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| 1 | Long-term results of subtotal colectomy with cecorectal anastomosis for isolated colonic inertia显示文摘AIM: To evaluate the results of sub total colectomy with cecorectal anastomosis (STC-CRA) for isolated colonic inertia (CI). METHODS: Fourteen patients (mean age 57.5 ± 16.5 year) underwent surgery for isolated CI between January 1986 and December 2002. The mean frequency of bowel motions with the aid of laxatives was 1.2 ± 0.6 per week. All subjects underwent colonoscopy, anorectal manometry, cinedefaecography and colonic transit time (CTT). CI was defined as diffuse markers delay on CTT without evidence of pelvic floor dysfunction. All patients underwent STC- CRA. Long-term follow-up was obtained prospectively by clinical visits between October 2005 and February 2006 at a mean of 10.5 ± 3.6 years (range 5-16 years) during which we considered the number of stool emissions, the presence of abdominal pain or digitations, the use of pain killers, laxatives and/or fibers. Patients were also asked if they were satisfied with the surgery. RESULTS: There was no postoperative mortality. Postoperative complications occurred in 21.4% (3/14). At the end of follow-up, bowel frequency was significantly (P < 0.05) increased to a mean of 4.8 ± 7.5 per day (range 1-30). One patient reported disabling diarrhea. Two patients used laxatives less than three times per month without complaining of what they called constipation. Overall, 78.5% of patients would have chosen surgery again if necessary. CONCLUSION: STC-CRA is feasible and safe in patientswith CI achieving 79% of success at a mean follow- up of 10.5 years. A prospective controlled evaluation is warranted to verify the advantages of this surgical approach in patients with CI. | Antonio Iannelli Thierry Piche Raffaella Dainese Pascal Fabiani Albert Tran Jean Mouiel Jean Gugenheim | 2007 | World Journal of Gastroenterology2007，13，18： | 14 |
| 2 | Dexmedetomidine Infusion for Analgesia and Prevention of Emergence Agitation in Children with Obstructive Sleep Apnea Syndrome Undergoing Tonsillectomy and Adenoidectomy显示文摘 | Anuradha Patel Melissa Davidson Minh C. J. Tran Huma Quraishi Catherine Schoenberg Manasee Sant Albert Lin Xiuru Sun | 2010 | Anesthesia & Analgesia2010，，4： | 2 |
| 3 | HCV/HIV co-infection, HCV viral load and mode of delivery: risk factors for mother-to-child transmission of hepatitis C virus?显示文摘 | Eugènia Mariné-Barjoan Alain Berrébi Valérie Giordanengo Sébastien Fournier Favre Hervé Haas Michel Moreigne Jacques Izopet Joelle Tricoire Albert Tran Christian Pradier André Bongain | 2007 | AIDS2007，，13： | 1 |
| 4 | M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease显示文摘 | Jinghong Wan Merieme Benkdane Fatima Teixeira‐Clerc Stéphanie Bonnafous Alexandre Louvet Fouad Lafdil Fran?oise Pecker Albert Tran Philippe Gual Ariane Mallat Sophie Lotersztajn Catherine Pavoine | 2014 | Hepatology2014，，1： | 1 |
| 5 | Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat depots显示文摘 | Anne-Sophie Schneck Antonio Iannelli Stéphanie Patouraux Déborah Rousseau Stéphanie Bonnafous Beatrice Bailly-Maitre Ophélia Thuc Carole Rovere Patricia Panaia-Ferrari Rodolphe Anty Albert Tran Philippe Gual Jean Gugenheim | 2014 | Surgical Endoscopy2014，，2： | 1 |
| 6 | Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients显示文摘 | Adeline Bertola Thomas Ciucci Déborah Rousseau Virginie Bourlier Carine Duffaut Stéphanie Bonnafous Claudine Blin-Wakkach Rodolphe Anty Antonio Iannelli Jean Gugenheim Albert Tran Anne Bouloumié Philippe Gual Abdelilah Wakkach | 2012 | Diabetes2012，，9： | 1 |
| 7 | Dexmedetomidine Infusion for Analgesia and Prevention of Emergence Agitation in Children with Obstructive Sleep Apnea Syndrome Undergoing Tonsillectomy and Adenoidectomy显示文摘 | Anuradha Patel Melissa Davidson Minh C. J. Tran Huma Quraishi Catherine Schoenberg Manasee Sant Albert Lin Xiuru Sun | 2010 | Anesthesia & Analgesia2010，，4： | 1 |
| 8 | Low incidence of spontaneous bacterial peritonitis in asymptomatic cirrhotic outpatients显示文摘AIM: To compare the incidence of spontaneous bacterial peritonitis in cirrhotic outpatients and inpatients undergoing therapeutic paracentesis METHODS: From January 1 to May 31, 2004, 1041 patients from 70 different hospitals underwent 2123 therapeutic abdominal paracentesis (AP) performed as a outpatient procedure in 355 and as inpatient procedure in 686 cases respectively. The following parameters were compared prospectively between outpatients and inpatients: spontaneous bacterial peritonitis (SBP) prevalence, age, gender, cause of cirrhosis, symptoms, score and grade according to Child-Pugh classification, cirrhosis complications, antibiotics treatment, serum creatinine, platelet count and ascitic protein concentration. RESULTS: SBP was observed in 91 patients. In the whole population the SBP prevalence was 8.7% (95%CI: 7.2-10.6) it was 11.7% (95%CI: 9.5-14.3) in inpatients and 3.1% (95%CI: 1.7-5.5) in outpatients (P < 0.00001). SBP prevalence was 8.3% (95%CI: 4.3-15.6) in symptomatic outpatients vs 1.2% (95%CI: 0.4-3.4) in asymptomatic outpatients (P < 0.002). Patients undergoing outpatient AP were significantly different from those undergoing inpatient AP; they were older (61.1 ± 11.1 years vs 59.4 ± 11.7 years; P = 0.028), cause of cirrhosis was less often alcohol (83 .7 vs 88.2%; P < 0.001), Child-Pugh score was lower (8.9 vs 10.1; P < 0.001) and more often B than C (63.7% vs 38%; P < 0.001). In addition, in outpatients the platelet count was higher (161 ± 93 Giga/L vs 143 ± 89 Giga/L; P = 0.003), serum total bilirubin concentration was lower (38.2 ± 60.7 μmol/L vs 96.3 ± 143.3 μmol/L; P < 0.0001), and ascitic protein concentration higher (17.9 ± 10.7 g/L vs 14.5 ± 10.9 g/L; P < 0.001) than in inpatients. CONCLUSION: In asymptomatic cirrhotic outpatients, the incidence of spontaneous bacterial peritonitis is low thus exploratory paracentesis could be avoided in these patients without significant risk. | Jean-Franois Cadranel Jean-Baptiste Nousbaum Christophe Bessaguet Pierre Nahon Eric Nguyen-Khac Richard Moreau Thierry Thévenot Christine Silvain Christophe Bureau Olivier Nouel Christophe Pilette Thierry Paupard Arnaud Pauwels Thierry Sapey Jean-Didier Grangé Albert Tran | 2013 | World Journal of Hepatology2013，5，3： | 1 |
| 9 | HCV/HIV co-infection, HCV viral load and mode of delivery: risk factors for mother-to-child transmission of hepatitis C virus?显示文摘 | Eugènia Mariné-Barjoan Alain Berrébi Valérie Giordanengo Sébastien Fournier Favre Hervé Haas Michel Moreigne Jacques Izopet Joelle Tricoire Albert Tran Christian Pradier André Bongain | 2007 | AIDS2007，，13： | 1 |
| 10 | Glucose intolerance and hypoadiponectinemia are already present in lean patients with chronic hepatitis C infected with genotype non-3 viruses显示文摘 | Rodolphe Anty Eve Gelsi Jean Giudicelli Eugenia Mariné-Barjoan Philippe Gual Sylvia Benzaken Marie-Christine Saint-Paul Jean Louis Sadoul Pierre Michel Huet Albert Tran | 2007 | European Journal of Gastroenterology & Hepatology2007，，8： | 1 |
| 11 | A single IL28B genotype SNP rs12979860 determination predicts treatment response in patients with chronic hepatitis C Genotype 1 virus显示文摘 | Philippe Halfon Marc Bourliere Denis Ouzan Yaakov Maor Christophe Renou Claire Wartelle Guillaume Pénaranda Albert Tran Danielle Botta Valérie Oules Paul Castellani Isabelle Portal Laurent Argiro Alain Dessein | 2011 | European Journal of Gastroenterology & Hepatology2011，，10： | 1 |
| 12 | HCV/HIV co-infection, HCV viral load and mode of delivery: risk factors for mother-to-child transmission of hepatitis C virus?显示文摘 | Eugènia Mariné-Barjoan Alain Berrébi Valérie Giordanengo Sébastien Fournier Favre Hervé Haas Michel Moreigne Jacques Izopet Joelle Tricoire Albert Tran Christian Pradier André Bongain | 2007 | AIDS2007，，13： | 1 |
| 13 | A single IL28B genotype SNP rs12979860 determination predicts treatment response in patients with chronic hepatitis C Genotype 1 virus显示文摘 | Philippe Halfon Marc Bourliere Denis Ouzan Yaakov Maor Christophe Renou Claire Wartelle Guillaume Pénaranda Albert Tran Danielle Botta Valérie Oules Paul Castellani Isabelle Portal Laurent Argiro Alain Dessein | 2011 | European Journal of Gastroenterology & Hepatology2011，，10： | 1 |
| 14 | Combustion-derived nano-particles: A review of their toxicology following inhalation exposure显示文摘 | Donaldson Ken Tran Lang Jimenez Luis Albert | 2005 | Particle andFibre Toxicology2005，2，1： | 1 |
| 15 | Tissue engineering using mesenchymal stem cells with periosteal wrap for bone defect repair in rabbits显示文摘Aim:Mesenchymal stem cells(MSCs)are an excellent potential source of cells for bone tissue engineering due to their excellent renewal ability and osteogenic differentiation capabilities.This study was designed to evaluate the bone formation properties of a demineralized cancellous bone scaffold seeded with MSCs,with or without periosteum,in a critical size bone defect model in rabbits.Methods:Rabbit culture-expanded bone marrow(BM)-MSCs were seeded onto a human demineralized cancellous bone(HDCB)scaffold.Bone defects measuring 15 mm in length were created in each radius.A total of 56 bone defects in 28 rabbits were randomly assigned to one of the 4 groups for scaffold implantation:Group 1:HDCB graft only;Group 2:periosteum-wrapped HDCB graft;Group 3:HDCB graft seeded with BM-MSCs and Group 4:periosteum-wrapped HDCB graft seeded with BM-MSCs.All rabbits were sacrificed 12 weeks after surgery for gross observation,radiological assessment,histological analyses and biomechanical measurements.Results:New bone(NB)formation and bone healing were successfully achieved,both radiologically and histologically,on demineralized cancellous bone graft seeded with BM-MSCs.Results were improved when BM-MSCs were associated with periosteum.Conclusion:This study demonstrates that repair of bone defects in a rabbit model can be achieved through bone grafting using BM-MSCs,implanted on a demineralized cancellous bone scaffold.The formation of NB was optimized when combined with the preservation of periosteum at the site of injury. | Trung-Hau LêThua Dang-Nhat Pham Khanh-Linh Lê Minh-Tuan Lê Quang-Ton-Quyen Nguyen Phan-Huy Nguyen Ngoc-Vu Tran Ngoc-Luong Nguyen Willy Boeckx Albert Demey | 2015 | Plastic and Aesthetic Research2015，2，1： | 0 |
| 16 | Second-line therapy for advanced hepatocellular carcinoma with regorafenib or cabozantinib:Multicenter French clinical experience in real-life after matching显示文摘BACKGROUND Starting a second-line systemic treatment for hepatocellular carcinoma(HCC)is a common situation.The only therapeutic options in France are two broadspectrum tyrosine kinase inhibitors(TKIs),regorafenib(REG)and cabozantinib(CBZ),but no comparative real-life studies are available.AIM To evaluate the progression-free survival(PFS)of patients treated with REG or CBZ,we investigated the disease control rate(DCR),overall survival(OS),and safety of both drugs.To identify the variables associated with disease progression over time.METHODS A retrospective multicenter study was performed on the clinical data of patients attending one of three referral centers(Avignon,Marseille,and Nice)between January 2017 and March 2021 using propensity score matching.PFS and OS were assessed using the Kaplan-Meier method.Multivariate analysis(MA)of progression risk factors over time was performed in matched-pair groups.RESULTS Fifty-eight patients 68(62-74)years old with HCC,Barcelona clinic liver cancer(BCLC)B/C(86%),Child-Pugh(CP)-A/B(24%)received REG for 3.4(1.4-10.5)mo as second-line therapy.Twentyeight patients 68(60-73)years,BCLC B/C(75%),CP-A/B(25%)received CBZ for 3.7(1.8-4.9)mo after first-line treatment with sorafenib[3(2-4)(CBZ)vs 4(2.9-11.8)mo(REG),P=0.0226].Twenty percent of patients received third-line therapy.After matching,PFS and DCR were not significantly different after a median follow-up of 6.2(2.7-11.7)mo(REG)vs 5.2(4-7.2)mo(CBZ),P=0.6925.There was no difference in grade 3/4 toxicities,dose reductions,or interruptions.The OS of CP-A patients was 8.3(5.2-24.8)vs 4.9(1.6-11.7)mo(CP-B),P=0.0468.The MA of risk factors for progression over time identified C-reactive protein(CRP)>10 mg/L,neutrophil-to-lymphocyte ratio(NLR)>3,and aspartate aminotransferase(AST)>45 IU as predictive factors.CONCLUSION This multicenter indirect comparative study found no significant difference in PFS between REG and CBZ as second-line therapy for advanced HCC.Elevated levels of inflammatory markers(CRP and NLR)and AST were associated with non-control of TKIs over time.A 2-mo online progression risk calculation is proposed. | Xavier Adhoute Marie De Matharel Laurent Mineur Guillaume Pénaranda Dann Ouizeman Clemence Toullec Albert Tran Paul Castellani Armelle Rollet Valérie Oules HervéPerrier Si Nafa Si Ahmed Marc Bourliere Rodolphe Anty | 2022 | World Journal of Gastrointestinal Oncology2022，14，8： | 0 |
| 17 | 肝内CD4^+淋巴细胞增高与慢性丙型肝炎病人的肝组织损伤显示文摘目的 该实验旨在研究慢性丙型肝炎病人周围血和肝内淋巴细胞各亚群变化与丙型肝炎病毒血症、肝脏组织病变活动指数等之间的关系。方法 采用流式细胞仪三色荧光标记单克隆抗体技术对慢性丙型肝炎病人和正常对照的周围血和肝内淋巴细胞各亚群进行了测定,同时应用逆转录—多聚酶链反应技术对丙型肝炎病毒血清浓度进行检测并进行了肝组织活检确定肝脏组织病变活动程度。结果 发现慢性丙型肝炎病人肝内CD4^+辅助淋巴细胞比例数显著高于正常对照(20.7±7.3%对10.2±4.6%,p=0.027),并与肝脏组织病变活动指数(Knodell score)呈显著正相关(r=0.48,p=0.004)。周围血淋巴细胞和肝内淋巴细胞亚群堤活性变化有很大不同,但该实验未发现周围血淋巴细胞与病变程度有任何相关。结论 提示机体的免疫反应特别是肝内的区域免疫反应的确在引起肝脏组织细胞损伤的过程中起重要作用,活性CD4^+辅助淋巴细胞可能通过正性调节CD8^+细胞毒性淋巴细胞在肝内造成肝脏组织细胞损伤。 | 杨光 杨黎红 Sylvia Benzakcn Alain Doglio Alain Bernard Patrick Rampal Albert Tran | 1999 | 实用肝脏病杂志1999，4，1： | 0 |
| 18 | Expected outcomes and patients’selection before chemoembolization—“Six-and-Twelve or Pre-TACE-Predict”scores may help clinicians:Real-life French cohorts results显示文摘BACKGROUND Careful selection of hepatocellular carcinoma(HCC)patients prior to chemoembolization treatment is a daily reality,and is even more necessary with new available therapeutic options in HCC.To propose two new models to better stratify patients and maximize clinical benefit:“6 and 12”and“pre/post-TACE-predict”(TACE,transarterial chemoembolization).METHODS We evaluated and compared their performance in predicting overall survival with other systems{Barcelona Clinic Liver Cancer(BCLC),Albumin-Bilirubin(ALBI)and NIACE[Number of tumor(s),Infiltrative HCC,alpha-fetoprotein,Child-Pugh(CP),and performance status]}in two HCC French cohorts of different stages enrolled between 2010 and 2018.RESULTS The cohorts included 324 patients classified as BCLC stages A/B(cohort 1)and 137 patients classified as BCLC stages B/C(cohort 2).The majority of the patients had cirrhosis with preserved liver function.“Pre-TACE-predict”and“6 and 12”models identified three distinct categories of patients exhibiting different prognosis in cohort 1.However,their prognostic value was no better than the BCLC system or NIACE score.Liver function based on CP and ALBI grades significantly impacted patient survival.Conversely,the“post-TACE-predict”model had a higher predictive value than other models.The stratification ability as well as predictive performance of these new models in an intermediate/advanced stage population was less efficient(cohort 2).CONCLUSION The newly proposed“Pre-TACE-predict”and“6 and 12”models offer an interesting stratification into three categories in a recommended TACE population,as they identify poor candidates,those with partial control and durable response.The models'contribution was reduced in a population with advanced stage HCCs. | Xavier Adhoute Edouard Larrey Rodolphe Anty Patrick Chevallier Guillaume Penaranda Albert Tran Jean-Pierre Bronowicki Jean-Luc Raoul Paul Castellani HervéPerrier Olivier Bayle Olivier Monnet Bernard Pol Marc Bourliere | 2021 | World Journal of Clinical Cases2021，9，18： | 0 |
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