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| 1 | Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum显示文摘典型药用的植物的主要成分,蓼 multiflorum (用汉语的 Heshouwu ) ,那导致特质的肝损害仍然保持不清楚。我们的以前的工作证明了有 lipopolysaccharide (LPS ) 的无毒的剂量和 Heshouwu 的治疗学的剂量的 cotreatment 能在老鼠导致肝损害,而独唱治疗不能导致看得见的损害。在现在的工作,用成分大美人和敲门在里面策略,我们发现 Heshouwu 的乙醇醋酸盐(EA ) 摘录在对待 LPS 的老鼠显示了可比较的特质的 hepatotoxicity 到整个摘录。结果显示血浆丙氨酸 aminotransferase, aspartate aminotransferase,和肝 histologic 的重要举起变化,而另外的分开的部分没能导致肝损害。有另外的分开的部分的 EA 摘录的混合在对待 LPS 的老鼠导致了可比较的特质的 hepatotoxicity 到整个摘录。化学分析进一步揭示了那 2,3,5,4-tetrahydroxy trans-stilbene-2-O -- 配糖物(trans-SG ) 和它的 cis 异构体是在 EA 的二主要混合物摘录。而且,孤立的 cis- ,并且不它的 trans 异构体,显示的可比较的特质的 hepatotoxicity 到在对待 LPS 的老鼠的 EA 摘录。cis-SG 的更高的内容从与收集的将军相比与 Heshouwu 联系的实际的肝沉醉病人在 Heshouwu 白酒或准备被检测样品。另外,血浆 metabolomics 分析证明 cis-SG-disturbing 充实显著地不同于的小径在对待 LPS 的老鼠的 trans-SG。所有这些结果建议 cis-SG 仔细与 Heshouwu 的特质的 hepatotoxicity 被联系。认为 trans-SG 的 cis-trans 异构化被紫外光或日光调停,我们的调查结果为在药发现控制 photoisomerization 并且为 Heshouwu 和芪相关的药的临床的使用用作参考。 | Chunyu Li Ming Niu Zhaofang Bai Congen Zhang Yanling Zhao Ruiyu Li Can Tu Huifang Li Jing Jing Yakun Meng Zhijie Ma Wuwen Feng Jinfa Tang Yun Zhu Jinjie Li Xiaoya Shang Zhengsheng Zou Xiaohe Xiao Jiabo Wang | 2017 | Frontiers of Medicine2017，11，2： | 41 |
| 2 | Immunological synergistic mechanisms of trans-/cis-stilbene glycosides in Heshouwu-related idiosyncratic liver injury显示文摘Heshouwu is a traditional non-toxic Chinese medicine commonly used in the clinical setting;however,clinical cases of Heshouwu-induced hepatotoxicity have been frequently reported^([1]).Pharmacoepidemiological studies have found that Heshouwu-induced liver injury occurs only in a small fraction of individuals taking the drug;these patients presented with the typ- | Lanzhi He Ping Yin Yakun Meng Jinfa Tang Tingting He Ming Niu Yuming Guo Yun Zhu Jing Jing Chunyu Li Zhijie Ma Jiabo Wang Zhaofang Bai Xiaohe Xiao | 2017 | Science Bulletin2017，62，11： | 29 |
| 3 | Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia显示文摘Male infertility, as a major issue of human reproduction health, prevents successful natural conception. Asthenoteratospermia mainly presents one or multiple anomalies in head, neck and tail of spermatozoa, and impairs sperm function and motility (Coutton et al., 2015). Recurrent abnormalities of the fibrous sheath lead to multiple morphological abnormaliries of the sperm flagella (MMAF), which is a quite frequent type of asthenoteratospermia in male infertility (Chemes et al., 1987;Ben Khelifa et al, 2014). | Wangjie Liu Huan Wu Li Wang Xiaoyu Yang Chunyu Liu Xiaojin He Weiyu Li Jiajia Wang Yujie Chen Hongyan Wang Yang Gao Shuyan Tang Shenmin Yang Li Jin Feng Zhang Yunxi Cao | 2019 | Journal of Genetics and Genomics2019，46，1： | 7 |
| 4 | Structural characteristics and magnetic properties of bulk nanocrystalline Fe_(84)Zr_2Nb_4B_(10) alloy prepared by mechanical alloying and spark plasma sintering consolidation显示文摘Magnetic properties of Fe84Zr2Nb4B10 sample were investigated. The sample was produced from nanocrystalline powders made by the mechanical alloying (MA) and consolidation using the spark plasma sintering (SPS) technique. Effects of milling time on phase transformation, structural characteristics, and magnetic properties of powders were examined by X-ray diffraction (XRD), scanning electron microscopy (SEM), and physical property measure system (PPMS), respectively. Results show that nanostructured α-Fe supersaturated solid solution is obtained in the final MAed products. The saturation magnetization (Ms) increased with increasing milling time and became constant at 130 h, but the coercivity (Hc) increased firstly and then decreased. The consolidated bulk sample exhibited a high density of 6.893 g·cm-3, there was no phase change during SPS process, and the saturation magnetization and susceptibility of the SPSed bulk sample improved in comparison with the milled powders. The variation of magnetic parameters can be explained by nano-scale effect and Herzer model. | Tang, Cuiyong Xiao, Zhiyu Luo, Fei Wang, Jun Ma, Chunyu Zhang, Wen | 2012 | Rare Metals2012，31，3： | 6 |
| 5 | Preparation and characterization of boron-doped corn straw biochar: Fe(Ⅱ) removal equilibrium and kinetics显示文摘Nowadays,iron ions as a ubiquitous heavy metal pollutant are gradually concerned and the convenient and quick removal of excessive iron ions in groundwater has become a major challenge for the safety of drinking water.In this study,boron-doped biochar(B-BC)was successfully prepared at various preparation conditions with the addition of boric acid.The as-prepared material has a more developed pore structure and a larger specific surface area(up to 897.97 m2/g).A series of characterization results shows that boric acid effectively activates biochar,and boron atoms are successfully doped on biochar.Compared with the ratio of raw materials,the pyrolysis temperature has a greater influence on the amount of boron doping.Based on Langmuir model,the maximum adsorption capacity of 800 B-BC1:2 at25℃,40℃,55℃ are 50.02 mg/g,95.09 mg/g,132.78 mg/g,respectively.Pseudo-second-order kinetic model can better describe the adsorption process,the adsorption process is mainly chemical adsorption.Chemical complexation,ions exchange,and co-precipitation may be the main mechanisms for Fe2+removal. | Long Sui Chunyu Tang Qing Du Ying Zhao Kui Cheng Fan Yang | 2021 | Journal of Environmental Sciences2021，33，8： | 6 |
| 6 | Thyristor Junction Temperature Estimation Based on Measured Temperature of Molybdenum Flat显示文摘为获得较准确的晶闸管结温,提出了基于晶闸管钼层实测温度计算结温的共扼梯度算法。分析了共轭梯度法用于求解结温的具体步骤,并通过FORTRAN语言编译形成LOG命令流,导入ANSYS软件中来实现算法,该方法对于未知的低频分量,以较少的迭代次数即可以得到准确解,对于未知的高频分量,通过多次的迭代也能够获得准确的返溯值,因而具备处理多个未知量且收敛速度快的优点。以KPD3000-72型晶闸管应用于直流输电领域为例,分别在直流稳态、单波次浪涌电流和3波次浪涌电流的试验条件下进行计算,结果表明所得结温准确,为传统热阻抗法提供了校核的依据。 | ZHANG Chunyu LI Chengrong HAN Xiaohui ZHA Kunpeng TANG Guangfu | 2012 | 中国电机工程学报2012，32，22： | 5 |
| 7 | Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia显示文摘Schizophrenia is a common disorder with a high heritability, but its genetic architecture is still elusive.We implemented whole-genome sequencing(WGS) analysis of 8 families with monozygotic(MZ) twin pairs discordant for schizophrenia to assess potential association of de novo mutations(DNMs) or inherited variants with susceptibility to schizophrenia. Eight non-synonymous DNMs(including one splicing site) were identified and shared by twins, which were either located in previously reported schizophrenia risk genes(p.V24689 I mutation in TTN, p.S2506 T mutation in GCN1L1, IVS3+1G > T in DOCK1) or had a benign to damaging effect according to in silico prediction analysis. By searching the inherited rare damaging or loss-of-function(LOF) variants and common susceptible alleles from three classes of schizophrenia candidate genes, we were able to distill genetic alterations in several schizophrenia risk genes, including GAD1, PLXNA2, RELN and FEZ1. Four inherited copy number variations(CNVs; including a large deletion at 16p13.11) implicated for schizophrenia were identified in four families, respectively. Most of families carried both missense DNMs and inherited risk variants, which might suggest that DNMs, inherited rare damaging variants and common risk alleles together conferred to schizophrenia susceptibility. Our results support that schizophrenia is caused by a combination of multiple genetic factors, with each DNM/variant showing a relatively small effect size. | Jinsong Tang Yu Fan Hong Li Qun Xiang Deng-Feng Zhang Zongchang Li Ying He Yanhui Liao Ya Wang Fan He Fengyu Zhang Yin Yao Shugart Chunyu Liu Yanqing Tang Raymond C.K.Chan Chuan-Yue Wang Yong-Gang Yao Xiaogang Chen | 2017 | Journal of Genetics and Genomics2017，44，6： | 4 |
| 8 | Features of long-term health monitored strains of a bridge with wavelet analysis显示文摘This paper analyses the five years' monitored strains collected from a long-term health monitoring system installed on a bridge with wavelet transform.In the analysis,the monitored strains are pre-processed,features of the monitored data are summarized briefly.The influences of the base functions on the results of wavelet analysis are studied simultaneously.The results show that the db wavelet is a good mother wavelet function in the analysis,and the order N should be larger than 20,but less than 46 in decomposing the monitored strains of the bridge.According to the strain variation features of concrete bridge,the proper decomposition level is 4 in the wavelet multi-resolution analysis.With the present method,the strains caused by random loads and daily sunlight can be accurately extracted from the monitored strains.The decomposed components of the monitored strains show that the amplitudes of the strains caused by random loads,daily sunlight,and annual temperature effect,are about 5 με,25 με,and 50 με respectively.The structural response under random load is smaller than the other parts. | Zejia Liu,Bin Jiang,Liqun Tang,Yiping Liu,Chunyu Zhang,and Yinghua Li School of Civil Engineering and Transportation,State Key Laboratory of Subtropical Building Science,South China University of Technology,Guangzhou 510640,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，5： | 3 |
| 9 | Neuroprotective role of edaravone and the effects of endoplasmic reticulum stress in an adult rat model of focal cerebral ischemia/reperfusion显示文摘BACKGROUND: Endoplasmic reticulum (ER) stress impairs ER functions and leads to the accumulation of unfolded or misfolded proteins in the ER lumen. ER stress-induced cell death plays an important role in cerebral ischemia. Edaravon (3-methyl-1-phenyl-2-pyrazolin-5-one) is a potent and novel scavenger of free radicals that inhibit delayed neuronal death, as demonstrated by in vitro and animal studies. However, its effect on ER stress and induced neuronal apoptosis in a rat model of brief middle cerebral artery occlusion remains unclear. OBJECTIVE: To explore the effects of edaravone on the expression of ER stress-related factors and neuronal apoptosis, based on the hypothesis that edaravone influences ER stress in a rat model of cerebral ischemia/reperfusion. DESIGN, TIME AND SETTING: A randomized, controlled, animal study was performed at the Laboratory of Department of Neurology, Xiangya Hospital and the Department of Laboratory Animals, Xiangya Medical College, Central South University in China from June 2005 to May 2006. MATERIALS: Edaravone was purchased from Simcere Pharmaceutical Group, China. METHODS: A total of 216 adult, male, Sprague Dawley rats were randomly assigned to sham-surgery, model and edaravone groups, with 72 rats in each group. Brief middle cerebral artery occlusion was established in the model and edaravone groups. In addition, the edaravone group rats were injected with 3 mg/kg edaravone through the tail vein. MAIN OUTCOME MEASURES: RNA-dependent protein kinase-like endoplasmic reticulum eukaryotic translation initiation factor 2α kinase (PERK) and C/EBP homology protein (CHOP) mRNA expression in the ischemic parietal cortex was determined by reverse transcription- polymerase chain reaction; phosphorylated PERK and CHOP protein expression was detected by immunohistochemistry; neuronal apoptosis was detected by TdT-mediated-dUTP nick end labeling. RESULTS: Neurological deficit scores were significantly reduced in the edaravone group compared to the model group at 12, 24, and 72 hours following reperfusion (P < 0.05). In addition, PERK and CHOP mRNA as well as phosphorylated PERK and CHOP protein expression were significantly reduced in the edaravone group compared to the model group at 1, 3, and 6 hours following reperfusion (P < 0.05, P < 0.01). CHOP mRNA expression was decreased in the edaravone group compared to the model group at 3, 6, 12, and 24 hours following reperfusion (P < 0.01), while CHOP protein expression was less than the model group at 6, 12, and 24 hours following reperfusion (P < 0.05). CONCLUSION: Edaravone treatment resulted in decreased PERK and CHOP expression following ischemia/reperfusion, as well as reduced neuronal apoptosis. Edaravone exhibited a neuroprotective role by inhibiting endoplasmic reticulum stress. | Xiangmin Shen Liming Tan Yunhai Liu Hainan Zhang Chunyu Wang Qidong Yang QingHuang Lin Zhou Zhenyu Tang | 2010 | Neural Regeneration Research2010，5，3： | 2 |
| 10 | Modeling multiple chemical equilibrium for reactive extraction of naproxen enantiomers with HP-β-CD as hydrophilic selector显示文摘Reactive extraction is an emerging technology for large-scale continuous resolution of drug enantiomers.The enantioselective extraction of R,S-naproxen by hydrophilic HP-β-CD in 1,2-dichloroethane was studied at 5 °C.The experimental data were described by a reactive extraction model with a homogeneous aqueous phase reaction of R,S-naproxen with HP-β-CD which couples a complete description of chemical equilibria in aqueous phase with the overall phase equilibria of the system.Important parameters of this model were determined experimentally.The physical distribution coefficients for molecular and ionic NAP were 0.041 and 1.730,respectively.Here we show that the efficiency of extraction depends strongly on two process variables including pH and HP-β-CD concentration.The model predictions are compared graphically with the results of previous experiments and there is a good agreement between each other.By the use of modeling and experiment,an optimized extraction condition with pH of 2.5 and HP-β-CD concentration of 0.1 mol/L was obtained with high enantioselectivity(α) of 1.59 and performance factor(pf) of 0.049.The model gives a good means of predicting enantiomers partitioning over a range of experimental conditions. | TANG KeWen ZHANG PanLiang PAN ChunYue LI HongJian | 2011 | Science China Chemistry2011，54，7： | 2 |
| 11 | Low-efficiency-droop InGaN quantum dot light-emitting diodes operating in the “green gap”显示文摘Gallium nitride(Ga N)-based light-emitting diodes(LEDs)are important for lighting and display applications.In this paper,we demonstrate green-emission(512 nm)In Ga N quantum dot(QD)LEDs grown on a c-plane sapphire substrate by metal-organic chemical vapor deposition.A radiative lifetime of 707 ps for the uniform In Ga N self-assembled QDs is obtained by time-resolved photoluminescence measurement at 18 K.The screening of the built-in fields in the QDs effectively improves the performance of QD LEDs.These high quantum efficiency and high temperature stability green QD LEDs are able to operate with negligible efficiency droop and with current density up to 106 A∕cm^2.Our results show that In Ga N QDs may be a viable option as the active medium for stable LEDs. | CHUNYU ZHAO CHAK WAH TANG BILLY LAI GUANGHUI CHENG JIANNONG WANG KEI MAY LAU | 2020 | Photonics Research2020，8，5： | 2 |
| 12 | Effects of duckweed(Spriodela polyrrhiza)remediation on the composition of dissolved organic matter in effluent of scale pig farms显示文摘The swine effluent studied was collected from scale pig farms,located in Yujiang County of Jiangxi Province,China,and duckweed(Spriodela polyrrhiza) was selected to dispose the effluent.The purpose of this study was to elucidate the effects of duckweed growth on the dissolved organic matter composition in swine effluent.Throughout the experiment period,the concentrations of organic matter were determined regularly,and the excitationemission matrix(3DEEM) spectroscopy was used to characterize the fluorescence component.Compared with no-duckweed treatments(controls),the specific ultra-violet absorbance at 254 nm(SUVA_(254)) was increased by a final average of 34.4%as the phytoremediation using duckweed,and the removal rate of DOC was increased by a final average of 28.0%.In swine effluent,four fluorescence components were identified,including two protein-like(tryptophan,tyrosine) and two humic-like(fulvic acids,humic acids) components.For all treatments,the concentrations of protein-like components decreased by a final average of 69.0%.As the growth of duckweed,the concentrations of humic-like components were increased by a final average of 123.5%than controls.Significant and positive correlations were observed between SUVA_(254) and humic-like components.Compared with the controls,the humification index(HIX) increased by a final average of 9.0%for duckweed treatments.Meanwhile,the duckweed growth leaded to a lower biological index(BIX) and a higher proportion of microbial-derived fulvic acids than controls.In conclusion,the duckweed remediation not only enhanced the removal rate of organic matter in swine effluent,but also increased the percent of humic substances. | Lei Li Ming Liu Meng Wu Chunyu Jiang Xiaofen Chen Xiaoyan Ma Jia Liu Weitao Li Xiaoxue Tang Zhongpei Li | 2017 | Journal of Environmental Sciences2017，29，5： | 2 |
| 13 | Carbon Materials Advancing Microorganisms in Driving Soil Organic Carbon Regulation显示文摘Carbon emission from soil is not only one of the major sources of greenhouse gases but also threatens biological diversity,agricultural productivity,and food security.Regulation and control of the soil carbon pool are political practices in many countries around the globe.Carbon pool management in engineering sense is much bigger and beyond laws and monitoring,as it has to contain proactive elements to restore active c arbon.Biogeochemistry teaches us that soil microorganisms are crucial to manage the carbon content efctivelye Adding carbon materials to soil is thereby not directly sequestration,as interaction of appropriately designed materials with the soil microbiome can result in both:metabolization and thereby nonsustainable use of the added carbon,or-more favorably-a biological amplifcation of human efforts and sequestration of extra CO,by microbial growth.We review here potential approaches to govern soil arbon,with a special focus set on the emerging practice of adding manufactured carbon materials to control soil carbon and its biological dynamiss.Notably,research on so called'biochar'is already relatively mature,while the role of artifidial humic substance(A-HS)in microbial carbon sequestration is still in the developing stage.However,it is shown that the preparation and application of A-HS are large biological levers,as they directly interact with the envir onment and community building of the biological soil system.We believe that A HS can play a central role in stabilzing carbon pools in soil. | Chunyu Tang Fan Yang Markus Antonietti | 2022 | Research2022，，2： | 2 |
| 14 | Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages显示文摘Myocardial dysfunction is the most serious complication of sepsis.Sepsis-induced myocardial dysfunction(SMD)is often associated with gastrointestinal dysfunction,but its pathophysiological significance remains unclear.The present study found that patients with SMD had higher plasma gastrin concentrations than those without SMD.In mice,knockdown of the gastrin receptor,cholecystokinin B receptor(Cckbr),aggravated lipopolysaccharide(LPS)-induced cardiac dysfunction and increased inflammation in the heart,whereas the intravenous administration of gastrin ameliorated SMD and cardiac injury.Macrophage infiltration plays a significant role in SMD because depletion of macrophages by the intravenous injection of clodronate liposomes,48 h prior to LPS administration,alleviated LPSinduced cardiac injury in Cckbr-deficient mice.The intravenous injection of bone marrow macrophages(BMMs)overexpressing Cckbr reduced LPS-induced myocardial dysfunction.Furthermore,gastrin treatment inhibited toll-like receptor 4(TLR4)expression through the peroxisome proliferator-activated receptor a(PPAR-a)signaling pathway in BMMs.Thus,our findings provide insights into the mechanism of the protective role of gastrin/CCKBR in SMD,which could be used to develop new treatment modalities for SMD. | Dandong Fang Yu Li Bo He Daqian Gu Mingming Zhang Jingwen Guo Hongmei Ren Xinyue Li Ziyue Zhang Ming Tang Xingbing Li Donghai Yang Chunmei Xu Yijie Hu Hongyong Wang Pedro AJose Yu Han Chunyu Zeng | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 1 |
| 15 | Thrombin receptor and ventricular arrhythmias after acute myocardial infarction显示文摘 | Lilong Tang Chunyu Deng Ming long | 2008 | Mol Med2008，14，34： | 1 |
| 16 | Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension显示文摘 | Zhang Qingyou Du Junbao Zhou Weijin Yan Hui Tang Chaoshu Zhang Chunyu | 2004 | Biochemical and Biophysical Research Communications2004，，1： | 1 |
| 17 | The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats显示文摘 | Zhang Chunyu Du Junbao Bu Dingfang Yan Hui Tang Xiuying Tang Chaoshu | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
| 18 | A homozygous frameshift mutation in ADAD2 causes male infertility with spermatogenic impairments显示文摘Male infertility is a complex reproductive disorder that impedes a huge number of couples from having children naturally in the world(Agarwal et al.,2021).As an important pathogenic factor of male infertility,spermatogenic impairments are mainly characterized by impaired male gamete production,reduced sperm quality,or function(Tournaye et al.,2017).Spermatogenesis is a delicate and complex biological process that requires the collaboration of a large number of proteins performing different biological functions(Liu et al.,2021). | Shixiong Tian Ziqi Wang Liting Liu Yiling Zhou Yue Lv Dongdong Tang Jiaxiong Wang Jing Jiang Huan Wu Shuyan Tang Guanxiong Wang Hao Geng Fangbiao Tao Hongbin Liu Xiaojin He Feng Zhang Jinsong Li Li Jin Tao Huang Chunyu Liu Yunxia Cao | 2023 | Journal of Genetics and Genomics2023，50，4： | 0 |
| 19 | New Insights of Neuromedin B and Its Receptor NMBR Involvement in Immunity显示文摘Neuromedin B(NMB)is a member of mammalian bombesin-like peptide family and almost all its potent biological actions take place exclusively through its receptor NMBR,which has been identified as a G-protein couple receptor with seven trans-membrane regions.NMB and NMBR represent an interesting signaling axis over which NMB/NMBR perform multiple biological activities,in particularly,they have been highlighted in the regulation of the immunology system.This review aims to provide a brief overview of the recent advancements in our understanding regarding the potential immunological functions of NMB and NMBR in cell proliferation,tumorigenesis,angiogenesis,neurogenic inflammation,anti-influenza A virus(IAV)infections,and briefly discusses the potential importance of these observations.All these implicated that targeting NMBR or developing analogues of NMB may represent a useful strategy for development of new anti-IAV agents. | Chunyu LI Yijie MA Shimao TIAN Qianhui WAN Mengyao TANG Hongya NING Shujie MA Guihong YANG | 2021 | Asian Agricultural Research2021，13，6： | 0 |
| 20 | Modeling of Mesoscale Creep Behaviors and Macroscale Creep Responses of Composite Fuels Under Irradiation Conditions显示文摘A finite-strain homogenization creep model for composite fuels under irradiation conditions is developed and verified,with the irradiation creep strains of the fuel particles and matrix correlated to the macroscale creep responses,excluding the contributions of volumetric strain induced by the irradiation swelling deformations of fuel particles.A finite element(FE)modeling method for uniaxial tensile creep tests is established with the irradiation effects of nuclear materials taken into account.The proposed models and simulation strategy are numerically implemented to a kind of composite nuclear fuel,and the predicted mesoscale creep behaviors and the macroscale creep responses are investigated.The research results indicate that:(1)the macroscale creep responses and the mesoscale stress and strain fields are all greatly affected by the irradiation swelling of fuel particles,owing to the strengthened mechanical interactions between the fuel particles and the matrix.(2)The effective creep rates for a certain case are approximately two constants before and after the critical fission density,which results from the accelerated fission gas swelling after fuel grain recrystallization,and the effects of macroscale tensile stress will be more enhanced at higher temperatures.(3)The macroscale creep contributions from the fuel particles and matrix depend mainly on the current volume fractions varying with fission density.(4)As a function of the macroscale stress,temperature,initial particle volume fraction and particle fission rate,a multi-variable mathematical model for effective creep rates is fitted out for the considered composite fuels,which matches well with the FE predictions.This study supplies important theoretical models and research methods for the multi-scale creep behaviors of various composite fuels and provides a basis for simulation of the thermal–mechanical behavior in related composite fuel elements and assemblies. | Jing Zhang Jingyu Zhang Haoyu Wang Changbing Tang Pan Yuan Chunyu Yin Shurong Ding Yuanming Li | 2022 | Acta Mechanica Solida Sinica2022，35，6： | 0 |
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