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1Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals.Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu 2016Chinese Journal of Cancer Research2016,28,6:13
2The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells显示文摘Qianqian Li Zewen Gao Ye Chen Min-Xin Guan 2017Protein & Cell2017,8,6:12
3Reaction environment self-modification on low-coordination Ni^(2+)octahedra atomic interface for superior electrocatalytic overall water splitting显示文摘Large scale synthesis of high-efficiency bifunctional electrocatalyst based on cost-effective and earth-abundant transition metal for overall water splitting in the alkaline environment is indispensable for renewable energy conversion.In this regard,meticulous design of active sites and probing their catalytic mechanism on both cathode and anode with different reaction environment at molecular-scale are vitally necessary.Herein,a coordination environment inheriting strategy is presented for designing low-coordination Ni^(2+)octahedra(L-Ni-8)atomic interface at a high concentration(4.6 at.%).Advanced spectroscopic techniques and theoretical calculations reveal that the self-matching electron delocalization and localization state at L-Ni-8 atomic interface enable an ideal reaction environment at both cathode and anode.To improve the efficiency of using the self-modification reaction environment at L-Ni-8,all of the structural features,including high atom economy,mass transfer,and electron transfer,are integrated together from atomic-scale to macro-scale.At high current density of 500 mA/cm2,the samples synthesized at gram-scale can deliver low hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)overpotentials of 262 and 348 mV,respectively.Kaian Sun Lei Zhao Lingyou Zeng Shoujie Liu Houyu Zhu Yanpeng Li Zheng Chen Zewen Zhuang Zhaoling Li Zhi Liu Dongwei Cao Jinchong Zhao Yunqi Liu Yuan Pan Chen Chen 2020Nano Research2020,13,11:12
4Denitrification and microbial community in MBBR using A. donax as carbon source and biofilm carriers for reverse osmosis concentrate treatment显示文摘In this study,raw Arundo donax(A.donax)pieces were applied as carbon source and biofilm carriers for denitrification in a lab-scale moving bed biofilm reactor(MBBR)for the treatment of reverse osmosis concentrate gathered from local wastewater reuse plant.At stable phase(about 60 days),efficient denitrification performance was obtained with73.2%±19.5%NO3--N average removal and 8.10±3.45 g N/(m3·day)NO3--N average volumetric removal rate.Mass balance analysis showed that 4.84 g A.donax was required to remove 1 g TN.Quantitative real-time PCR analysis results showed that the copy numbers of 16S r-RNA,narG,nirS,nosZ and anammox gene of carrier biofilm and suspended activated sludge in the declination phase(BF2 and AS2)were lower than those of samples in the stable phase(BF1 and AS1),and relatively higher copy numbers of nirS and nirK genes with lower abundance of narG and nosZ genes were observed.High-throughput sequencing analysis was conducted for BF2 and AS2,and similar dominant phyla and classes with different abundance were obtained.The class Gammaproteobacteria affiliated with the phylum Proteobacteria was the most dominant microbial community in both BF2(52.6%)and AS2(41.7%).The PICRUSt prediction results indicated that 33 predictive specific genes were related to denitrification process,and the relative abundance of 18 predictive specific genes in BF2 were higher than those in AS2.Li Li Guokai Yan Haiyan Wang Zhaosheng Chu Zewen Li Yu Ling Tong Wu 2019Journal of Environmental Sciences2019,31,10:11
5Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions.Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li 2018Chinese Journal of Cancer Research2018,30,3:4
6Intercomparison of GPS radiosonde soundings during the eastern tropical Indian Ocean experiment显示文摘Temperature and relative humidity profiles derived from two China-made global positioning system(GPS)radiosondes(GPS-TK and CF-06-A)during the east tropical Indian Ocean(ETIO)experiment were compared with Vaisala RS92-SGP to assess the performances of China-made radiosondes over the tropical ocean.The results show that there have relative large biases in temperature observations between the GPSTK and the RS92-SGP in the low troposphere,with a warm bias of greater than 2 K in the day and a cooling bias of 0.6 K at night.The temperature differences of the CF-06-A were small in the troposphere both in daytime and nighttime,and became large peak-to-peak fluctuations in the stratosphere.The intercomparison of the relative humidity showed that the CF-06-A had large random errors due to the limitation of sensors and the lack of correction scheme,and the GPS-TK had large systematic biases in the low troposphere which might be related to the temperature impact.GPS height measurements are clearly suitable for China-made radiosonde systems operation.At night,the CF-06-A and the GPS-TK could provide virtual potential temperature and atmospheric boundary layer height measurements of suitable quality for both weather and climate research.As a result of the intercomparison experiment,major errors in the Chinamade radiosonde systems were well indentified and subsequently rectified to ensure improving accuracy for historical and future radiosondes.XIE Qiang HUANG Ke WANG Dongxiao YANG Lei CHEN Ju WU Zewen LI Daning LIANG Zhiyan 2014Acta Oceanologica Sinica2014,33,1:4
7N2O emission in partial nitritation-anammox process显示文摘Nitrous oxide(N2O)is one of the significant greenhouse gases,and partial nitritation-anammox(PNA)process emits higher N2O than traditional nitrogen removal processes.N2O production in PNA mainly occurs in three different pathways,i.e.,the ammonia oxidizing bacteria(AOB)denitrification,the hydroxylamine(NH2 OH)oxidation and heterotrophic denitrifiers denitrification.N2O emission data vary significantly because of the different operational conditions,bioreactor configurations,monitoring systems and quantitative methods.Under the common operational parameter scopes of PNA,N2O emission via NH2 OH oxidation dominates at relatively low dissolved oxygen(DO),low inorganic carbon(IC),high pH or low N02-concentration,while N2O emission via AOB denitrification dominates at relative higher DO,higher IC.lower pH or higher N2O-concentration.AOB are highly enriched while nitriteoxidizing bacteria(NOB)are rarely found in partial nitritation process,and the order Nitrosomonadales of AOB is the dominant group and N2O producer.Anammox bacteria,AOB and certain amount of heterotrophic denitrifying bacteria are observed in the anammox process,the genus Denitratisoma and the heterotrophic denitrifying bacteria in the deep layer of anammox granules are the dominant N2O generation bacteria.In one-stage PNA reactors,anammox bacteria account for a large fraction of the biomass,AOB account for small portion,and NOB account for even less.The microbial community,diversity and N2O producers in one-stage PNA reactors are similar with those in two-stage PNA reactors.The dominant anammox bacteria,AOB and NOB in PNA are the species Candidatus Brocadia,the genera of Nitrotoga,Nitrospira and Nitrobacter,and the genus Nitrosomonas,respectively.The relations between N2O emission pathways and microbial communities need further study in the future.Li Li Yu Ling Haiyan Wang Zhaosheng Chu Guokai Yan Zewen Li Tong Wu 2020Chinese Chemical Letters2020,31,1:3
8Factors Affecting the Catalytic Performance of Nano-catalysts显示文摘Comprehensive Summary Nano-catalysis plays a vital role in the industrially chemical transformations.The increasingly severe energy crisis and environmental issues spur scientists to exploit novel nano-catalysts in diverse fields.It is essential to understand the fundamental physicochemical properties of nano-catalysts to develop efficient systems,whose design can be subsequently precisely tuned at the atomic level.In this review,we summarize several key factors affecting the catalytic activity of nano-catalysts,including structure,composition,size,and interface,providing guidance for the atomic level control of high-efficient nano-catalysts.Finally,we present a brief conclusion and some thoughts on nano-catalysis.Hongling Yang Yue Wu Zewen Zhuang Yang Li Chen Chen 2022Chinese Journal of Chemistry2022,40,4:3
9Antimony doped Cs2SnCl6 with bright and stable emission显示文摘Lead halide perovskites,with high photoluminescence efficiency and narrow・band emission,are promising materials for display and lighting.However,the lead toxicity and environmental sensitivity hinder their potential applications.Herein,a new antimony・doped lead-free inorganic perovskites variant Cs2SnCl6:xSb is designed and synthesized.The perovskite variant Cs2SnCl6:xSb exhibits a broadband orange-red emission,with a photoluminescence quantum yield(PLQY)of 37%.The photoluminescence of Cs2SnCl6:xSb is caused by the ionoluminescence of Sb3+within Cs2SnCl6 matrix,which is verified by temperature dependent photoluminescence(PL)and PL decay measurements.In addition,the all inorganic structure renders Cs2SnCl6:xSb with excellent thermal and water stability.Finally,a white light-emitting diode(white-LED)is fabricated by assembling Cs2SnCl6:0.59%Sb,Cs2SnCl6:2.75%Bi and Ba2Sr2SiO4:Eu2+onto the commercial UV LED chips,and the color rendering index(CRI)reaches 81.Jinghui LI Zhifang TAN Manchen HU Chao CHEN Jiajun LUO Shunran LI Liang GAO Zewen XIAO Guangda NIU Jiang TANG 2019Frontiers of Optoelectronics2019,12,4:2
10Realization of a Series Contact MEMS Switch with SiON Dielectric Bridge显示文摘HU Guangwei LIU Zewen HOU Zhihao LI Zhijian LIU Litian 2008Chinese Journal of Electronics2008,17,2:2
11Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip显示文摘EGFR mutations companion diagnostics have been proved to be crucial for the efficacy of tyrosine kinase inhibitor targeted cancer therapies. To uncover multiple mutations occurred in minority of EGFR-mutated cells,which may be covered by the noises from majority of unmutated cells, is currently becoming an urgent clinical requirement. Here we present the validation of a microfluidic-chip-based method for detecting EGFR multimutations at single-cell level. By trapping and immunofluorescently imaging single cells in specifically designed silicon microwells, the EGFR-expressed cellswere easily identified. By in situ lysing single cells, the cell lysates of EGFR-expressed cells were retrieved without cross-contamination. Benefited from excluding the noise from cells without EGFR expression, the simple and cost-effective Sanger's sequencing, but not the expensive deep sequencing of the whole cell population, was used to discover multi-mutations. We verified the new method with precisely discovering three most important EGFR drugrelated mutations from a sample in which EGFR-mutated cells only account for a small percentage of whole cell population. The microfluidic chip is capable of discovering not only the existence of specific EGFR multi-mutations,but also other valuable single-cell-level information: on which specific cells the mutations occurred, or whether different mutations coexist on the same cells. This microfluidic chip constitutes a promising method to promote simple and cost-effective Sanger's sequencing to be a routine test before performing targeted cancer therapy.Ren Li Mingxing Zhou Jine Li Zihua Wang Weikai Zhang Chunyan Yue Yan Ma Hailin Peng Zewen Wei Zhiyuan Hu 2018Nano-Micro Letters2018,10,1:2
12Rapid and selective uranium extraction from aqueous solution under visible light in the absence of solid photocatalyst显示文摘Extraction of uranium from radioactive waste-water is of significant importance for environmental protection and the recovery of uranium resource.Different from the previous reports to use the solid absorbent/photocatalyst for U(VI)removal,herein,we proposed a new eco-friendly method for the rapid and selective extraction of uranium from aqueous solutions under visible light without solid materials.At optimal pH value and in the presence of organics like alcohols,the U(VI)could be extracted efficiently to form brown uranium solid over wide uranium concentrations under anaerobic condition and visible light,by utilizing the excitation of the given U(VI)species.With comprehensive modelling of the electronic ultraviolet-visible(UV-Vis)properties,it is proved that pH adjusting towards U(VI)could induce efficient ligand-to-metal-charge-transfer(LMCT)within the uranyl complex under visible light and the reduction of U(VI)to form U(V),which can be transformed into U(IV)via disproportionation reaction.The resulting U(IV)in solid phase makes the extraction much more convenient in operation.More importantly,the excellent selectivity for uranium extraction over interfering alkali metal ions,transition metal ions and the lanthanide metal ions shows a powerful application potential.Shaojun Li Yezi Hu Zewen Shen Yawen Cai Zhuoyu Ji Xiaoli Tan Zhixin Liu Guixia Zhao Shuxian Hu Xiangke Wang 2021Science China Chemistry2021,64,8:2
13A review on photo-, electro- and photoelectro- catalytic strategies for selective oxidation of alcohols显示文摘Traditional conversion of alcohols into carbonyl compounds exists a few drawbacks such as harsh reaction conditions,production of large amounts of hazardous wastes,and poor selectivity.The newly emerging conversion approaches via photo-,electro-,and photoelectro-catalysis to oxidize alcohols into high value-added corresponding carbonyl compounds as well as the possible simultaneous production of clean fuel hydrogen(H_(2))under mild conditions are promising to substitute the traditional approach to form greener and sustainable reaction systems and thus have aroused tremendous investigations.In this review,the state-of-the-art photocatalytic,electrocatalytic,and photoelectrocatalytic strategies for selective oxidation of different types of alcohols(aromatic and aliphatic alcohols,single alcohol,and polyols,etc.)as well as the simultaneous production of H_(2) in certain systems are discussed.The design of photocatalysts,electrocatalysts,and photoelectrocatalysts as well as reaction mechanism is summarized and discussed in detail.In the end,current challenges and future research directions are proposed.It is expected that this review will not only deepen the understanding of environmentally friendly catalytic systems for alcohol conversion as well as H_(2) production,but also enlighten significance and inspirations for the follow-up study of selective oxidation of various types of organic molecules to value-added chemicals.Duoyue Tang Guilong Lu Zewen Shen Yezi Hu Ling Yao Bingfeng Li Guixia Zhao Baoxiang Peng Xiubing Huang 2023Journal of Energy Chemistry2023,,2:1
14State-of-the-art progress in the selective photo-oxidation of alcohols显示文摘Photocatalytic oxidation of alcohols has received more and more attention in recent years following the numerous studies on the degradation of pollutants, hydrogen evolution, and CO_(2) reduction by photocatalysis. Instead of the total oxidation of organics in the degradation process, the photo-oxidation of alcohols aims at the selective conversion of alcohols to produce carbonyl/acid compounds. Promising results have been achieved in designing the catalysts and reaction system, as well as in the mechanistic investigations in the past few years. This review summarizes the state-of-the-art progress in the photo-oxidation of alcohols, including the development of photocatalysts and cocatalysts, reaction conditions including the solvent and the atmosphere, and the exploration of mechanisms with scavengers experiment, electron paramagnetic resonance (EPR) and diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy. The challenges and outlook for the further research in this field are also discussed.Zewen Shen Yezi Hu Bingfeng Li Yingtong Zou Shaojun Li GWilma Busser Xiangke Wang Guixia Zhao Martin Muhler 2021Journal of Energy Chemistry2021,30,11:1
15One-pot synthesis of toluene from methane and methanol catalyzed by GaN nanowire显示文摘The generation of aromatic benzene,toluene,xylene(BTX)compounds from non-petroleum feedstocks is of particular interest for chemists in the eyes of sustainability.Herein,a novel synthesis of toluene catalyzed by GaN semiconductor nanowire arrays is reported.Using methane and methanol as starting materials,the GaN nanowire arrays can synergistically facilitate the facile generation of toluene under either photo-irradiation or thermal-conditions.The detailed computational studies unveiled different mechanisms involved for the photo-and thermal-toluene synthesis.Mingxin Liu Zewen Wu Xianghua Kong Xu Zhang Lida Tan Hong Guo Chao-Jun Li 2023Nano Research2023,16,5:1
16Power grid fault traveling wave network protection scheme 显示文摘Li Zewen Yao Jianggang Zeng Xiangjun Deng Feng 2011Electrical Power and Energy Systems2011,33,:1
17Multiple plasmon couplings in 3D hybrid Au-nanoparticles-decorated Ag nanocone arrays boosting highly sensitive surface enhanced Raman scattering显示文摘Plasmon coupling is an essential strategy to realize strong local electromagnetic(EM)field which is crucial for high-performance plasmonic devices.In this work,multiple plasmon couplings are demonstrated in three-dimensional(3D)hybrid plasmonic systems composed of polydimethylsiloxane-supported ordered silver nanocone(AgNC)arrays decorated with high-density gold nanoparticles(AuNPs)which are fabricated by a template-assisted physical vapor deposition process.Strong interparticle coupling,particle-film coupling,inter-cone coupling,and particle-cone coupling are revealed by numerical simulations in such composite nanostructures,which produce intense and high-density EM hot spots,boosting highly sensitive and reproducible surface enhanced Raman scattering(SERS)detection with an enhancement factor of-1.74×10^(8).Furthermore,a linear correlation between logarithmic Raman intensity and logarithmic concentration of probe molecules is observed in a large concentration range.These results offer new ideas to develop novel plasmonic devices,and provide alternative strategy to realize flexible and high-performance SERS sensors for trace molecule detection and quantitative analysis.Zewen Zuo Lianye Sun Yongbin Guo Lujun Zhang Junhu Li Kuanguo Li Guanglei Cui 2022Nano Research2022,15,1:0
18Atomic mechanisms of hexagonal close-packed Ni nanocrystallization revealed by in situ liquid cell transmission electron microscopy显示文摘The fundamental understanding of the mechanism underlying the early stages of crystallization of hexagonal-close-packed(hcp)nanocrystals is crucial for their synthesis with desired properties,but it remains a significant challenge.Here,we report using in situ liquid cell transmission electron microscopy(TEM)to directly capture the dynamic nucleation process and track the real-time growth pathway of hcp Ni nanocrystals at the atomic scale.It is demonstrated that the growth of amorphous-phase-mediated hcp Ni nanocrystals is from the metal-rich liquid phases.In addition,the reshaped preatomic facet development of a single nanocrystal is also imaged.Theoretical calculations further identify the non-classical features of hcp Ni crystallization.These discoveries could enrich the nucleation and growth model theory and provide useful information for the rational design of synthesis pathways of hcp nanocrystals.Junyu Zhang Miao Li Zewen Kang Bensheng Xiao Haichen Lin Jingyu Lu Haodong Liu Xue Zhang Dong-Liang Peng Qiaobao Zhang 2022Nano Research2022,15,7:0
19Scattering Inversion Study for Suspended Label-Free Lymphocytes with Complex Fine Structures显示文摘Objective and Impact Statement.Distinguishing malignant lymphocytes from normal ones is vital in pathological examination.We proposed an inverse light scattering(ILS)method for label-free suspended lymphocytes with complex fine structures to identify their volumes for pathological state.Introduction.Light scattering as cell’s“fingerprint”provides valuable morphology information closely related to its biophysical states.However,the detail relationships between the morphology with complex fine structures and its scattering characters are not fully understood.Methods.To quantitatively inverse the volumes of membrane and nucleus as the main scatterers,clinical lymphocyte morphologies were modeled combining the Gaussian random sphere geometry algorithm by 750 reconstructed results after confocal scanning,which allowed the accurate simulation to solve ILS problem.For complex fine structures,the specificity for ILS study was firstly discussed(to our knowledge)considering the differences of not only surface roughness,posture,but also the ratio of nucleus to the cytoplasm and refractive index.Results.The volumes of membrane and nucleus were proved theoretically to have good linear relationship with the effective area and entropy of forward scattering images.Their specificity deviations were less than 3.5%.Then,our experimental results for microsphere and clinical leukocytes showed the Pearson product-moment correlation coefficients(PPMCC)of this linear relationship were up to 0.9830~0.9926.Conclusion.Our scattering inversion method could be effectively applied to identify suspended label-free lymphocytes without destructive sample pretreatments and complex experimental systems.Lu Zhang Huijun Wang Jianyi Liu Shuang Chen He Yang Zewen Yang Zhenxi Zhang Hong Zhao Li Yuan Lifang Tian Bo Zhong Xiaolong Liu 2022Biomedical Engineering Frontiers2022,3,1:0
20Enhanced galloping energy harvester with cooperative mode of vibration and collision显示文摘The low power and narrow speed range remain bottlenecks that constrain the application of small-scale wind energy harvesting.This paper proposes a simple,lowcost,and reliable method to address these critical issues.A galloping energy harvester with the cooperative mode of vibration and collision(GEH-VC)is presented.A pair of curved boundaries attached with functional materials are introduced,which not only improve the performance of the vibration energy harvesting system,but also convert more mechanical energy into electrical energy during collision.The beam deforms and the piezoelectric energy harvester(PEH)generates electricity during the flow-induced vibration.In addition,the beam contacts and separates from the boundaries,and the triboelectric nanogenerator(TENG)generates electricity during the collision.In order to reduce the influence of the boundaries on the aerodynamic performance and the feasibility of increasing the working area of the TENG,a vertical structure is designed.When the wind speed is high,the curved boundaries maintain a stable amplitude of the vibration system and increase the frequency of the vibration system,thereby avoiding damage to the piezoelectric sheet and improving the electromechanical conversion efficiency,and the TENG works with the PEH to generate electricity.Since the boundaries can protect the PEH at high wind speeds,its stiffness can be designed to be low to start working at low wind speeds.The electromechanical coupling dynamic model is established according to the GEH-VC operating principle and is verified experimentally.The results show that the GEH-VC has a wide range of operating wind speeds,and the average power can be increased by 180%compared with the traditional galloping PEH.The GEH-VC prototype is demonstrated to power a commercial temperature sensor.This study provides a novel perspective on the design of hybrid electromechanical conversion mechanisms,that is,to combine and collaborate based on their respective characteristics.Qiong WANG Zewen CHEN Linchuan ZHAO Meng LI Hongxiang ZOU Kexiang WEI Xizheng ZHANG Wenming ZHANG 2022Applied Mathematics and Mechanics(English Edition)2022,43,7:0
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