genotypes exhibited significant effects( P < 0. 05) on the total number of eggs at 300 days of age. The total number of eggs at 300 days of age of AA genotype was significantly higher than that of BB genotype( P < 0. 05). Therefore,the polymorphic site of NPY gene could be used as a candidate molecular marker that affects egg laying in Donglan black-bone chicken. | Yuying LIAO Junli SUN Xinwang WEN Yingfei HUANG Bing ZHANG Fengying WEI | 2015 | Agricultural Biotechnology2015，4，4： | 1 |
| 15 | Targeted hepatitis C screening among ex‐injection drug users in the community显示文摘 | Vincent Wai‐Sun Wong Grace Lai‐Hung Wong Angel Mei‐Ling Chim Tsz‐Fai Cheng Shirley Wing‐Yan Cheung Carol Man‐Sze Lai Kylie Joan‐Yi Szeto Sharon Tsang Stephen Ho‐Chun Wu Kenneth Kar‐Lung Yan Alex Yui Hui Desmond Chi‐Him Yiu Brian Bing‐Ying Wu David Cheung | 2014 | J Gastroenterol Hepatol2014，，1： | 1 |
| 16 | Short- and midterm repeatability of magnetic resonance elastography in healthy volunteers at 3.0T显示文摘 | Yu Shi Qiyong Guo Fei Xia Jiaxing Sun Yuying Gao | 2014 | Magnetic Resonance Imaging2014，，： | 1 |
| 17 | Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China显示文摘 | Zongtang Sun Taoyang Chen Snorri S. Thorgeirsson Qimin Zhan Jianguo Chen Ju-Hyun Park Peixin Lu Chu Chieh Hsia Nengjin Wang Libin Xu Lingling Lu Fei Huang Yuanrong Zhu Jianhua Lu Zhengping Ni Qinan Zhang Yuying Wu Guoting Liu Zhiyuan Wu Chunfeng Qu Mitche | 2013 | Carcinogenesis2013，，8： | 1 |
| 18 | HTR2A agonists play a therapeutic role by restricting ILC2 activation in papain-induced lung inflammation显示文摘Group 2 innate lymphoid cells(ILC2s)are a category of heterogeneous cells that produce the cytokines IL-5 and IL-13,which mediate the type 2 immune response.However,specific drug targets on lung ILC2s have rarely been reported.Previous studies have shown that type 2 cytokines,such as IL-5 and IL-13,are related to depression.Here,we demonstrated the negative correlation between the depression-associated monoamine neurotransmitter serotonin and secretion of the cytokines IL-5 and IL-13 by ILC2s in individuals with depression.Interestingly,serotonin ameliorates papain-induced lung inflammation by suppressing ILC2 activation.Our data showed that the serotonin receptor HTR2A was highly expressed on ILC2s from mouse lungs and human PBMCs.Furthermore,an HTR2A selective agonist(DOI)impaired ILC2 activation and alleviated the type 2 immune response in vivo and in vitro.Mice with ILC2-specific depletion of HTR2A(Il5^(cre/+)·Htr2a^(flox/flox)mice)abolished the DOI-mediated inhibition of ILC2s in a papain-induced mouse model of inflammation.In conclusion,serotonin and DOI could restrict the type 2 lung immune response,indicating a potential treatment strategy for type 2 lung inflammation by targeting HTR2A on ST2+ILC2s. | Zhishuo Wang Chenghua Yan Qizhen Du Yuying Huang Xuezhen Li Dan Zeng Ruizhi Mao Rama Krishna Gurram Shipeng Cheng Wangpeng Gu Lin Zhu Weiguo Fan Liyan Ma Zhiyang Ling Ju Qiu Dangsheng Li Enmei Liu Yaguang Zhang Yiru Fang Jinfang Zhu Bing Sun | 2023 | Cellular & Molecular Immunology2023，20，4： | 1 |
| 19 | Spontaneous movement of a retrotransposon generated genic dominant male sterility providing a useful tool for rice breeding显示文摘Male sterility in plants provides valuable breeding tools in germplasm innovation and hybrid crop production.However,genetic resources for dominant genic male sterility,which hold great promise to facilitate breeding processes,are extremely rare in natural germplasm.Here we characterized the Sanming Dominant Genic Male Sterility in rice and identified the gene SDGMS using a map-based cloning approach.We found that spontaneous movement of a 1978-bp long terminal repeat(LTR)retrotransposon into the promoter region of the SDGMS gene activates its expression in anther tapetum,which causes abnormal programmed cell death of tapetal cells resulting in dominant male sterility.SDGMS encodes a ribosome inactivating protein showing N-glycosidase activity.The activation of SDGMS triggers transcription reprogramming of genes responsive to biotic stress leading to a hypersensitive response which causes sterility.The results demonstrate that an ectopic gene activation by transposon movement can give birth to a novel trait which enriches phenotypic diversity with practical utility. | Conghao Xu Yifeng Xu Zhengji Wang Xiaoyu Zhang Yuying Wu Xinyan Lu Hongwei Sun Lei Wang Qinglu Zhang Qinghua Zhang Xianghua Li Jinghua Xiao Xu Li Mingfu Zhao Yidan Ouyang Xianbo Huang Qifa Zhang | 2023 | National Science Review2023，10，9： | 1 |
| 20 | Experimental study on controlling technique of surface deflection显示文摘 | SUN Zhenzhong YANG Yuying SHI Lei | 2008 | Journal of Materials Processing Technology2008，199，： | 1 |
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