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| 1 | Current pattern of Chinese dialysis units: a cohort study in a representative sample of units显示文摘 | ZHOU Qiu-gen JIANG Jian-ping WU Sheng-jie TIAN Jian-wei CHEN Jiang-hua YU Xue-qing CHEN Ping-yan MEI Chang-lin XIONG Fei SHI Wei ZHOU Wei LIU Xu-sheng SUN Shi-ren XIE Di LIU Jun XU Xin HOU Fan-fan | 2012 | Chinese Medical Journal2012，，19： | 69 |
| 2 | Cold-chain food contamination as the possible origin of COVID-19 resurgence in Beijing显示文摘COVID-19,caused by SARS-CoV-2[1,2],has been contained in China through stringent non-pharmaceutical interventions.Border control and quarantine have effectively prevented the virus from being spread by infected travellers,but the risk of resurgence caused by other routes of introduction and transmission remains unclear,and current strategies to prevent resurgence could be flawed.Since July,SARS-CoV-2 RNA contaminations in frozen food imported from countries with ongoing epidemics have been reported in nine provinces in China[3,4].However,there is no robust evidence of COVID-19 outbreaks initiated by environmentto-human transmission.Here we add to evidence of such transmission by investigating the recent COVID-19 resurgence in Beijing. | Xinghuo Pang Lili Ren Shuangsheng Wu Wentai Ma Jian Yang Lin Di Jie Li Yan Xiao Lu Kang Shichang Du Jing Du Jing Wang Gang Li Shuguang Zhai Lijuan Chen Wenxiong Zhou Shengjie Lai Lei Gao Yang Pan Quanyi Wang Mingkun Li Jianbin Wang Yanyi Huang Jianwei Wang COVID-19 Field Response Group COVID-19 Laboratory Testing Group | 2020 | National Science Review2020，7，12： | 51 |
| 3 | The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间活跃地对感染作为本地保护者参予母亲胎儿的有免疫力的忍耐和行为的建立和维护。然而, dNK 房间怎么在怀孕期间维持在忍耐和反感染免疫者回答之间的有免疫力的平衡,仍然保持未知。这里,我们证明禁止的分子 T 房间免疫球蛋白领域和粘蛋白包含域的 molecule-3 (Tim-3 ) 在超过 60 % 上被表示;dNK 房间。Tim-3 + dNK 房间显示更高的 interleukin (IL )-4 和更低的肿瘤坏死因素(TNF )-α并且 perforin 生产。人的 trophoblast 房间能经由 galectin-9 (Gal-9 ) 和在 Gal-9 和 Tim-3 之间的相互作用的分泌物导致外部 NK 房间的转变进象 dNK 一样显型。另外, trophoblasts 禁止导致的 lipopolysaccharide (LPS ) 由 dNK 房间的支持 inflammatory cytokine 和 perforin 生产,它能被抵销抗体的 Tim-3 稀释。有趣地, Tim-3-expressing dNK 房间的一个减少的百分比在人的流产和鼠科的流产容易的模型被观察。而且, T 助手(Th )2 类型 cytokines 被减少, Th1 类型 cytokines 从人和老鼠流产在 Tim-3 + 然而并非 Tim-3 − dNK 房间被增加。因此,我们的结果建议 Gal-9/Tim-3 信号为 dNK 房间功能的规定是重要的,它为正常怀孕的维护是有益的。 | Yan-Hong Li Wen-Hui Zhou Yu Tao Song-Cun Wang Yun-Lan Jiang Di Zhang Hai-Lan Piao Qiang Fu Da-Jin Li Mei-Rong Du | 2016 | Cellular & Molecular Immunology2016，13，1： | 40 |
| 4 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 5 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 6 | Upreguiation of human telomerase reverse transcriptase mRNA expression by in vitro transfection of hepatitis B virus X gene into human hepatocarcinoma and cholangiocarcinoma cells显示文摘AIM: To study the changes of human telomerase reverse transcriptase (hTERT) mRNA expression in human hepatocarcinoma cell lines (HepG2) and cholangiocarcinoma cell lines (QBC939) after HBx gene transfection and to illustrate the significance of transcriptional regulation of hTERT gene by HBx gene in the carcinogenesis.METHODS: HepG2 and QBC939 cell lines were cultured and co-transfected with eukaryotic expression vector containing the HBx coding region and cloning vector containing enhanced green fluorescent protein (EGFP) coding sequence using lipid-mediated gene transduction technique. Thirty-six hours after transfection, EGFP expression in cells was used as the indicator of successful transfection. Flow cytometry was performed to determine the transfection efficiency.Cells were harvested and total RNA was extracted using TRIzol() reagent. The expression of hTERT mRNA in HepG2and QBC939 cell lines was assayed by reverse transcriptionpolymerase chain reaction. The expression of HBx protein in both cell lines was detected by immunocytochemical staining and Western blotting.RESULTS: Flow cytometry showed that the transfection efficiency was 46.4% in HepG2 cells and 29.6% in QBC939cells for both HBx gene expression vector and blank vector. The expression of hTERT mRNA was meaningfully increased in HepG2 and QBC939 cell lines when transfected with HBx gene expression vector compared to those transfected with OPTI-MEM medium and blank vector.Immunocytochemical staining and Western blotting revealed HBx protein expression in HepG2 and QBC939cells only when transfected with HBx gene.CONCLUSION: HBx gene transfection can upregulate the transcriptional expression of hTERT mRNA. The transactivation of hTERT gene by HBx gene is a newfound mechanism for pathogenesis of hepatocarcinomas and cholangiocarcinomas after HBV infection. | Zhen-Liang Qu Sheng-Quan Zou Nai-Qiang Cui Xian-Zhong Wu Ming-Fang Qin Di Kong Zhen-Li Zhou | 2005 | World Journal of Gastroenterology2005，11，36： | 21 |
| 7 | Seasonal variations and size distributions of water-soluble ions in atmospheric aerosols in Beijing, 2012显示文摘The characteristics of water-soluble ions in airborne particulate matter in Beijing were investigated using ion chromatography. The results showed that the total concentrations of ions were 83.7 ± 48.9 μg/m3 in spring, 54.0 ± 17.0 μg/m3 in summer, 54.1 ± 42.9 μg/m3 in autumn, and 88.8 ± 47.7 μg/m3 in winter, respectively. Furthermore, out of all the ions, NO3-,SO42-and NH4+accounted for 81.2% in spring, 78.5% in summer, 74.6% in autumn, and 76.3%in winter. Mg2+and Ca2+were mainly associated with coarse particles, with a peak that ranged from 5.8 to 9.0 μm. Na+, NH4+and Cl-had a multi-mode distribution with peaks that ranged from 0.43 to 1.1 μm and 4.7 to 9.0 μm. K+, NO3-, and SO42-were mainly associated with fine particles, with a peak that ranged from 0.65 to 2.1 μm. The concentrations of Na+, K+,Mg2+, Ca2+, NH4+, Cl-, NO3-and SO42-were 2.69, 2.32, 1.01, 4.84, 16.9, 11.8, 42.0, and 44.1 μg/m3 in particulate matter(PM) on foggy days, respectively, which were 1.4 to 7.3 times higher than those on clear days. The concentrations of these ions were 2.40, 1.66, 0.92, 4.95, 17.5,7.00, 32.6, and 34.7 μg/m3 in PM on hazy days, respectively, which were 1.2–5.7 times higher than those on clear days. | Yongjie Yang Rui Zhou Jianjun Wu Yue Yu Zhiqiang Ma Lejian Zhang Yi'an Di | 2015 | Journal of Environmental Sciences2015，27，8： | 19 |
| 8 | Comparison of membrane fouling during short-term filtration of aerobic granular sludge and activated sludge显示文摘氧气的小粒的污泥被栽培采用定序批空运反应堆的内部传播。关于短期的膜在氧气的小粒的污泥系统和活性污泥系统之间犯规的对比的实验被调查。膜肮脏蚂蚁被 Fourier 变换也描绘红外线(FTIR ) 光谱学技术。结果证明氧气的小粒的污泥有优秀脱氮能力;TN 的移动效率能到达 90% 。氧气的小粒的污泥能减轻有效地犯规的膜。氧气的小粒的污泥的稳定的膜流动是两次像活性污泥系统的一样。另外,氧气的小粒的污泥能导致严重的膜,这被发现堵住毛孔然而,活性污泥能引起犯规的严重蛋糕。肮脏蚂蚁的主要部件作为蛋白质和多糖材料包括被识别。 | ZHOU Jun YANG Feng-lin MENG Fan-gang AN Peng WANG Di | 2007 | Journal of Environmental Sciences2007，19，11： | 18 |
| 9 | Size-resolved aerosol water-soluble ions at a regional background station of Beijing, Tianjin, and Hebei, North China显示文摘The characteristics of water-soluble ions in size-resolved particulate matter were investigated usingion chromatography at Shangdianzi,a regional background station of Beijing,Tianjin,and Hebei.Seasonal total concentrations of ions(Na^+,Mg^(2+),K^+,Ca^(2+),NH_4^+,Cl^-,SO_4^(2-) and NO_3^-) were75.5±52.9 μg/m^3 in spring,26.5±12.3μg/m^3 in summer,22.7±20.4μg/m^3 in autumn,and31.1±23.9 μg/m^3 in winter,respectively.The secondary ions(NO_3^-,SO_4^(2-) and NH_4^+),mainly associated with fine particles,accounted for 84.2%in spring,82.1%in summer,81.5%in autumn and 76.3%in winter of all ions.Strong correlations were found between NH_4^+ and SO_4^(2-)(r=0.95,p<0.01) as well as NH_4^+ and NO_3^-(r=0.90,p<0.01) in fine particles;while in coarse particles,correlations between Mg^(2+) and NO_3^-(r=0.80,p<0.01),and Ca^(2+) and NO_3^-(r=0.85,p<0.01) were found.The concentrations of Na^+,K^+,Mg^(2+),Ca^(2+),NH_4^+,Cl^-,NO_3^-,and SO_4^(2-) were 2.02,0.81,0.36,1.65,9.58,4.01,18.9,and 18.4 μg/m^3 in particulate matter from southeast-derived air masses,which were typically 1.58-3.37 times higher than in northwest trajectories.Thus,concentrations of water-soluble ions at this background station were heavily influenced by regional transport of serious pollution derived from biomass burning,coal combustion,industrial and vehicle exhaust emissions from Beijing,Tianjin,and Hebei. | Yongjie Yang Rui Zhou Yue Yu Yan Yan Yan Liu Yi'an Di Dan Wu Weiqi Zhang | 2017 | Journal of Environmental Sciences2017，29，5： | 16 |
| 10 | Stretching characteristics and its dynamic significance of the northern continental margin of South China Sea显示文摘To investigate the thinning of the whole crust, and the contribution of the upper versus lower crust to the stretching since Cenozoic, we calculated the stretching factor of the northern margin of South China Sea with data such as whole crustal thickness, depth of Cenozoic sedimentary basement and the horizontal displacement of faults. An isometric line drawing on whole crustal stretching factor is then obtained. Along the seismic Line 1530 in Baiyun sag, we also calculated the stretching factors of the upper and lower crust. The results suggest that the whole crustal thickness decreases seaward while the whole crustal stretching factor increases from shelf to slope. The Moho upwells highest beneath where the crust is thinned most. The value of the whole crustal stretching factor ranges from 1.5 to 6. Two areas were thinned intensely: the center of Yinggehai Basin, and the Baiyun sag in the Pearl River Mouth Basin. The calculation of the upper and lower crustal stretching factors from DSP1530 in Baiyun sag shows that the original crust of Baiyun sag should be thinned before deformation. Its pre-Cenozoic evolution as well as tectonic position during Cenozoic might be responsible for that. | ZHANG YunFan SUN Zhen ZHOU Di GUO XingWei SHI XiaoBin WU XiangJie PANG Xiong | 2008 | Science China Earth Sciences2008，51，3： | 15 |
| 11 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 12 | High precision landing site mapping and rover localization for Chang'e-3 mission显示文摘This paper presents the comprehensive results of landing site topographic mapping and rover localization in Chang’e-3 mission.High-precision topographic products of the landing site with extremely high resolutions(up to 0.05 m)were generated from descent images and registered to CE-2 DOM.Local DEM and DOM with 0.02 m resolution were produced routinely at each waypoint along the rover traverse.The lander location was determined to be(19.51256°W,44.11884°N,-2615.451 m)using a method of DOM matching.In order to reduce error accumulation caused by wheel slippage and IMU drift in dead reckoning,cross-site visual localization and DOM matching localization methods were developed to localize the rover at waypoints;the overall traveled distance from the lander is 114.8 m from cross-site visual localization and 111.2 m from DOM matching localization.The latter is of highest accuracy and has been verified using a LRO NAC image where the rover trajeactory is directly identifiable.During CE-3 mission operations,landing site mapping and rover localization products including DEMs and DOMs,traverse maps,vertical traverse profiles were generated timely to support teleoperation tasks such as obstacle avoidance and rover path planning. | LIU ZhaoQin DI KaiChang PENG Man WAN WenHui LIU Bin LI LiChun YU TianYi WANG BaoFeng ZHOU JianLiang CHEN HongMin | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，1： | 15 |
| 13 | Chromosome-scale genome assembly provides insights into the evolution and flavor synthesis of passion fruit (Passiflora edulis Sims)显示文摘Passion fruit(Passiflora edulis Sims)is an economically valuable fruit that is cultivated in tropical and subtropical regions of the world.Here,we report an~1341.7Mb chromosome-scale genome assembly of passion fruit,with 98.91%(~1327.18Mb)of the assembly assigned to nine pseudochromosomes.The genome includes 23,171 protein-coding genes,and most of the assembled sequences are repetitive sequences,with long-terminal repeats(LTRs)being the most abundant.Phylogenetic analysis revealed that passion fruit diverged after Brassicaceae and before Euphorbiaceae.Ks analysis showed that two whole-genome duplication events occurred in passion fruit at 65 MYA and 12 MYA,which may have contributed to its large genome size.An integrated analysis of genomic,transcriptomic,and metabolomic data showed that‘alpha-linolenic acid metabolism’,‘metabolic pathways’,and‘secondary metabolic pathways’were the main pathways involved in the synthesis of important volatile organic compounds(VOCs)in passion fruit,and this analysis identified some candidate genes,including GDP-fucose Transporter 1-like,Tetratricopeptide repeat protein 33,protein NETWORKED 4B isoform X1,and Golgin Subfamily A member 6-like protein 22.In addition,we identified 13 important gene families in fatty acid pathways and eight important gene families in terpene pathways.Gene family analysis showed that the ACX,ADH,ALDH,and HPL gene families,especially ACX13/14/15/20,ADH13/26/33,ALDH1/4/21,and HPL4/6,were the key genes for ester synthesis,while the TPS gene family,especially PeTPS2/3/4/24,was the key gene family for terpene synthesis.This work provides insights into genome evolution and flavor trait biology and offers valuable resources for the improved cultivation of passion fruit. | Zhiqiang Xia Dongmei Huang Shengkui Zhang Wenquan Wang Funing Ma Bin Wu Yi Xu Bingqiang Xu Di Chen Meiling Zou Huanyu Xu Xincheng Zhou Rulin Zhan Shun Song | 2021 | Horticulture Research2021，8，1： | 15 |
| 14 | Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK显示文摘Accumulation of plasma advanced oxidation protein products(AOPPs) promotes progression of proteinuria and glomerulo-sclerosis.To investigate the molecular basis of AOPPs-induced proteinuria,normal Sprague-Dawley rats were treated with AOPPs-modified rat serum albumin.The expression of glomerular podocyte slit diaphragm(PSD)-associated proteins,nephrin and podocin,was significantly decreased coincident with the onset of albuminuria in rats treated with AOPPs.Chronic inhibi-tion of NADPH oxidase by apocynin prevented down-regulation of nephrin and podocin and decreased albuminuria in AOPPs-challenged rats.This suggested that accumulation of AOPPs promotes proteinuria,possibly via down-regulating the expression of PSD-associated proteins. | YANG Li,LIANG Min,ZHOU QiuGen,XIE Di,LOU AiJu,ZHANG Xun & HOU FanFan Key Laboratory for Organ Failure Research,Division of Nephrology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. | 2010 | Science China(Life Sciences)2010，53，1： | 14 |
| 15 | CD56^brightCD25^+ NK cells are preferentially recruited to the maternal/fetal interface in early human pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间被相信批评因为维持母亲 / 胎儿的忍耐并且调整胎盘的脉管的改变在早怀孕期间在他们的丰富和唯一的显型之上基于。然而, dNK 房间怎么在成功的怀孕起如此的重要作用的机制仍然保持未定义。这里,我们识别了作为有 CD3 − CD56 明亮的 CD25 + 显型。我们发现那 CD56 明亮的 CD25 + NK 房间优先地在早人的怀孕期间本地化到母亲 / 胎儿的接口。CD25 + dNK 房间说明约 75 %表示 CD25 蜕膜的有免疫力的房间(DIC ) 。然而,不到 5 %CD25 积极的外部血 mononuclear 中,房间是 CD25 + NK 房间。而且, CD25 + 和 CD25 − dNK 房间展出不同显型:CD25 + dNK 房间显示更多的激活的显型和更大的秘密 cytokine 能力。有趣地,有主要 trophoblasts upregulates 的外部 NK (pNK ) 房间的 coculture 表示 CD25 pNK 房间的百分比,由 pNK 房间导致激活标记和 cytokine 生产的增加的表示。另外,我们证明 CXCL12/CXCR4 轴为 CD25 + dNK 房间的招募是关键的并且贡献 CD3 − CD56 明亮的 在母亲 / 胎儿的接口的 CD25 + dNK 房间。因此,我们的数据表明在 trophoblasts 之间的串音和 pNK 房间导致 CD3 − CD56 明亮的 CD25 + dNK 房间,它在母亲 / 胎儿的接口施加调整效果。 | Yu Tao Yan-Hong Li Hai-Lan Piao Wen-Jie Zhou Di Zhang Qiang Fu Song-Cun Wang Da-Jin Li Mei-Rong Du | 2015 | Cellular & Molecular Immunology2015，12，1： | 14 |
| 16 | Regulation of activin receptor-interacting protein 2 expression in mouse hepatoma Hepa1-6 cells and its relationship with collagen type Ⅳ显示文摘AIM: To investigate the regulation of activin receptor-interacting protein 2 (ARIP2) expression and its possible relationships with collagen type Ⅳ (collagen Ⅳ) in mouse hepatoma cell line Hepal-6 cells. METHODS: The ARIP2 mRNA expression kinetics in Hepal-6 cells was detected by RT-PCR,and its regulation factors were analyzed by treatment with signal transduction activators such as phorbol 12-myristate 13-acetate (PMA),forskolin and A23187. After pcDNA3-ARIP2 was transfected into Hepal-6 cells,the effects of ARIP2 overexpression on activin type Ⅱ receptor (ActRⅡ) and collagen Ⅳ expression were evaluated. RESULTS: The expression levels of ARIP2 mRNA in Hapel-6 cells were elevated in time-dependent manner 12 h after treatment with activin A and endotoxin LPS,but not changed evidently in the early stage of stimulation (2 or 4 h). The ARIP2 mRNA expression was increased after stimulated with signal transduction activators such as PMA and forskolin in Hepal-6 cells,whereas decreased after treatment with A23187 (25.3% ± 5.7% vs 48.1% ± 3.6%,P < 0.01). ARIP2 overexpression could remarkably suppress the expression of ActRⅡA mRNA in dose-dependent manner,but has no effect on ActRⅡB in Hepal-6 cells induced by activin A. Furthermore,we have found that overexpression of ARIP2 could inhibit collagen Ⅳ mRNA and protein expressions induced by activin A in Hapel-6 cells. CONCLUSION: These findings suggest that ARIP2 expression can be influenced by various factors. ARIP2 may participate in the negative feedback regulation of signal transduction in the late stage by affecting the expression of ActRⅡA and play an important role in regulation of development of liver fibrosis induced by activin. | Hong-Jun Zhang Gui-Xiang Tai Jing Zhou Di Ma Zhong-Hui Liu | 2007 | World Journal of Gastroenterology2007，13，41： | 14 |
| 17 | Numerical modeling of the anomalous post-rift subsidence in the Baiyun Sag,Pearl River Mouth Basin显示文摘The Baiyun Sag is the deepest sag in the Pearl River Mouth Basin in northern continental margin of South China Sea,with the maximum sediment thickness over 12.5 km above the basement including >6.5 km sediments above the 30 Ma breakup unconformity.According to the theoretical models for the rifted basins,the post-rift subsidence is driven solely by the thermal contraction and can be calculated as the function of the lithospheric stretching factor.A method combining the forward modeling and reverse backstripping was designed to estimate lithospheric stretching factor.Using the 2D forward modeling based on the flexural cantilever model,we simulated the multi-rifting process of the Baiyun Sag with constrain of the backstripped profiles.By doing this the lithospheric stretching factor was obtained,and then the theoretical post-rift subsidence was calculated.The calculated theoretical subsidence was much smaller than the observed subsidence given by backstripping.Along the 1530 line in the Baiyun Sag,the anomalous post-rift subsidence is over 2 km in the sag center,and varies slightly to the north and south edges of the sag.This suggests that the anomalous post-rift subsidence continues beyond the sag both in the continental shelf to the north and in the continental slope to the south.The sensitivity tests in the forward modeling process indicate that only the use of low-angle faults (≤13°) can we simulate the shape of the backstripped profile. | LIAO Jie ZHOU Di ZHAO ZhongXian ZHANG YunFan XU ZiYing | 2011 | Science China Earth Sciences2011，54，8： | 14 |
| 18 | Trajectory control strategy of cathodes in blisk electrochemical machining显示文摘A turbine blisk, which combines blades and a disk together, is one of the most important components of an aero engine. In the process of blisk electrochemical machining (ECM), the sheet cathode, which is usually used as a tool electrode, has a complicated structure. In addition to that, the channel between the adjacent blades is narrow and twisted, so interference is apt to happen when the sheet cathode feeds into the channel. Therefore, it is important to choose suitable trajectory control strategy. In this paper, a new trajectory control strategy of the sheet cathode is presented and corresponding simulation analysis is conducted on the basis of an actual blisk model. The simulation results demonstrate that the sheet cathode can feed into the channel by a spatial line trajectory without interference. Moreover, the verification experiments are carried out according to the simulation. The experimental results show that the cathode can move into the channel without interference. It is verified that the new trajectory control strategy is correct and can be used in the blisk ECM process successfully. | Zhu Dong Zhu Di Xu Zhengyang Zhou Laishui | 2013 | Chinese Journal of Aeronautics2013，26，4： | 14 |
| 19 | Dynamics Analysis of the Baiyun Sag in the Pearl River Mouth Basin,North of the South China Sea显示文摘摘要:Baiyun 下垂是在珍珠河嘴盆的斜坡上发展的深的。它水平地作为合成 graben 发生,并且由二亚 sags 对亚 sags 构成低高举。垂直地,沉积建筑学能被划分成三层,即底部,在中间的差错可锻的拉长层和顶上的 draping 层上的指责的层。sag 的主要 rifting 阶段应当被可锻的扩展描绘并且外壳变瘦。特殊变丑模式可能被归因于事实 Baiyun 下垂位于弱地区,使 sag 成为了一个强烈使变形的区域,由极大地变瘦的岩石圈和活跃 magmatism 描绘了的先存在的转移地区。在 Baiyun 下面的高度升起的披风下垂应该是为可锻的变丑负责的重要机制,它引起了上面的披风的部分融化。Upwelling 到上面的外壳和沉积的层,部分融化材料提供了 extensional 紧张并且引起了非指责的垂直沉淀。岩浆在 rifting 的第一个阶段以后在转移地区下面被收集,并且沿着趋势 NW 基础差错在对对 sag 和 upwelled 的 ENE 和 WSW 部分的扩展垂直的一个方向旁边地转了,在的地方趋势 WNW 砍差错在群发展了。指责的活动和 Baiyun 的沉积历史下垂可能被海洋山脉影响了在 24 妈和海地板在 16 妈附近传播的停止附近跳。 | SUN Zhen ZHONG Zhihong ZHOU Di PANG Xiong HUANG Chunju CHEN Changmin HE Min XU Hehua | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 13 |
| 20 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
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