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| 1 | Dual Functions of Microglia in Ischemic Stroke显示文摘Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia are the principal immune cells of the brain, and the first to respond to the pathophysiological changes induced by ischemic stroke. Traditionally, it has been thought that microglial activation is deleterious in ischemic stroke, and therapies to suppress it have been intensively explored. However,increasing evidence suggests that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia. Here, we comprehensively review the dual role of microglia during the different phases of ischemic stroke, and the possible mechanisms controlling the post-ischemic activity of microglia. In addition, we discuss the dynamic interactions between microglia and other cells, such as neurons, astrocytes, oligodendrocytes,and endothelial cells within the brain parenchyma and the neurovascular unit. | Chuan Qin Luo-Qi Zhou Xiao-Tong Ma Zi-Wei Hu Sheng Yang Man Chen Dale B. Bosco Long-Jun Wu Dai-Shi Tian | 2019 | Neuroscience Bulletin2019，35，5： | 64 |
| 2 | EGF promoter SNPs, plasma EGF levels and risk of breast cancer in Chinese women显示文摘 | Wang, Y. | 2008 | 南京医科大学学报(自然科学版)2008，28，12： | 32 |
| 3 | Common Genetic Variants in Pre-MicroRNAs Were Associated With Increased Risk of Breast Cancer in Chinese Women显示文摘 | Hu, Z. B. Liang, J. Wang, Z. W. Tian, T. Zhou, X. Y. Chen, J. P. Miao, R. F. Wang, Y. Wang, X. R. Shen, H. B. | 2009 | 南京医科大学学报(自然科学版)2009，29，4： | 29 |
| 4 | RHEOCASTING OF A356 ALLOY BY LOW SUPERHEAT POURING WITH A SHEARING FIELD显示文摘A novel semi-solid slurry-making process was developed, which was a controlled nucleation and growth technique using a specially designed rotational barrel. Experimental study was undertaken to investigate the effects of pouring temperature and rotation speed of barrel on the microstructure of A356 alloy. Localized rapid cooling, combined with vigorous mixing during the initial stage of solidification enhanced wall nucleation and nuclei survival. High nuclei density combined with a much gradual cooling afterwards led to the formation of the near-ideal semi-solid slurry under a large processing window for the pouring temperature. Primary phase presented in mean equivalent diameter of 50-70μm and shape factor of 0.812-0.847, and featured zero-entrapped eutectic. | H.M. Guo X.J. Yang B. Hu | 2006 | Acta Metallurgica Sinica(English Letters)2006，19，5： | 20 |
| 5 | PERSPECTIVES IN MECHANICS OF HETEROGENEOUS SOLIDS显示文摘The Microand Nano-mechanics Working Group of the Chinese Society of Theoretical and Applied Mechanics organized a forum to discuss the perspectives,trends,and directions in mechanics of heterogeneous materials in January 2010.The international journal,Acta Mechanica Solida Sinica,is devoted to all fields of solid mechanics and relevant disciplines in science,technology,and engineering,with a balanced coverage on analytical,experimental,numerical and applied investigations.On the occasion of the 30 th anniversary of Acta Mechanica Solida Sinica,its editor-in-chief,Professor Q.S.Zheng invited some of the forum participants to review the state-of-the-art of mechanics of heterogeneous solids,with a particular emphasis on the recent research development results of Chinese scientists.Their reviews are organized into five research areas as reported in different sections of this paper.§I firstly brings in focus on microand nano-mechanics,with regards to several selective topics,including multiscale coupled models and computational methods,nanocrystal superlattices,surface effects,micromechanical damage mechanics,and microstructural evolution of metals and shape memory alloys.§II shows discussions on multifield coupled mechanical phenomena,e.g.,multi-fields actuations of liquid crystal polymer networks,mechanical behavior of materials under radiations,and micromechanics of heterogeneous materials.In §III,we mainly address the multiscale mechanics of biological nanocomposites,biological adhesive surface mechanics,wetting and dewetting phenomena on microstructured solid surfaces.The phononic crystals and manipulation of elastic waves were elaborated in §IV.Finally,we conclude with a series of perspectives on solid mechanics.This review will set a primary goal of future science research and engineering application on solid mechanics with the effort of social and economic development. | C.Q. Chen J.Z. Cui H.L. Duan X.Q. Feng L.H. He G.K. Hu M.J. Huang Y.Z. Huo B.H. Ji B. Liu X.H. Peng H.J. Shi Q.P. Sun J.X. Wang Y.S. Wang H.P. Zhao Y.P. Zhao Q.S. Zheng W.N. Zou | 2011 | Acta Mechanica Solida Sinica2011，24，1： | 18 |
| 6 | Interactions of IL-12A and IL-12B Polymorphisms on the Risk of Cervical Cancer in Chinese Women显示文摘 | Chen, X. J. Han, S. P. Wang, S. N. Zhou, X. Y. Zhang, M. F. Dong, J. Shi, X. Y. Qian, N. F. Wang, X. R. Wei, Q. Y. Shen, H. B. Hu, Z.B. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 16 |
| 7 | First report of a novel abluminal groove filled biodegradable polymer rapamycin-eluting stent in de novo coronary artery disease: results of the first in man FIREHAWK trial显示文摘 | QIAN Jie XU Bo Alexandra J. Lansky YANG Yue-jin QIAO Shu-bin WU Yong-jian CHEN Jue HU Feng-huan YANG Wei-xian Gary S. Mintz Martin B. Leon GAO Run-lin | 2012 | Chinese Medical Journal2012，，6： | 14 |
| 8 | 从精准医学到精准公共卫生显示文摘精准医学是根据患者不同的基因型、代谢状态、生活方式及环境,为其制定最合理的治疗及预防方案。精准医学的特色包括在数据搜集阶段对可穿戴设备等新技术的应用,以及对组学数据和大数据分析方法的利用。将精准医学的概念推广到公共卫生领域,利用组学技术和大数据分析方法,研究基因与环境的交互作用,可以提高疾病风险预测的精度,并促进个体化且精准的膳食营养、生活方式干预和疾病预防,最终使更广泛的人群受益,并降低总体医疗费用。 | 王冬 Frank B. Hu | 2016 | 中华内分泌代谢杂志2016，32，9： | 9 |
| 9 | Variant alleles of TGFB1 and TGFBR2 are associated with a decreased risk of gastric cancer in a Chinese population显示文摘 | Jin, G. F. Wang, L. N. Chen, W. S. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Shen, J. Zhang, Z. F. Wang, X. R. Xul, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 7 |
| 10 | Variant genotypes and haplotypes of the epidermal growth factor gene promoter are associated with a decreased risk of gastric cancer in a high-risk Chinese population显示文摘 | Jin, G. F. Miao, R. F. Deng, Y. M. Hu, Z. B. Zhou, Y. Tan, Y. F. Wang, J. M. Hua, Z. L. Ding, W. L. Wang, L. Chen, W. S. Shen, J. Wang, X. R. Xu, Y. C. Shen, H. B. | 2007 | 南京医科大学学报(自然科学版)2007，27，10： | 7 |
| 11 | Phosphate limitation of phytoplankton growth in the Changjiang Estuary显示文摘Laboratory experiments of bioassay with Pltaeodaetytum tricornutum, Chatoceros didymus, Chaetoreros calcitraus and Heterogtoea sp. sampled from the Changjiang Estuary in spring and summer, 1986, indicated that both N and P limit phytoplankton growth in the medium with N : P ranged between 8-30, and N limits phytoplankton production in the medium with N: P<8, while P is the limitary nutrient in the N : P>30. Generally, N : P in the Changjiang Estuary waters is 2 times higher than Redfield ratio. The bioassay experiments with high N : P water samples collected from Changjiang Estuary show that phytoplankton production is limited by P. Phytopiankton appears to give priority to the uptake of P at all periods of time. And the optimum N:P for phytoplankton growth is determined to be 18. | Hu Minghui, Yang Yiping, Xu Chunling and P. J. Harrison Oceanography Department of Xiamen University, Xiamen, ChinaSub-bureau of East China Sea, State Oceanic Administration, Shanghai, ChinaOceanography Department, U. B. C. , Canada | 1990 | Acta Oceanologica Sinica1990，9，3： | 4 |
| 12 | RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes显示文摘开发或者激活(M2 ) 巨噬细胞显型是被小径和因素的过多并列地调整的一个复杂过程。这里,我们报导那 RBP-J,集成的 DNA 有约束力的蛋白质包括槽口小径从多重小径发信号,极其涉及 M2 巨噬细胞的极化。在在 myeloid 分隔空间的 RBP-J 缺乏的老鼠在 M2 极化的一个导致几丁质的模型在 vivo 展出了损害 M2 显型。与一致在里面 vivo 调查结果, M2 极化部分在包括 arginase 由 M2 受动器分子的一个子集的减少的表示示威了的 Rbpj 缺乏的巨噬细胞在 vitro 被损害 1。机能上地, myeloid Rbpj 缺乏包括嗜曙红血球的招募和 T 房间增长的抑制损害了 M2 受动器功能。一起,我们作为区别的一个必要管理者和或者激活的巨噬细胞的功能识别了 RBP-J。 | Julia Foldi Yingli Shang Baohong Zhao Lionel B. Ivashkiv Xiaoyu Hu | 2016 | Protein & Cell2016，7，3： | 3 |
| 13 | Forecasting with artificial neural networks:显示文摘 | Guoqiang Zhang B. Eddy Patuwo Michael Y. Hu | 1998 | International Journal of Forecasting1998，，1： | 3 |
| 14 | Metastatic Nonfunctioning Pancreatic Neuroendocrine Carcinoma to Liver: Surgical Treatment and Outcomes显示文摘 | Daniel Cusati Lizhi Zhang William S. Harmsen Amy Hu Michael B. Farnell David M. Nagorney John H. Donohue Florencia G. Que Kaye M. Reid-Lombardo Michael L. Kendrick | 2012 | Journal of the American College of Surgeons2012，，1： | 3 |
| 15 | A Predictive GIS Model for Potential Mapping of Copper, Lead, and Zinc in Langping Area, China显示文摘Mineral resource potential mapping is a complex analytical process,which requires the consideration and the inte-gration of a number of spatial evidences like geological,geomorphological,and wall rock alteration.The aim of this paper is to establish mineral exploration model for copper,lead,and zinc in Lanping basin area using the capability of analytical tools of Geographic Information System(GIS) and remote sensing data to generate maps showing favorable mineralized area.The geo-exploration dataset used for the research includes copper,lead,and zinc deposits,geological maps,topographic maps,structural maps,and ETM+ imagery.Geological features indicative of potential copper,lead,and zinc were extracted from the datasets input in the predictive model.The method of weights of evidence modeling is a probability-based technique for generating mineral potential maps using the spatial distribution of indicative features with respect to the known mineral occur-rences.The method of weights of evidence probabilistic modeling provides a quantitative method for delineating areas with potential of copper,lead,and zinc mineral deposits in the Lanping Basin area.weights(W+,W-) and contrast(C=(W+) -(W-) ) calculations guide the data-driven modeling.The four most important spatial features for exploration guide for copper,lead,and zinc mineralization hosted in the Lanping Basin area are alteration zones,faults,host rocks,and lineaments.The host rocks and deep faults have the strongest spatial association with the known copper,lead,and zinc deposits.The hydrothermal alteration zones have the moderate spatial association with the copper,lead,and zinc deposits.The predicted high-favorability zones do not show the strong affinity with lineaments.The distribution of 22(copper,lead,and zinc) occur-rences in the Lanping Basin was examined in terms of spatial association with various geological phenomena.The analysis of these relationships using GIS and weights of evidence modeling has predicted areas of high and moderate mineral potential,where a little or no mining activities exist. | Tarik. B. Benomar HU Guangdao BIAN Fuling | 2009 | Geo-Spatial Information Science2009，12，4： | 3 |
| 16 | Highly sensitive phototransistors based on twodimensional GaTe nanosheets with direct bandgap显示文摘 | Pingan Hu Jia Zhang Mina Yoon Xiao-Fen Qiao Xin Zhang Wei Feng Pingheng Tan Wei Zheng Jingjing Liu Xiaona Wang Juan C. Idrobo David B. Geohegan Kai Xiao | 2014 | Nano Research2014，7，5： | 3 |
| 17 | Soil microbial biomass and activity in organic tomato farming systems: Effects of organic inputs and straw mulching显示文摘 | Cong Tu Jean B. Ristaino Shuijin Hu | 2005 | Soil Biology and Biochemistry2005，，2： | 2 |
| 18 | Nonvolatile waveguide transmission tuning with electrically-driven ultra-small GST phase-change material显示文摘Low-power reconfigurable optical circuits are highly demanded to satisfy a variety of different applications. Conventional electro-optic and thermo-optic refractive index tuning methods in silicon photonics are not suitable for reconfiguration of optical circuits due to their high static power consumption and volatility. We propose and demonstrate a nonvolatile tuning method by utilizing the reversible phase change property of GST integrated on top of the silicon waveguide. The phase change is enabled by applying electrical pulses to the lm-sized GST active region in a sandwich structure. The experimental results show that the optical transmission of the silicon waveguide can be tuned by controlling the phase state of GST. | Hanyu Zhang Linjie Zhou Jian Xu Ningning Wang Hao Hu Liangjun Lu B. M. A. Rahman Jianping Chen | 2019 | Science Bulletin2019，64，11： | 2 |
| 19 | ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-experienced Patients with HCV Genotype 1b Infection显示文摘 | Pietro Andreone Massimo G. Colombo Jeffrey V. Enejosa Iftihar Koksal Peter Ferenci Andreas Maieron Beat Müllhaupt Yves Horsmans Ola Weiland Henk W. Reesink Lino Rodrigues Yiran B. Hu Thomas Podsadecki Barry Bernstein | 2014 | Gastroenterology2014，，： | 2 |
| 20 | Size-resolved aerosol water-soluble ionic compositions in the summer of Beijing: implication of regional secondary formation显示文摘 | Guo S. Hu M. Wang Z. B. Slanina J. Zhao Y. L | 2010 | Atmospheric Chemistry and Physics2010，，188： | 2 |
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