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| 1 | 这项临床试验完成注册了吗?——国际医学杂志编辑委员会声明显示文摘 | Catherine De Angelis Jeffrey M. Drazen Frank A. Frizelle Charlotte Haug John Hoey Richard Horton Sheldon Kotzin Christine Laine Ana Marusic A. John P.M. Overbeke Torben V.Schroeder Harold C. Sox Martin B. Van Der Weyden 刁骧(译) 孙丁(审校) 秦莉(审校) | 2006 | 中国循证医学杂志2006，6，4： | 11 |
| 2 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 3 | Regulation of epithelium-specific Ets-like factors ESE-1 and ESE-3 in airway epithelial cells: potential roles in airway inflammation显示文摘航线发炎是许多呼吸障碍的特点,例如气喘和膀胱的纤维变性。在发炎触发的航线基因表示的变化在这些疾病的致病起一个关键作用。基因连接研究建议 ESE-2 和 ESE-3,编码上皮特定的 Ets-domain-containing 抄写因素,是候选人气喘危险性基因。我们这里报导 et 家庭抄写因素 ESE-1 的另一个成员的表示,以及 ESE-3,起来在支气管的上皮的房间线由煽动性的 cytokines interleukin-1beta (IL-1beta ) 和肿瘤坏死 factor-alpha (TNF-alpha ) 调整了。有 IL-1beta 和 TNF-alpha 的这些房间的处理为 ESE-1 和 ESE-3 导致了信使 rna 表示的戏剧的增加。我们证明导致的表示被抄写因素 NF-kappaB 的激活调停。我们描绘了 ESE-1 和 ESE-3 倡导者并且识别了为导致 cytokine 的表达式被要求的 NF-kappaB 有约束力的序列。另外,我们也表明那 ESE-1 在上面调整 ESE-3 表示, down 由 cytokines 调整它的自己的正式就职。最后,我们在 Elf3 显示出那(对人的 ESE-1 相应) 猛烈老鼠,煽动性的 cytokine interleukin-6 (IL-6 ) 的表示是调整的 down。我们的调查结果建议 ESE-1 和 ESE-3 在航线发炎起一个重要作用。 | Jing Wu Rongqi Duan Huibi Cao Deborah Field Catherine M Newnham David R Koehler Noe Zamel Melanie A Pritchard Paul Hertzog Martin Post A Keith Tanswell Jim Hu | 2008 | Cell Research2008，18，6： | 6 |
| 4 | Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice显示文摘 | Tiphaine Le Roy Marta Llopis Patricia Lepage Aurélia Bruneau Sylvie Rabot Claudia Bevilacqua Patrice Martin Catherine Philippe Francine Walker André Bado Gabriel Perlemuter Anne-Marie Cassard-Doulcier Philippe Gérard | 2013 | Gut2013，，12： | 3 |
| 5 | Characterization of artificial spherical particles for DEM validation studies显示文摘This paper describes a study in which advanced particle-scale characterization was carried out on spherical particles that can be used in experimental tests to validate discrete element method (DEM) simulations. Two types of particle, alkaline and borosilicate glass beads, made from two different materials, were considered. The particle shape, stiffness, contact friction properties and surface roughness were measured. The influences of hardness and roughness on the mechanical response of the particles were carefully considered. Compared to the alkaline beads, the borosilicate beads were more spherical and more uniform in size, and they exhibited mechanical characteristics closer to natural quartz sand. While only two material types were studied, the work has the broader implication as a methodology for selecting particles suitable for use in DEM studies and the key parameters that should be considered in the selection process are highlighted. | Ignazio Cavarretta Catherine O'Sullivan Erdin Ibraim Martin Lings Simon Hamlin David Muir Wood | 2012 | Particuology2012，10，2： | 3 |
| 6 | Mutational Processes Molding the Genomes of 21 Breast Cancers显示文摘 | Serena Nik-Zainal Ludmil B. Alexandrov David C. Wedge Peter Van Loo Christopher D. Greenman Keiran Raine David Jones Jonathan Hinton John Marshall Lucy A. Stebbings Andrew Menzies Sancha Martin Kenric Leung Lina Chen Catherine Leroy Manasa Ramakrishna Ric | 2012 | Cell2012，，5： | 2 |
| 7 | 多病并存的多重挑战 这个时代已经到来——关注日益增长的脆弱人群的需求显示文摘多病并存(或称多重病)现象在初级卫生保健中已不是个别现象。最近在加拿大魁北克省沙格奈河地区进行的一项有21个社区医院参加的研究表明,在18~44岁组多重病的患病率为69%,45~64岁组为93%,65岁以上组达到98%,患慢性病的个数在年轻组为2.8而在老年组升至6.4。其他国家也报告了类似的疾病负担状况,如美国多病并存的患者人数将由2000年的6000万上升到2020年的8100万。 | Martin Fortin Hassan Soubhi Catherine Hudon Elizabeth A Bayliss Marian van den Akker 赛晓勇 | 2007 | 英国医学杂志中文版2007，10，5： | 2 |
| 8 | Preoperative serum YKL-40 is a marker for detection and prognosis of endometrial cancer显示文摘 | Catherine S.M. Diefenbach Zharna Shah Alexia Iasonos Richard R. Barakat Douglas A. Levine Carol Aghajanian Paul Sabbatini Martee L. Hensley Jason Konner William Tew David Spriggs Martin Fleisher Howard Thaler Jakob Dupont | 2006 | Gynecologic Oncology2006，，： | 2 |
| 9 | Molting cycle-dependent expression of CYP4C15, a cytochrome P450 enzyme putatively involved in ecdysteroidogenesis in the crayfish, Orconectes limosus显示文摘 | Santiago Aragon Stéphanie Claudinot Catherine Blais Martine Ma??bèche Chantal Dauphin-Villemant | 2002 | Insect Biochemistry and Molecular Biology2002，，2： | 1 |
| 10 | More rumination and less effective emotion regulation in previously depressed women with preserved executive functions显示文摘 | Martin Aker Catherine Harmer Nils Inge Landr | 2014 | BMC Psychiatry2014，14，： | 1 |
| 11 | Single risk fact or interventions to promote physical activity among patients with chronic disease显示文摘 | Catherine H Martin F Hassan S | 2008 | Cana Fami Physiei2008，54，8： | 1 |
| 12 | Association Between Cardiovascular Autonomic Neuropathy and Left Ventricular Dysfunction in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study显示文摘 | Rodica Pop-Busui Patricia A. Cleary Barbara H. Braffett Catherine L. Martin William H. Herman Phillip A. Low Joao A.C. Lima David A. Bluemke | 2012 | Journal of the American College of Cardiology2012，，： | 1 |
| 13 | Comparison of fluconazole with oral polyenes in the prevention of fungal infections in neutropenic patients显示文摘 | Thomas Egger Alois Gratwohl André Tichelli Mario Uhr Christine Stebler Gysi Jakob Passweg Miklos Pless Martin Wernli Ulrich Buser Jürg Wuhrmann R.N. Reno Frei Catherine Nissen Bruno Speck | 1995 | Supportive Care in Cancer1995，，2： | 1 |
| 14 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 15 | Reduced expression of lamin A/C results in modified cell signaling withchangesinexpression of and metabolism coupled structural proteins显示文摘 | Chen Songbi Martin Catherine Maya-Mendoza Apoli- nat | 2009 | Journal of Proteome Research2009，8，11： | 1 |
| 16 | The Export Effect of Immigration into the USA 显示文摘 | CO CATHERINE Y Euzent Patricia Martin Thomas | 2004 | Applied Economics2004，36，6： | 1 |
| 17 | Liver resection (and associated extrahepatic resections) for metastatic well-differentiated endocrine tumors: A 15-year single center prospective study显示文摘 | Dominique Elias Philippe Lasser Michel Ducreux Pierre Duvillard Jean-Francois Ouellet Clarice Dromain Martin Schlumberger Marc Pocard Valérie Boige Catherine Miquel Eric Baudin | 2003 | Surgery2003，，4： | 1 |
| 18 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 19 | A new measure of acute physiological derangement for patients with exacerbations of obstructive airways disease: The COPD and Asthma Physiology Score显示文摘 | Martin J. Wildman David A. Harrison Catherine A. Welch Colin Sanderson | 2007 | Respiratory Medicine2007，，9： | 1 |
| 20 | Genome-wide differences in hepatitis C-vs alcoholism-associated hepatocellular carcinoma显示文摘AIM:To look at a comprehensive picture of etiology- dependent gene abnormalities in hepatocellular carcinoma in Western Europe. METHODS:With a liver-oriented microarray,transcript levels were compared in nodules and cirrhosis from a training set of patients with hepatocellular carcinoma (alcoholism,12;hepatitis C,10)and 5 controls.Loose or tight selection of informative transcripts with an abnormal abundance was statistically valid and the tightly selected transcripts were next quantified by qRTPCR in the nodules from our training set(12+10) and a test set(6+7). RESULTS:A selection of 475 transcripts pointed to significant gene over-representation on chromosome 8 (alcoholism)or-2(hepatitis C)and ontology indicated a predominant inflammatory response(alcoholism)or changes in cell cycle regulation,transcription factors and interferon responsiveness(hepatitis C).A stringent selection of 23 transcripts whose differences betweenetiologies were significant in nodules but not in cirrhotic tissue indicated that the above dysregulations take place in tumor but not in the surrounding cirrhosis.These 23 transcripts separated our test set according to etiologies. The inflammation-associated transcripts pointed to limited alterations of free iron metabolism in alcoholic vs hepatitis C tumors. CONCLUSION:Etiology-specific abnormalities(chromo- some preference;differences in transcriptomes and related functions)have been identified in hepatocellular carcinoma driven by alcoholism or hepatitis C.This may open novel avenues for differential therapies in this disease. | Céline Derambure Cédric Coulouarn Frédérique Caillot Romain Daveau Martine Hiron Michel Scotte Arnaud Franois Celia Duclos Odile Goria Marie Gueudin Catherine Cavard Benoit Terris Maryvonne Daveau Jean-Philippe Salier | 2008 | World Journal of Gastroenterology2008，14，11： | 1 |
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