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| 1 | Speckle tracking echocardiography to assess regional ventricular function in patients with apical hypertrophic cardiomyopathy显示文摘AIM To explore regional systolic strain of midwall and endocardial segments using speckle tracking echocardiography in patients with apical hypertrophic cardiomyopathy(HCM).METHODS We prospectively assessed 20 patients(mean age 53 ± 16 years,range:18-81 years,10 were male),with apical HCM. We measured global longitudinal peak systolic strain(GLPSS) in the midwall and endocardium of the left ventricle. RESULTS The diastolic thickness of the 4 apical segments was 16.25 ± 2.75 mm. All patients had a normal global systolicfunction with a fractional shortening of 50% ± 8%. In spite of supernormal left ventricular(LV) systolic function,midwall GLPSS was decreased in all patients,more in the apical(-7.3% ±-8.8%) than in basal segments(-15.5% ±-6.93%),while endocardial GLPPS was significantly greater and reached normal values(apical:-22.8% ±-7.8%,basal:-17.9% ±-7.5%). CONCLUSION This study shows that two-dimensional strain was decreased mainly confined to the mesocardium,while endocardium myocardial deformation was preserved in HCM and allowed to identify subclinical LV dysfunction. This transmural heterogeneity in systolic strain had not been previously described in HCM and could be explained by the distribution of myofibrillar disarray in deep myocardial areas. The clinical application of this novel finding may help further understanding of the pathophysiology of HCM. | María Cristina Saccheri Tomás Francisco Cianciulli Luis Alberto Morita Ricardo JoséMéndez Martín Alejandro Beck Juan Enrique Guerra Alberto Cozzarin Luciana Jimena Puente Lorena Romina Balletti Jorge Alberto Lax | 2017 | World Journal of Cardiology2017，9，4： | 7 |
| 2 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 3 | Lagrangean relaxation with clusters for point-feature cartographic label placement problems显示文摘 | Ribeiro G M Lorena L A N | 2008 | Computers & Operations Research2008，35，7： | 1 |
| 4 | A new mathematical model and a Lagrangean decomposition for the point-feature cartographic label placement problem显示文摘 | Mauri G R Ribeiro G M Lorena L A N | 2010 | Computers & Operations Research2010，37，12： | 1 |
| 5 | Orocecal transit time in patients with functional dyspepsia显示文摘 | Lorena S L de Souza Almeida J R Mesquita M A | 2002 | Journal of clinical gastroenterology2002，35，1： | 1 |
| 6 | A review on the combination of binary classifiers in multiclass problems 显示文摘 | LORENA A C DE CARVALHO C P L F GAMA J M P | 2008 | Artificial Intelligence Review2008，30，1234： | 1 |
| 7 | Nutrient composition and, identification/quantification of major phenolic compounds in Sarcocornia ambigua (Amaranthaceae) using HPLC–ESI-MS/MS显示文摘 | Renata Labronici Bertin Luciano Valdemiro Gonzaga Graciele da Silva Campelo Borges M?nia Stremel Azevedo Heloisa Fran?a Maltez Melina Heller Gustavo Amadeu Micke Lorena Benathar Ballod Tavares Roseane Fett | 2014 | Food Research International2014，，： | 1 |
| 8 | Anti-carbamylated protein antibodies in patients with ageing associated inflammatory chronic disorders显示文摘 | Marcos L Lorena A Michael M | 2015 | Rheumatology2015，11，： | 1 |
| 9 | Tabu Search Heuristic for Point-Feature Cartographic Label Placement 显示文摘 | Yamamoto M Camara G Lorena L A N | 2002 | GeoInformatica2002，6，1： | 1 |
| 10 | Hydrolysis of soybean isoflavones by Debaryomyces hansenii UFV-1 immobilised cells and free β-glucosidase显示文摘 | GABR1ELA P M A LORENA G D A L MAIRA A | 2014 | Food Chem2014，，146： | 1 |
| 11 | Prolactin (PRL) induction of cyclooxygenase 2 (COX2) expression and prostaglandin (PG) production in hamster Leydig cells显示文摘 | María Eugenia Matzkin Verónica Ambao Mónica Herminia Carino Soledad Paola Rossi Lorena González Daniel Turyn Stella Campo Ricardo Saúl Calandra Mónica Beatriz Frungieri | 2011 | Molecular and Cellular Endocrinology2011，，： | 1 |
| 12 | Tabu Search Heuristic for Point-Feature Cartographic Label Placement显示文摘 | Yamamoto M Camara G Lorena L A N | 2002 | GeoInformatica2002，6，1： | 1 |
| 13 | Soil nitrogen in relation to quality and decomposability of plant litter in the Patagonian Monte, Argentina 显示文摘 | Lorena C A Noe V D Victoria C M | 2005 | Plant Ecology2005，181，： | 1 |
| 14 | Xanthogranulomatous salpingitis :ease report and review of the literature显示文摘 | Franco V lorena A M Guarneri G | 1990 | Acta Eur Fertil1990，21，： | 1 |
| 15 | Direct evidence of nanowires formation from a Cu(I)coordination polymer显示文摘 | Eva M M Lorena W Pilar A O | 2008 | Chem Comm2008，8，： | 1 |
| 16 | Multiple DTI index analysis in normal aging, amnestic MCI and AD, Rela- tionship with neuropsychological performance 显示文摘 | BEATRIZ B EIDER M A LORENA R | 2012 | Neurobiol Aging2012，33，： | 1 |
| 17 | Tabu Search Heuristic for Point-Feature Cartographic Label Placement 显示文摘 | YAMAMOTO M CAMARA G LORENA L A N | 2002 | Geolnformatica2002，6，1： | 1 |
| 18 | Tabu Search Heuristic for Point-Feature Cartographic Label Placement显示文摘 | YAMAMOTO M CAMARA G LORENA L A N | 2002 | GeoInformatica2002，6，1： | 1 |
| 19 | Strong formulation for the spot 5 daily photograph scheduling problem显示文摘 | Ribeiro G M Constantino M F Lorena L A N | 2010 | Journal of Combinatorial Optimization2010，20，38： | 1 |
| 20 | A review on the combination of binary classifiers in multiclass problems显示文摘 | Lorena A C de Carvalho C P L F Gama J M P | 2008 | Artificial /ntelligence Review2008，30，14： | 1 |
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