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| 1 | The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling显示文摘The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation.Ovarian tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious diseases.However,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains unclear.Here,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory cytokines.In addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against colitis.Mechanistically,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy controls.Furthermore,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal inflammation.Taken together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD. | Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu Xuemei Zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 2 | The earthquake precursor detected in a granular medium and a proposed model for the propagation of precursive stress-strain signal显示文摘A way to detect the seismic precursor in granular medium is described and a model of propagation for precursive stress-strain signals is proposed.A strain sensor buried in a sandpit is used to measure a seismic precursor signal.The signal has been investigated and confirmed to originate from a specific earthquake.A comparison of simulated and experimental signals indicates that the signal results from the strain in the earth's strata.Based on the behavioral characteristics of granular materials,an analysis of why this method can be so sensitive to the seismic strain signal is undertaken and a model for the propagation of this stress-strain signal is proposed.The Earth's lithosphere is formed of tectonic plates,faults and fault gouges at their boundaries.In the case of the quasi-static mechanics of seismic precursory stress-strain propagation,the crustal lithosphere should be treated as a large-scale granular system.During a seismogenic event,accumulated force generates the stick-slip motion of adjacent tectonic plates and incrementally pushes blocks farther apart through stick-slip shift.The shear force released through this plate displacement causes soil compression deformation.The discrete properties of the sand in the sandpit lead to the sensitive response of the sensor to the deformation signal which enables it to detect the seismic precursor.From the analysis of the mechanism of the stress-strain propagation in the lithosphere,an explanation is found for the lack of signal detection by sensors installed in rocks.The principles and method presented in this paper provide a new technique for investigating seismic precursors to shallow-source earthquakes. | LU KunQuan HOU MeiYing WANG Qiang PENG Zheng SUN Wei SUN XiaoMing WANG YuYing TONG XiaoHui JIANG ZeHui LIU JiXing | 2011 | Chinese Science Bulletin2011，56，11： | 2 |
| 3 | Transition metal doped mesoporous titania with a crystalline framework as catalysts for oxidation of p-bromotoluene to pbromobenzaldehyde显示文摘Transition metal M(M=Mn,Fe,Co,Ni,Cu,and Zn)doped mesoporous titania with a crystalline framework was employed as catalysts for the oxidation of p-bromotoluene(PBT)to p-bromobenzaldehyde(BBD)in acetic acid using aqueous hydrogen peroxide as oxidant.It was found that mesoporous TiO_(2) doped with those metals(Fe,Co and Ni)whose atomic radii are relatively smaller exhibited higher conversion rate of PBT.Among these catalysts,the Co/meso-TiO_(2) exhibited high substrate conversion and good product(p-bromobenzaldehyde)selectivity plus it can be reused once with almost the same activity.The effect of different Ti/Co(molar)ratio on the activities of Co/meso-TiO_(2) was also investigated. | Zehui YANG Lihui YIN Encai OU Yunan WANG Li PENG Jiaqiang WANG | 2008 | Frontiers of Chemical Science and Engineering2008，2，3： | 1 |
| 4 | Protocol and fault detection design for nonlinear networked control systems显示文摘 | MAO Zehui JIANG Bin SHI Peng | 2009 | IEEE Transactions on Circuits and Systems- II: Express Briefs2009，56，3： | 1 |
| 5 | Observer based fault-tolerant control for a class of nonlinear networked control systems显示文摘 | MAO Zehui JIANG Bin SHI Peng | 2010 | Journal of the Franklin Institute2010，347，6： | 1 |
| 6 | Fault-tolerant control for a class of nonlinear sampled-data systems via a Euler ap- proximate observer显示文摘 | Mao Zehui Jiang Bin Shi Peng | 2010 | Automatica2010，46，11： | 1 |
| 7 | Performance Analysis of Compound Parabolic Concentration Photothermal and Photoelectricity Device for Soil Heating in Facility Agriculture显示文摘It is difficult for solanum crops to grow continuously during winter in severe cold regions. Thus, a soil heating system for facility agriculture based on solar concentration technology was proposed, and a novel compound parabolic concentration photothermal and photoelectricity device(CTPV) equipped in the system was designed to address this problem. In accordance with the structure of the device, LightTools optical software was selected to analyze the variation trend of the light escape rate of the device with the diff erent incident angles. On the basis of the calculation results, an experimental test system was used to investigate the relationship of the air temperature of the inlet and the outlet, total output power of the solar cells, and photothermal and photoelectricity efficiency of the device with the operation time during a sunny day. Research results reveal that the light escape rate of the device is 5.36% at an incidence angle of 12°. At a velocity of 1.5 m/s, the maximum air temperature of the outlet can reach 55.6 ℃, and the total output power of the solar cells is 474.4 W. The variation of the total power of the solar cells is consistent with the simulation results. The maximum instantaneous heat collection and the maximum photothermal and photoelectricity efficiency of the device are 306 W and 60.4%, respectively, and the average efficiency is 44.9%. This study can serve as a reference for compound parabolic concentration technology applied for soil heating in facility agricultural soil heating systems. | Zehui Chang Yanan Peng Xuedong Liu Jing Hou Shuaijun Guo | 2022 | Transactions of Tianjin University2022，28，2： | 1 |
| 8 | Fault-tolerant control for a class of nonlinear sampled-data systems via a Euler approximate observer 显示文摘 | Mao Zehui Bin Jiang Peng Shi | 2010 | Automatiea 462010，46，11： | 1 |
| 9 | Ancient DNA traces a Chinese 5400-year-old cat specimen as leopard cat(Prionailurus bengalensis)显示文摘Now,widely distributed modern cats are the descendant of wildcat(Felis silvestris lybica),which are assumed to have originally taken advantage of resources in human settlements,before being tamed in the Near East via a commensal pathway(Driscoll et al.,2007;Larson and Fuller,2014). | Shilun Zhu Zehui Chen Songmei Hu Weilin Wang Peng Cao Feng Liu Qingyan Dai Xiaotian Feng Ruowei Yang Wanjing Ping Qiaomei Fu | 2022 | Journal of Genetics and Genomics2022，49，11： | 1 |
| 10 | H∞ fault detection filter design for networked control systems modeled by discrete Markovian jump systems 显示文摘 | MAO Zehui JIANG Bin SHI Peng | 2007 | IET Control Theory and Application2007，1，5： | 1 |
| 11 | H-infinity fault detection filter design for networked control systems modelled by discrete Markovian jump systems 显示文摘 | Mao Zehui Jiang Bin Shi Peng | 2007 | IET Proc Control Theory and Application2007，1，5： | 1 |
| 12 | Reliability analysis on the δ-shock model of complex systems 显示文摘 | LI Zehui ZHAO Peng | 2007 | IEEE Transactions on Reliability2007，56，2： | 1 |
| 13 | filter design for a classof networked control systems via T-S fuzzy-model approach显示文摘 | JIANG Bin MAO Zehui SHI Peng | 2010 | IEEE Transactions on Fuzzy System2010，18，1： | 1 |
| 14 | Observer based fauh-tol- erant control for a class of nonlinear networked control sys- terns 显示文摘 | MAO Zehui JIANG Bin SHI Peng | 2010 | Journal of the Franklin Institute2010，347，6： | 1 |
| 15 | Brain-like synaptic memristor based on lithiumdoped silicate for neuromorphic computing显示文摘Artificial synapse is one of the potential electronics for constructing neural network hardware.In this work,Pt/LiSiO_(x)/TiN analog artificial synapse memristor is designed and investigated.With the increase of compliance current(C.C.)under 0.6 mA,1 mA,and 3 mA,the current in the high resistance state(HRS)presents an increasing variation,which indicates lithium ions participates in the operation process for Pt/LiSiO_(x)/TiN memristor.Moreover,depending on the movement of lithium ions in the functional layer,the memristor illustrates excellent conduction modulation property,so the long-term potentiation(LTP)or depression(LTD)and paired-pulse facilitation(PPF)synaptic functions are successfully achieved.The neural network simulation for pattern recognition is proposed with the recognition accuracy of 91.4%.These findings suggest the potential application of the LiSiO_(x)memristor in the neuromorphic computing. | Shanwu Ke Li Jiang Yifan Zhao Yongyue Xiao Bei Jiang Gong Cheng Facai Wu Guangsen Cao Zehui Peng Min Zhu Cong Ye | 2022 | Frontiers of physics2022，17，5： | 1 |
| 16 | H- fault detection filter design for networked control systems modeled by discrete Markovian jump systems 显示文摘 | Mao Zehui Jiang Bin Shi Peng | 2007 | IET Control Theory & Applications2007，1，5： | 1 |
| 17 | Evidence of aircraft activity impact on local air quality: A study in the context of uncommon airport operation显示文摘Wuhan Tianhe International Airport (WUH) was suspended to contain the spread of COVID-19,while Shanghai Hongqiao International Airport (SHA) saw a tremendousflight reduction.Closure of a major international airport is extremely rare and thus represents a unique opportunity to straightforwardly observe the impact of airport emissions on local air quality.In this study,a series of statistical tools were applied to analyze the variations in air pollutant levels in the vicinity of WUH and SHA.The results of bivariate polar plots show that airport SHA and WUH are a major source of nitrogen oxides.NOx,NO_(2)and NO diminished by 55.8%,44.1%,76.9%,and 40.4%,33.3% and 59.4% during the COVID-19 lockdown compared to those in the same period of 2018 and 2019,under a reduction in aircraft activities by 58.6%and61.4%.The concentration of NO_(2),SO_(2)and PM_(2.5)decreased by 77.3%,8.2%,29.5%,right after the closure of airport WUH on 23 January 2020.The average concentrations of NO,NO_(2)and NOxscatter plots at downwind of SHA after the lockdown were 78.0%,47.9%,57.4%and 62.3%,34.8%,41.8%lower than those during the same period in 2018 and 2019.However,a significant increase in O_(3)levels by 50.0% and 25.9%at WUH and SHA was observed,respectively.These results evidently show decreased nitrogen oxides concentrations in the airport vicinity due to reduced aircraft activities,while amplified O_(3)pollution due to a lower titration by NO under strong reduction in NOxemissions. | Hao Xu Kai Xiao Jun Pan Qingyan Fu Xiaodong Wei Junrui Zhou Yamei Yu Xue Hu Huarui Ren Jinping Cheng Shitao Peng Ningning Hong Yin Ye Ning Su Zehui He Tao Hu | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 18 | Circulating cell-free mtDNA as a new biomarker for cancer detection and management显示文摘Cancer is a major cause of death worldwide,and was responsible for 19.29 million new cases and 9.96 million deaths in 2020 alone.The total number of patients with cancer worldwide is estimated to reach 28 million by 2040.The American Association for Cancer Research has also estimated approximately 16.2 million cancer deaths by 20401. | Fan Peng Siyuan Wang Zehui Feng Kaixiang Zhou Huanqin Zhang Xu Guo Jinliang Xing Yang Liu | 2024 | Cancer Biology & Medicine2024，21，2： | 0 |
| 19 | Cooperative catalysis of Co single atoms and nanoparticles enables selective CAr-OCH_(3) cleavage for sustainable production of lignin-based cyclohexanols显示文摘In this work,a dual-size MOF-derived Co catalyst(0.2Co_(1-NPs)@NC)composed of single atoms(Co_(1))and highly dispersed nanoparticles(Co NPs)was prepared by in-situ Zn evaporation for the highperformance conversion of lignin-derived o-methoxyphenols(lignin oil)to cyclohexanols(up to 97%yield)via cascade demethoxylation and dearomatization.Theoretical calculations elaborated that the dual-size Co catalyst exhibited a cooperative effect in the selective demethoxylation process,in which the Co NPs could initially dissociate hydrogen at lower energies while Co1remarkably facilitated the cleavage of the C_(Ar)-OCH_(3)bond.Moreover,the intramolecular hydrogen bonds formed in the omethoxy-containing phenols were found to result in a decrease in the bond energy of the C_(Ar)-OCH_(3)bond,which was more prone to be activated by the dual-size Co sites.Notably,the pre-hydrogenated intermediate(e.g.,2-methoxycyclohexanol from guaiacol)is difficult to undergo demethoxylation,indicating that the selective C_(Ar)-OCH_(3)bond cleavage is a prerequisite for the synthesis of cyclohexanols.The 0.2Co_(1-NPs)@NC catalyst was highly recyclable with a neglect decline in activity during five consecutive cycles.This cooperative catalytic strategy based on the metal size effect opens new avenues for biomass upgrading via enhanced C-O bond cleavage of high selectivity. | Baoyu Wang Peng Zhou Ximing Yan Hu Li Hongguo Wu Zehui Zhang | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
| 20 | One-proton Knockout from ^(16)C at around 240 MeV/u显示文摘One-nucleon knockout reactions have been used to get spectroscopic factor information of unstable nuclei for decadesl[1-4],and a systematic analysis of experiment for intermediate energies of around 80 MeV/u knockout reactions based on the eikonal model indicates a strong isospin asymmetry dependence of the reduction of the extracted spectroscopic strength relative to the shell-model predictionsl[2,3]. | Zhao Yixuan Sun Yazhou Wang Shitao Sun Zhiyu Zhang Xueheng Yan Duo Pang Danyang Ma Peng Yu Yuhong Yue Ke Tang Shuwen Wang Shaoming Fang Fang Sun Yu Cheng Zehui Liu Xiangman Yang Herun Lu Chengui Duan Limin | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
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