|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microbial treatment in chronic constipation显示文摘Chronic functional constipation is a kind of common intestinal disease that occurs in children, adults and elderly people. This disease not only causes great influence to physiological function, but also results in varying degrees of psychological barriers. At present, constipation treatments continue to rely on traditional methods such as purgative therapy and surgery. However, these approaches can disrupt intestinal function. Recent research between intestinal diseases and gut microbiota has gradually revealed a connection between constipation and intestinal flora disturbance, providing a theoretical basis for microbial treatment in chronic constipation. Microbial treatment mainly includes probiotic preparations such as probiotics, prebiotics, synbiotics and fecal microbiota transplantation(FMT). Due to its safety, convenience and curative effect, probiotic preparations have been widely accepted, especially gradually developed FMT with higher curative effects. Microbial treatment improves clinical symptoms, promotes the recovery of intestinal flora, and has no complications during the treatment process. Compared with traditional treatments, microbial treatment in chronic constipation has advantages, and is worthy of further promotion from clinical research to clinical application. | Linsheng Huang Qi Zhu Xiao Qu Huanlong Qin | 2018 | Science China(Life Sciences)2018，61，7： | 40 |
| 2 | Dysbiosis of gut microbiota was closely associated with psoriasis显示文摘Psoriasis is an autoimmune disease and gut microbiota participate in the establishment of intestinal immunity. This study was performed to identify the fecal microbial composition of psoriasis patients, and investigated the influence of subgroup(type and severity) on the fecal microbial composition, and to define the key microbiota in the pathogenesis of psoriasis. Fecal samples from 35 psoriasis patients and 27 healthy controls were sequenced by 16 S rRNA and then analyzed by informatics methods. We found that the microbiota of the psoriasis group differed from that of the heathy group. The relative abundances of Firmicutes and Bacteroidetes were inverted at the phylum level, and 16 kinds of phylotype at the genus level were found with significant difference. No microbial diversity and composition alteration were observed among the four types of psoriasis. The microbiota of psoriasis patients in the severe state differs from those of psoriasis patients with more mild conditions and also the healthy controls. The veillonella in fecal microbiota showed a positive relationship with h-CRP in blood. This research proved that psoriasis patients have a significant disturbed microbiota profiles. Further study of psoriasis based on microbiota may provide novel insights into the pathogenesis of psoriasis and more evidence for the prevention and treatment of psoriasis. | Linsheng Huang Renyuan Gao Ning Yu Yefei Zhu Yangfeng Ding Huanlong Qin | 2019 | Science China(Life Sciences)2019，62，6： | 9 |
| 3 | Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome显示文摘Accumulating evidence suggests that ketogenic diets(KDs)mediate the rise of circulating ketone bodies and exert a potential antiinflammatory effect;however,the consequences of this unique diet on colitis remain unknown.We performed a series of systematic studies using a dextran sulfate sodium(DSS)animal model of inflammatory colitis.Animals were fed with a KD,low-carbohydrate diet(LCD),or normal diet(ND).Germ-free mice were utilized in validation experiments.Colon tissues were analyzed by transcriptome sequencing,RT2 profiler PCR array,histopathology,and immunofluorescence.Serum samples were analyzed by metabolic assay kit.Fecal samples were analyzed by 16S rRNA gene sequencing,liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry.We observed that KD alleviated colitis by altering the gut microbiota and metabolites in a manner distinct from LCD.Quantitative diet experiments confirmed the unique impact of KD relative to LCD with a reproducible increase in Akkermansia,whereas the opposite was observed for Escherichia/Shigella.After colitis induction,the KD protected intestinal barrier function,and reduced the production of R0Ryt+CD3_group 3 innate lymphoid cells(ILC3s)and related inflammatory cytokines(IL-17a,IL-18,IL-22,Ccl4).Finally,fecal microbiota transplantation into germ-free mice revealed that the KD-mediated colitis inhibition and ILC3 regulation were dependent on the modification of gut microbiota.Taken together,our study presents a global view of microbiome-metabolomics changes that occur during KD colitis treatment,and identifies the regulation of gut microbiome and ILC3s as novel targets involving in IBD dietary therapy. | Cheng Kong Xuebing Yan Yongqiang Liu Linsheng Huang Yefei Zhu Jide He Renyuan Gao Matthew F.Kalady Ajay Goel Huanlong Qin Yanlei Ma | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 8 |
| 4 | Recent advances in Raman technology with applications in agriculture, food and biosystems: A review显示文摘Raman technology,which covers Raman spectroscopy(RS)and its various derivativemethods,has been widely applied in detection of various substances in agriculture,food and biosystems.This article reviews the recent advances in two mainstream Raman technologies as RS and SERS,including technical evolution,application and challenges,and spectral processing methods.Firstly,the origin,principle,defect,and development of RSwere introduced.Then,the current situation,existing problems,and development trend of RS and SERS were discussed in agriculture,food,and biosystems,such as adulteration recognition,plant diseases identification,farm chemicals detection,food additives determination,and toxins analysis.At last,the spectral analysis methods include noise reduction,feature extraction or variable selection,and modelingwere introduced in detail,which can realize the automatic and intelligent analysis of spectra without relying on professionals. | Shizhuang Weng Wenxiu Zhu Xueyan Zhang Hecai Yuan Ling Zheng Jinling Zhao Linsheng Huang Ping Han | 2019 | Artificial Intelligence in Agriculture2019，，3： | 3 |
| 5 | Complete Lie algebras with maximal-rank nilpotent radicals显示文摘Ccmplete Lie algebras with maximal-rank nilpotent radicals are constructed by using the representation theory of complex semisimple Lie algebras. A structure theorem and an isomorphism theorem for this kind of complete Lie algebras are obtained. As an application of these theorems, the complete Lie algebras with abelian nilpotont radicals are classified. At last, it is proved that there exists no complete Lie algebra whose radical is a nilpotent Lie algebra with maximal rank. | ZHU Linsheng and MENG Daoji Department of Mathematics, Changshu College , Changshu 215500, China Department of Mathematics, Nankai University, Tianjin 300071, China | 1999 | Chinese Science Bulletin1999，44，4： | 2 |
| 6 | Molecular cloning and responsive expression to injury stimulus of a defender against cell deathl (DAD1) gene from bay scallops Argopecten irrad/ans显示文摘 | Zhu Ling Song Linsheng Zhang Huan | 2008 | Molecular Biology Reports2008，35，2： | 1 |
| 7 | The classification of complete Lie algebras with low dimensions显示文摘 | Zhu Linsheng Meng Daoji | 1997 | Algebra Colloquium1997，4，1： | 1 |
| 8 | Selenium in soil and endemic diseases in China显示文摘 | Jian'an Tan Wenyu Zhu Wuyi Wang Ribang Li Shaofan Hou Dacheng Wang Linsheng Yang | 2002 | Science of the Total Environment2002，，1： | 1 |
| 9 | Simple Lie color algebras of Weyl type显示文摘 | SU YUCAI ZHAO KAIMING ZHU LINSHENG | 2003 | Israel J Math2003，137，： | 1 |
| 10 | Solvable Complete Liealgebras I 显示文摘 | Zhu Linsheng | 1996 | Comm Algebra1996，，24： | 1 |
| 11 | Preliminary study on a potential antibacterial peptide derived from histone H2A in hemocytes of scallop Chlamys farreri显示文摘 | Chenghua Li Linsheng Song Jianmin Zhao Ling Zhu Huibin Zou Huan Zhang Hao Wang Zhonghua Cai | 2006 | Fish and Shellfish Immunology2006，，6： | 1 |
| 12 | Identification of a C-type lectin from the bay scallop Argopecten irradians显示文摘 | Zhu Ling Song Linsheng Xu Wei | 2009 | Mol Biol Rep2009，36，5： | 1 |
| 13 | Solvable quadratic Lie algebras显示文摘A Lie algebra endowed with a nondegenerate, symmetric, invariant bilinear form is called a quadratic Lie algebra. In this paper, the author investigates the structure of solvable quadratic Lie algebras, in particular, the solvable quadratic Lie algebras whose Cartan subalgebras consist of semi-simple elements, the author presents a procedure to construct a class of quadratic Lie algebras from the point of view of cohomology and shows that all solvable quadratic Lie algebras can be obtained in this way. | ZHU Linsheng | 2006 | Science China Mathematics2006，49，4： | 1 |
| 14 | Structure of Degenerate Block Algebras显示文摘 | Linsheng Zhu Daoji Meng | 2003 | Algebra Colloquium2003，，1： | 1 |
| 15 | Selenium in soil and endemic diseases in China显示文摘 | Jian’an Tan Wenyu Zhu Wuyi Wang Ribang Li Shaofan Hou Dacheng Wang Linsheng Yang | 2002 | Science of the Total Environment2002，，1： | 1 |
| 16 | Non-degenerate Invariant Bilinear Forms on Leibniz Algebras显示文摘在这份报纸,我们与非退化的 Leibniz 对称的不变的双线性的形式 B 学习 Leibniz 代数学,如此的对被称为二次的 Leibniz 代数学。我们的第一结果概括对二次的 Leibniz 代数学的两倍扩展的观点。这个观点被 Medina 和 Revoy 介绍学习二次的谎言代数学。在第二条定理,我们为是由两倍延期的二次的 Leibniz 代数学的二次的 Leibniz 代数学给一个足够的条件。 | Song Wang Linsheng Zhu | 2015 | Algebra Colloquium2015，22，4： | 0 |
| 17 | Correlation and Cluster Analysis on the Quality Characters of New Middle-ripe Japonica Rice Varieties in Jiangsu Province显示文摘[Objective] This study aimed to analyze the quality characteristics of the new middle-ripe japonica rice varieties in Jiangsu Province. [Method] Fourteen new rice varieties included in the Middle-ripe Japonica Rice Regional Test in 2011 were selected as the materials. Correlation analysis and cluster analysis were carried out on their quality traits. [Result] The rice cultivars possessed stable characteristics, which were difficult to be further improved. In addition, their quality traits had extremely complicated relationships, and the differences were significant between different groups. [Conclusion] This study will provide reference for improving the quality traits of japonica rice. | Guoyong ZHU Mingfa SUN Guohong YAN Chongxiao HE Linsheng WAN | 2013 | Agricultural Biotechnology2013，2，3： | 0 |
| 18 | HSP27在左侧结肠癌和右侧结肠癌差异表达的实验研究(英文)显示文摘Objective:The aim of the study was to screen differentially expressed proteins between left-and right-sided colon cancers by proteomics techniques and provide molecular genetic basis for oncobiological difference between left-and rightsided colon cancers.Methods:Tissue samples including left-and right-sided colon cancers were collected and preserved in the-80 ℃ refrigeratory.In the first part of our experiment,protein separating was performed by using two-dimensional gel electrophoresis(2-DE) and the images of the gels were acquired by the scanner and then analyzed to find the differentially expression protein-spots in different groups.The peptide mass fingerprintings(PMF) was acquired by matrix assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF-MS) and the proteins were identified by data searching in the Mascot-database.Differentially expression proteins were assayed by RT-PCR,Western blot,and immunohistochemical methods.Results:The 55 differentially expressed protein spots were screened and 23 spots of them were identified.Compared to right-sided colon cancer,15 proteins up-regulated and 8 proteins down-regulated including HSP27 in left-sided colon cancer.HSP27 expressed higher in right-sided than in left-sided colon cancers by RT-PCR,Western blot and immunohistochemical methods.Conclusion:There were differentially expressed proteins between left-and right-sided colon cancers,especially differences in HSP27 expression in mRNA and protein level,which were molecular genetic basis for oncobiological difference between left-and right-sided colon cancers. | Liang Zeng Hong Zhu Haiping Pei Li Liu Linsheng Huang | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，4： | 0 |
| 19 | Homology and Cohomology of the Super Schrodinger Algebra 5(1/1)with Coefficients in the Trivial Module显示文摘In this paper we study the homology and cohomology groups of the super Schrodinger algebra S(1/1)in(1+l)-dimensional spacetime.We explicitly compute the homology groups of S(1/1)with coefficients in the trivial module.Then using duality,we finally obtain the dimensions of the cohomology groups of S(1/1)with coefficients in the trivial module. | Yan He Yuezhu Wu Linsheng Zhu Jiping Zhang | 2019 | Algebra Colloquium2019，26，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员