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| 1 | Propofol Attenuates a-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke显示文摘a-Synuclein is a soluble monomer abundant in the central nervous system. Aggregates of a-synuclein,consisting of higher-level oligomers and insoluble fibrils,have been observed in many chronic neurological diseases and are implicated in neurotoxicity and neurodegeneration.a-Synuclein has recently been shown to aggregate following acute ischemic stroke, exacerbating neuronal damage.Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke. While propofol has demonstrated neuroprotective properties following brain injury, the mechanism of protection in the setting of ischemic stroke is unclear. In this study, propofol administration significantly reduced the neurotoxic aggregation of a-synuclein, decreased the infarct area, and attenuated the neurological deficits after ischemic stroke in a mouse model. We then demonstrated that the propofol-induced reduction of a-synuclein aggregation was associated with increased mammalian target of rapamycin/ribosomal protein S6 kinase beta-1 signaling pathway activity and reduction of the excessive autophagy occurring after acute ischemic stroke. | Yuzhu Wang Dan Tian Changwei Wei Victoria Cui Huan Wang Yanbing Zhu Anshi Wu Yun Yue | 2020 | Neuroscience Bulletin2020，36，3： | 14 |
| 2 | Modeling permafrost properties in the Qinghai-Xizang(Tibet) Plateau显示文摘Water and heat dynamics in the active layer at a monitoring site in the Tanggula Mountains, located in the permafrost region of the Qinghai-Xizang(Tibet) Plateau(QXP), were studied using the physical-process-based COUPMODEL model, including the interaction between soil temperature and moisture under freeze-thaw cycles. Meteorological, ground temperature and moisture data from different depths within the active layer were used to calibrate and validate the model. The results indicate that the calibrated model satisfactorily simulates the soil temperatures from the top to the bottom of the soil layers as well as the moisture content of the active layer in permafrost regions. The simulated soil heat flux at depths of 0 to 20 cm was consistent with the monitoring data, and the simulations of the radiation balance components were reasonable. Energy consumed for phase change was estimated from the simulated ice content during the freeze/thaw processes from 2007 to 2008. Using this model, the active layer thickness and the energy consumed for phase change were predicted for future climate warming scenarios. The model predicts an increase of the active layer thickness from the current 330 cm to approximately 350–390 cm as a result of a 1–2°C warming. However, the effect active layer thickness of more precipitation is limited when the precipitation is increased by 20%–50%. The COUPMODEL provides a useful tool for predicting and understanding the fate of permafrost in the QXP under a warming climate. | HU GuoJie ZHAO Lin WU XiaoDong LI Ren WU TongHua XIE ChangWei PANG QiangQiang XIAO Yao LI WangPing QIAO YongPing SHI JianZong | 2015 | Science China Earth Sciences2015，58，12： | 7 |
| 3 | Changes in the Thermal and Hydraulic Regime within the Active Layer in the Qinghai-Tibet Plateau显示文摘The change trends of air temperature,precipitation and evaporation from 1999 to 2008 shows that the climate in the Qinghai-Tibet Plateau permafrost region had become warmer.The analysis of the systematic active-layer data monitoring network along the Qinghai-Tibet Highway indicated that the active-layer thickness had been increasing and the soil temperature was rising.The soil temperature was rising in winter but not at the end of spring or during the entire summer.With thickening and warming of the active layer,the liquid water content of the active layer had an obvious downward migration and liquid water content in the top horizons decreased,but in the deeper horizons it increased. | XIE Changwei ZHAO Lin WU Tonghua DONG Xicheng | 2012 | Journal of Mountain Science2012，9，4： | 7 |
| 4 | Efficacy and advantages of modified Traditional Chinese Medicine treatments based on'kidney reinforcing'for chronic aplastic ane-mia:a randomized controlled clinical trial显示文摘OBJECTIVE:To compare the efficacy of modified treatments based on 'kidney reinforcing' in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),'kidney reinforcing and Qi tonifying'(KQ),and 'kidney reinforcing and blood circulation invigorating'(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery. | Wu Dijiong Shen Yiping Ye Baodong Fang Bingmu Lin Shengyun Chen Zhilu Jiang Huifang Feng Changwei He Lüyuan Gao Yanting Liu Yonglin Liu Yonghua Zhu Jiajia Wu Liqiang Shao Keding Zhou Yuhong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 6 |
| 5 | An analytical model for estimating soil temperature profiles on the Qinghai-Tibet Plateau of China显示文摘Soil temperature is a key variable in the control of underground hydro-thermal processes. To estimate soil temperature more accurately, this study proposed a solution method of the heat conduction equation of soil temperature(improved heat conduction model) by applying boundary conditions that incorporate the annual and diurnal variations of soil surface temperature and the temporal variation of daily temperature amplitude, as well as the temperature difference between two soil layers in the Tanggula observation site of the Qinghai-Tibet Plateau of China. We employed both the improved heat conduction model and the classical heat conduction model to fit soil temperature by using the 5 cm soil layer as the upper boundary for soil depth. The results indicated that the daily soil temperature amplitude can be better described by the sinusoidal function in the improved model, which then yielded more accurate soil temperature simulating effect at the depth of 5 cm. The simulated soil temperature values generated by the improved model and classical heat conduction model were then compared to the observed soil temperature values at different soil depths. Statistical analyses of the root mean square error(RMSE), the normalized standard error(NSEE) and the bias demonstrated that the improved model showed higher accuracy, and the average values of RMSE, bias and NSEE at the soil depth of 10–105 cm were 1.41°C, 1.15°C and 22.40%, respectively. These results indicated that the improved heat conduction model can better estimate soil temperature profiles compared to the traditional model. | HU Guojie ZHAO Lin WU Xiaodong LI Ren WU Tonghua XIE Changwei QIAO Yongping SHI Jianzong CHENG Guodong | 2016 | Journal of Arid Land2016，8，2： | 4 |
| 6 | Morphological and physiological analysis of narrow and striped leaf 1(nsl1) mutant of rice(Oryza sativa L.) and the gene mapping显示文摘The shape and color of rice leaves are important agronomic traits that directly influence the proportion of sunlight energy utilization and ultimately affect the yield and quality.A new mutant exhibiting stable inheritance was identified as derived from ethyl methane sulfonate(EMS)-treated restorer Jinhui 10,tentatively named as narrow and striped leaf 1(nsl1).The nsl1 displayed pale white leaves at the seeding stage and then white striped leaves in parallel to the main vein at the jointing stage.Meanwhile,its leaf blades are significantly narrower than the control group of Jinhui 10.The chloroplast structures of cells in the white striped area of the nsl1 mutant break down,and the photosynthetic pigments are significantly lower than that of the wild type.Moreover,fluorescence parameters,such as F0,F v/F m,U psII,qp,and ETR,in the nsl1 mutant are significantly lower than those of the wild type,and the photosynthetic efficiency is also significantly decreased.These changes in leaf color and shape,together with physiological changes in the nsl1,result in smaller plant height and a decrease in the most important agronomic traits,such as the number of grains per panicle,grain weight,etc.Genetic analysis shows that the narrow and striped traits of the nsl1 mutant are controlled by a single recessive nuclear gene,which is located between InDel 16and InDel 12 in chromosome 3.The physical distance is204 kb.So far,no similar genes of such leaf color and shape in this area have been reported.This study has laid a solid foundation for the gene cloning and function analysis of NSL1. | Fangming Zhao Yong Zhang Yanru Wu Tongming Wang Ling Ma Zhenglin Yang Xia Wei Xianchun Sang Yinghua Ling Nan Wang Changwei Zhang Guanghua He | 2014 | Chinese Science Bulletin2014，59，9： | 3 |
| 7 | Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke显示文摘Dear Editor,Emergency intravascular thrombectomy is the best treatment for acute ischemic stroke [1]. However, it is controversial whether the use of general anesthesia during emergency intravascular thrombectomy affects patient recovery. | Yuzhu Wang Dan Tian Yushang Zhao Mengyao Qu Yuhualei Pan Changwei Wei Yanbing Zhu Anshi Wu | 2021 | Neuroscience Bulletin2021，37，5： | 3 |
| 8 | Multimorphism and gap opening of charge-density-wave phases in monolayer VTe2显示文摘Vanadium dichalcogenides have attracted increasing interests for the charge density wave phenomena and possible ferromagnetism.Here,we report on the multiphase behavior and gap opening in monolayer VTe2 grown by molecular beam epitaxy.Scanning tunneling microscopy(STM)and spectroscopy study revealed the(4×4)metallic and gapped(2√3×2√3)charge-density wave(CDW)phases with an energy gap of≈40 meV.Through the in-plane condensation of vanadium atoms,the typical star-of-David clusters and truncated triangle-shaped clusters are formed in the(4×4)and(2√3×2√3)phases respectively,resulting in different surface morphologies and electronic structures as confirmed by density functional theory(DFT)calculations with on-site Coulomb repulsion.The CDW-driven reorganization of the atomic structure weakens the ferromagnetic superexchange coupling and strengthens the antiferromagnetic exchange coupling on the contrary,suppressing the long-range magnetic order in monolayer VTe2.The electron correlation is found to be important to explain the gap opening in the(2√3×2√3)phase. | Meizhuang Liu Changwei Wu Zizhao Liu Zhiqiang Wang Dao-Xin Yao Dingyong Zhong | 2020 | Nano Research2020，13，6： | 2 |
| 9 | High-temperature oxidation behavior of SiBN fibers in air显示文摘SiBN fibers are one of the most admirable microwave-transparent reinforced materials for high Mach number aircrafts.Currently,the detailed high-temperature oxidation behavior of SiBN fibers has not been studied yet.In this work,we studied the high-temperature oxidation behavior of SiBN fibers with different boron contents at the temperature range of 1000-1400℃in air.SiBN fibers started to be oxidized at 1100℃,with Si_(3)N_(4) and BN phase oxidized to SiO2 and B_(2)O_(3),respectively.Due to the gasification and the escape of molten B_(2)O_(3) at high temperatures,amorphous SiO_(2) could be remained at the fiber surface.As the fiber further oxidized,the molten B_(2)O_(3) at the inside may infiltrate into the fiber interior to react with Si_(3)N_(4),causing the precipitation of hexagonal boron nitride(h-BN)nanoparticles and the formation of SiO_(2)/BN layer.Finally,complex oxidation layers with two distinct concentric sublayers accompanied with two transition sublayers could be formed after the oxidizing treatment. | Xin LONG Zhenyu WU Changwei SHAO Xiaozhou WANG Yingde WANG | 2021 | Journal of Advanced Ceramics2021，10，4： | 2 |
| 10 | Structure and luminescence properties of SrAl 2 O 4 :Eu 2+ , Dy 3+ by Ba 2+ and Ca 2+ co-doping显示文摘 | Wei Xie Jun Quan Haoyi Wu Lexi Shao Changwei Zou Jun Zhang Xiaoyu Shi Yinhai Wang | 2011 | Journal of Alloys and Compounds2011，，： | 1 |
| 11 | DNA Self‐Assembly of Targeted Near‐Infrared‐Responsive Gold Nanoparticles for Cancer Thermo‐Chemotherapy显示文摘 | Zeyu Xiao Changwei Ji Jinjun Shi Eric M. Pridgen Jillian Frieder Jun Wu Omid C. Farokhzad | 2012 | Angew Chem Int Ed2012，，47： | 1 |
| 12 | Comparison and validation of SRTM and ASTER GDEM for a subtropical landscape in Southeastern China显示文摘This paper evaluates the quality characteristics of existing versions of 3-arc-second SRTM and 1-arc-second GDEM over Anji County,Zhejiang,China using reference elevations from a high-quality 1:10 k topographic map.Results show that SRTM has higher accuracy(RMSE=12.44 m)than GDEM(RMSE=14.20 m for Version 1,12.76 m for Version 2);however,unsatisfactory void filling and an overall 1/2 pixel shift exits in SRTM version 4.1.Although spurious elevations over omitted water bodies still persist,GDEM Version 2 demonstrated significant improvement over Version 1.Accuracies of both SRTM and GDEM decrease on steeper slopes.Aspect also influences both the magnitude and the sign of errors.DEM accuracy in non-forested areas is considerably higher than that in forested areas.SRTM version 4.1 and GDEM version 2 possessed actual spatial resolutions of 90 m,despite both of them failed to match their nominal accuracies.SRTM Version 4.1 could be the first choice,while ASTER GDEM Version 2 would be a good alternative for areas where extensive voids exist in SRTM. | Changwei Jing Ashton Shortridge Shengpan Lin Jiaping Wu | 2014 | International Journal of Digital Earth2014，7，12： | 1 |
| 13 | Modeling of hemophilia A using patient-specific induced pluripotent stem cells derived from urine cells显示文摘 | Bei Jia Shen Chen Zhiju Zhao Pengfei Liu Jinglei Cai Dajiang Qin Juan Du Changwei Wu Qianyu Chen Xiujuan Cai Hui Zhang Yanhong Yu Duanqing Pei Mei Zhong Guangjin Pan | 2014 | Life Sciences2014，，： | 1 |
| 14 | Polar or nonpolar?That is not the question for perovskite solar cells显示文摘Perovskite solar cells(PSC)are promising next generation photovoltaic technologies,and there is considerable interest in the role of possible polarization of organic-inorganic halide perovskites(OIHPs)in photovoltaic conversion.The polarity of OIHPs is still hotly debated,however.In this review,we examine recent literature on the polarity of OIHPs from both theoretical and experimental points of view,and argue that they can be both polar and nonpolar,depending on composition,processing and environment.Implications of OIHP polarity to photovoltaic conversion are also discussed,and new insights gained through research efforts.In the future,integration of a local scanning probe with global macroscopic measurements in situ will provide invaluable microscopic insight into the intriguing macroscopic phenomena,while synchrotron diffractions and scanning transmission electron microscopy on more stable samples may ultimately settle the debate. | Boyuan Huang Zhenghao Liu Changwei Wu Yuan Zhang Jinjin Zhao Xiao Wang Jiangyu Li | 2021 | National Science Review2021，8，8： | 1 |
| 15 | Study on several mesoporous materials catalysts applied to the removal of trace olefins from aromatics and commercial sidestream tests 显示文摘 | CHEN Changwei WU Wenjuan ZENG Xiansong | 2009 | Industrial&Engineering Chemistry Research2009，48，10： | 1 |
| 16 | Structure and luminescence properties of SrAl 2 O 4 :Eu 2+ , Dy 3+ by Ba 2+ and Ca 2+ co-doping显示文摘 | Wei Xie Jun Quan Haoyi Wu Lexi Shao Changwei Zou Jun Zhang Xiaoyu Shi Yinhai Wang | 2011 | Journal of Alloys and Compounds2011，，： | 1 |
| 17 | 查看详情显示文摘 | Pang Changwei Wu Weidong Sheng Wei | | 0，，08： | 1 |
| 18 | Research on the Localization of High-Quality Teaching Resources显示文摘The emergence of the MOOC leads to the revolution of education.All people can be taught by excellent teachers.But the interest of most of the MOOC learners only last less than two weeks.The main reasons may be the courses too difficult to study and without the restraint mechanism.This paper tries to solve the problem that learners cannot last in a MOOC.We put forward that it is feasible to bring the MOOC of elite courses to general university classroom after the localization of high quality teaching resources.We imported Information and Entropy of MIT to the curriculum of Heilongjiang Institute of Technology.First,we combine with own school characteristics in Information and Entropy.Second,we brought part of Information and Entropy in our class and edit of the original video in some part.Third,we have a test in the end of the course.At last all of students of class finished the instructional video and got good grades in test.The method of bringing the MOOC of elite courses to the curriculum of general university outperforms that of traditional teaching meth. | Deng Hong Haoliang Qi Leilei Kong Changwei Wu An Bo | 2016 | 国际计算机前沿大会会议论文集2016，，2： | 1 |
| 19 | Is integrated coastal management an effective framework for promoting coastalsustainability in China's coastal cities? 显示文摘 | Guanqiong Ye Loke Ming Chou Shengyun Yang Jiap- ing Wu Pei Liu Changwei Jin | 2015 | Marine Poli- cy2015，，： | 1 |
| 20 | The Antimicrobial Protein REG3A Regulates Keratinocyte Proliferation and Differentiation after Skin Injury显示文摘 | Yuping Lai Dongqing Li Changwei Li Beda Muehleisen Katherine A. Radek Hyun Jeong Park Ziwei Jiang Zhiheng Li Hu Lei Yanchun Quan Tian Zhang Yelin Wu Paul Kotol Shin Morizane Tissa R. Hata Keiji Iwatsuki Ce Tang Richard L. Gallo | 2012 | Immunity2012，，1： | 1 |
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