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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Adaptive and Intelligent Digital Signal Processing for Improved Optical Interconnection显示文摘In recent years, explosively increasing data traffic has been boosting the con?tinuous demand of high speed optical interconnection inside or among data centers, high performance computers and even consumer electronics. To pursue the improved intercon?nection performance of capacity, energy efficiency and simplicity, effective approaches are demonstrated including particularly advanced digital signal processing (DSP) meth?ods. In this paper, we present a review about the enabling adaptive DSP methods for opti?cal interconnection applications, and a detailed summary of our recent and ongoing works in this field. In brief, our works focus on dealing with the specific issues for short-reach interconnection scenarios with adaptive operation, including signal-to-noise-ratio (SNR) limitation, level nonlinearity distortion, energy efficiency consideration and the de?cision precision. | SUN Lin DU Jiangbing HUA Feng TANG Ningfeng HE Zuyuan | 2020 | ZTE Communications2020，18，2： | 0 |
| 3 | A NEW TEXTURE IMAGE RETRIEVAL WAY显示文摘This paper proposes a new texture image retrieval method for the considering of the population search and random information exchange merits of evolving programming which can be used to optimize image feature vector extraction. The experimental results show that this way can efficiently improve the retrieval accuracy and realize fasttips with the advantage of evolving programming algorithm. | Wang Zuyuan Luo Lin Zhuang Zhenquan(Dept. of Electronic Science and Technology, University of Science & Technology of China, Hefei 230026) | 2001 | Journal of Electronics(China)2001，18，4： | 0 |
| 4 | Aromaticity Concerto in Polycyclic Conjugated Hydrocarbons:Fusion Pattern on Combined Aromaticity Strategy Leads to Distinctive Excited State Photophysics of Dinaphthopentalenes显示文摘Understanding the structure-property relationships in polycyclic conjugated hydrocarbons(PCHs)is crucial in controlling their electronic properties and developing new optically functional materials.Aromaticity is a fundamentally important and intriguing property of numerous organic chemical structures and has stimulated a myriad of experimental and theoretical investigations.Exploiting aromaticity rules for the rational design of optoelectronic materials with the desired photophysical characteristics is a challenging yet fascinating task.Herein we present an in-depth computational and spectroscopic study on the structure-property relationships of dinaphthopentalenes(DNPs).Results highlight that the different fusion patterns between 4nπand 4n+2πunits endow these PCHs with the tunable aromaticity in the ground state/excited state,which leads to the diverse electronic structures and consequently the distinctive excited state photophysics.Accordingly,we propose a combined aromaticity design strategy for rationally modulating and tailoring electronic and optical properties of PCH skeletons.These outcomes not only present a full picture of the excited state dynamics of the DNP system and afford a new class of efficient singlet fission-active materials but also provide some basic guidelines for exploiting aromaticity rules to design and develop new optical function materials. | Long Wang Lu Lin Teng-Shuo Zhang Shaoting Guo Zuyuan Liu Mengfan Zhang Senhao Wang Ganglong Cui Wei-Hai Fang Jun Zhu Hongbing Fu Jiannian Yao | 2023 | CCS Chemistry2023，5，10： | 0 |
| 5 | Extrahepatic organs in the development of non-alcoholic fatty liver disease in liver transplant patients显示文摘Background and Objective:Non-alcoholic fatty liver disease(NAFLD)is highly prevalent in patients who undergo liver transplantation(LT).Whereas there is huge data on NAFLD,little is known about NAFLD in LT.In this review,we aim to explore extrahepatic organs and their potential mechanisms in the development of NAFLD in LT patients and discuss current limitations in preclinical and clinical scenarios with suggestions for future study.Methods:The following keywords,such as NAFLD,NASH,liver transplant,therapy,pathogenesis and biomarkers,were set for literature retrieval.The articles which were published articles in English till 25th June 2020 in PubMed database were included,and there is no limit for the study design type.Key Content and Findings:Following LT,there are significant shifts in the microbiota and farnesoid X receptor may be a potential therapeutic target for NAFLD in LT settings.The roles of probiotics and diet on NALFD remain inconclusive in LT background.Nevertheless,the adipokines and cytokines disorder and local insulin resistance of adipose tissue may contribute to NAFLD process.Bariatric surgeries are promising in controlling de novo and recurrent NAFLD with significant reduction in abdominal adipose tissue,despite the optimal timing is inconclusive in LT cases.Furthermore,circumstantial evidence indicates that miRNA-33a may function as a mediator bridging sarcopenia and NAFLD of post-LT.β-Hydroxy-β-Methyl-Butyrate treatment could improve muscle status in graft recipients and shows protective potential for NAFLD in LT settings.Conclusions:Gut,adipose tissue and muscle are intricately intertwined in promoting NAFLD in LT cases.Further animal studies are needed to deepen our understanding of mechanisms in multi-organ crosstalk.High quality clinical trials are warrant for making guidelines and developing management strategies on NAFLD after LT. | Renyi Su Xuyong Wei Qiang Wei Di Lu Zuyuan Lin Shuo Wang Chuxiao Shao Xiao Xu | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 0 |
| 6 | Double-negative T cells:a promising avenue of adoptive cell therapy in transplant oncology显示文摘Tumor recurrence is one of the major life-threatening complications after liver transplantation for liver cancer.In addition to the common mechanisms underlying tumor recurrence,another unavoidable problem is that the immunosuppressive therapeutic regimen after transplantation could promote tumor recurrence and metastasis.Transplant oncology is an emerging field that addresses oncological challenges in transplantation.In this context,a comprehensive therapeutic management approach is required to balance the anti-tumor treatment and immunosuppressive status of recipients.Double-negative T cells(DNTs)are a cluster of heterogeneous cells mainly consisting of two subsets stratified by T cell receptor(TCR)type.Among them,TCRαβ^(+)DNTs are considered to induce immune suppression in immune-mediated diseases,while TCRγδ^(+)DNTs are widely recognized as tumor killers.As a composite cell therapy,healthy donor-derived DNTs can be propagated to therapeutic numbers in vitro and applied for the treatment of several malignancies without impairing normal tissues or being rejected by the host.In this work,we summarized the biological characteristics and functions of DNTs in oncology,immunology,and transplantation.Based on the multiple roles of DNTs,we propose that a new balance could be achieved in liver transplant oncology using them as an off-the-shelf adoptive cell therapy(ACT). | Zhihang HU Modan YANG Hao CHEN Chiyu HE Zuyuan LIN Xinyu YANG Huigang LI Wei SHEN Di LU Xiao XU | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，5： | 0 |
| 7 | TNFR2 is a potent prognostic biomarker for post-transplant lung metastasis in patients with hepatocellular carcinoma显示文摘Objective:Lung metastasis is a common and fatal complication of liver transplantation for hepatocellular carcinoma(HCC).The precise prediction of post-transplant lung metastasis in the early phase is of great value.Methods:The mRNA profiles of primary and paired lung metastatic lesions were analyzed to determine key signaling pathways.We enrolled 241 HCC patients who underwent liver transplantation from three centers.Tissue microarrays were used to evaluate the prognostic capacity of tumor necrosis factor(TNF),tumor necrosis factor receptor 1(TNFR1),and TNFR2,particularly for post-transplant lung metastasis.Results:Comparison of primary and lung metastatic lesions revealed that the TNF-dependent signaling pathway was related to lung metastasis of HCC.The expression of TNF was degraded in comparison to that in para-tumor tissues(P<0.001).The expression of key receptors in the TNF-dependent signaling pathway,TNFR1 and TNFR2,was higher in HCC tissues than in para-tumor tissues(P<0.001).TNF and TNFR1 showed no relationship with patients’outcomes,whereas elevated TNFR2 in tumor tissue was significantly associated with worse overall survival(OS)and increased recurrence risk(5-year OS rate:31.9%vs.62.5%,P<0.001).Notably,elevated TNFR2 levels were also associated with an increased risk of post-transplant lung metastasis(hazard ratio:1.146;P<0.001).Cox regression analysis revealed that TNFR2,Hangzhou criteria,age,and hepatitis B surface antigen were independent risk factors for post-transplant lung metastasis,and a novel nomogram was established accordingly.The nomogram achieved excellent prognostic efficiency(area under time-dependent receiver operating characteristic=0.755,concordance-index=0.779)and was superior to conventional models,such as the Milan criteria.Conclusions:TNFR2 is a potent prognostic biomarker for predicting post-transplant lung metastasis in patients with HCC.A nomogram incorporating TNFR2 deserves to be a helpful prognostic tool in liver transplantation for HCC. | Huigang Li Zuyuan Lin Jianyong Zhuo Modan Yang Wei Shen Zhihang Hu Yichen Ding Hao Chen Chiyu He Xinyu Yang Siyi Dong Xuyong Wei Beicheng Sun Shusen Zheng Ren Lang Di Lu Xiao Xu | 2023 | Chinese Journal of Cancer Research2023，35，1： | 0 |
| 8 | Targeting tumor microenvironment as a treatment strategy for hepatocellular carcinoma显示文摘Liver cancer was ranked the sixth most commonly diagnosed cancer with the fourth leading cause of cancer-related deaths worldwide in 2018(1).Notably,hepatocellular carcinoma(HCC)constitutes 75-85%among all the liver cancer cases,and ranks first morbidity and mortality of malignancies in Chinese males under 60.Due to hypervascularity in liver and high heterogeneity,HCC was regarded as an aggressive disease.Recent clinical trials focusing on resection and transplantation after targeted therapy for advanced HCC show encouraging results.However,the adjuvant therapy for patients with high risk of recurrence after surgery still raises attention.Currently,emerging evidence suggested that the crosstalk between tumor cells and the microenvironment plays a pivotal role in tumorigenesis and metastasis. | Zuyuan Lin Xiaonan Xiang Di Lu Xiao Xu | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 0 |
| 9 | Integrated sensing and communication in an optical fibre显示文摘The integration of high-speed optical communication and distributed sensing could bring intelligent functionalities to ubiquitous optical fibre networks,such as urban structure imaging,ocean seismic detection,and safety monitoring of underground embedded pipelines.This work demonstrates a scheme of integrated sensing and communication in an optical fibre(ISAC-OF)using the same wavelength channel for simultaneous data transmission and distributed vibration sensing.The scheme not only extends the intelligent functionality for optical fibre communication system,but also improves its transmission performance.A periodic linear frequency modulation(LFM)light is generated to act as the optical carrier and sensing probe in PAM4 signal transmission and phase-sensitive optical time-domain reflectometry(Φ-OTDR),respectively.After a 24.5 km fibre transmission,the forward PAM4 signal and the carriercorrespondence Rayleigh backscattering signal are detected and demodulated.Experimental results show that the integrated solution achieves better transmission performance(~1.3 dB improvement)and a larger launching power(7 dB enhancement)at a 56 Gbit/s bit rate compared to a conventional PAM4 signal transmission.Meanwhile,a 4m spatial resolution,4.32-nε/√Hz strain resolution,and over 21 kHz frequency response for the vibration sensing are obtained.The proposed solution offers a new path to further explore the potential of existing or future fibre-optic networks by the convergence of data transmission and status sensing.In addition,such a scheme of using shared spectrum in communication and distributed optical fibre sensing may be used to measure non-linear parameters in coherent optical communications,offering possible benefits for data transmission. | Haijun He Lin Jiang Yan Pan Anlin Yi Xihua Zou Wei Pan Alan E.Willner Xinyu Fan Zuyuan He Lianshan Yan | 2023 | Light(Science & Applications)2023，12，5： | 0 |
| 10 | FGF21-mediated autophagy:Remodeling the homeostasis in response to stress in liver diseases显示文摘Liver diseases are worldwide problems closely associated with various stresses,such as endoplasmic reticulum stress.The exact interplay between stress and liver diseases remains unclear.Autophagy plays an essential role in maintaining homeostasis,and recent studies indicate tight crosstalk between stress and autophagy in liver diseases.Once the bal-ance between damage and autophagy is broken,autophagy can no longer resist injury or main-tain homeostasis.In recent years,FGF21(fibroblast growth factor 21)-induced autophagy has attracted much attention.FGF21 is regarded as a stress hormone and can be up-regulated by an abundance of signaling pathways in response to stress.Also,increased FGF21 activates autophagy by a complicated signaling network in which mTOR plays a pivotal role.This review summarizes the mechanism of FGF21-mediated autophagy and its derived application in the defense of stress in liver diseases and offers a glimpse into its promising prospect in future clinical practice. | Wei Shen Modan Yang Hao Chen Chiy He Huigang Li Xinyu Yang Jianyong Zhuo Zuyuan Lin Zhihang Hu Di Lu Xiao Xu | 2024 | Genes & Diseases2024，11，3： | 0 |
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