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283篇 您的检索式：作者名="Zeidan"

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	题名	作者	年代	出处	被引量
1	Stem cells in gastrointestinal cancers: The road less travelled显示文摘Cancer stem cells(CSC) are thought to be malignant cells that have the capacity to initiate and maintain tumor growth and survival. Studies have described CSC in various gastrointestinal neoplasms such as colon, pancreas and liver and gastroesophageal tumors. The mechanism by which CSC develop remains unclear. Several studies have explored the role of dysregulation of the Wnt/β-catenin, transformation growth factor-beta and hedhog pathways in generation of CSC. In this review, we discuss the various molecular abnormalities that may be related to formation of CSC in gastrointestinal malignancies, strategies to identify CSC and therapeutic strategies that are based on these concepts. Identification and targeting CSC is an intriguing area and may provide a new therapeutic option for patients with cancer including gastrointestinal malignancies. Although great progress has been made, many issues need to be addressed. Precise targeting of CSC will require precise isolation and characterization of those cells. This field is also evolving but further research is needed to identify markers that are specific for CSC.Although the application of this field has not entered the clinic yet, there continues to be significant optimism about its potential utility in overcoming cancer resistance and curing patients with cancer.	Sameh Mikhail Amer Zeidan	2014	World Journal of Stem Cells2014，6，5：	5
2	Update on acute myeloid leukemia stem cells:New discoveries and therapeutic opportunities显示文摘The existence of cancer stem cells has been wellestablished in acute myeloid leukemia. Initial proof of the existence of leukemia stem cells(LSCs) was accomplished by functional studies in xenograft models making use of the key features shared with normal hematopoietic stem cells(HSCs) such as the capacity of self-renewal and the ability to initiate and sustain growth of progenitors in vivo. Significant progress has also been made in identifying the phenotype and signaling pathways specific for LSCs. Therapeutically, a multitude of drugs targeting LSCs are in different phases of preclinical and clinical development. This review focuses on recent discoveries which have advanced our understanding of LSC biology and provided rational targets for development of novel therapeutic agents. One of the major challenges is how to target the selfrenewal pathways of LSCs without affecting normal HSCs significantly therefore providing an acceptable therapeutic window. Important issues pertinent to the successful design and conduct of clinical trials evaluating drugs targeting LSCs will be discussed as well.	Maximilian Stahl Tae Kon Kim Amer M Zeidan	2016	World Journal of Stem Cells2016，8，10：	2
3	Anaysis of global systolic and diastolic left ventricular performance using volume-time curves by real-time three-dimensional echocardiography 显示文摘	Zeidan Z Erbel R Barkhausen J	2003	J Am Soc Echocardiogr2003，16，2：	1
4	Yield and quality of maize as affected by slow-release nitrogen in newly reclaimed sand- y soil显示文摘	Amany A B Zeidan M S Hozayn M	2006	American-Eurasian Journal of Agricultural & Environmental2006，1，3：	1
5	Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei显示文摘	Zeidan A Javadov S Chakrabarti S		0，，01：	1
6	A GroEL homologue from endosymbiotic bacteria of the whitefly Bemisia tabaci is implicated in the circulative transmission of tomato yellow leaf curl virus显示文摘	Morin S Ghanim M Zeidan M	1999	Virology1999，256，1：	1
7	Current therapy of myelodysplastic syndromes显示文摘	Zeidan AM Linhares Y Gore SD	2013	Blood Rev2013，27，5：	1
8	Analysis of global systolic and diastolic left ventricular performance using volume-time curves by real-time three-dimensional echocardiography显示文摘	Zeidan Z Erbel R Barkhausen J	2003	J Am Soc Echocardiogr2003，16，1：	1
9	Bladder augmentation and! or continent urinary diversion: IO-year experience 显示文摘	Daher P Zeidan S Riachy E	2007	Eur J Pe?diatr Surg2007，17，2：	1
10	A novel daily QA system for proton therapy显示文摘	Ding X Zheng Y Zeidan O	2013	J Appl Clin Med Phys2013，14，2：	1
11	Daily variations in delivered doses in patients treated with radiotherapy for localized prostate cancer 显示文摘	Kupelian PA Langen KM Zeidan OA	2006	Int J Radiat Oncol Biol Phys2006，66，3：	1
12	Structure-function correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery 显示文摘	CHENG J ZEIDAN R MISHRA S	2006	Med Chem2006，49，22：	1
13	A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury显示文摘	Zeidan YH Wu BX Jenkins RW	2008	FASEB J2008，22，18：	1
14	Analysis of global systolic and diastolic left ventricular performance using volume-time curves by real-time three- dimensional echocardiography显示文摘	Zeidan Z Erbel R Barkhausen J Hunold P Bartel T Buck T	2003	J Am Soc Echocardiography2003，16，1：	1
15	Evalution of image- guidance protocols in the treatment of head and neck cancers显示文摘	Zeidan MA Langen KM Meeks SL et aI	2007	Int J Radial Oncol Biolhys2007，67，3：	1
16	Real-time three-dimensional echocardiography for improved evaluation of diastolic function using volume-time curves显示文摘	Zeidan Z Buck T Barkhausen J	2002	Herz2002，27，3：	1
17	Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation显示文摘	Zeidan YH Hannun YA	2007	J Biol Chem2007，282，11：	1
18	Pegasparaginase: where do we stand 显示文摘	ZEIDAN A WANG E S WETZLER M	2009	Expert Opin Biol Ther2009，9，1：	1
19	Analysis of global systolic and diastolic left ventricular performance using volume-time curves by real-time three-dimensional echocardiography显示文摘	Ziad Zeidan Raimund Erbel Joerg Barkhausen Peter Hunold Thomas Bartel Thomas Buck	2003	Journal of the American Society of Echocardiography2003，，1：	1
20	Intraarticular tramadol-bupivacaine combination prolongs the duration of postoperative analgesia after outpatient arthroscopic knee surgery显示文摘	Zeidan A Kassem R Nahleh N	2008	Anesth Analg2008，107，1：	1

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