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| 1 | Inactivation gating determines drug potency:a common mechanism for drug blockade of HERG channels显示文摘AIM: To determine the mechanisms of interactions between different drugs and HERG channels. METHODS:Various antiarrhythmic (dofetilide, quinidine, azimilide, RP58866) and non-antiarrhythmic (terfenadine, nicotine)agents were used on HERG channels expressed in Xenopus oocyte. Whole-cell voltage-clamp techniques wereused. RESULTS: All drugs produced concentration-dependent block of HERG current. The inhibition was mark-edly facilitated with voltage protocols favoring channel inactivation (eg, less negative holding potentials). Maneu-vers that weakened channel inactivation (eg, elevation of external K+), relieved HERG blockade by all drugs. Moreover,the inhibitory potency was reduced by at least 20-300 fold with varying compounds when rapid C-type inactivationwas removed by a mutation located between the transmembrane domains 5 and 6 (S631A). CONCLUSION: Theinactivation gating of HERG channels determines the blocking potency of drugs. This mechanism might be com-mon to drugs of various classes. | Bao-fengYANG Dong-huiXU Chao-qianXU ZheLI,Zhi-minDU Hui-zhenWANG De-liDONG | 2004 | Acta Pharmacologica Sinica2004，25，5： | 14 |
| 2 | 香蕉新品种“南天黄”在琼北试验研究显示文摘在海南省澄迈县香蕉产区开展抗香蕉枯萎病品种'南天黄'大田试验研究,测定果实性状变化、株产以及调查几种病害发生情况。结果表明,该品种生育期362 d,从抽蕾后至采收,可溶性糖呈增加趋势,维生素C变化反之;通过增施钾肥,最高株产达24.19 kg,枯萎病发病率仅为0.8%,与对照品种'巴西蕉'差异极显著。 | 何应对 林妃 王丽霞 殷晓敏 刘永霞 王必尊 苏璐 DING Zheli JING Tao HAN Lina | 2019 | 中国南方果树2019，48，3： | 4 |
| 3 | Climate change impact and adaptation on wheat yield, water use and water use efficiency at North Nile Delta显示文摘Investigation of climate change impacts on food security has become a global hot spot.Even so,efforts to mitigate these issues in arid regions have been insufficient.Thus,in this paper,further research is discussed based on data obtained from various crop and climate models.Two DSSATcrop models(CMs)(CERESWheat and N-Wheat)were calibrated with two wheat cultivars(Gemiza9 and Misr1).A baseline simulation(1981-2010)was compared with different scenarios of simulations using three Global Climate Models(GCMs)for the 2030s,2050s and 2080s.Probable impacts of climate change were assessed using the GCMs and CMs under the high emission Representative Concentration Pathway(RCP8.5).Results predicted decreased wheat grain yields by a mean of 8.7%,11.4%and 13.2%in the 2030s,2050s and 2080s,respectively,relative to the baseline yield.Negative impacts of climatic change are probable,despite some uncertainties within the GCMs(i.e.,2.1%,5.0%and 8.0%)and CMs(i.e.,2.2%,6.0%and 9.2%).Changing the planting date with a scenario of plus or minus 5 or 10 days from the common practice was assessed as a potentially effective adaptation option,which may partially offset the negative impacts of climate change.Delaying the sowing date by 10 days(from 20 November to 30 November)proved the optimum scenario and decreased further reduction in wheat yields resulting from climate change to 5.2%,6.8%and 8.5%in the 2030s,2050s and 2080s,respectively,compared with the 20 November scenario.The planting 5-days earlier scenario showed a decreased impact on climate change adaptation.However,the 10-days early planting scenario increased yield reduction under projected climate change.The cultivar Misr1 was more resistant to rising temperature than Gemiza9.Despite the negative impacts of projected climate change on wheat production,water use efficiency would slightly increase.The ensemble of multi-model estimated impacts and adaptation uncertainties of climate change can assist decision-makers in planning climate adaptation strategies. | Marwa Gamal Mohamed Ali Mahmoud Mohamed Ibrahim Ahmed El Baroudy Michael Fullen El-Said Hamad Omar Zheli Ding Ahmed Mohammed Saad Kheir | 2020 | Frontiers of Earth Science2020，14，3： | 2 |
| 4 | SecureWeb: Protecting Sensitive Information Through the Web Browser Extension with a Security Token显示文摘The leakage of sensitive data occurs on a large scale and with increasingly serious impact. It may cause privacy disclosure or even property damage. Password leakage is one of the fundamental reasons for information leakage, and its importance is must be emphasized because users are likely to use the same passwords for different Web application accounts. Existing approaches use a password manager and encrypted Web application to protect passwords and other sensitive data; however, they may be compromised or lack accessibility. The paper presents Secure Web, which is a secure, practical, and user-controllable framework for mitigating the leakage of sensitive data. Secure Web protects users' passwords and aims to provide a unified protection solution to diverse sensitive data. The efficiency of the developed schemes is demonstrated and the results indicate that it has a low overhead and are of practical use. | Shuang Liang Yue Zhang Bo Li Xiaojie Guo Chunfu Jia Zheli Liu | 2018 | Tsinghua Science and Technology2018，23，5： | 2 |
| 5 | Cetus:an efficient symmetric searchable encryption against file-injection attack with SGX显示文摘Symmetric searchable encryption(SSE)allows the users to store and query their private data in the encrypted database.Many SSE schemes for different scenarios have been proposed in the past few years,however,most of these schemes still face more or fewer security issues.Using these security leakages,many attacks against the SSE scheme have been proposed,and especially the non-adaptive file injection attack is the most serious.Non-adaptive file injection attack(NAFA)can effectively recover some extremely important private information such as keyword plaintext.As of now,there is no scheme that can effectively defend against such attacks.We first propose the new security attribute called toward privacy to resist nonadaptive file injection attacks.We then present an efficient SSE construction called Cetus to achieve toward privacy.By setting up a buffer and designing the efficient oblivious reading algorithm based on software guard extensions(SGX),we propose the efficient one-time oblivious writing mechanism.Oblivious writing protects the update pattern and allows search operations to be performed directly on the data.The experiment results show that Cetus achieves O(aw)search time and O(1)update communication.The practical search time,communication,and computation overheads incurred by Cetus are lower than those of state-of-the-art. | Yanyu HUANG Siyi LV Zheli LIU Xiangfu SONG Jin LI Yali YUAN Changyu Dong | 2021 | Science China(Information Sciences)2021，64，8： | 2 |
| 6 | An Efficient Format-Preserving Encryption Mode for Practical Domains显示文摘Format-preserving encryption (FPE), which makes sure that ciphertext has the same format as plaintext, has been widely used in protecting sensitive data in a database. Aiming at efficiently solving the FPE problem on a collection of practical domains, we propose the RREM (random reference-based encryption mode), which constructs bijection between the original domain and integer set through distance computation. If an appropriate distance function is predefined, the proposed mode can solve the FPE problem on linear equidistance domain in a more efficient way than previous methods. Furthermore, we make a classification on various types of domains, show the application of RREM in some practical domains, and specify RREM's capability of solving the FPE problem on frequently-used fields in database quite efficiently. | LI Jingwei LIU Zheli XU Li JIA Chunfu | 2012 | Wuhan University Journal of Natural Sciences2012，17，5： | 2 |
| 7 | Efficient Identity- based Broadcast Encryption without Random Oracles 显示文摘 | HU Liang LIU Zheli CHENG Xiaochun | 2010 | Journal of Conjurers2010，5，3： | 1 |
| 8 | A Distributed Model of WebGIS Based on Java Servlett显示文摘 | Zheli Liu Shuming Wang Yongjian Yang Xuiqin Yu | 2006 | 通讯和计算机(中英文版)2006，3，7： | 1 |
| 9 | Scaled Ex- periment Study on Maximum Smoke Temperature along Corridor Subject to a Room Fires 显示文摘 | Xing Zheli Mao Jinfeng Huang Yuliang | 2015 | Sustainability2015，7，11： | 1 |
| 10 | L-Enc DB:a lightweight framework for privacy-preserving data queries in cloud computing显示文摘 | Li Jin Liu Zheli Chen Xiaofeng | 2015 | Knowledge-Based Systems2015，79，： | 1 |
| 11 | Labrador:towards fair and auditable data sharing in cloud computing with long-term privacy显示文摘Data are one of the most important sources of power that drives the world today.However,aggregating data is not an easy task with increasing legal regulations and concerns from users about their data privacy,and therefore incentives might be needed to encourage data sharing.In this paper,we present Labrador(LB),a system to handle the above problems.Our result demonstrates long-term privacy that reveals only an analytic result to the data analyst.An analytic task is delegated to clouds,which holds users’homomorphically encrypted data.We develop a lightweight verifiable blind decryption technique over the linearly homomorphic encryption scheme to verify the final result.Thus,its verifiability and blindness rely on over-determined and under-determined systems,respectively.To support incentives in data sharing,we leverage smart contract to realize binding contracts between mutually distrusted parties.In the game theory model with a non-collusion assumption,Labrador is secure against any rational adversary.Our evaluation demonstrates that the computational overhead for the data analyst and the data owner is insignificant(i.e.,only a few seconds and milliseconds,respectively). | Xiaojie GUO Jin LI Zheli LIU Yu WEI Xiao ZHANG Changyu DONG | 2022 | Science China(Information Sciences)2022，65，5： | 1 |
| 12 | Finite element simulation of multi-point sheet forming process based on implicit scheme显示文摘 | ZHONG Yicai MING Zheli | 2005 | Journal of Material Processing Technology2005，161，： | 1 |
| 13 | A Novel Cu-Mo/ZSM-5 Catalyst for NO_x Catalytic Reduction with Ammonia显示文摘The Cu-Mo/ZSM-5 catalysts with different Cu/Mo ratios were prepared by wet impregnation method, and their catalytic performance for selective catalytic reduction of NOx was studied. The results showed that Cu-Mo/ZSM-5 is a very effective catalyst for NOx catalytic reduction with ammonia, especially when Cu/Mo molar ratio is about 1.5. It not only exhibited the extremely high catalytic activity, but also showed good stability for O2. The bulk phase structure of Cu-Mo/ZSM-5 catalysts was determined by XRD technique, and the results indicated that there is a maximum dispersion for Cu species when Cu/Mo molar ratio is 1.5, and an interaction between Cu and Mo along with HZSM-5 may be present in Cu-Mo/ZSM-5, which may possibly result in a special structure favorable for the catalytic reduction of NOx over Cu-Mo/ZSM-5 catalyst. | ZheLi DangLi WeiHuang KechangXie | 2005 | Journal of Natural Gas Chemistry2005，14，2： | 1 |
| 14 | New order preserving encryption model for outsourced databases in cloud environments显示文摘 | Zheli Liu Xiaofeng Chen Jun Yang Chunfu Jia Ilsun You | 2014 | Journal of Network and Computer Applications2014，，： | 1 |
| 15 | Interaction between BRCA1/BRCA2 and ATM/ATR associate with breast cancer susceptibility in a Chinese Han population显示文摘 | Keren Wang Yuqin Ye Zheli Xu Xuan Zhang Zhifu Hou Youbin Cui Yan Song | 2010 | Cancer Genetics and Cytogenetics2010，，1： | 1 |
| 16 | Effect of Banana Stalk Organic Fertilizer on the Growth of Chinese Cabbage显示文摘In order to solve the problem of waste disposal after banana harvest,we use banana stalk to produce banana stalk organic fertilizer,through a plot experiment. We compare the influence of normal organic fertilizer( Wanlubao) and banana stalk organic fertilizer as base fertilizers on Chinese cabbage growth,and evaluate the economic benefits of banana stalk organic fertilizer. The results show that organic fertilizer has little effect on water content and nutrient content of Chinese cabbage,but has significant effect on plant height and leaf width. Using organic fertilizer can increase the production of Chinese cabbage by 22. 50%- 43. 10%. With 6750 kg / ha normal organic fertilizer,Chinese cabbage gets the highest yield,which reaches 30135 kg / ha,followed by the treatment of 6750 kg / ha stalk organic fertilizer. At farmers' conventional fertilization level( 4500 kg / ha),stalk organic fertilizer can increase the yield by more than 3. 50% in comparison with the normal organic fertilizer,and the economic benefit increases by 1800 yuan / ha. As a kind of banana waste cycling product,banana stalk organic fertilizer is of low cost and good effect,and can be used instead of normal organic fertilizer. | Zheli DING Lina HAN Zhiqiang JIN Bizun WANG Huicai ZENG Wei ZHENG Yingdui HE Xiaoping ZANG | 2016 | Asian Agricultural Research2016，8，7： | 0 |
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