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| 1 | Inhibition of adipogenic differentiation by myostatin is alleviated by arginine supplementation in porcine-muscle-derived mesenchymal stem cells显示文摘Porcine mesenchymal stem cells in postnatal muscle have been demonstrated to differentiate into adipocytes.This increases adipocyte number and lipid accumulation,and is thought to be the origin of intramuscular fat.In this study,the effects of myostatin and arginine on adipogenic differentiation in mesenchymal stem cells derived from porcine muscle (pMDSCs) were investigated in vitro.Intracellular triglyceride levels were reduced by exogenous myostatin and increased by arginine supplementation or myostatin antibody (P<0.01).The inhibition of lipid accumulation by myostatin in pMDSCs was alleviated by arginine supplementation (P<0.01).Expression patterns of adipogenic transcription factors showed that exogenous myostatin suppressed PPARγ2 and aP2 expression (P<0.01),while supplemental arginine or myostatin antibody promoted ADD1 expression (P<0.01).Furthermore,compared with the addition of either myostatin protein or antibody alone,ADD1 and PPARδ expression were promoted by the combination of arginine and myostatin (P<0.01),and arginine combined with myostatin antibody promoted the expression of ADD1,PPAR,C/EBP,PPAR 2 and LPL in pMDSCs (P<0.05).These results suggest that myostatin inhibits adipogenesis in pMDSCs,and that this can be alleviated by arginine supplementation,at least in part,through promoting ADD1 and PPAR expression. | LEI HuLong YU Bing YANG XueRong LIU ZeHui HUANG ZhiQing MAO XiangBing TIAN Gang HE Jun HAN GuoQuan CHEN Hong MAO Qian CHEN DaiWen | 2011 | Science China(Life Sciences)2011，54，10： | 4 |
| 2 | Effect of silica nanoparticles/poly(vinylidene fluoride-hexafluoropropylene) coated layers on the performance of polypropylene separator for lithium-ion batteries显示文摘In an effort to reduce thermal shrinkage and improve electrochemical performance of porous polypropylene(PP) separators for lithium-ion batteries, a new composite separator is developed by introducing ceramic coated layers on both sides of PP separator through a dip-coating process. The coated layers are comprised of heat-resistant and hydrophilic silica nanoparticles and polyvinylidene fluoride-hexafluoropropylene(PVDF-HFP) binders. Highly porous honeycomb structure is formed and the thickness of the layer is only about 700 nm. In comparison to the pristine PP separator, the composite separator shows significant reduction in thermal shrinkage and improvement in liquid electrolyte uptake and ionic conduction, which play an important role in improving cell performance such as discharge capacity, C-rate capability, cycle performance and coulombic efficiency. | Hongyu Liu Zehui Dai Jun Xu Baohua Guo Xiangming He | 2014 | Journal of Energy Chemistry2014，23，5： | 3 |
| 3 | Ultrasound guided neural stem cell transplantation through the lateral ventricle for treatment of cerebral palsy in children显示文摘A total of 24 children with cerebral palsy were enrolled in this study and underwent ultrasound guided transplantation of neural stem cells through the lateral ventricle. Neural stem cells (3.8 × 106-7.3 × 107) were injected into the lateral ventricles. Mild injury of lateral ventricular blood vessels occurred in only two cases (8.3%). Seven cases (29.2%) experienced a fever. Clinical manifestations were improved to varying degrees in eight cases (28.0%) within 3 months after transplantation. Patient condition did not worsen, and no patient experienced severe adverse reactions. | Sheng He Zuo Luan Suqing Qu Xuan Qiu Daqing Xin Wenkai Jia Yanhua Shen Zehui Yu Tao Xu | 2012 | Neural Regeneration Research2012，7，32： | 2 |
| 4 | Federated transfer learning for disaster classification in social computing networks显示文摘Social media analytics have played an important role in disaster identification.Recent advances in deep learning(DL)technologies have been applied to design disaster classification models.However,the DL-based models are hindered by insufficient training samples,because data collection and labeling are very expensive and time-consuming.To solve this issue,a privacy-preserving federated transfer learning approach for disaster classification(FedTL)is proposed,which can allow distributed social computing nodes to collaboratively train a comprehensive model.In the FedTL,Paillier homomorphic encryption method is used to protect the social computing nodes’data privacy.In particular,the transfer learning technology is adopted as a novel application to reduce the computation and communication costs in the federated learning system.The FedTL is verified by a real disaster image dataset collected from social networks.Theoretical analyses and experiment results show that the FedTL is effective,secure,efficient.In addition,the FedTL is highly extensible and can be easily applied in other transfer learning models. | Zehui Zhang Ningxin He Dongyu Li Hang Gao Tiegang Gao Chuan Zhou | 2022 | Journal of Safety Science and Resilience2022，3，1： | 1 |
| 5 | Regulatory Polymorphisms in the Promoter of CXCL10 Gene and Disease Progression in Male Hepatitis B Virus Carriers显示文摘 | Guohong Deng Gangqiao Zhou Rong Zhang Yun Zhai Wenli Zhao Zehui Yan Chunqing Deng Xiaoyan Yuan Baoyan Xu Xiaojia Dong Xiumei Zhang Xuqing Zhang Zhijian Yao Yan Shen Boqing Qiang Yuming Wang Fuchu He | 2008 | Gastroenterology2008，，3： | 1 |
| 6 | Regulatory Polymorphisms in the Promoter of CXCL10 Gene and Disease Progression in Male Hepatitis B Virus Carriers显示文摘 | Guohong Deng Gangqiao Zhou Rong Zhang Yun Zhai Wenli Zhao Zehui Yan Chunqing Deng Xiaoyan Yuan Baoyan Xu Xiaojia Dong Xiumei Zhang Xuqing Zhang Zhijian Yao Yan Shen Boqing Qiang Yuming Wang Fuchu He | 2008 | Gastroenterology2008，，3： | 1 |
| 7 | Telbivudine Prevents Vertical Transmission of Hepatitis B Virus from Women High Viral Loads: A Prospective Long-term Study显示文摘 | Quanxin Wu Hongfei Huang Xiaowen Sun Meiming Pan Yun He Shun Tan Yi Zeng Li Li Guohong Deng Zehui Yan Dengming He Junnan Li Yuming Wang | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
| 8 | Regulatory Polymorphisms in the Promoter of CXCL10 Gene and Disease Progression in Male Hepatitis B Virus Carriers显示文摘 | Guohong Deng Gangqiao Zhou Rong Zhang Yun Zhai Wenli Zhao Zehui Yan Chunqing Deng Xiaoyan Yuan Baoyan Xu Xiaojia Dong Xiumei Zhang Xuqing Zhang Zhijian Yao Yan Shen Boqing Qiang Yuming Wang Fuchu He | 2008 | Gastroenterology2008，，3： | 1 |
| 9 | Improving the Properties of Fast-Growing Chinese Fir by Vacuum Hot Pressing Treatment显示文摘Chinese fir was compressed by vacuum hot pressing and conventional hot pressing at different temperatures(180℃,200℃ and 220℃),respectively.The color parameters of the heat-compressed sample were measured,the relative mechanical properties of the material were tested and changes in the chemistry of fir were investigated using Fourier transform infrared spectroscopy(FTIR)and Xray photoelectron spectroscopy(XPS).The results indicated that the color difference between compressed and untreated wood increased gradually with the increase of temperature.Compared with the conventional hot pressing treatment,the color difference(ΔE*)of the Chinese fir treated by vacuum hot pressing decreased by 43.73%,69.91%,and 77.17%,respectively.The mechanical properties(bending elastic modulus and bending strength)of Chinese fir treated by vacuum hot pressing were significantly improved.The 24-hour water absorption thickness expansion rate of fir treated by vacuum hot pressing is smaller than that of conventional hot pressing.It is implied that vacuum hot pressing treatment is an effective method to produce compressed wood,which can improve the mechanical properties and dimensional stability of wood,and reduce the influence of carbonization on wood color. | Lu Hong Biqing Shu Qian He Zehui Ju Haiyang Zhang Xiaoning Lu | 2021 | Journal of Renewable Materials2021，9，1： | 0 |
| 10 | Evidence of aircraft activity impact on local air quality: A study in the context of uncommon airport operation显示文摘Wuhan Tianhe International Airport (WUH) was suspended to contain the spread of COVID-19,while Shanghai Hongqiao International Airport (SHA) saw a tremendousflight reduction.Closure of a major international airport is extremely rare and thus represents a unique opportunity to straightforwardly observe the impact of airport emissions on local air quality.In this study,a series of statistical tools were applied to analyze the variations in air pollutant levels in the vicinity of WUH and SHA.The results of bivariate polar plots show that airport SHA and WUH are a major source of nitrogen oxides.NOx,NO_(2)and NO diminished by 55.8%,44.1%,76.9%,and 40.4%,33.3% and 59.4% during the COVID-19 lockdown compared to those in the same period of 2018 and 2019,under a reduction in aircraft activities by 58.6%and61.4%.The concentration of NO_(2),SO_(2)and PM_(2.5)decreased by 77.3%,8.2%,29.5%,right after the closure of airport WUH on 23 January 2020.The average concentrations of NO,NO_(2)and NOxscatter plots at downwind of SHA after the lockdown were 78.0%,47.9%,57.4%and 62.3%,34.8%,41.8%lower than those during the same period in 2018 and 2019.However,a significant increase in O_(3)levels by 50.0% and 25.9%at WUH and SHA was observed,respectively.These results evidently show decreased nitrogen oxides concentrations in the airport vicinity due to reduced aircraft activities,while amplified O_(3)pollution due to a lower titration by NO under strong reduction in NOxemissions. | Hao Xu Kai Xiao Jun Pan Qingyan Fu Xiaodong Wei Junrui Zhou Yamei Yu Xue Hu Huarui Ren Jinping Cheng Shitao Peng Ningning Hong Yin Ye Ning Su Zehui He Tao Hu | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 11 | Abnormal anti-oxidation behavior of hexagonal boron nitride grown on copper显示文摘Atomic-layered hexagonal boron nitride(hBN)is expected to be the best two-dimensional(2D)anti-oxidation layer on metals for its incomparable impermeability,insulativity,and stability,as well as the progressive bottom-up growth techniques to ensure fast coating on metal surface in large area.However,its real anti-oxidation ability in practice is found to be unsatisfactory and nonuniform,and the main obstacle to achieving ideal anti-oxidation performance lies in unclear anti-oxidation behavior at special interface between 2D hBN and three-dimensional(3D)metals.Herein,system of monolayer hBN grown on copper(Cu)foils with various lattice orientations was grown to investigate the anti-oxidation behavior of different interlayer configurations.By using structural characterizations together with analysis of topography,we surprisingly found that stronger interlayer coupling led to worse anti-oxidation performance owing to fast diffusion of O2 through higher hBN corrugations generated at the commensurate hBN/Cu(111)configuration.In view of this,we developed the approach of cyclic reannealing that can effectively flatten corrugations and steps,and therefore improve the anti-oxidation performance to a great extent.This work provides a more indepth understanding of anti-oxidation behavior of 2D materials grown on 3D metals,and a practical method to pave the way for its large-scale applications in future. | Li Wang Jiajie Qi Shuai Zhang Mingchao Ding Wei Wei Jinhuan Wang Zhihong Zhang Ruixi Qiao Zhibin Zhang Zehui Li Kehai Liu Ying Fu Hao Hong Can Liu Muhong Wu Wenlong Wang Jun He Yi Cui Qunyang Li Xuedong Bai Kaihui Liu | 2022 | Nano Research2022，15，8： | 0 |
| 12 | Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1显示文摘Aging increases the risks of various diseases and the vulnerability to death.Cellular senescence is a hallmark of aging that contributes greatly to aging and aging-related diseases.This study demonstrates that extracellular vesicles from human urine-derived stem cells(USC-EVs)efficiently inhibit cellular senescence in vitro and in vivo.The intravenous injection of USC-EVs improves cognitive function,increases physical fitness and bone quality,and alleviates aging-related structural changes in different organs of senescence-accelerated mice and natural aging mice.The anti-aging effects of USC-EVs are not obviously affected by the USC donors’ages,genders,or health status.Proteomic analysis reveals that USC-EVs are enriched with plasminogen activator urokinase(PLAU)and tissue inhibitor of metalloproteinases 1(TIMP1).These two proteins contribute importantly to the anti-senescent effects of USC-EVs associated with the inhibition of matrix metalloproteinases,cyclin-dependent kinase inhibitor 2A(P16INK4a),and cyclin-dependent kinase inhibitor 1A(P21cip1).These findings suggest a great potential of autologous USC-EVs as a promising anti-aging agent by transferring PLAU and TIMP1 proteins. | Shanshan Rao Zehui He Zun Wang Hao Yin Xiongke Hu Yijuan Tan Tengfei Wan Hao Zhu Yi Luo Xin Wang Hongming Li Zhenxing Wang Xinyue Hu Chungu Hong Yiyi Wang Mingjie Luo Wei Du Yuxuan Qian Siyuan Tang Hui Xie Chunyuan Chen | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
| 13 | The truncated form of fagellin (tFlic) provides the 2dCap subunit vaccine with better immunogenicity and protective efects in mice显示文摘Porcine circovirus type 2(PCV2)is the main causative agent of porcine circovirus-associated diseases,and it causes substantial economic losses in the swine industry each year.It is crucial to develop an efective vaccine against the circulating strain PCV2d,which is prone to substantial degrees of mutation.In this study,a truncated form of fagellin(tFlic:85-111 aa)was inserted into the C-terminal sequence of 2dCap,and Western blotting results showed that recombinant Cap-tFlic VLPs were successfully expressed.Transmission electron microscopy(TEM)and dynamic light scattering(DLS)data indicated that purifed recombinant Cap-tFlic fusion proteins existed in the form of polymers and that tFlic could not afect the formation and internalization of VLPs.Integrated Cap-tFlic VLPs induced the expression of antigen presentation-related factors(MHC-II and CD86)by bone marrow-derived dendritic cells(BM-DCs),and the expression of TLR5-related factors(TNF-α)was dramatically elevated.Mice intramuscularly immunized with Cap-tFlic VLPs exhibited signifcantly higher levels of Cap-specifc antibodies and neutralizing antibodies than mice immunized with wild-type Cap VLPs.The data obtained in the current study indicate that Cap-tFlic may be a candidate for a subunit vaccine against PCV2 in the future. | Ying Lu Zehui Liu Yingxiang Li Zhuofan Deng Weihuan Fang Fang He | 2022 | Animal Diseases2022，2，2： | 0 |
| 14 | Steam Exploded Peanut Shell Fiber as the Filler in the Rigid Polyurethane Foams显示文摘In this study,steam exploded peanut shell fibers(SE-PSFs)were utilized to fabricate with rigid polyurethane foam(RPUF)in order to improve sound absorption performance and hydrothermal weather resistance.Optimized method of SE treatment,RPUF preparation and flame retardant treatment were selected to prepare SE-PSF/RPUF composites in this experiment.Physical and mechanical properties including density,water absorption capacity,thickness swelling rate,compressive strength,thermal conductivity and average sound absorption coefficient of SE-PSF/RPUF were investigated and compared with the control(PRUF).The results showed that the density,water absorption capacity,thickness swelling rate and thermal conductivity showed an increasing trend with the increase of SE-PSFs content.The strength of the composite material showed a downward trend with the increase of the SE-PSFs content.The average sound absorption coefficient of the SE-PSFs/RPUF compared with PRUF significant increased,and the average sound absorption coefficient of the SE-PSFs/RPUF with SE-PSFs 40%was 0.47.The study getted the best ratio of flame retardants for 10%EG and 3%DMMP.The oxygen index was 35.56 vol%. | Zehui Ju Qian He Tianyi Zhan Haiyang Zhang Lin Sun Lu Hong Xinyi Shi Xiaoning Lu | 2019 | Journal of Renewable Materials2019，7，11： | 0 |
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